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- This topic has 69 replies, 22 voices, and was last updated 9 years, 3 months ago by
casagrayson.
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- September 7, 2016 at 2:55 pm
Hi everyone-
Just wanted to give an update. So after fevers wouldn't relent, my onc did more blood work and blood cultures. Blood work showed elevated liver enzymes. Though she said not horrible, there was significant increase in AST, ALT and Alklaine Phosphate. Also slight decrease in urea nitrogen but didn't appear to be overly significant. LDH shot up to 423 which has typically hovered around 170-200. Follow up blood test showed decrease in LDH…now 323. AST went down a bit while ALT stayed the same and Alkaline Phosphate went up. I'm not quite sure what all this means but I know it's not good. She said its either the disease or yervoy(immune hepatitis). So another set of blood work tomorrow and abdomen CT. I'm scared to say the least.These numbers keep me out of Adoptive Cell trial at MDA. I have to hope it immune system and I'm trying to be positive but I'm struggling. Constant disappointment. Not to mention that a new plan will need to be figured out. I have TIL product which I'm so grateful for but I have to get in line so there's a wait there…what to do in the interim. Any suggestions? Heard about s trial at Duke. Just feel a sense of urgency. MDA trial finish line is within steps…..
Josh
- Replies
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- September 7, 2016 at 5:03 pm
Hey Josh!
Really sorry you keep finding those bumps in the road, but, maybe it's not totally bad… Did you take any medicine for those fevers you have been having? Many medicine for fevers (among others) are known to mess up liver enzymes…
Hang in there and we all hope for some more encouraging results tomorrow…
love,
Patrisa
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- September 7, 2016 at 5:03 pm
Hey Josh!
Really sorry you keep finding those bumps in the road, but, maybe it's not totally bad… Did you take any medicine for those fevers you have been having? Many medicine for fevers (among others) are known to mess up liver enzymes…
Hang in there and we all hope for some more encouraging results tomorrow…
love,
Patrisa
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- September 7, 2016 at 5:03 pm
Hey Josh!
Really sorry you keep finding those bumps in the road, but, maybe it's not totally bad… Did you take any medicine for those fevers you have been having? Many medicine for fevers (among others) are known to mess up liver enzymes…
Hang in there and we all hope for some more encouraging results tomorrow…
love,
Patrisa
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- September 7, 2016 at 5:08 pm
Josh, my dad had a fever and then elevated enzymes. It was due to the Yervoy. Immidiatelt stabilized with steroids. It is probably drug related. Thinking of you. Keep us updated. -
- September 7, 2016 at 5:08 pm
Josh, my dad had a fever and then elevated enzymes. It was due to the Yervoy. Immidiatelt stabilized with steroids. It is probably drug related. Thinking of you. Keep us updated. -
- September 7, 2016 at 5:08 pm
Josh, my dad had a fever and then elevated enzymes. It was due to the Yervoy. Immidiatelt stabilized with steroids. It is probably drug related. Thinking of you. Keep us updated. -
- September 7, 2016 at 5:27 pm
Josh, it's hard not to fixate on the worst possible scenario. An elevated liver enzyme on it's own does not paint a diagnostic picture, but looking at the big picture, having all three elevated (and those three in particular) are in line with drug induced hepatitis. Unfortunately, when it comes to medicines our livers seem to take the biggest hit.
I will be saving my prayers for you tonight Josh! You deserve some good news! You are an inspiration. All the best tomorrow.
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- September 7, 2016 at 5:27 pm
Josh, it's hard not to fixate on the worst possible scenario. An elevated liver enzyme on it's own does not paint a diagnostic picture, but looking at the big picture, having all three elevated (and those three in particular) are in line with drug induced hepatitis. Unfortunately, when it comes to medicines our livers seem to take the biggest hit.
I will be saving my prayers for you tonight Josh! You deserve some good news! You are an inspiration. All the best tomorrow.
