Stage IV , Metastatic Liver
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Stage IV , Metastatic Liver

› Forums › General Melanoma Community › Stage IV , Metastatic Liver

  • Post
    • January 20, 2014 at 9:22 pm
    Nadia
    Participant

    Diagnosed Stage IV in September, PET found 3cm X 4cm tumor inside liver, nodules in the lungs, unresectable.  Prognosis grim, 8 months to 16 months.  I am told that when the tumours are inside the liver the prognosis is very bad.  I am enrolled in pd-1 trial, scans in first week of february.

    Anybody with liver mets that can share any light in this?  I was very positive until I was told that liver mets are hard to keep under control and treatments are not very succesful.

Viewing 17 reply threads
  • Replies
      • January 20, 2014 at 10:57 pm
      tschmith
      Participant

      I had one small mass in the liver.  I had two infusions of Yervoy and then had to stop due to pituitary problems.  The scans after the Yervoy showed more mets here and there but the liver met disappeared.

      Best of luck to you in the pd-1 trial.  I've heard good things about the trials and my doctor has been trying to get me into one.  

      Terrie

      • January 20, 2014 at 10:57 pm
      tschmith
      Participant

      I had one small mass in the liver.  I had two infusions of Yervoy and then had to stop due to pituitary problems.  The scans after the Yervoy showed more mets here and there but the liver met disappeared.

      Best of luck to you in the pd-1 trial.  I've heard good things about the trials and my doctor has been trying to get me into one.  

      Terrie

      • January 20, 2014 at 10:57 pm
      tschmith
      Participant

      I had one small mass in the liver.  I had two infusions of Yervoy and then had to stop due to pituitary problems.  The scans after the Yervoy showed more mets here and there but the liver met disappeared.

      Best of luck to you in the pd-1 trial.  I've heard good things about the trials and my doctor has been trying to get me into one.  

      Terrie

      • January 20, 2014 at 11:11 pm
      love4life
      Participant

      I must admit that when I found out last January that my melanoma had spread to my liver among a couple of other sites I felt my hope slowly diminishing.  Now, a year later my tumours have all shrunk In my liver so much so that they can't be measured.  I'm on Zelboraf (Vemurafinib) and everything has remained stable.  I was told 4years ago when I was first diagnosed with brain mets that my prognosis wasn't good but here we are!  This disease is so different for each individual that you never know where your path will lead.  I have heard that there have been great results with pd-1.  Good luck with your treatment!  

      Natalie

      • January 20, 2014 at 11:11 pm
      love4life
      Participant

      I must admit that when I found out last January that my melanoma had spread to my liver among a couple of other sites I felt my hope slowly diminishing.  Now, a year later my tumours have all shrunk In my liver so much so that they can't be measured.  I'm on Zelboraf (Vemurafinib) and everything has remained stable.  I was told 4years ago when I was first diagnosed with brain mets that my prognosis wasn't good but here we are!  This disease is so different for each individual that you never know where your path will lead.  I have heard that there have been great results with pd-1.  Good luck with your treatment!  

      Natalie

      • January 20, 2014 at 11:11 pm
      love4life
      Participant

      I must admit that when I found out last January that my melanoma had spread to my liver among a couple of other sites I felt my hope slowly diminishing.  Now, a year later my tumours have all shrunk In my liver so much so that they can't be measured.  I'm on Zelboraf (Vemurafinib) and everything has remained stable.  I was told 4years ago when I was first diagnosed with brain mets that my prognosis wasn't good but here we are!  This disease is so different for each individual that you never know where your path will lead.  I have heard that there have been great results with pd-1.  Good luck with your treatment!  

      Natalie

      • January 20, 2014 at 11:38 pm
      Mat
      Participant

      As someone with liver mets, I think I've read that IL-2 is less successful with liver mets.  I don't think I've seen or heard of other treatments–targeted therapy or immune checkpoint inhibitors–being less successful. 

      • January 20, 2014 at 11:38 pm
      Mat
      Participant

      As someone with liver mets, I think I've read that IL-2 is less successful with liver mets.  I don't think I've seen or heard of other treatments–targeted therapy or immune checkpoint inhibitors–being less successful. 

      • January 20, 2014 at 11:38 pm
      Mat
      Participant

      As someone with liver mets, I think I've read that IL-2 is less successful with liver mets.  I don't think I've seen or heard of other treatments–targeted therapy or immune checkpoint inhibitors–being less successful. 

      • January 21, 2014 at 4:00 am
      Nadia
      Participant

      Thank you for the answers, I guess it's wait and see at the scan. I hate this waiting game already!

      robert

      • January 21, 2014 at 4:00 am
      Nadia
      Participant

      Thank you for the answers, I guess it's wait and see at the scan. I hate this waiting game already!

      robert

      • January 21, 2014 at 4:00 am
      Nadia
      Participant

      Thank you for the answers, I guess it's wait and see at the scan. I hate this waiting game already!

      robert

      • January 21, 2014 at 3:18 pm
      Gene_S
      Participant

      Hello,

      Don't give up because you have lesions in the liver.  My husband had three in the liver in different sections and also in his lungs along with an unresectable lesion pushing on the cervical vertebrae around C1-C2.  He started on a clinical trial with Ipi and GM-CSF in March of 2011 and has been cancer free for over a year now.  You can read more on his profile.

