TIL treatment response

Jerry,

L-2 treatment during the expansion phase was detrimental to the survival of rapidly dividing effector T cells. In contrast,

IL-2 therapy was highly beneficial during the death phase, resulting in increased proliferation and survival of Tumor-specific T cells.

IL-2 treatment also increased proliferation of resting memory T cells in the host that controlled the disease. Tumor-specific T cells in chronically infected Host also responds to IL-2 resulting in decreased tumor burden. Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies (Blattman et al., 2003).

Best regards,

Jimmy B

Jerry,

L-2 treatment during the expansion phase was detrimental to the survival of rapidly dividing effector T cells. In contrast,

IL-2 therapy was highly beneficial during the death phase, resulting in increased proliferation and survival of Tumor-specific T cells.

IL-2 treatment also increased proliferation of resting memory T cells in the host that controlled the disease. Tumor-specific T cells in chronically infected Host also responds to IL-2 resulting in decreased tumor burden. Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies (Blattman et al., 2003).

Best regards,

Jimmy B

Graphic of IL-2 and T-cells

http://2.bp.blogspot.com/-bnN8oemwz8Y/TodCXLycjRI/AAAAAAAAAg0/tJqm3oFqI10/s1600/Conventional%2BEffector%2BT-Cells%2Bsecrete%2BIL-2%2B2011.jpg

Graphic of IL-2 and T-cells

http://2.bp.blogspot.com/-bnN8oemwz8Y/TodCXLycjRI/AAAAAAAAAg0/tJqm3oFqI10/s1600/Conventional%2BEffector%2BT-Cells%2Bsecrete%2BIL-2%2B2011.jpg

Jim.

I understand that the timing can be critical, but if the timing is appropriate, Wouldn't any IL-2 be beneficial?

Jim.

I understand that the timing can be critical, but if the timing is appropriate, Wouldn't any IL-2 be beneficial?

Jerry,

The timing and how much IL-2 plays a role. If there are a lot of Tregs  around, (Increase Tregs are  found in stage I and Stage IV along with IL-10) then the Tregs can create a IL-2 sink where the Il-2 that is secreted by the CD4+ helper T-cell is taken up by the Treg that it is closest to. See diagram.

The Tregs compete for the screted IL-2. Depending on the location and how close the CD4+ T cell to the Tregs, The tregs can gain the upper hand by creating a IL-2 sink.

How much is secreted and the distance between the cells (T-cell and Treg) Is a major factor.

I hope this helps

Jimmy B

Jerry,

The timing and how much IL-2 plays a role. If there are a lot of Tregs  around, (Increase Tregs are  found in stage I and Stage IV along with IL-10) then the Tregs can create a IL-2 sink where the Il-2 that is secreted by the CD4+ helper T-cell is taken up by the Treg that it is closest to. See diagram.

The Tregs compete for the screted IL-2. Depending on the location and how close the CD4+ T cell to the Tregs, The tregs can gain the upper hand by creating a IL-2 sink.

How much is secreted and the distance between the cells (T-cell and Treg) Is a major factor.

I hope this helps

Jimmy B

Seems any should be of some help, the question then becomes how many Tregs are around and how much IL-2 is enough to overcome the sink.

Thanks; Jimmy

Jerry

Seems any should be of some help, the question then becomes how many Tregs are around and how much IL-2 is enough to overcome the sink.

Thanks; Jimmy

Jerry

It is under Jerry's question Val. It's just the screwy way the site displays replies.

Anyway, great to read your post!

It is under Jerry's question Val. It's just the screwy way the site displays replies.

Anyway, great to read your post!

Dear Val,

  I am so incredibly pleased for you and this wonderfully fantastic news!!!!!! I do not like that old fashioned approach of the Montreal oncologist to take aside your son and speak to him instead of speaking to YOU along with your husband and son and whoever you wanted to be there…and he obviously didnt know what he should know about TIL.

Now I jst wish I could understand what Jimmy B posts the way he understands it! (Thanks Jimmy B…you are amazing).

Hugs,

Vermont_Donna, stage 3a, NED

Dear Val,

  I am so incredibly pleased for you and this wonderfully fantastic news!!!!!! I do not like that old fashioned approach of the Montreal oncologist to take aside your son and speak to him instead of speaking to YOU along with your husband and son and whoever you wanted to be there…and he obviously didnt know what he should know about TIL.

Now I jst wish I could understand what Jimmy B posts the way he understands it! (Thanks Jimmy B…you are amazing).

Hugs,

Vermont_Donna, stage 3a, NED

I wish we all could understand it like Jimmy.  I wish that all the Oncologist even did.  I am so far behind Jimmy, but do so much appreciate his work and postings!  I hope at least a small amount sticks with me from each.  (OH WELL, never did think I learned as fast as I wanted too!)

I wish we all could understand it like Jimmy.  I wish that all the Oncologist even did.  I am so far behind Jimmy, but do so much appreciate his work and postings!  I hope at least a small amount sticks with me from each.  (OH WELL, never did think I learned as fast as I wanted too!)