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- September 7, 2016 at 5:27 pm
Josh, it's hard not to fixate on the worst possible scenario. An elevated liver enzyme on it's own does not paint a diagnostic picture, but looking at the big picture, having all three elevated (and those three in particular) are in line with drug induced hepatitis. Unfortunately, when it comes to medicines our livers seem to take the biggest hit.
I will be saving my prayers for you tonight Josh! You deserve some good news! You are an inspiration. All the best tomorrow.
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- September 7, 2016 at 6:15 pm
Oh man!!! Gosh Josh this just stinks! I hate it that you have to hurry up and wait all of this while the clock is ticking!
As others have said, Ipi and Pembro have whacked out my liver enzymes. Steroids put the numbers back in to the normalish range. Maybe this will work for you to? Don't know. Just know that I am praying for you and your team that you will get a good, healing plan in place. Oh yea, and also for peace for your heart.
Shalom,
Julie
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- September 7, 2016 at 6:15 pm
Oh man!!! Gosh Josh this just stinks! I hate it that you have to hurry up and wait all of this while the clock is ticking!
As others have said, Ipi and Pembro have whacked out my liver enzymes. Steroids put the numbers back in to the normalish range. Maybe this will work for you to? Don't know. Just know that I am praying for you and your team that you will get a good, healing plan in place. Oh yea, and also for peace for your heart.
Shalom,
Julie
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- September 7, 2016 at 6:15 pm
Oh man!!! Gosh Josh this just stinks! I hate it that you have to hurry up and wait all of this while the clock is ticking!
As others have said, Ipi and Pembro have whacked out my liver enzymes. Steroids put the numbers back in to the normalish range. Maybe this will work for you to? Don't know. Just know that I am praying for you and your team that you will get a good, healing plan in place. Oh yea, and also for peace for your heart.
Shalom,
Julie
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- September 7, 2016 at 7:47 pm
So very sorry, Joshie!! Will be waiting to hear about the upcoming scans. But…why not keep this simple and do Nivo (Opdivo) or Pembro (Keytruda)? You haven't used an anti-PD1 product, right????
There is also this trial currently recruiting: https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
It seems to have two arms. One arm will be given pembro with a JAK inhibitor and the other will get pembro with a Pl3K-delta inhibitor.
There were also these ideas that I had mentioned before: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html
Hang in there. You are tough enough to handle this even though it sucks great big green hairy wizard balls. Keep us posted. Love, celeste
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- September 7, 2016 at 8:12 pm
Unfortunately I did Nivo, that when I progressed in May. So far it's been ipi 2x for total of 7 doses and like 5 months of Nivo. Really hoping this is immune hepatitis and we can get under control quick. I need to put one in the win column. And thanks again for trial info, I've kept those on file. Still hoping this adoptive cell will happen or I'll get on TIL list ASAP. You're awesome Celeste.
Josh
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- September 7, 2016 at 9:46 pm
Ok…I was having a brain fart and couldn't quite remember how all that went. But…still good…cause that would mean you should qualify for this trial – it is specifically for folks who advanced on anti-PD1 (which I thought was you, but then second guessed myself when I couldn't find a record of it in your stuff!!) It is the one with the 2 arms (Pembro with JAK inhibitor OR pembro and the delta inhibitor) – https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
But….there is this one also….that I meant to be the one I included in the first response….https://clinicaltrials.gov/ct2/show/NCT02475213 It is pembro with enoblituzumab….and it doesn't seem to matter if you have had anti-PD1 or not.
Sorry for the confusion. Anyhow…I agree with you…and am mostly hoping that this glitch works itself out and you can just carry on with the plan you had!!! love, c
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- September 7, 2016 at 9:46 pm
Ok…I was having a brain fart and couldn't quite remember how all that went. But…still good…cause that would mean you should qualify for this trial – it is specifically for folks who advanced on anti-PD1 (which I thought was you, but then second guessed myself when I couldn't find a record of it in your stuff!!) It is the one with the 2 arms (Pembro with JAK inhibitor OR pembro and the delta inhibitor) – https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
But….there is this one also….that I meant to be the one I included in the first response….https://clinicaltrials.gov/ct2/show/NCT02475213 It is pembro with enoblituzumab….and it doesn't seem to matter if you have had anti-PD1 or not.
