› Forums › General Melanoma Community › Radiation before chemo or biochemo
- This topic has 22 replies, 7 voices, and was last updated 14 years, 6 months ago by
gabsound.
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- July 20, 2011 at 4:38 am
I have a tentative plan to start biochemo in 7-10 days. I was researching last week about radiation and could swear I read something about an ongoing study with very good results when radiation was used before starting chemo or possibly biochemo.
Does this sound familiar to anyone?
I’m thinking it was being done in the pacific northwest.
If anyone has a source for this could you please post?
I need to get more organized about this searching I do online.
I found out my original tumor was at a Caris lab and us currently being tested for mutations as well as what treatments it may respond to. I’m hoping this cones back soon. It would be nicest have more facts to base treatment decisions on.
Welcome to our new posters.Hanging in there in las Vegas,
Julie
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- July 20, 2011 at 5:14 am
Hi Julie,
I did read somewhere that the radiation in conjunction with the biochemicals is better. I tried to find it but I couldn't. But just so you know your not going crazy I read it too!! I'll see if I can find it, if I do I'll repost with the link.
Denise
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- July 20, 2011 at 5:14 am
Hi Julie,
I did read somewhere that the radiation in conjunction with the biochemicals is better. I tried to find it but I couldn't. But just so you know your not going crazy I read it too!! I'll see if I can find it, if I do I'll repost with the link.
Denise
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- July 20, 2011 at 8:47 am
The last report I saw on this refered to lymph node basins. I am not too sure about the wide spread radiation some radiolgists wanted to do on me. Others I talked to that had the wide spread abdominal radiation had sever problems. Other than these two articles by radiologists I have not heard much favorable news on radiology and Melanoma.
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- July 20, 2011 at 8:47 am
The last report I saw on this refered to lymph node basins. I am not too sure about the wide spread radiation some radiolgists wanted to do on me. Others I talked to that had the wide spread abdominal radiation had sever problems. Other than these two articles by radiologists I have not heard much favorable news on radiology and Melanoma.
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- July 20, 2011 at 9:27 am
You might be thinking about adoptive cell therapy (also called TIL treatment) as used by
Dr Rosenberg at the National Institutes of HealthSee http://wgalinat.blogspot.com/ and
http://jco.ascopubs.org/content/26/32/5233.long (This is an old article, but it explains
the procedure in great detail).Best wishes
Frank from Australia
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- July 20, 2011 at 9:27 am
You might be thinking about adoptive cell therapy (also called TIL treatment) as used by
Dr Rosenberg at the National Institutes of HealthSee http://wgalinat.blogspot.com/ and
http://jco.ascopubs.org/content/26/32/5233.long (This is an old article, but it explains
the procedure in great detail).Best wishes
Frank from Australia
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- July 20, 2011 at 10:58 am
Someone posted the other day that in Portland Oregon they are doing radiation before IL2. That particular IL2 center is saying that they are having success with that. That does not mean that your center will be willing to do that or that it is sucessful.
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- July 20, 2011 at 10:58 am
Someone posted the other day that in Portland Oregon they are doing radiation before IL2. That particular IL2 center is saying that they are having success with that. That does not mean that your center will be willing to do that or that it is sucessful.
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- July 20, 2011 at 11:28 am
You are right about there being studies done on radiation prior to systematic treatment. NIH is doing radiation in addition to TIL and IL-2, and also Providence Cancer Center is doing a study on radiation prior to IL-2, which they are opening a new study. We asked Daves oncologist if he would consider it, and he stated if it is part of a clinical study or trial, he would have to travel to Portland, OR to do the IL-2. Not an option for us, as we are in Buffalo, NY. Dr. Curti is the oncologist doing the studies at Providence, and they are very willing to work with any oncologist interested in doing this treatment. Unfortunately, Dave's wasn't so thrilled about the idea. His next appointment is 7/27, so I plan to push it on him again before he starts IL-2 on 8/1.
Best wishes, and I hope you get the information you are looking for.
Maria and Dave
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- July 20, 2011 at 11:28 am
You are right about there being studies done on radiation prior to systematic treatment. NIH is doing radiation in addition to TIL and IL-2, and also Providence Cancer Center is doing a study on radiation prior to IL-2, which they are opening a new study. We asked Daves oncologist if he would consider it, and he stated if it is part of a clinical study or trial, he would have to travel to Portland, OR to do the IL-2. Not an option for us, as we are in Buffalo, NY. Dr. Curti is the oncologist doing the studies at Providence, and they are very willing to work with any oncologist interested in doing this treatment. Unfortunately, Dave's wasn't so thrilled about the idea. His next appointment is 7/27, so I plan to push it on him again before he starts IL-2 on 8/1.
Best wishes, and I hope you get the information you are looking for.
Maria and Dave
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- July 21, 2011 at 3:18 am
I did surgery, radiation (Vandy), and biochemo (MD Anderson) last year following a Stage 3 diagnosis (14 cancerous lymph nodes) – starting in April 2010 and finishing Oct 2010. I was NED for only a few months, and have now been 'upgraded' to Stage 4 with 2 bone mets. I could not do the interferon part of the biochemo because of the damage the radiation did to my skin and the other side effects I was still having. Now I'm wishing I hadn't wasted precious months with my family on the biochemo since it didn't seem to help. Biochemo is rough, rough, rough!
