The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Eisai Inc. – E7080

Forums General Melanoma Community Eisai Inc. – E7080

  • Post
    vickirs
    Participant

      Dr Rene Gonzalez has opened thie study at univ of colorado.  After failing many trials including compasionate us ipi, i am finally responding to something.  2 weeks ago i was told i had about 2 months to live.  I started this trial then instead of hospice and there is already a noticable improvement.  I lost 13 pounds in fluid wait above my liver and down my right leg.  I started readintg again after months of not being able to.  my upper abdonan no loner feels 10 months pregnat.  when dr gonzalez felt aound today he can tell there is definately shrin

      Dr Rene Gonzalez has opened thie study at univ of colorado.  After failing many trials including compasionate us ipi, i am finally responding to something.  2 weeks ago i was told i had about 2 months to live.  I started this trial then instead of hospice and there is already a noticable improvement.  I lost 13 pounds in fluid wait above my liver and down my right leg.  I started readintg again after months of not being able to.  my upper abdonan no loner feels 10 months pregnat.  when dr gonzalez felt aound today he can tell there is definately shrinkage going on.  It doesn't matter if you are BRAF or not.  I am not BRAF.  And it is as simple as taking pills once a day. Uf any buddy else is on this trial let me know.  up unti know there have only been about 50 people on this study but with such great results they are expanding the the trial.   This definately brings new hope to me.

      Loading spinner
    Viewing 30 reply threads
    • Replies
        Amy K
        Participant

          That is wonderful you found this trial and it's helping you!!  Love your motto.

          Loading spinner
          Amy K
          Participant

            That is wonderful you found this trial and it's helping you!!  Love your motto.

            Loading spinner
            EmilyandMike
            Participant
              Great to hear! This seems to a big new study with 90 locations. Here is the link http://clinicaltrials.gov/ct2/show/study/NCT01136967?show_locs=Y#locn

              Please keep us updated on your progress!

              Loading spinner
              EmilyandMike
              Participant
                Great to hear! This seems to a big new study with 90 locations. Here is the link http://clinicaltrials.gov/ct2/show/study/NCT01136967?show_locs=Y#locn

                Please keep us updated on your progress!

                Loading spinner
                Elizabeth Peters
                Participant

                  I know this website is for Melanoma but my husband who has brain cancer is also taking E7080 and had his first MRI in February.  He had a complete response to the medicine.  Three tumors gone from his MRI.  I know the results aren't the same for everyone.  But so happy to hear someone else having good results.  God bless and continued success.

                  Loading spinner
                  Elizabeth Peters
                  Participant

                    I know this website is for Melanoma but my husband who has brain cancer is also taking E7080 and had his first MRI in February.  He had a complete response to the medicine.  Three tumors gone from his MRI.  I know the results aren't the same for everyone.  But so happy to hear someone else having good results.  God bless and continued success.

                    Loading spinner
                    killmel
                    Participant

                      Vickie,

                       

                      so happy that you finally got a response.

                      I would appreciate anyone with experience with this trial, what are the side effects of this drug??

                      Loading spinner
                        Elizabeth Peters
                        Participant

                          My husband's side effects include fatigue, high blood pressure and occasional sore places on his tongue.  

                          Loading spinner
                          KellieSue
                          Participant

                            I'm so excited for you that you are having a response and I hope it continues.

                            Kellie(from Iowa) Stage IV currently on B-RAF

                            Loading spinner
                            stillhopeful
                            Participant

                              Does anyone know what the phase I results were for this study?  Or where I can find them?  I am considering this trial, and I would be in the B-RAF negative arm. Thanks!

                              Loading spinner
                              kylez
                              Participant

                                This might be it, a summary of phase I results presented at ASCO 2010 for E7080, with Eisai as one of the group of presenters:

                                http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=74&abstractID=47731

                                Loading spinner
                                stillhopeful
                                Participant

                                  Thanks for the link.  It's a little technical, but I'll try to sort through it!

                                  Loading spinner
                                  stillhopeful
                                  Participant

                                    Thanks for the link.  It's a little technical, but I'll try to sort through it!

                                    Loading spinner
                                    kylez
                                    Participant

                                      This might be it, a summary of phase I results presented at ASCO 2010 for E7080, with Eisai as one of the group of presenters:

                                      http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=74&abstractID=47731

                                      Loading spinner
                                      stillhopeful
                                      Participant

                                        Does anyone know what the phase I results were for this study?  Or where I can find them?  I am considering this trial, and I would be in the B-RAF negative arm. Thanks!