Sorry for the confusion. Anyhow…I agree with you…and am mostly hoping that this glitch works itself out and you can just carry on with the plan you had!!! love, c
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- September 7, 2016 at 9:46 pm
Ok…I was having a brain fart and couldn't quite remember how all that went. But…still good…cause that would mean you should qualify for this trial – it is specifically for folks who advanced on anti-PD1 (which I thought was you, but then second guessed myself when I couldn't find a record of it in your stuff!!) It is the one with the 2 arms (Pembro with JAK inhibitor OR pembro and the delta inhibitor) – https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
But….there is this one also….that I meant to be the one I included in the first response….https://clinicaltrials.gov/ct2/show/NCT02475213 It is pembro with enoblituzumab….and it doesn't seem to matter if you have had anti-PD1 or not.
Sorry for the confusion. Anyhow…I agree with you…and am mostly hoping that this glitch works itself out and you can just carry on with the plan you had!!! love, c
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- September 7, 2016 at 8:12 pm
Unfortunately I did Nivo, that when I progressed in May. So far it's been ipi 2x for total of 7 doses and like 5 months of Nivo. Really hoping this is immune hepatitis and we can get under control quick. I need to put one in the win column. And thanks again for trial info, I've kept those on file. Still hoping this adoptive cell will happen or I'll get on TIL list ASAP. You're awesome Celeste.
Josh
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- September 7, 2016 at 8:12 pm
Unfortunately I did Nivo, that when I progressed in May. So far it's been ipi 2x for total of 7 doses and like 5 months of Nivo. Really hoping this is immune hepatitis and we can get under control quick. I need to put one in the win column. And thanks again for trial info, I've kept those on file. Still hoping this adoptive cell will happen or I'll get on TIL list ASAP. You're awesome Celeste.
Josh
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- September 7, 2016 at 7:47 pm
So very sorry, Joshie!! Will be waiting to hear about the upcoming scans. But…why not keep this simple and do Nivo (Opdivo) or Pembro (Keytruda)? You haven't used an anti-PD1 product, right????
There is also this trial currently recruiting: https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
It seems to have two arms. One arm will be given pembro with a JAK inhibitor and the other will get pembro with a Pl3K-delta inhibitor.
There were also these ideas that I had mentioned before: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html
Hang in there. You are tough enough to handle this even though it sucks great big green hairy wizard balls. Keep us posted. Love, celeste
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- September 7, 2016 at 7:47 pm
So very sorry, Joshie!! Will be waiting to hear about the upcoming scans. But…why not keep this simple and do Nivo (Opdivo) or Pembro (Keytruda)? You haven't used an anti-PD1 product, right????
There is also this trial currently recruiting: https://clinicaltrials.gov/ct2/show/NCT02646748?term=JAK&recr=Open&cond=%22Melanoma%22&rank=1
It seems to have two arms. One arm will be given pembro with a JAK inhibitor and the other will get pembro with a Pl3K-delta inhibitor.
There were also these ideas that I had mentioned before: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html
Hang in there. You are tough enough to handle this even though it sucks great big green hairy wizard balls. Keep us posted. Love, celeste
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- September 7, 2016 at 8:37 pm
I will be participating in a trial Duke the this month. I was not a yervoy responder . The trial at DUKE Durvalumab, Tremelimumab, IMCgp100. I have no idea what to expectect. The info in on the DUKE Web sight.
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- September 7, 2016 at 8:37 pm
I will be participating in a trial Duke the this month. I was not a yervoy responder . The trial at DUKE Durvalumab, Tremelimumab, IMCgp100. I have no idea what to expectect. The info in on the DUKE Web sight.
