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mommydog

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      mommydog
      Participant

      My husband has been on this trial (GSK BRAF with randomized MEK) for over eight months now.  As of the last PET scan three weeks ago, his tumors had decreased in size by 81.7%.  Basically, there's very little left.  He is doing so well that he was given permission to go ahead with knee replacement surgery.  As far as we've heard, people are responding well to this treatment with few side effects.  There was a recent article in the SF Chronicle about a women in my husband's study who has been in the trial for 9 months and has had tumor reduction of 85%.  I think I'm just going to stop thinking about the other shoe dropping, because, for now, things are great.

      Deborah

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      mommydog
      Participant

      My husband has been on this trial (GSK BRAF with randomized MEK) for over eight months now.  As of the last PET scan three weeks ago, his tumors had decreased in size by 81.7%.  Basically, there's very little left.  He is doing so well that he was given permission to go ahead with knee replacement surgery.  As far as we've heard, people are responding well to this treatment with few side effects.  There was a recent article in the SF Chronicle about a women in my husband's study who has been in the trial for 9 months and has had tumor reduction of 85%.  I think I'm just going to stop thinking about the other shoe dropping, because, for now, things are great.

      Deborah

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      mommydog
      Participant

      My husband has been on this trial (GSK BRAF with randomized MEK) for over eight months now.  As of the last PET scan three weeks ago, his tumors had decreased in size by 81.7%.  Basically, there's very little left.  He is doing so well that he was given permission to go ahead with knee replacement surgery.  As far as we've heard, people are responding well to this treatment with few side effects.  There was a recent article in the SF Chronicle about a women in my husband's study who has been in the trial for 9 months and has had tumor reduction of 85%.  I think I'm just going to stop thinking about the other shoe dropping, because, for now, things are great.

      Deborah

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      mommydog
      Participant
      My husband was on the GSK b-raf trial with randomized MEK ( he had the highest dosage) and after being NED after nine months developed resistance to the drug or drugs, and developed several brain mets, had two craniotomies and has lost the use of the left side of his body.
      He is now having Yervoy infusions and is taking Zelboraf. Too early to see if anything is working. His onc at Ucsf had a patient who was not successful on the gsk braf inhibitor, but responded to zelboraf. Who knows.

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      mommydog
      Participant
      My husband was on the GSK b-raf trial with randomized MEK ( he had the highest dosage) and after being NED after nine months developed resistance to the drug or drugs, and developed several brain mets, had two craniotomies and has lost the use of the left side of his body.
      He is now having Yervoy infusions and is taking Zelboraf. Too early to see if anything is working. His onc at Ucsf had a patient who was not successful on the gsk braf inhibitor, but responded to zelboraf. Who knows.

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      mommydog
      Participant
      My husband was on the GSK b-raf trial with randomized MEK ( he had the highest dosage) and after being NED after nine months developed resistance to the drug or drugs, and developed several brain mets, had two craniotomies and has lost the use of the left side of his body.
      He is now having Yervoy infusions and is taking Zelboraf. Too early to see if anything is working. His onc at Ucsf had a patient who was not successful on the gsk braf inhibitor, but responded to zelboraf. Who knows.

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      mommydog
      Participant
      My husband has had two craniotomies. The surgeries themselves went well and he recovered easily and without much pain. However, since his tumors were located in and near the motor strip on the right side and had bled, he has lost the use of his left arm and leg.
      Deborah

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      mommydog
      Participant
      My husband has had two craniotomies. The surgeries themselves went well and he recovered easily and without much pain. However, since his tumors were located in and near the motor strip on the right side and had bled, he has lost the use of his left arm and leg.
      Deborah

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      mommydog
      Participant
      My husband has had two craniotomies. The surgeries themselves went well and he recovered easily and without much pain. However, since his tumors were located in and near the motor strip on the right side and had bled, he has lost the use of his left arm and leg.
      Deborah

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      mommydog
      Participant

      Not bad.  He has had some fevers and chills, at times quite severe, but those symptoms have subsided.

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      mommydog
      Participant

      Not bad.  He has had some fevers and chills, at times quite severe, but those symptoms have subsided.

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      mommydog
      Participant

      Andrea Kantor

      Clinical Research Coordinator

      Cutaneous Oncology Program

      UCSF Helen Diller Family Comprehensive Cancer Center

      Investigational Trials Resource

      Room A736| Box 1297

      415.885.3855 /phone

      415.514.6969 /fax

      [email protected]

       

      try this, and good luck.

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      mommydog
      Participant

      Andrea Kantor

      Clinical Research Coordinator

      Cutaneous Oncology Program

      UCSF Helen Diller Family Comprehensive Cancer Center

      Investigational Trials Resource

      Room A736| Box 1297

      415.885.3855 /phone

      415.514.6969 /fax

      [email protected]

       

      try this, and good luck.

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      mommydog
      Participant

      Dave,

      The trial no. is NCT01072175.  It is sponsored by GSK and they are still recruiting.  According to the info on the gov. site, the trial is being conducted in several places, including Southern Ca.

      Here's a link to the info in clinicaltrials.gov

      http://clinicaltrials.gov/ct2/show/NCT01072175?term=melanoma+mek&spons=%22GlaxoSmithKline%22&spons_ex=Y&rank=4

       

      Let me know if there's any other informaiton that I can provide.

      Deborah

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      mommydog
      Participant

      Dave,

      The trial no. is NCT01072175.  It is sponsored by GSK and they are still recruiting.  According to the info on the gov. site, the trial is being conducted in several places, including Southern Ca.

      Here's a link to the info in clinicaltrials.gov

      http://clinicaltrials.gov/ct2/show/NCT01072175?term=melanoma+mek&spons=%22GlaxoSmithKline%22&spons_ex=Y&rank=4

       

      Let me know if there's any other informaiton that I can provide.

      Deborah

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