                                        Loading spinner
                                        KellieSue
                                        Participant

                                          I'm so excited for you that you are having a response and I hope it continues.

                                          Kellie(from Iowa) Stage IV currently on B-RAF

                                          Loading spinner
                                          Elizabeth Peters
                                          Participant

                                            My husband's side effects include fatigue, high blood pressure and occasional sore places on his tongue.  

                                            Loading spinner
                                            vickirs
                                            Participant

                                              my side effects are not to bad.  i get fatigue, sores on tongues, high biood pressure. 

                                              what makes this so good is that it is pills you take daily instead of infusions.  I was told i had unden 2 months when i started this trial.   My dr had to go through hoops to get me in.   I was to the point of calling hospice because of my failure of ipi  my dr had to convince me strongly to at least trial.   after so many failures i wasn't sure i wanted more to go throuth it again with all the progression i had in my liver.  i am glad i did

                                               

                                              Vicki

                                              Loading spinner
                                              vickirs
                                              Participant

                                                my side effects are not to bad.  i get fatigue, sores on tongues, high biood pressure. 

                                                what makes this so good is that it is pills you take daily instead of infusions.  I was told i had unden 2 months when i started this trial.   My dr had to go through hoops to get me in.   I was to the point of calling hospice because of my failure of ipi  my dr had to convince me strongly to at least trial.   after so many failures i wasn't sure i wanted more to go throuth it again with all the progression i had in my liver.  i am glad i did

                                                 

                                                Vicki

                                                Loading spinner
                                              killmel
                                              Participant

                                                Vickie,

                                                 

                                                so happy that you finally got a response.

                                                I would appreciate anyone with experience with this trial, what are the side effects of this drug??

                                                Loading spinner
                                                mayeast
                                                Participant

                                                  Hi! I just started this trial on Friday at Atlantic Health, Morristown,NJ.

                                                  Keep me posted. I hope to hear that you improve.

                                                  Cheryl

                                                  Loading spinner
                                                  mayeast
                                                  Participant

                                                    Hi! I just started this trial on Friday at Atlantic Health, Morristown,NJ.

                                                    Keep me posted. I hope to hear that you improve.

                                                    Cheryl

                                                    Loading spinner
                                                      vickirs
                                                      Participant

                                                        I am doing great on this drug.  I am going shopping with friends without wheelchair, I am feeling a lot stronger and my liver no longer protrudes out of my side.  Let me know how you do.   The drug works really fast and within a week and a half i was feeling better

                                                         

                                                        vicki

                                                        Loading spinner
                                                        vickirs
                                                        Participant

                                                          I am doing great on this drug.  I am going shopping with friends without wheelchair, I am feeling a lot stronger and my liver no longer protrudes out of my side.  Let me know how you do.   The drug works really fast and within a week and a half i was feeling better

                                                           

                                                          vicki

                                                          Loading spinner
                                                          mayeast
                                                          Participant

                                                            I'm so happy to hear that for both our sakes! ( greedy aren't I !)

                                                            Loading spinner
                                                            mayeast
                                                            Participant

                                                              I'm so happy to hear that for both our sakes! ( greedy aren't I !)

                                                              Loading spinner
                                                            SuzannefromCA
                                                            Participant

                                                              I am so happy to hear this! I have been wondering how you've been doing! We are facebook friends and it is so wonderful to hear good news, keep on keeping on Vicki!

                                                              Suzanne

                                                              Loading spinner
                                                              SuzannefromCA
                                                              Participant

                                                                I am so happy to hear this! I have been wondering how you've been doing! We are facebook friends and it is so wonderful to hear good news, keep on keeping on Vicki!

                                                                Suzanne

                                                                Loading spinner
                                                                djmiller
                                                                Participant

                                                                  Just started this treatment in February down at the University of Colorado and this month I have my first MRI and CT Scan since then. I am truly encouraged by the results of the drug. I tried radiation and IL2 and didn't qualify for BRAF, so this drug is a blessing. I've only had a few side effects from the drug, but nothing bad.

