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Questions regarding TAF/MEK Combo
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Questions regarding TAF/MEK Combo

› Forums › General Melanoma Community › Questions regarding TAF/MEK Combo

  • Post
    • February 1, 2017 at 3:27 pm
    Jahendry12
    Participant

      Hello – I have 2 questions I wanted to pose to the group regarding the TAF/MEK combo.

       

      1)  Has anyone NEVER had a fever but still responded?

      2)  For those that did have fevers, how long did it take for them to start?

       

      Thanks for any input you can provide.  Much appreciated!

    Viewing 5 reply threads
    • Replies
        • February 1, 2017 at 6:00 pm
        Mat
        Participant

          Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

          • February 1, 2017 at 6:00 pm
          Mat
          Participant

            Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

              • February 1, 2017 at 6:02 pm
              Jahendry12
              Participant

                Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

                • February 5, 2017 at 10:45 pm
                ilikepralinen
                Participant

                  I had fever after 2 months (38 – 39 Degrees with Shivering).

                  Doctor advised me to take Paracetamol 500mg (1-1-1)..

                  The fever went away after 3 Days.

                  Doctor also advised me not to STOP TAF/MEK combo because of fever.

                  These days i have fever every 2 – 4 Weeks.

                  • February 5, 2017 at 10:45 pm
                  ilikepralinen
                  Participant

                    I had fever after 2 months (38 – 39 Degrees with Shivering).

                    Doctor advised me to take Paracetamol 500mg (1-1-1)..

                    The fever went away after 3 Days.

                    Doctor also advised me not to STOP TAF/MEK combo because of fever.

                    These days i have fever every 2 – 4 Weeks.

                    • February 5, 2017 at 10:45 pm
                    ilikepralinen
                    Participant

                      I had fever after 2 months (38 – 39 Degrees with Shivering).

                      Doctor advised me to take Paracetamol 500mg (1-1-1)..

                      The fever went away after 3 Days.

                      Doctor also advised me not to STOP TAF/MEK combo because of fever.

                      These days i have fever every 2 – 4 Weeks.

                      • February 1, 2017 at 6:02 pm
                      Jahendry12
                      Participant

                        Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

                        • February 1, 2017 at 6:02 pm
                        Jahendry12
                        Participant

                          Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

                        • February 1, 2017 at 6:00 pm
                        Mat
                        Participant

                          Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

                          • February 1, 2017 at 7:05 pm
                          Polymath
                          Participant

                            After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

                            Gary

                              • February 1, 2017 at 7:08 pm
                              Jahendry12
                              Participant

                                Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

                                • February 2, 2017 at 3:29 pm
                                Polymath
                                Participant

                                  Hi Julie,

                                  I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

                                  Gary

                                  • February 2, 2017 at 3:29 pm
                                  Polymath
                                  Participant

                                    Hi Julie,

                                    I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

                                    Gary

                                    • February 2, 2017 at 3:29 pm
                                    Polymath
                                    Participant

                                      Hi Julie,

                                      I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

                                      Gary

                                      • February 1, 2017 at 7:08 pm
                                      Jahendry12
                                      Participant

                                        Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

                                        • February 1, 2017 at 7:08 pm
                                        Jahendry12
                                        Participant

                                          Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

                                        • February 1, 2017 at 7:05 pm
                                        Polymath
                                        Participant

                                          After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

                                          Gary

                                          • February 1, 2017 at 7:05 pm
                                          Polymath
                                          Participant

                                            After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

                                            Gary

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