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- July 22, 2011 at 3:47 am
I’m sorry to hear that. That’s the thing. We are always hoping for good results. But some of these treatments are pretty awful. So far just high dose interferon, but that didn’t help me. I’ll be having talk w oncologist soon. Would like more info as to why this is 1st choice for current situation. The thought of going thru this, and it not working, and having to turn around and do the next thing, is not very attractive!Thanks,
Julie
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- July 22, 2011 at 3:47 am
I’m sorry to hear that. That’s the thing. We are always hoping for good results. But some of these treatments are pretty awful. So far just high dose interferon, but that didn’t help me. I’ll be having talk w oncologist soon. Would like more info as to why this is 1st choice for current situation. The thought of going thru this, and it not working, and having to turn around and do the next thing, is not very attractive!Thanks,
Julie
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- July 21, 2011 at 3:18 am
I did surgery, radiation (Vandy), and biochemo (MD Anderson) last year following a Stage 3 diagnosis (14 cancerous lymph nodes) – starting in April 2010 and finishing Oct 2010. I was NED for only a few months, and have now been 'upgraded' to Stage 4 with 2 bone mets. I could not do the interferon part of the biochemo because of the damage the radiation did to my skin and the other side effects I was still having. Now I'm wishing I hadn't wasted precious months with my family on the biochemo since it didn't seem to help. Biochemo is rough, rough, rough!
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- July 21, 2011 at 5:27 am
http://www.ro-journal.com/content/pdf/1748-717x-6-12.pdf
Adjuvant radiation therapy in metastatic lymph nodes from melanoma
Abstract
Purpose: To analyze the outcome after adjuvant radiation therapy with standard fractionation regimen in metastatic lymph nodes (LN) from cutaneous melanoma.
Patients and methods: 86 successive patients (57 men) were treated for locally advanced melanoma in our institution. 60 patients (69%) underwent LN dissection followed by radiation therapy (RT), while 26 patients (31%) had no radiotherapy.
Results: The median number of resected LN was 12 (1 to 36) with 2 metastases (1 to 28). Median survival after the first relapse was 31.8 months. Extracapsular extension was a significant prognostic factor for regional control (p = 0.019). Median total dose was 50 Gy (30 to 70 Gy). A standard fractionation regimen was used (2 Gy/fraction).
Median number of fractions was 25 (10 to 44 fractions). Patients were treated with five fractions/week. Patients with extracapsular extension treated with surgery followed by RT (total dose ≥50 Gy) had a better regional control than patients treated by surgery followed by RT with a total dose <50 Gy (80% vs. 35% at 5-year follow-up; p = 0.004).
Conclusion: Adjuvant radiotherapy was able to increase regional control in targeted sub-population (LN with extracapsular extension).-
- July 22, 2011 at 3:42 am
Jerry,
Thanks for the link. That was not the study I was reading, but will print out and to list of things to discuss with oncologist.
The reference I recall was an ongoing study with a comment about not wanting to say just yet how good the results were, but that they were very promising.I appreciate your posts. They are always thoughtful and helpful.
Thanks,
Julie -
- July 22, 2011 at 3:42 am
Jerry,
Thanks for the link. That was not the study I was reading, but will print out and to list of things to discuss with oncologist.
The reference I recall was an ongoing study with a comment about not wanting to say just yet how good the results were, but that they were very promising.I appreciate your posts. They are always thoughtful and helpful.
Thanks,
Julie
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- July 21, 2011 at 5:27 am
http://www.ro-journal.com/content/pdf/1748-717x-6-12.pdf
Adjuvant radiation therapy in metastatic lymph nodes from melanoma
Abstract
Purpose: To analyze the outcome after adjuvant radiation therapy with standard fractionation regimen in metastatic lymph nodes (LN) from cutaneous melanoma.
Patients and methods: 86 successive patients (57 men) were treated for locally advanced melanoma in our institution. 60 patients (69%) underwent LN dissection followed by radiation therapy (RT), while 26 patients (31%) had no radiotherapy.
Results: The median number of resected LN was 12 (1 to 36) with 2 metastases (1 to 28). Median survival after the first relapse was 31.8 months. Extracapsular extension was a significant prognostic factor for regional control (p = 0.019). Median total dose was 50 Gy (30 to 70 Gy). A standard fractionation regimen was used (2 Gy/fraction).
Median number of fractions was 25 (10 to 44 fractions). Patients were treated with five fractions/week. Patients with extracapsular extension treated with surgery followed by RT (total dose ≥50 Gy) had a better regional control than patients treated by surgery followed by RT with a total dose <50 Gy (80% vs. 35% at 5-year follow-up; p = 0.004).
Conclusion: Adjuvant radiotherapy was able to increase regional control in targeted sub-population (LN with extracapsular extension).
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