                                                                  Loading spinner
                                                                  djmiller
                                                                  Participant

                                                                    Just started this treatment in February down at the University of Colorado and this month I have my first MRI and CT Scan since then. I am truly encouraged by the results of the drug. I tried radiation and IL2 and didn't qualify for BRAF, so this drug is a blessing. I've only had a few side effects from the drug, but nothing bad.

                                                                    Loading spinner
                                                                    mayeast
                                                                    Participant

                                                                      How are you doing on E7080? I am into my second week of it.

                                                                      Loading spinner
                                                                        djmiller
                                                                        Participant

                                                                          I am doing pretty good. Not very many side effects. The worst is my hands and feet peeling and a little tender.

                                                                          Loading spinner
                                                                          mayeast
                                                                          Participant

                                                                            I'm having nausea now and stomach pain, but I guess it's better than other side-effects. I'm glad you're doing ok.

                                                                            Loading spinner
                                                                            djmiller
                                                                            Participant

                                                                              I had a little bit of stomach pain the first few weeks. I think it was my body getting used to the drug. But I'm feeling better now.

                                                                              Loading spinner
                                                                              djmiller
                                                                              Participant

                                                                                I had a little bit of stomach pain the first few weeks. I think it was my body getting used to the drug. But I'm feeling better now.

                                                                                Loading spinner
                                                                                mayeast
                                                                                Participant

                                                                                  I'm having nausea now and stomach pain, but I guess it's better than other side-effects. I'm glad you're doing ok.

                                                                                  Loading spinner
                                                                                  djmiller
                                                                                  Participant

                                                                                    I am doing pretty good. Not very many side effects. The worst is my hands and feet peeling and a little tender.

                                                                                    Loading spinner
                                                                                  mayeast
                                                                                  Participant

                                                                                    How are you doing on E7080? I am into my second week of it.

                                                                                    Loading spinner
                                                                                    ADSCLT
                                                                                    Participant

                                                                                      Hi,

                                                                                      Just curious how often you have to visit the trial clinic?  I looked it up and the closest was TN or VA.  We live in NC.  My Dad really doesn't want to travel often if he doesn't have to.  Thanks!  So glad to hear it is working for you!

                                                                                      Loading spinner
                                                                                        mayeast
                                                                                        Participant

                                                                                          I was given a month's supply, but go every 2 weeks for blood/urine tests. Perhaps they could be done closer to you.

                                                                                          Loading spinner
                                                                                          mayeast
                                                                                          Participant

                                                                                            I was given a month's supply, but go every 2 weeks for blood/urine tests. Perhaps they could be done closer to you.

                                                                                            Loading spinner
                                                                                          ADSCLT
                                                                                          Participant

                                                                                            Hi,

                                                                                            Just curious how often you have to visit the trial clinic?  I looked it up and the closest was TN or VA.  We live in NC.  My Dad really doesn't want to travel often if he doesn't have to.  Thanks!  So glad to hear it is working for you!

                                                                                            Loading spinner
                                                                                            EricNJill
                                                                                            Participant

                                                                                              God has a funny way of getting my attention.  Today we got the devistating news that after 2 months on the BRAF/MEK Trial with HUGE improvement the cancer has started to come back.  They asked us to consider this drug you are taking and sent us home with the consent forms.  I had never heard of this trial and was very skeptical, then I log on here and see your post at the top of the forum…

                                                                                              I can't help but wonder if God is trying to get my attention.  I'm so happy to hear your response.

                                                                                              JillNEric in OH

                                                                                              Loading spinner
                                                                                                Carol Taylor
                                                                                                Participant

                                                                                                  Jill & Eric,

                                                                                                  Sorry to hijack the original post and get off her topic. I've been following but can't contribute medically. But when you start talking about a "Holy Coincidence" and wondering if God's trying to get your attention and you get forms for the very drug that has a new post on the same day…that I can speak to.

                                                                                                  This is the kind of stuff that gets me excited!  Go to  http://www.facebook.com/pages/Melanoma-Prayer-Center/136617429740982

                                                                                                  find "About Sparrows", you don't need to be on facebook to read.  That's a true story of a chaplain friend of mine and it will blow you away.

                                                                                                  If you think God's trying to get your attention, he probably is.  Looking at where Eric is, do you have anything to lose by trying this? What will you lose if you don't try it? Seriously. Weigh those answers on a scale.