      Judy (loving wife of Gene Stage IV and now NED)

      • January 21, 2014 at 3:18 pm
      Gene_S
      Participant

      Hello,

      Don't give up because you have lesions in the liver.  My husband had three in the liver in different sections and also in his lungs along with an unresectable lesion pushing on the cervical vertebrae around C1-C2.  He started on a clinical trial with Ipi and GM-CSF in March of 2011 and has been cancer free for over a year now.  You can read more on his profile.

      Judy (loving wife of Gene Stage IV and now NED)

      • January 21, 2014 at 3:18 pm
      Gene_S
      Participant

      Hello,

      Don't give up because you have lesions in the liver.  My husband had three in the liver in different sections and also in his lungs along with an unresectable lesion pushing on the cervical vertebrae around C1-C2.  He started on a clinical trial with Ipi and GM-CSF in March of 2011 and has been cancer free for over a year now.  You can read more on his profile.

      Judy (loving wife of Gene Stage IV and now NED)

      • January 22, 2014 at 2:11 am
      Jahendry12
      Participant

      Keep the faith Robert.  Read the positive stories on this site and try to stay positive.  I know it's hard, but it beats the alternative. 

      Stay strong!

      • January 22, 2014 at 2:11 am
      Jahendry12
      Participant

      Keep the faith Robert.  Read the positive stories on this site and try to stay positive.  I know it's hard, but it beats the alternative. 

      Stay strong!

      • January 22, 2014 at 2:11 am
      Jahendry12
      Participant

      Keep the faith Robert.  Read the positive stories on this site and try to stay positive.  I know it's hard, but it beats the alternative. 

      Stay strong!

        • January 22, 2014 at 8:03 pm
        Zam1940
        Participant

        You are very fortunate, Robert, to have been accepted into a PD-1 trial; I am stage 4, with mets in left lung, liver, spine and humerus bone; when I began an anti PD-1 Merck trial at UCLA, in April 2012 under the guidance of Antoni Ribas, M.D., both my lung and liver mets were over 10×10 cm. My left lung was almost completely obliterated by tumor mass and fluid; I was on 24 hour oxygen and confined to a wheelchair. I needed help in eating on the rare occasions when I would eat; by July 2012 my ,liver and lung mets had shrunk over 50%; As of November 2013, my lung met measures 36×21 mm and my liver met measures 36×18 mm. They are essentiall stable over the past year. I continue in the Merck trial and am totally active, playing tennis three times per week on average; You have much cause for OPTIMISM with the PD1 trial!  I wish you good luck with your clincal trial.  Best regards, Thomas

        • January 22, 2014 at 8:03 pm
        Zam1940
        Participant

        You are very fortunate, Robert, to have been accepted into a PD-1 trial; I am stage 4, with mets in left lung, liver, spine and humerus bone; when I began an anti PD-1 Merck trial at UCLA, in April 2012 under the guidance of Antoni Ribas, M.D., both my lung and liver mets were over 10×10 cm. My left lung was almost completely obliterated by tumor mass and fluid; I was on 24 hour oxygen and confined to a wheelchair. I needed help in eating on the rare occasions when I would eat; by July 2012 my ,liver and lung mets had shrunk over 50%; As of November 2013, my lung met measures 36×21 mm and my liver met measures 36×18 mm. They are essentiall stable over the past year. I continue in the Merck trial and am totally active, playing tennis three times per week on average; You have much cause for OPTIMISM with the PD1 trial!  I wish you good luck with your clincal trial.  Best regards, Thomas

        • January 22, 2014 at 8:03 pm
        Zam1940
        Participant

        You are very fortunate, Robert, to have been accepted into a PD-1 trial; I am stage 4, with mets in left lung, liver, spine and humerus bone; when I began an anti PD-1 Merck trial at UCLA, in April 2012 under the guidance of Antoni Ribas, M.D., both my lung and liver mets were over 10×10 cm. My left lung was almost completely obliterated by tumor mass and fluid; I was on 24 hour oxygen and confined to a wheelchair. I needed help in eating on the rare occasions when I would eat; by July 2012 my ,liver and lung mets had shrunk over 50%; As of November 2013, my lung met measures 36×21 mm and my liver met measures 36×18 mm. They are essentiall stable over the past year. I continue in the Merck trial and am totally active, playing tennis three times per week on average; You have much cause for OPTIMISM with the PD1 trial!  I wish you good luck with your clincal trial.  Best regards, Thomas

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