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Those on anti-dp1 trials…previous steroid use an exclusion?
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Those on anti-dp1 trials…previous steroid use an exclusion?

› Forums › General Melanoma Community › Those on anti-dp1 trials…previous steroid use an exclusion?

  • Post
    • April 2, 2012 at 11:42 am
    MeNDave
    Participant

      OK folks, quick question.  Will Dave's previous history of optic neuropathy and need for high dose steroids on IL-2 exclude him from the anti-pd1 trials?  He goes to the Hillman Cancer Center on the 12th to see about the MK-3475 trial.  His oncologist (God Bless him), although pushing Dave to do the IPI,  is also calling Memorial Sloan directly for him to see about their IPI/MDX-1106 combo (or any anti-pd1s).  Hopefully we'll hear back from him soon.

      OK folks, quick question.  Will Dave's previous history of optic neuropathy and need for high dose steroids on IL-2 exclude him from the anti-pd1 trials?  He goes to the Hillman Cancer Center on the 12th to see about the MK-3475 trial.  His oncologist (God Bless him), although pushing Dave to do the IPI,  is also calling Memorial Sloan directly for him to see about their IPI/MDX-1106 combo (or any anti-pd1s).  Hopefully we'll hear back from him soon.

      I just don't want to wait two weeks for an appointment, only to find out he won't qualify anyways.

      As always, thank you….

       

      Maria

    Viewing 5 reply threads
    • Replies
        • April 2, 2012 at 1:42 pm
        FormerCaregiver
        Participant

          Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
          http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
          The eligibility criteria says that: "No concurrent medical condition requiring the use
          of immunosuppressive doses of systemic or absorbable topical corticosteroids."

          Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
          treatment. However, that would need to be confirmed by the oncologist.

          Take care
              
          Frank from Australia

          • April 2, 2012 at 1:42 pm
          FormerCaregiver
          Participant

            Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
            http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
            The eligibility criteria says that: "No concurrent medical condition requiring the use
            of immunosuppressive doses of systemic or absorbable topical corticosteroids."

            Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
            treatment. However, that would need to be confirmed by the oncologist.

            Take care
                
            Frank from Australia

            • April 2, 2012 at 1:42 pm
            FormerCaregiver
            Participant

              Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
              http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
              The eligibility criteria says that: "No concurrent medical condition requiring the use
              of immunosuppressive doses of systemic or absorbable topical corticosteroids."

              Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
              treatment. However, that would need to be confirmed by the oncologist.

              Take care
                  
              Frank from Australia

              • April 3, 2012 at 2:37 pm
              LynnLuc
              Participant

                Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

                  • April 3, 2012 at 9:58 pm
                  MeNDave
                  Participant

                    Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

                    Keep your fingers crossed!! 

                    • June 16, 2014 at 7:12 am
                    amandakohring
                    Participant

                      Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

                      thanks…Amanda

                      • June 16, 2014 at 7:12 am
                      amandakohring
                      Participant

                        Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

                        thanks…Amanda

                        • June 16, 2014 at 7:12 am
                        amandakohring
                        Participant

                          Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

                          thanks…Amanda

                          • April 3, 2012 at 9:58 pm
                          MeNDave
                          Participant

                            Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

                            Keep your fingers crossed!! 

                            • April 3, 2012 at 9:58 pm
                            MeNDave
                            Participant

                              Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

                              Keep your fingers crossed!! 

                            • April 3, 2012 at 2:37 pm
                            LynnLuc
                            Participant

                              Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

                              • April 3, 2012 at 2:37 pm
                              LynnLuc
                              Participant

                                Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

                            Viewing 5 reply threads
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