                                                                                                  God works in mysterious ways sometimes.  This may just be one of them. Prayers are with you as you learn, discern, and decide where to turn.

                                                                                                  Grace and peace,

                                                                                                  Carol

                                                                                                  Loading spinner
                                                                                                  EricNJill
                                                                                                  Participant

                                                                                                    Thank you Carol.  I am on facebook so I will look that up. 

                                                                                                    Loading spinner
                                                                                                    o2bcheri
                                                                                                    Participant

                                                                                                      i was hoping that Jill would see this post..

                                                                                                       

                                                                                                      and its not about hijacking.. its about sharing.. and taking care of each other..

                                                                                                       

                                                                                                      peace.. and hope to all

                                                                                                       

                                                                                                      Cheri

                                                                                                      Loading spinner
                                                                                                      o2bcheri
                                                                                                      Participant

                                                                                                        i was hoping that Jill would see this post..

                                                                                                         

                                                                                                        and its not about hijacking.. its about sharing.. and taking care of each other..

                                                                                                         

                                                                                                        peace.. and hope to all

                                                                                                         

                                                                                                        Cheri

                                                                                                        Loading spinner
                                                                                                        EricNJill
                                                                                                        Participant

                                                                                                          Thank you Carol.  I am on facebook so I will look that up. 

                                                                                                          Loading spinner
                                                                                                          Carol Taylor
                                                                                                          Participant

                                                                                                            Jill & Eric,

                                                                                                            Sorry to hijack the original post and get off her topic. I've been following but can't contribute medically. But when you start talking about a "Holy Coincidence" and wondering if God's trying to get your attention and you get forms for the very drug that has a new post on the same day…that I can speak to.

                                                                                                            This is the kind of stuff that gets me excited!  Go to  http://www.facebook.com/pages/Melanoma-Prayer-Center/136617429740982

                                                                                                            find "About Sparrows", you don't need to be on facebook to read.  That's a true story of a chaplain friend of mine and it will blow you away.

                                                                                                            If you think God's trying to get your attention, he probably is.  Looking at where Eric is, do you have anything to lose by trying this? What will you lose if you don't try it? Seriously. Weigh those answers on a scale.

                                                                                                            God works in mysterious ways sometimes.  This may just be one of them. Prayers are with you as you learn, discern, and decide where to turn.

                                                                                                            Grace and peace,

                                                                                                            Carol

                                                                                                            Loading spinner
                                                                                                          EricNJill
                                                                                                          Participant

                                                                                                            God has a funny way of getting my attention.  Today we got the devistating news that after 2 months on the BRAF/MEK Trial with HUGE improvement the cancer has started to come back.  They asked us to consider this drug you are taking and sent us home with the consent forms.  I had never heard of this trial and was very skeptical, then I log on here and see your post at the top of the forum…

                                                                                                            I can't help but wonder if God is trying to get my attention.  I'm so happy to hear your response.

                                                                                                            JillNEric in OH

                                                                                                            Loading spinner
                                                                                                            premedy
                                                                                                            Participant

                                                                                                              wow this sounds really promising for people that are not braf positive. Does anyone know how this drug works? Is it a pathway inhibitor of a different mutation?

                                                                                                              Loading spinner
                                                                                                                vickirs
                                                                                                                Participant

                                                                                                                  had my first cat scan today,  get the results on wed.  I am not to worried because i have had such a turn around on how I feel. 

                                                                                                                  wish me luck  has anybody else had their first scan yet.

                                                                                                                   

                                                                                                                   

                                                                                                                  vicki

                                                                                                                  Loading spinner
                                                                                                                  vickirs
                                                                                                                  Participant

                                                                                                                    had my first cat scan today,  get the results on wed.  I am not to worried because i have had such a turn around on how I feel. 

                                                                                                                    wish me luck  has anybody else had their first scan yet.

                                                                                                                     

                                                                                                                     

                                                                                                                    vicki

                                                                                                                    Loading spinner
                                                                                                                    vickirs
                                                                                                                    Participant

                                                                                                                      Oh and by the way you can be braf positive to be on this study.

                                                                                                                      Loading spinner
                                                                                                                      vickirs
                                                                                                                      Participant

                                                                                                                        Oh and by the way you can be braf positive to be on this study.

                                                                                                                        Loading spinner
                                                                                                                        Carol Taylor
                                                                                                                        Participant

                                                                                                                          Holding you in thought and prayers.  You'll let us know, I'm sure.

