› Forums › General Melanoma Community › Update – 14 months into GSK BRAF/MEK Trial
- This topic has 27 replies, 9 voices, and was last updated 11 years, 2 months ago by
Tina D.
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- July 16, 2012 at 4:40 pm
I'm now more than a year into this trial, and I'm doing very well. No new tumors observed, all the soft tissue tumors are gone, and the couple of bone mets that are still seen on the CT are not showing any activity on the PET. The drugs have proven very easy to tolerate. While I had lots of joint pains and fevers a month or two into the trial, the only issues I now have are mild fatigue and the occasional (every couple of months) high fever.
I'm now more than a year into this trial, and I'm doing very well. No new tumors observed, all the soft tissue tumors are gone, and the couple of bone mets that are still seen on the CT are not showing any activity on the PET. The drugs have proven very easy to tolerate. While I had lots of joint pains and fevers a month or two into the trial, the only issues I now have are mild fatigue and the occasional (every couple of months) high fever.
The initial results from the trial (as reported at ASCO) indicate that this combo of BRAF and MEK inhibitors may be more effective than a single agent (e.g. Zelboraf) and is easier to tolerate, with fewer side effects. My experience seems to bear this out. I hope that this treatment indeed proves effective, and that it will benefit many others. It is becoming somewhat of a hassle to keep up with all the scans and tests and appointments, but I keep reminding myself that besides perhaps saving my own life, I'm also doing my little bit to advance knowledge.
Best wishes,
Harry
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- July 16, 2012 at 5:52 pm
Congrats Harry, thank you for posting your good news. Gives us all hope.
I understand that there is going to be a Phase 3 for this trial.Do you know anything about that?
How often do you have scans & apptments for this trial??
Continued succcess on these drug.
A.
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- July 16, 2012 at 5:52 pm
Congrats Harry, thank you for posting your good news. Gives us all hope.
I understand that there is going to be a Phase 3 for this trial.Do you know anything about that?
How often do you have scans & apptments for this trial??
Continued succcess on these drug.
A.
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- July 16, 2012 at 7:32 pm
I don't have details as to when or where on the Phase 3 trial, except that the daily dose will be the same as what I'm getting (300 mg of the BRAF and 2 mg of the MEK).
I have clinic appointments every 4 weeks. I get scans of chest, abdomen and pelvis every 8 weeks. MRI of head every 16 weeks. ECHO cardiogram every 12 weeks. And derm exams every 8 weeks.
Best wishes,
Harry
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- July 16, 2012 at 7:32 pm
I don't have details as to when or where on the Phase 3 trial, except that the daily dose will be the same as what I'm getting (300 mg of the BRAF and 2 mg of the MEK).
I have clinic appointments every 4 weeks. I get scans of chest, abdomen and pelvis every 8 weeks. MRI of head every 16 weeks. ECHO cardiogram every 12 weeks. And derm exams every 8 weeks.
Best wishes,
Harry
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- July 16, 2012 at 7:32 pm
I don't have details as to when or where on the Phase 3 trial, except that the daily dose will be the same as what I'm getting (300 mg of the BRAF and 2 mg of the MEK).
I have clinic appointments every 4 weeks. I get scans of chest, abdomen and pelvis every 8 weeks. MRI of head every 16 weeks. ECHO cardiogram every 12 weeks. And derm exams every 8 weeks.
Best wishes,
Harry
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- July 16, 2012 at 5:52 pm
Congrats Harry, thank you for posting your good news. Gives us all hope.
I understand that there is going to be a Phase 3 for this trial.Do you know anything about that?
How often do you have scans & apptments for this trial??
Continued succcess on these drug.
A.
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- July 16, 2012 at 6:20 pm
Way to go Harry.Hopefully this is an answer to Zelboraf staying an affective drug against melanoma.I will keep you in my prayers that you are like the Energizer Bunny.Just keep going and going. Beat the Beast. Al
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- July 16, 2012 at 6:20 pm
Way to go Harry.Hopefully this is an answer to Zelboraf staying an affective drug against melanoma.I will keep you in my prayers that you are like the Energizer Bunny.Just keep going and going. Beat the Beast. Al
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- July 16, 2012 at 6:20 pm
Way to go Harry.Hopefully this is an answer to Zelboraf staying an affective drug against melanoma.I will keep you in my prayers that you are like the Energizer Bunny.Just keep going and going. Beat the Beast. Al
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- July 16, 2012 at 6:55 pm
Harry
Great to be able to reead this kind of news, keep it up.
Dick
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- July 17, 2012 at 10:44 am
Harry,
So nice to hear your positive news. We go in soon for my husbands scans and it's people like you that inspire us and give us hope! I hope you keep hearing good news and melanoma leaves you alone permanently.
Congratulations!
Rebecca
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- July 17, 2012 at 10:44 am
Harry,
So nice to hear your positive news. We go in soon for my husbands scans and it's people like you that inspire us and give us hope! I hope you keep hearing good news and melanoma leaves you alone permanently.
Congratulations!
Rebecca
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- July 17, 2012 at 10:44 am
Harry,
So nice to hear your positive news. We go in soon for my husbands scans and it's people like you that inspire us and give us hope! I hope you keep hearing good news and melanoma leaves you alone permanently.
Congratulations!
Rebecca
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- July 17, 2012 at 5:21 pm
This is encouraging news. As someone who is on Zelboraf alone at the moment, I want to personally thank you for all of the extra effort it requires to be a part of a trial. Because of folks like you, hopefully this new combo will be approved in short arder and available for others who need it. Sooo happy for the good news for you!! Thank you for posting!!
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- July 17, 2012 at 5:21 pm
This is encouraging news. As someone who is on Zelboraf alone at the moment, I want to personally thank you for all of the extra effort it requires to be a part of a trial. Because of folks like you, hopefully this new combo will be approved in short arder and available for others who need it. Sooo happy for the good news for you!! Thank you for posting!!
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- July 17, 2012 at 5:21 pm
This is encouraging news. As someone who is on Zelboraf alone at the moment, I want to personally thank you for all of the extra effort it requires to be a part of a trial. Because of folks like you, hopefully this new combo will be approved in short arder and available for others who need it. Sooo happy for the good news for you!! Thank you for posting!!
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