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- September 7, 2016 at 8:37 pm
I will be participating in a trial Duke the this month. I was not a yervoy responder . The trial at DUKE Durvalumab, Tremelimumab, IMCgp100. I have no idea what to expectect. The info in on the DUKE Web sight.
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- September 7, 2016 at 9:08 pm
I get my 4th round of Yervoy/Opdivo on 09/09/2016. I have been running fever for 6 weeks. When it first started I went to the ER like I was told. Blood work was all normal. Dr put me on antibiotics and sent me home. Two days later my fever has not gone away so they told me to come back in for more labs. In 3 days my liver count was 6 times above the max number so they hospitilized me and stopped the antibiotics. They ran every test for infection they could even drawing 10 tubes of blood at one time. After 3 days my liver count had went way down and all tests were negative and they sent me home. Two weeks later my liver count is still elevated some but still goes down. It may be high due to the amount of medicine I take to keep the fever under control, every 4 hours or it returns. It is like no other fever I have had. The chills are so bad that even in the hot tub I still shiver. It did stop for 4 days last week but it returned. This will be my last dose of Yervoy so I hope the fever stops.
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- September 7, 2016 at 9:08 pm
I get my 4th round of Yervoy/Opdivo on 09/09/2016. I have been running fever for 6 weeks. When it first started I went to the ER like I was told. Blood work was all normal. Dr put me on antibiotics and sent me home. Two days later my fever has not gone away so they told me to come back in for more labs. In 3 days my liver count was 6 times above the max number so they hospitilized me and stopped the antibiotics. They ran every test for infection they could even drawing 10 tubes of blood at one time. After 3 days my liver count had went way down and all tests were negative and they sent me home. Two weeks later my liver count is still elevated some but still goes down. It may be high due to the amount of medicine I take to keep the fever under control, every 4 hours or it returns. It is like no other fever I have had. The chills are so bad that even in the hot tub I still shiver. It did stop for 4 days last week but it returned. This will be my last dose of Yervoy so I hope the fever stops.
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- September 7, 2016 at 9:08 pm
I get my 4th round of Yervoy/Opdivo on 09/09/2016. I have been running fever for 6 weeks. When it first started I went to the ER like I was told. Blood work was all normal. Dr put me on antibiotics and sent me home. Two days later my fever has not gone away so they told me to come back in for more labs. In 3 days my liver count was 6 times above the max number so they hospitilized me and stopped the antibiotics. They ran every test for infection they could even drawing 10 tubes of blood at one time. After 3 days my liver count had went way down and all tests were negative and they sent me home. Two weeks later my liver count is still elevated some but still goes down. It may be high due to the amount of medicine I take to keep the fever under control, every 4 hours or it returns. It is like no other fever I have had. The chills are so bad that even in the hot tub I still shiver. It did stop for 4 days last week but it returned. This will be my last dose of Yervoy so I hope the fever stops.
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- September 7, 2016 at 9:19 pm
Gosh Josh,
You are giving me a case of survivor guilt. As you continue to struggle with side-effects of treatment, and emotional grief brought on by the uncertainty of the future, I am feeling bad because despite my own issues, I am skating along whistling Dixie. Of course running an LDH count at or above 500 for the last 6 months is reminder that there's something rotten in Denmark, I am really feeling your pain and frustration. I have little to add but that we all hope your scans, and short-term diagnosis is such that your desired treatment gets back on track in a hurry. Remember our fight, is to find, and sometimes demand the treatments we desire, and not an internal battle which only serves to weaken the body and mind we are trying to heal. Hang in there buddy!
Gary
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- September 7, 2016 at 9:19 pm
Gosh Josh,
You are giving me a case of survivor guilt. As you continue to struggle with side-effects of treatment, and emotional grief brought on by the uncertainty of the future, I am feeling bad because despite my own issues, I am skating along whistling Dixie. Of course running an LDH count at or above 500 for the last 6 months is reminder that there's something rotten in Denmark, I am really feeling your pain and frustration. I have little to add but that we all hope your scans, and short-term diagnosis is such that your desired treatment gets back on track in a hurry. Remember our fight, is to find, and sometimes demand the treatments we desire, and not an internal battle which only serves to weaken the body and mind we are trying to heal. Hang in there buddy!