                                                                                                                          Grace and peace,

                                                                                                                          Carol

                                                                                                                          Loading spinner
                                                                                                                          Carol Taylor
                                                                                                                          Participant

                                                                                                                            Holding you in thought and prayers.  You'll let us know, I'm sure.

                                                                                                                            Grace and peace,

                                                                                                                            Carol

                                                                                                                            Loading spinner
                                                                                                                            djmiller
                                                                                                                            Participant

                                                                                                                              Had my scan last week after two months on the drug and everything is stable. No new tumors or growths and the existing tumors have not grown. God is good. Now for another two months and see what happens.

                                                                                                                              Loading spinner
                                                                                                                              mayeast
                                                                                                                              Participant

                                                                                                                                That's very comforting. I am 5 weeks into it and will have scans in a couple of weeks . I 'm having blood pressure issues now, so I hope to get that under control in order to stay in this trial. Please keep me in the loop.

                                                                                                                                Loading spinner
                                                                                                                                mayeast
                                                                                                                                Participant

                                                                                                                                  That's very comforting. I am 5 weeks into it and will have scans in a couple of weeks . I 'm having blood pressure issues now, so I hope to get that under control in order to stay in this trial. Please keep me in the loop.

                                                                                                                                  Loading spinner
                                                                                                                                  Carol Taylor
                                                                                                                                  Participant

                                                                                                                                    Yea DJ!  The happy dance continues! Prayers are with you. Lord, in Your mercy, we thank You for this good news and ask that it keep coming. Amen.

                                                                                                                                    Grace and peace,

                                                                                                                                    Carol

                                                                                                                                    Loading spinner
                                                                                                                                    Terra
                                                                                                                                    Participant

                                                                                                                                      Hi, just wondering if Vicki has posted since her scans and I have missed it.  She posted on the 8th that she was expecting the results in a day or two.  I am hoping it is good news.  

                                                                                                                                      Loading spinner
                                                                                                                                      Sue26
                                                                                                                                      Participant

                                                                                                                                        I am glad I searched for E7080 trial on this site! My husband commenced the BRAF/MEK trial 9 weeks ago and scans done this past Monday have revealed no shrinkage in tumour size but rapid increase. He was immediately taken off the trial and has been offered a place in E7080 but has to have a 30 day washout period prior to commencing, after ceasing the BRAF/MEK tablets (he had also been on the BRAF trial which initially helped with reduction in size of tumours and cessation of pain) the pain immediately escalated and pain relief has been increased. He will also have radiotherapy.  Again we will put all our postive thoughts into this new trial – glad to see ther have been many positive stories so far.

                                                                                                                                        Loading spinner
                                                                                                                                        Sue26
                                                                                                                                        Participant

                                                                                                                                          I am glad I searched for E7080 trial on this site! My husband commenced the BRAF/MEK trial 9 weeks ago and scans done this past Monday have revealed no shrinkage in tumour size but rapid increase. He was immediately taken off the trial and has been offered a place in E7080 but has to have a 30 day washout period prior to commencing, after ceasing the BRAF/MEK tablets (he had also been on the BRAF trial which initially helped with reduction in size of tumours and cessation of pain) the pain immediately escalated and pain relief has been increased. He will also have radiotherapy.  Again we will put all our postive thoughts into this new trial – glad to see ther have been many positive stories so far.

                                                                                                                                          Loading spinner
                                                                                                                                          Terra
                                                                                                                                          Participant

                                                                                                                                            Hi, just wondering if Vicki has posted since her scans and I have missed it.  She posted on the 8th that she was expecting the results in a day or two.  I am hoping it is good news.  

                                                                                                                                            Loading spinner
                                                                                                                                            Carol Taylor
                                                                                                                                            Participant

                                                                                                                                              Yea DJ!  The happy dance continues! Prayers are with you. Lord, in Your mercy, we thank You for this good news and ask that it keep coming. Amen.

                                                                                                                                              Grace and peace,

                                                                                                                                              Carol

                                                                                                                                              Loading spinner
                                                                                                                                              mayeast
                                                                                                                                              Participant

                                                                                                                                                Are you having stomach pain? I have it everyday.

                                                                                                                                                Stay well. Stay stable.

