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Where find clinical trial details?
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Where find clinical trial details?

› Forums › General Melanoma Community › Where find clinical trial details?

  • Post
    • December 11, 2012 at 9:10 pm
    POW
    Participant

      My brother's melanoma recently started to become resistant to Zelboraf so I am looking into clinical trials on his behalf. I have found a number of sites similar to clinicaltrials.gov that present a summary of the trial– which drug(s), length of time of study, inclusion/exclusion criteria, etc.

      My brother's melanoma recently started to become resistant to Zelboraf so I am looking into clinical trials on his behalf. I have found a number of sites similar to clinicaltrials.gov that present a summary of the trial– which drug(s), length of time of study, inclusion/exclusion criteria, etc.

      What I can't find is the details about exactly what the treatment regimen will be. Are these oral medications or injectable? Will the patients be hospitalized or not? If hospitalized, will the protocol be 1 day or 5 days and then home for 3 weeks? Will they have to come in for blood tests or scans every week or every month or what?

      Transportation, mental confusion, and the "hassle factor" will be very important to my brother when choosing a trial. Does anyone know where I can find such details?

    Viewing 5 reply threads
    • Replies
        • December 12, 2012 at 12:54 am
        jim Breitfeller
        Participant

          Pow,

          If you go to clinicaly trials.gov

          do a search on melanoma and or the drug of interest example (Anti-PD-1)

          http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti-pd1&rank=2 

          It will show the information that you are looking for. See assign intervention

           
          It says:

          Biological: BMS-936558 (Anti-PD-1)  

          Solution, Intravenous infusion, 3 mg/kg, Every 2 weeks, Up to 2 years depending on response 

           

          I hope this helps

           

          Jimmy B

          • December 12, 2012 at 12:54 am
          jim Breitfeller
          Participant

            Pow,

            If you go to clinicaly trials.gov

            do a search on melanoma and or the drug of interest example (Anti-PD-1)

            http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti-pd1&rank=2 

            It will show the information that you are looking for. See assign intervention

             
            It says:

            Biological: BMS-936558 (Anti-PD-1)  

            Solution, Intravenous infusion, 3 mg/kg, Every 2 weeks, Up to 2 years depending on response 

             

            I hope this helps

             

            Jimmy B

            • December 12, 2012 at 12:54 am
            jim Breitfeller
            Participant

              Pow,

              If you go to clinicaly trials.gov

              do a search on melanoma and or the drug of interest example (Anti-PD-1)

              http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti-pd1&rank=2 

              It will show the information that you are looking for. See assign intervention

               
              It says:

              Biological: BMS-936558 (Anti-PD-1)  

              Solution, Intravenous infusion, 3 mg/kg, Every 2 weeks, Up to 2 years depending on response 

               

              I hope this helps

               

              Jimmy B

                • December 12, 2012 at 1:57 am
                POW
                Participant

                  Thanks, Jimmy. I see now that some of the listings on clinicaltrials.gov have some details listed, but others do not. There seems to be a lot of variation.

                  What I am really looking for is some any other "specialized" web site like a patent application site or a specialized pharmaceutical industry site that has all the boring technical details. I mean, where do the doctors go to find out how to conduct a clinical trial? I know I'm reaching for the stars here, but it doesn't hurt to ask.  

                  • December 12, 2012 at 6:16 am
                  jeffjohn78
                  Participant

                    Hi Pow,

                    Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                     

                    I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                    I hope this helps!

                     

                    Jeff

                    • December 12, 2012 at 6:16 am
                    jeffjohn78
                    Participant

                      Hi Pow,

                      Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                       

                      I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                      I hope this helps!

                       

                      Jeff

                      • December 12, 2012 at 6:16 am
                      jeffjohn78
                      Participant

                        Hi Pow,

                        Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                         

                        I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                        I hope this helps!

                         

                        Jeff

                        • December 12, 2012 at 6:17 am
                        jeffjohn78
                        Participant

                          Hi Pow,

                          Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                           

                          I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                          I hope this helps!

                           

                          Jeff

                          • December 12, 2012 at 6:17 am
                          jeffjohn78
                          Participant

                            Hi Pow,

                            Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                             

                            I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                            I hope this helps!

                             

                            Jeff

                            • December 12, 2012 at 6:17 am
                            jeffjohn78
                            Participant

                              Hi Pow,

                              Well the 1st step would be to ask your brothers doctor! I wold advise you fina a known melanoma specialst rather then some genceral oncologist your HMO may send your brother to.  (assuing he has a HMO of course).  Without knowing yur brothers staging etc. , I am guessing he hs been seeing a surgical oncologist, as that is always the preferred treatment for Melanoma.  I would ask to be referred to a Medical Oncologist and again make sure its a Melnoma specialist.  

                               

                              I see you are in Atlanta, I suggest you Google "Melanoma Medical Oncology Specilist Atlanta" and see if you see somebody you like and maybe ask your brother's current doctor about him/her.

                              I hope this helps!