Gary
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- September 7, 2016 at 9:19 pm
Gosh Josh,
You are giving me a case of survivor guilt. As you continue to struggle with side-effects of treatment, and emotional grief brought on by the uncertainty of the future, I am feeling bad because despite my own issues, I am skating along whistling Dixie. Of course running an LDH count at or above 500 for the last 6 months is reminder that there's something rotten in Denmark, I am really feeling your pain and frustration. I have little to add but that we all hope your scans, and short-term diagnosis is such that your desired treatment gets back on track in a hurry. Remember our fight, is to find, and sometimes demand the treatments we desire, and not an internal battle which only serves to weaken the body and mind we are trying to heal. Hang in there buddy!
Gary
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- September 7, 2016 at 9:55 pm
Hi josh
thanks for updating us. Not surprised that our liver functions are struggling. Mine is also 4 times normal ( partly because of antibiotics that I am getting for possible tb, caused by infliximab for immuno side effects!)
but we will get there. You are the best advocate I've seen on here. Just keep doing what you are doing. An inspiration to us all
anne-Louise
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- September 7, 2016 at 9:55 pm
Hi josh
thanks for updating us. Not surprised that our liver functions are struggling. Mine is also 4 times normal ( partly because of antibiotics that I am getting for possible tb, caused by infliximab for immuno side effects!)
but we will get there. You are the best advocate I've seen on here. Just keep doing what you are doing. An inspiration to us all
anne-Louise
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- September 7, 2016 at 9:55 pm
Hi josh
thanks for updating us. Not surprised that our liver functions are struggling. Mine is also 4 times normal ( partly because of antibiotics that I am getting for possible tb, caused by infliximab for immuno side effects!)
but we will get there. You are the best advocate I've seen on here. Just keep doing what you are doing. An inspiration to us all
anne-Louise
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- September 8, 2016 at 12:29 am
Hi Josh-
I am going to remain hopeful that all your elevated numbers are medication induced….Keeping my fingers crossed for a good scan tomorrow.
Though i know you are trying to stay one step ahead, and always have the next plan, lets get your scan results back, and go from there…..
Im going with immune hepatitis until proven otherwise.
For now, sending you my best thoughts!!!!!!!
Will wait for your next post,
best,
jenny
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- September 8, 2016 at 12:29 am
Hi Josh-
I am going to remain hopeful that all your elevated numbers are medication induced….Keeping my fingers crossed for a good scan tomorrow.
Though i know you are trying to stay one step ahead, and always have the next plan, lets get your scan results back, and go from there…..
Im going with immune hepatitis until proven otherwise.
For now, sending you my best thoughts!!!!!!!
Will wait for your next post,
best,
jenny
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- September 8, 2016 at 12:29 am
Hi Josh-
I am going to remain hopeful that all your elevated numbers are medication induced….Keeping my fingers crossed for a good scan tomorrow.
Though i know you are trying to stay one step ahead, and always have the next plan, lets get your scan results back, and go from there…..
Im going with immune hepatitis until proven otherwise.
For now, sending you my best thoughts!!!!!!!
