Viagra and Cialis — Cause of melanoma & lawsuits

Hehehe!! 🙂

Gene, Gene the alternative medicine machine, here are two links for you. The first is from the host of this forum MRF, so there is that!!! The second link is to CRI and a general article causes of cancer but not specific to melanoma. https://melanoma.org/melanoma-education/understand-melanoma/facts-stats/ https://www.cancerresearch.org/blog/april-2019/what-causes-cancer-risk-factors

CDC seems to think so….Melanoma and the Environment
Melanoma is a type of cancer in skin cells that produce the pigment that colors the skin (melanin). It is the most dangerous and one of the most common cancers among adolescents and adults under 40. If this type of skin cancer is found early, it can be cured. However, melanoma can spread through the body much more quickly than other types of skin cancers and can cause death.
Between 65 and 90% of melanomas are caused by exposure to ultraviolet (UV) radiation from sunlight. Small amounts of UV radiation are good for people and needed for the body to produce vitamin D. But too much exposure to the sun’s rays can cause skin damage such as sunburn, wrinkles, and skin cancers. Peoples’ behavior in the sun is believed to be a major reason for the rise in skin cancer rates, including melanoma, over the last few decades

Hi Anonymous’s, with all due respect, why is it that the Africans in Africa (non-White) and Indigenous people’s of South America, Australia, New Zealand etc. Have statistically the lowest forms of cancer especially that of Melanoma? And dont discredit stats because of lack of insurance or medical attention, They are far more exposed to the UV Ray’s then American culture (for example)….Has their DNA over hundreds of years manipulated their melanocytes to confirm with their enviornment? Let’s ponder on this one, any input anyone?

CDC seems to think so….Melanoma and the Environment
Melanoma is a type of cancer in skin cells that produce the pigment that colors the skin (melanin). It is the most dangerous and one of the most common cancers among adolescents and adults under 40. If this type of skin cancer is found early, it can be cured. However, melanoma can spread through the body much more quickly than other types of skin cancers and can cause death.
Between 65 and 90% of melanomas are caused by exposure to ultraviolet (UV) radiation from sunlight. Small amounts of UV radiation are good for people and needed for the body to produce vitamin D. But too much exposure to the sun’s rays can cause skin damage such as sunburn, wrinkles, and skin cancers. Peoples’ behavior in the sun is believed to be a major reason for the rise in skin cancer rates, including melanoma, over the last few decades

Just Keep it up Gene!!!! You are making it Hard for anyone to want to help you with your erectile dysfunction law suite!!!

Hahahahahahahahahahaha (cough) hahahahahahahahahah(cough) hahahahahaha that was good!

Hi Bubbles – I appreciate those links since I am worried about being on Silendafil. I do have a question though– do you have any other studies showing this non-association? Those are all from the same Stacy Loeb MD which I’m on the cautious side since she’s a paid consultant for Eli Lilly (The company that makes Cialis which is also a PDE5 inhibitor.) Trying to make sure this isn’t some kind of a cover-up from somebody close to the source. Thank you!! Below you will find her credentials so I am skeptical of this study refuting it without seeing others.

Stacy Loeb
Honoraria: MDxHealth, Boehringer Ingelheim, Astellas Pharma

Consulting or Advisory Role: Bayer, GenomeDx, Eli Lilly

Expert Testimony: Eli Lilly

Travel, Accommodations, Expenses: Sanofi, Minomic

My best advice:

#1 – Talk to your melanoma specialist.

#2 – Read the study yourself and contact the author with your questions. Re the data. Re the related employment. (FYI – It is incredibly hard to find a researcher at a major institution who is not affiliated in some way to drug companies. Not say’n your concern is not legit….just say’n.) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437700/ Author information: “Correspondence to: Stacy Loeb, MD, MSc, 550 1st Ave, VZ30 (6th floor, #612), New York, NY 10016 (e-mail: moc.liamg@beolycats).”

#3 – Read the reference articles listed at the bottom.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046205/ Pottegard et al = “We found little evidence for a causal association between PDEI use and risk of melanoma. The marginally increased risk of early stage disease likely resulted from more frequent health-care contacts among PDEI users.”

https://www.ncbi.nlm.nih.gov/pubmed/27178449 Lian et al = “CONCLUSIONS: The use of PDE5-Is was not associated with an overall increased risk of melanoma skin cancer. The increased risks observed in the highest prescription and pill categories require further validation.

PATIENT SUMMARY: In this study, the use of phosphodiesterase type 5 inhibitors was not associated with an increased risk of melanoma skin cancer.”

https://www.ncbi.nlm.nih.gov/pubmed/27299522 Matthews et al = “CONCLUSIONS: Our results were not consistent with PDE5 inhibitors being causally associated with melanoma risk, and strongly suggest that observed risk increases are driven by greater sun exposure among patients exposed to a PDE5 inhibitor.”

That’s just a start. Hope that helps. Celeste

Bubbles- you are fantastic! Those were great reads! It does not appear causal as many of the studies failed to show any association. Except for 250 to 500 tablets where there may be a slight increase but could still be detection bias.

Hahahaaha!!! Your puns are hard to swallow Ed!

Lawsuits and mayhem aside– do any of you think there is a plausible link? I asked only because I was diagnosed with an early melanoma and wanted to try Sildenafil but got scared after I read some of the research. I hate that these stupid class-action lawsuits came in when all I wanted to know was the truth in this medication. I read somewhere that the person that refuted the link was a Dr. Loeb who was actually a paid rep for the company that makes Cialis. So on with a couple of other studies that I had in question.

Newer studies include one not on Viagra but on Sildenafil use for Pulmonary Hypertension (you have to use a PC to see the study details)

2018 study: https://www.jaad.org/article/S0190-9622(18)31117-4/fulltext – This article shows an OR of 2.98, 95% CI or a 298% increase over controls. Could this be valid?