                               

                              Jeff

                              • December 12, 2012 at 8:51 pm
                              awillett1991
                              Participant
                                You need to find a human involved with the trial – either a Dr or clinical trials nurse. Lots of times you’ll find some of the larger details online, but there are lots of boxes to be checked behind the scenes for each patient before all the test results are even submitted to a drug company to determine eligibility. These people can also tell you how often the drug cycle is, testing is, if there is a local hospital maybe they could work with for blood draws, or not, etc. if you’re not up to all this, pick a couple of the big centers and start w consults.
                                • December 12, 2012 at 8:51 pm
                                awillett1991
                                Participant
                                  You need to find a human involved with the trial – either a Dr or clinical trials nurse. Lots of times you’ll find some of the larger details online, but there are lots of boxes to be checked behind the scenes for each patient before all the test results are even submitted to a drug company to determine eligibility. These people can also tell you how often the drug cycle is, testing is, if there is a local hospital maybe they could work with for blood draws, or not, etc. if you’re not up to all this, pick a couple of the big centers and start w consults.
                                  • December 12, 2012 at 9:33 pm
                                  POW
                                  Participant

                                    Thank you all for your responses. Apparently, I will have to wait until we meet with the oncologist to get the details about clinical trials. In reading your posts, I started to ask myself, "Why am I getting so frantic about finding this information BEFORE meeting with the doctor?" The answer lies in my perception of my role as a caregiver. I decided to post about that on the "Off Topic" forum. So if anyone wants to know what preparing for clinical trials can mean to a caregiver, take a look. Thanks again to all who responded. You helped me a lot.

                                    • December 12, 2012 at 9:33 pm
                                    POW
                                    Participant

                                      Thank you all for your responses. Apparently, I will have to wait until we meet with the oncologist to get the details about clinical trials. In reading your posts, I started to ask myself, "Why am I getting so frantic about finding this information BEFORE meeting with the doctor?" The answer lies in my perception of my role as a caregiver. I decided to post about that on the "Off Topic" forum. So if anyone wants to know what preparing for clinical trials can mean to a caregiver, take a look. Thanks again to all who responded. You helped me a lot.

                                      • December 12, 2012 at 9:33 pm
                                      POW
                                      Participant

                                        Thank you all for your responses. Apparently, I will have to wait until we meet with the oncologist to get the details about clinical trials. In reading your posts, I started to ask myself, "Why am I getting so frantic about finding this information BEFORE meeting with the doctor?" The answer lies in my perception of my role as a caregiver. I decided to post about that on the "Off Topic" forum. So if anyone wants to know what preparing for clinical trials can mean to a caregiver, take a look. Thanks again to all who responded. You helped me a lot.

                                        • December 12, 2012 at 8:51 pm
                                        awillett1991
                                        Participant
                                          You need to find a human involved with the trial – either a Dr or clinical trials nurse. Lots of times you’ll find some of the larger details online, but there are lots of boxes to be checked behind the scenes for each patient before all the test results are even submitted to a drug company to determine eligibility. These people can also tell you how often the drug cycle is, testing is, if there is a local hospital maybe they could work with for blood draws, or not, etc. if you’re not up to all this, pick a couple of the big centers and start w consults.
                                          • December 12, 2012 at 1:57 am
                                          POW
                                          Participant

                                            Thanks, Jimmy. I see now that some of the listings on clinicaltrials.gov have some details listed, but others do not. There seems to be a lot of variation.

                                            What I am really looking for is some any other "specialized" web site like a patent application site or a specialized pharmaceutical industry site that has all the boring technical details. I mean, where do the doctors go to find out how to conduct a clinical trial? I know I'm reaching for the stars here, but it doesn't hurt to ask.  

                                            • December 12, 2012 at 1:57 am
                                            POW
                                            Participant

                                              Thanks, Jimmy. I see now that some of the listings on clinicaltrials.gov have some details listed, but others do not. There seems to be a lot of variation.

                                              What I am really looking for is some any other "specialized" web site like a patent application site or a specialized pharmaceutical industry site that has all the boring technical details. I mean, where do the doctors go to find out how to conduct a clinical trial? I know I'm reaching for the stars here, but it doesn't hurt to ask.  

                                            • December 12, 2012 at 10:25 pm
                                            madeclaire
                                            Participant

                                              try contacting [email protected].  Her name is Jeanine and she works for a trial matching service.  She will search a number of data bases once you give her a summary of your brothers condition.  She works for a consortioum of docs and pharma and is very prompt and thorough.  hope this helps

                                              • December 12, 2012 at 10:25 pm
                                              madeclaire
                                              Participant

                                                try contacting [email protected].  Her name is Jeanine and she works for a trial matching service.  She will search a number of data bases once you give her a summary of your brothers condition.  She works for a consortioum of docs and pharma and is very prompt and thorough.  hope this helps

                                                • December 12, 2012 at 10:25 pm
                                                madeclaire
                                                Participant

                                                  try contacting [email protected].  Her name is Jeanine and she works for a trial matching service.  She will search a number of data bases once you give her a summary of your brothers condition.  She works for a consortioum of docs and pharma and is very prompt and thorough.  hope this helps

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