                                                                                                                                                Loading spinner
                                                                                                                                                mayeast
                                                                                                                                                Participant

                                                                                                                                                  Are you having stomach pain? I have it everyday.

                                                                                                                                                  Stay well. Stay stable.

                                                                                                                                                  Loading spinner
                                                                                                                                                  djmiller
                                                                                                                                                  Participant

                                                                                                                                                    Had my scan last week after two months on the drug and everything is stable. No new tumors or growths and the existing tumors have not grown. God is good. Now for another two months and see what happens.

                                                                                                                                                    Loading spinner
                                                                                                                                                  premedy
                                                                                                                                                  Participant

                                                                                                                                                    wow this sounds really promising for people that are not braf positive. Does anyone know how this drug works? Is it a pathway inhibitor of a different mutation?

                                                                                                                                                    Loading spinner
                                                                                                                                                    dgkendall
                                                                                                                                                    Participant

                                                                                                                                                      Vicki,

                                                                                                                                                      Just joining this blog and haven't seen a posting of the results of your scan on the 8th. Hope is was good news. Anyone else with results of E7080? See my wife's profile on her latest condition and other trials.. 

                                                                                                                                                       

                                                                                                                                                      dkendall

                                                                                                                                                      Loading spinner
                                                                                                                                                        vickirs
                                                                                                                                                        Participant

                                                                                                                                                          Hi

                                                                                                                                                          This is Vicki.  have not been on the computer lately been busy getting a garden started.  My results to the scans was stable possible dead tumor.  I am so glad.  Get a whole month off of seeing the doctor.  I am now having problems with my blood pressure which is being treated.  Everything else is going good.  Wishing you the best.  Vicki

                                                                                                                                                          Loading spinner
                                                                                                                                                          djmiller
                                                                                                                                                          Participant

                                                                                                                                                            vicki,

                                                                                                                                                            That is great. If blood pressure is the big thing, My tumors are stable also and now I'm going to Denver only once a month. I'll continue to pray for you and everyone on this site.

                                                                                                                                                            Loading spinner
                                                                                                                                                            djmiller
                                                                                                                                                            Participant

                                                                                                                                                              vicki,

                                                                                                                                                              That is great. If blood pressure is the big thing, My tumors are stable also and now I'm going to Denver only once a month. I'll continue to pray for you and everyone on this site.

                                                                                                                                                              Loading spinner
                                                                                                                                                              vickirs
                                                                                                                                                              Participant

                                                                                                                                                                Hi

                                                                                                                                                                This is Vicki.  have not been on the computer lately been busy getting a garden started.  My results to the scans was stable possible dead tumor.  I am so glad.  Get a whole month off of seeing the doctor.  I am now having problems with my blood pressure which is being treated.  Everything else is going good.  Wishing you the best.  Vicki

                                                                                                                                                                Loading spinner
                                                                                                                                                              dgkendall
                                                                                                                                                              Participant

                                                                                                                                                                Vicki,

                                                                                                                                                                Just joining this blog and haven't seen a posting of the results of your scan on the 8th. Hope is was good news. Anyone else with results of E7080? See my wife's profile on her latest condition and other trials.. 

                                                                                                                                                                 

                                                                                                                                                                dkendall

                                                                                                                                                                Loading spinner
                                                                                                                                                                LynnLuc
                                                                                                                                                                Participant

                                                                                                                                                                  I found some info from ASCO

                                                                                                                                                                  A phase I study of E7080 in patients (pts) with advanced malignancies

                                                                                                                                                                  H. Glen, D. R. Boss, R. Morrison, M. Roelvink, J. Wanders, A. Mazur, A. Gupta, A. Das, T. R. Evans and J. H. Schellens

                                                                                                                                                                  Beatson Institute for Cancer Research, Glasgow, United Kingdom; Nederlands Kanker Instituut, Amsterdam, Netherlands Antilles; Beatson West of Scotland Cancer Center, Glasgow, United Kingdom; Nederlands Kanker Instituut, Amsterdam, Netherlands Antilles; Eisai Medical Research, London, United Kingdom; University of Glasgow, Glasgow, United Kingdom