2018 Study: https://www.ncbi.nlm.nih.gov/pubmed/29884444 – shows just a slight increase over controls but still an increase

2017 Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644484/ – 2016 article telling how PDE5 inhibitors release the brakes on Melanoma growth.

Those being said– what do you think? Is it safe or should I wait to hear of other studies before taking something that is (no turning back) The only thing that really worried me was the last study and it explains pretty clearly how “pathway is hyperactivated in the majority of melanomas, typically through somatic gain-of-function mutations of the BRAF gene”

The studies seem pretty plausible. I just wanted to know the general consensus from real experts from the MRF. These money-maker lawyers need to step aside until ALL evidence is proven.

I couldn’t find too much on the Dr. Stacy Loeb (the person that refuted the link) but she is cited as a paid consultant for the company that makes Cialis. Sorry- I just wanted some honest opinions of PDE5 inhibitors (Viagra…etc) before I take that road.

https://books.google.com/books?id=3d49DwAAQBAJ&pg=PR3&lpg=PR3&dq=eli+lilly+consultant+Stacy+Loeb&source=bl&ots=G7560P5waL&sig=ACfU3U0dcXj-w8z7WKu1njdtx60UEGF0Cg&hl=en&sa=X&ved=2ahUKEwiHvNL29IjkAhUROK0KHWVIBrMQ6AEwCnoECAkQAQ#v=onepage&q=eli%20lilly%20consultant%20Stacy%20Loeb&f=false

Sorry one of the links was broken:

https://www.jaad.org/article/S0190-9622(18)31117-4/fulltext/

“”Viagra Gate”” i meant…haha

Hi Mike! I’ve been hanging on this website for 9 years and was really active the first couple years, when it was a very peaceful website. But then a few new members joined and it became very volitile!
I was diagnosed Stage 4 right out the gate and not given long to live! I had a dear friend that came to visit and she suggested the Budwig diet, which I have followed since 2011l. I’ve tried to share my success but it was quickly shot down by the big hitters on this site. While I respect their opinions immensely, I also know there are many paths to our recovery. What I do and say is just a suggestion!
I knew early on I was in a serious situation but because I also learned early on,. that I had an over active immune system and I didn’t respond well to immunotherapy. I’m all on board and all set to go with TIL at SCCA. I believe in modern medicine but I also believe in simple answers too! So far the Budwig diet has helped me immensely. I know it may not be a complete cure but for me, I do believe it has slowed the progression of my cancer. I love your humor Mike, you are someone that I would love to know (and I kinda do know:) and you could be from my family! I pray for your complete recovery and continued longevity, you are a sweet, loving and kind person and I wish you all the best! The thing is about this website is….so many people are on it and following, but we may or may not make comments or have other reasons why we no longer respond to posts! So make no mistake, there are so many people here who are rooting for you Mike, you are a shining star on this website and we are all following your journey with the greatest and biggest hopes for you! Sending BIG HUGE HUGS AND LOVE to you! Swanee

Swanee. I could not agree more with everything you have said. Scientific studies are all fine and dandy but they only scratch the tip of the iceberg and there is much that we do not know. Just because something is not scientifically proven yet does not mean it has no merit. My biggest issue is that when the standard scientific protocol fails what then? Simply offer to have a cup of tea and a hug with a person? I cannot accept that. No one knows our bodies like we do and we need to be our own best advocates. God gave us brains so we need to use them and decide our own plan of action, adjusting it along as we go and as our situation changes. Life is in a constant state of flux and as long as we are on this side of the grass, we need to be as well. Cancer of any kind is a complex disease and as such it only stands to reason that we should attack it from multiple avenues and diet is paramount. You battled stage IV melanoma for almost ten years and know and have experienced it firsthand. Wishing you continued success.
Melanie

Swanee! Thank you for your reply! Ha, i originally thought the post about Viagra was a true thing, the corelation between Melanoma and Viagra but, who knows, i never took that stuff and i have Melanoma!!!, plus, i was a nucklehead growing up since i was 12 and being in and out of then Juvenile hall then Prison, i didnt get the Sun exposure like most folks did, so, the Sun is probably not my cause, on the other hand though, Dioxine (Agent Orange, my dad was in Vietnam) as a birth defect “Maybe”, theres a study on it, but no 100% proof, and why would it ly and wait til 2008 to sprout? Melanoma and its cause is still up in the air, one day we will learn of its origin but as of now we can only focus on fighting it when we have it…thanks again for your support! And i wish you well to! We will Beat this Crap!! Thanks Swanee….

With all due respect Anonymous , why is it that the Africans in Africa (non-White) and Indigenous people’s of South America, Australia, New Zealand etc. Have statistically the lowest forms of cancer especially that of Melanoma? And dont discredit stats because of lack of insurance or medical attention, They are far more exposed to the UV Ray’s then American culture (for example)….Has their DNA over hundreds of years manipulated their melanocytes to confirm with their enviornment? Let’s ponder on this one, any input anyone?

Here you go Gene, some more information for your law suite!!! First link is article from Harvard health talking to melanoma specialist, second link is dr. from article. https://www.health.harvard.edu/blog/erectile-dysfunction-drugs-skin-cancer-worry-201406057197 https://www.massgeneral.org/doctors/doctor.aspx?id=17035

Oh Gene_S be nice! I know you two have been battling back & forth about various things, in fact Ed Williams is very knowledgeable & if theres something he does not know “how” to explain it, hell provide a Link JUST LIKE YOU DO!… lets get along! Were trying to Fight Melanoma here NOT eachother!

153 of them was Yours Gene..