Will wait for your next post,
best,
jenny
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- September 8, 2016 at 1:18 am
Josh I have read your post so many times today trying to come up with something inspirational to say. The fact is i just hurt for you man. I know how your feeling so much it scares the crap out of me. I think this is why people call us and others warriors. Not because we can and have to put up with the physical pain from disease and all the meds but because we dig deep and find a way to battle the mental process it takes to survive. You have it my friend, I know you’ll find a way to beat this bump and come through. Your strong just like many others here. I’m grateful to know you even though we never met I feel like we have. I know you talked to Luke and I looked at there site today… IF you can’t get in your trial maybe something at the University? They seem to have a bunch of stuff geared towards people failing pd-1. Also remember Mat failed ipi and nivo separately but together is doing something different for him. I’m praying for you tonight thanks for the update. -
- September 8, 2016 at 1:18 am
Josh I have read your post so many times today trying to come up with something inspirational to say. The fact is i just hurt for you man. I know how your feeling so much it scares the crap out of me. I think this is why people call us and others warriors. Not because we can and have to put up with the physical pain from disease and all the meds but because we dig deep and find a way to battle the mental process it takes to survive. You have it my friend, I know you’ll find a way to beat this bump and come through. Your strong just like many others here. I’m grateful to know you even though we never met I feel like we have. I know you talked to Luke and I looked at there site today… IF you can’t get in your trial maybe something at the University? They seem to have a bunch of stuff geared towards people failing pd-1. Also remember Mat failed ipi and nivo separately but together is doing something different for him. I’m praying for you tonight thanks for the update. -
- September 8, 2016 at 1:18 am
Josh I have read your post so many times today trying to come up with something inspirational to say. The fact is i just hurt for you man. I know how your feeling so much it scares the crap out of me. I think this is why people call us and others warriors. Not because we can and have to put up with the physical pain from disease and all the meds but because we dig deep and find a way to battle the mental process it takes to survive. You have it my friend, I know you’ll find a way to beat this bump and come through. Your strong just like many others here. I’m grateful to know you even though we never met I feel like we have. I know you talked to Luke and I looked at there site today… IF you can’t get in your trial maybe something at the University? They seem to have a bunch of stuff geared towards people failing pd-1. Also remember Mat failed ipi and nivo separately but together is doing something different for him. I’m praying for you tonight thanks for the update. -
- September 8, 2016 at 1:48 am
Josh,
Sorry man. As the others have said I hope this is just treatment induced issues that can be quickly resolved so you can get started on the MDA trial.
The Duke trial Lee is entering is:
https://clinicaltrials.gov/ct2/show/:?term=IMCgp100&rank=3
The interesting part about that trial is the IMCGP100. The other two drugs in the trial is another version of PD-L1 and Ipi. There is a site in St. Louis that may be more convenient to you.
NCI had a couple trials they recommended to me:
https://clinicaltrials.gov/ct2/show/study/NCT02517398?show_locs=Y#locn
This is some info on the drug in the above trial
http://cancerintel.com/msb0011359c-overview-m7824/
The 2nd trial is:
https://clinicaltrials.gov/ct2/show/NCT02452268
Hang in there.
Brian
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- September 8, 2016 at 1:48 am
Josh,
Sorry man. As the others have said I hope this is just treatment induced issues that can be quickly resolved so you can get started on the MDA trial.
The Duke trial Lee is entering is:
https://clinicaltrials.gov/ct2/show/:?term=IMCgp100&rank=3
The interesting part about that trial is the IMCGP100. The other two drugs in the trial is another version of PD-L1 and Ipi. There is a site in St. Louis that may be more convenient to you.
NCI had a couple trials they recommended to me:
https://clinicaltrials.gov/ct2/show/study/NCT02517398?show_locs=Y#locn
This is some info on the drug in the above trial
http://cancerintel.com/msb0011359c-overview-m7824/
The 2nd trial is:
https://clinicaltrials.gov/ct2/show/NCT02452268
Hang in there.