                                                                                                                                                                  3526

                                                                                                                                                                  Background: E7080 is a potent inhibitor of the split-kinase family of transmembrane growth factor receptors including VEGFRs 1 and 2, and also potently inhibits FGFR-1 and PDGFR-β tyrosine kinase activities. E7080 inhibited VEGF-driven umbilical vein endothelial cell proliferation and tube formation in vitro, and inhibited tumor growth in H460 and Colo205 mouse xenografts models in vivo at doses of 1–100mg/kg. Methods: The primary objective of this study was to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of E7080 in pts with advanced solid tumors refractory to standard therapies. Eligible pts were those with ECOG PS < 2 and adequate haematologic, renal and hepatic function. E7080 was administered orally on a once daily continuous schedule in 4-week cycles. Dose escalation was by an accelerated design (100% dose increases until the 1st pt experienced toxicity  grade 2). Samples for pharmacokinetic (PK) analyses were collected on days 1, 8, 15, 22 and 29. A food effect PK sub-study is ongoing at the MTD. Results: 59 pts (35 m, 24 f), median age = 55 yrs (range 25–84) were treated at dose levels (mg/day) of 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 12.5, 16, 20, 25 and 32 mg. Median number cycles = 5 (0–22). 53 pts are evaluable for toxicity so far. DLTs included 2 pts at 32mg (both proteinuria), 1 pt each at 16mg (hypertension), 12.5mg (proteinuria) and 6.4mg (febrile neutropenia). The MTD is 25mg daily. Dose reductions (n=12pts) were most commonly for  grade 2 proteinuria (5 pts) and hypertension (5 pts). Other grade 3/4 toxicities include haemorrhage and thrombosis (n=1) and tachycardia (n=1). 37 pts are now evaluable for response: 5 pts have confirmed PR (1 sarcoma, 2 melanoma, 2 renal carcinoma), 25 pts have had stable disease for a median of 16 weeks (range 8–88). The PK was described by a 2- compartment model. Clearance was linear with dose and unchanged with multiple dosing. A saturable decrease in the distribution volume was observed with dose from 0.2 up to 1.6 mg. The covariate and food effect analyses will be reported in the full presentation. Conclusions: E7080 displays linear PK and is safe and well tolerated at doses up to 25mg daily with signs of anti-cancer activity.

                                                                                                                                                                   

                                                                                                                                                                  http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/3526

                                                                                                                                                                  Loading spinner
                                                                                                                                                                  LynnLuc
                                                                                                                                                                  Participant

                                                                                                                                                                    I found some info from ASCO

                                                                                                                                                                    A phase I study of E7080 in patients (pts) with advanced malignancies

                                                                                                                                                                    H. Glen, D. R. Boss, R. Morrison, M. Roelvink, J. Wanders, A. Mazur, A. Gupta, A. Das, T. R. Evans and J. H. Schellens

                                                                                                                                                                    Beatson Institute for Cancer Research, Glasgow, United Kingdom; Nederlands Kanker Instituut, Amsterdam, Netherlands Antilles; Beatson West of Scotland Cancer Center, Glasgow, United Kingdom; Nederlands Kanker Instituut, Amsterdam, Netherlands Antilles; Eisai Medical Research, London, United Kingdom; University of Glasgow, Glasgow, United Kingdom

                                                                                                                                                                    3526

                                                                                                                                                                    Background: E7080 is a potent inhibitor of the split-kinase family of transmembrane growth factor receptors including VEGFRs 1 and 2, and also potently inhibits FGFR-1 and PDGFR-β tyrosine kinase activities. E7080 inhibited VEGF-driven umbilical vein endothelial cell proliferation and tube formation in vitro, and inhibited tumor growth in H460 and Colo205 mouse xenografts models in vivo at doses of 1–100mg/kg. Methods: The primary objective of this study was to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of E7080 in pts with advanced solid tumors refractory to standard therapies. Eligible pts were those with ECOG PS < 2 and adequate haematologic, renal and hepatic function. E7080 was administered orally on a once daily continuous schedule in 4-week cycles. Dose escalation was by an accelerated design (100% dose increases until the 1st pt experienced toxicity  grade 2). Samples for pharmacokinetic (PK) analyses were collected on days 1, 8, 15, 22 and 29. A food effect PK sub-study is ongoing at the MTD. Results: 59 pts (35 m, 24 f), median age = 55 yrs (range 25–84) were treated at dose levels (mg/day) of 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 12.5, 16, 20, 25 and 32 mg. Median number cycles = 5 (0–22). 53 pts are evaluable for toxicity so far. DLTs included 2 pts at 32mg (both proteinuria), 1 pt each at 16mg (hypertension), 12.5mg (proteinuria) and 6.4mg (febrile neutropenia). The MTD is 25mg daily. Dose reductions (n=12pts) were most commonly for  grade 2 proteinuria (5 pts) and hypertension (5 pts). Other grade 3/4 toxicities include haemorrhage and thrombosis (n=1) and tachycardia (n=1). 37 pts are now evaluable for response: 5 pts have confirmed PR (1 sarcoma, 2 melanoma, 2 renal carcinoma), 25 pts have had stable disease for a median of 16 weeks (range 8–88). The PK was described by a 2- compartment model. Clearance was linear with dose and unchanged with multiple dosing. A saturable decrease in the distribution volume was observed with dose from 0.2 up to 1.6 mg. The covariate and food effect analyses will be reported in the full presentation. Conclusions: E7080 displays linear PK and is safe and well tolerated at doses up to 25mg daily with signs of anti-cancer activity.

