Those on anti-dp1 trials…previous steroid use an exclusion?
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Those on anti-dp1 trials…previous steroid use an exclusion?

› Forums › General Melanoma Community › Those on anti-dp1 trials…previous steroid use an exclusion?

  • Post
    • April 2, 2012 at 11:42 am
    MeNDave
    Participant

    OK folks, quick question.  Will Dave's previous history of optic neuropathy and need for high dose steroids on IL-2 exclude him from the anti-pd1 trials?  He goes to the Hillman Cancer Center on the 12th to see about the MK-3475 trial.  His oncologist (God Bless him), although pushing Dave to do the IPI,  is also calling Memorial Sloan directly for him to see about their IPI/MDX-1106 combo (or any anti-pd1s).  Hopefully we'll hear back from him soon.

    OK folks, quick question.  Will Dave's previous history of optic neuropathy and need for high dose steroids on IL-2 exclude him from the anti-pd1 trials?  He goes to the Hillman Cancer Center on the 12th to see about the MK-3475 trial.  His oncologist (God Bless him), although pushing Dave to do the IPI,  is also calling Memorial Sloan directly for him to see about their IPI/MDX-1106 combo (or any anti-pd1s).  Hopefully we'll hear back from him soon.

    I just don't want to wait two weeks for an appointment, only to find out he won't qualify anyways.

    As always, thank you….

     

    Maria

Viewing 5 reply threads
  • Replies
      • April 2, 2012 at 1:42 pm
      FormerCaregiver
      Participant

      Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
      http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
      The eligibility criteria says that: "No concurrent medical condition requiring the use
      of immunosuppressive doses of systemic or absorbable topical corticosteroids."

      Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
      treatment. However, that would need to be confirmed by the oncologist.

      Take care
          
      Frank from Australia

      • April 2, 2012 at 1:42 pm
      FormerCaregiver
      Participant

      Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
      http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
      The eligibility criteria says that: "No concurrent medical condition requiring the use
      of immunosuppressive doses of systemic or absorbable topical corticosteroids."

      Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
      treatment. However, that would need to be confirmed by the oncologist.

      Take care
          
      Frank from Australia

      • April 2, 2012 at 1:42 pm
      FormerCaregiver
      Participant

      Maria, I have been reading the info on an anti-PD1 (MDX-1106) trial at:
      http://www.clinicaltrials.gov/ct2/show/NCT01176461?term=anti-pd1&rank=3
      The eligibility criteria says that: "No concurrent medical condition requiring the use
      of immunosuppressive doses of systemic or absorbable topical corticosteroids."

      Therefore, it looks like Dave would need to be off steriods before starting MDX-1106
      treatment. However, that would need to be confirmed by the oncologist.

      Take care
          
      Frank from Australia

      • April 3, 2012 at 2:37 pm
      LynnLuc
      Participant

      Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

        • April 3, 2012 at 9:58 pm
        MeNDave
        Participant

        Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

        Keep your fingers crossed!! 

        • June 16, 2014 at 7:12 am
        amandakohring
        Participant

        Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

        thanks…Amanda

        • June 16, 2014 at 7:12 am
        amandakohring
        Participant

        Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

        thanks…Amanda

        • June 16, 2014 at 7:12 am
        amandakohring
        Participant

        Hi.  It is late and I am scared and reading.  I am just curious about PD-1.  My husband is not offered much at his cancer treatment hospital and it seems like your husband was offered trials 2 years ago.  My husband needs the PD-1 but is on 10mg steroid for brain swelling.  Any suggestions.  You seem to possiby know way more than me.  This is the first time I have ever posted anything on here.  We are desperate.

        thanks…Amanda

        • April 3, 2012 at 9:58 pm
        MeNDave
        Participant

        Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

        Keep your fingers crossed!! 

        • April 3, 2012 at 9:58 pm
        MeNDave
        Participant

        Well, according to Memorial Sloan and Dr. Wolchuk (who Khushalani spoke with today), he doesn't qualify for the MDX-1106/IPI combo because of his previous optic neuropathy.  However, Khushalani,  after conferring with his associates in the Mel community, has decided that the anti-pdl-1 mdx-1105 (offered at Roswell) is a better next line treatment than IPI.  So tommorow we will meet with the trial nurse.

        Keep your fingers crossed!! 

      • April 3, 2012 at 2:37 pm
      LynnLuc
      Participant

      Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

      • April 3, 2012 at 2:37 pm
      LynnLuc
      Participant

      Frank is right…no concurrant use because MDX 1106 boosts the immune system and steroids lower it…my onc would not let me do steroids for a blistery rash on my hands and feet  that the derm doc prescribed …NO steroids while on Anti PD 1…it defeats the purpose… Prior use will not exclude him however…

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