Brian
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- September 8, 2016 at 3:15 am
Good luck Josh, will be praying for you
i am hoping the liver results are ipi related – this is what happened to me after only one ipi does and the numbers improved markedly after taking steroids
But i dont know what taking steroids would imply in terms of your treatment
appreciate your posts and your support for all of us
hope the scans and blood tests are good
good luck
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- September 8, 2016 at 3:15 am
Good luck Josh, will be praying for you
i am hoping the liver results are ipi related – this is what happened to me after only one ipi does and the numbers improved markedly after taking steroids
But i dont know what taking steroids would imply in terms of your treatment
appreciate your posts and your support for all of us
hope the scans and blood tests are good
good luck
-
- September 8, 2016 at 3:15 am
Good luck Josh, will be praying for you
i am hoping the liver results are ipi related – this is what happened to me after only one ipi does and the numbers improved markedly after taking steroids
But i dont know what taking steroids would imply in terms of your treatment
appreciate your posts and your support for all of us
hope the scans and blood tests are good
good luck
-
- September 8, 2016 at 1:48 am
Josh,
Sorry man. As the others have said I hope this is just treatment induced issues that can be quickly resolved so you can get started on the MDA trial.
The Duke trial Lee is entering is:
https://clinicaltrials.gov/ct2/show/:?term=IMCgp100&rank=3
The interesting part about that trial is the IMCGP100. The other two drugs in the trial is another version of PD-L1 and Ipi. There is a site in St. Louis that may be more convenient to you.
NCI had a couple trials they recommended to me:
https://clinicaltrials.gov/ct2/show/study/NCT02517398?show_locs=Y#locn
This is some info on the drug in the above trial
http://cancerintel.com/msb0011359c-overview-m7824/
The 2nd trial is:
https://clinicaltrials.gov/ct2/show/NCT02452268
Hang in there.
Brian
-
- September 8, 2016 at 1:16 pm
Thoughts and prayers headed your way, Josh! Every treatment I’ve been through, I’ve had to stop because of skyrocketing liver enzymes. Try and focus on one day at a time, one problem at a time. We’re all with you!PS this BETTER not be your last update! 😉
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- September 8, 2016 at 1:16 pm
Thoughts and prayers headed your way, Josh! Every treatment I’ve been through, I’ve had to stop because of skyrocketing liver enzymes. Try and focus on one day at a time, one problem at a time. We’re all with you!PS this BETTER not be your last update! 😉
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- September 8, 2016 at 6:00 pm
I agree! When I saw the title of the post I immediately said to myself "oh no you don't"! Much love, Josh.
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- September 8, 2016 at 6:00 pm
I agree! When I saw the title of the post I immediately said to myself "oh no you don't"! Much love, Josh.
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- September 8, 2016 at 6:00 pm
I agree! When I saw the title of the post I immediately said to myself "oh no you don't"! Much love, Josh.
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- September 8, 2016 at 1:16 pm
Thoughts and prayers headed your way, Josh! Every treatment I’ve been through, I’ve had to stop because of skyrocketing liver enzymes. Try and focus on one day at a time, one problem at a time. We’re all with you!PS this BETTER not be your last update! 😉
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- September 8, 2016 at 1:50 pm
Hey Josh,
Tried to do some research/info gathering on this yesterday. Definitely sounds like Ipi induced liver hepatitis reaction. I also tried to find out how quickly steroids could bring down the lab values but seems like people's reactions are all over the board, data wise.
So I'm keeping fingers crossed and prayers in the air for a quick reduction in your liver numbers. Gotta get you to MDA!
Many prayers for quick turnaround,
Jackie
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- September 8, 2016 at 1:50 pm
Hey Josh,
Tried to do some research/info gathering on this yesterday. Definitely sounds like Ipi induced liver hepatitis reaction. I also tried to find out how quickly steroids could bring down the lab values but seems like people's reactions are all over the board, data wise.
So I'm keeping fingers crossed and prayers in the air for a quick reduction in your liver numbers. Gotta get you to MDA!
Many prayers for quick turnaround,
Jackie
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- September 8, 2016 at 1:50 pm
Hey Josh,
Tried to do some research/info gathering on this yesterday. Definitely sounds like Ipi induced liver hepatitis reaction. I also tried to find out how quickly steroids could bring down the lab values but seems like people's reactions are all over the board, data wise.
So I'm keeping fingers crossed and prayers in the air for a quick reduction in your liver numbers. Gotta get you to MDA!
Many prayers for quick turnaround,
Jackie
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