                                                                                                                                                                     

                                                                                                                                                                    http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/3526

                                                                                                                                                                    Loading spinner
                                                                                                                                                                    mearnold
                                                                                                                                                                    Participant

                                                                                                                                                                      Hi All,

                                                                                                                                                                      Sydney, Australia here =D

                                                                                                                                                                      Today, my mother started on Phase ll trial drug E7080 and it is so reassuring to hear such positive results.

                                                                                                                                                                      A BIG thank you all for sharing.

                                                                                                                                                                      Loading spinner
                                                                                                                                                                      mearnold
                                                                                                                                                                      Participant

                                                                                                                                                                        Hi All,

                                                                                                                                                                        Sydney, Australia here =D

                                                                                                                                                                        Today, my mother started on Phase ll trial drug E7080 and it is so reassuring to hear such positive results.

                                                                                                                                                                        A BIG thank you all for sharing.

                                                                                                                                                                        Loading spinner
                                                                                                                                                                        WillieB
                                                                                                                                                                        Participant

                                                                                                                                                                          Well,
                                                                                                                                                                            A week ago I noticed my first sub-q melanoma tumor growing again. This came after 3 months Zelboraf.  Local Onco not very uplifting about this. Very disappointed but will keep on with the good fight. 
                                                                                                                                                                           

                                                                                                                                                                          Went to my specialist at MD Anderson in Houston who is looking into this trial for me. Really uplifted my spirts.  I am glad to see the almost amazing results. I hope my evaluation will get me in.  Should know in two weeks.
                                                                                                                                                                           

                                                                                                                                                                          Stay Positive…

                                                                                                                                                                          Loading spinner
                                                                                                                                                                          WillieB
                                                                                                                                                                          Participant

                                                                                                                                                                            Well,
                                                                                                                                                                              A week ago I noticed my first sub-q melanoma tumor growing again. This came after 3 months Zelboraf.  Local Onco not very uplifting about this. Very disappointed but will keep on with the good fight. 
                                                                                                                                                                             

                                                                                                                                                                            Went to my specialist at MD Anderson in Houston who is looking into this trial for me. Really uplifted my spirts.  I am glad to see the almost amazing results. I hope my evaluation will get me in.  Should know in two weeks.
                                                                                                                                                                             

                                                                                                                                                                            Stay Positive…

                                                                                                                                                                            Loading spinner
                                                                                                                                                                            WillieB
                                                                                                                                                                            Participant

                                                                                                                                                                              Well,
                                                                                                                                                                                A week ago I noticed my first sub-q melanoma tumor growing again. This came after 3 months Zelboraf.  Local Onco not very uplifting about this. Very disappointed but will keep on with the good fight. 
                                                                                                                                                                               

                                                                                                                                                                              Went to my specialist at MD Anderson in Houston who is looking into this trial for me. Really uplifted my spirts.  I am glad to see the almost amazing results. I hope my evaluation will get me in.  Should know in two weeks.
                                                                                                                                                                               

                                                                                                                                                                              Stay Positive…

                                                                                                                                                                              Loading spinner
                                                                                                                                                                          Viewing 30 reply threads
                                                                                                                                                                          • You must be logged in to reply to this topic.
                                                                                                                                                                          About the MRF Patient Forum

                                                                                                                                                                          The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

                                                                                                                                                                          The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.