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Patient Needs Help – Liver Mets
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Patient Needs Help – Liver Mets

› Forums › General Melanoma Community › Patient Needs Help – Liver Mets

  • Post
    • April 26, 2012 at 10:55 pm
    acyr
    Participant

      Hi all,

      I has been some time since I have posted on this website that was so helpful in supporting me through my last round of this disease.  I have since been up to my elbows working to get our Canadian organization off the ground.  I would say we have made great progress http://www.melanomanetwork.ca

      Hi all,

      I has been some time since I have posted on this website that was so helpful in supporting me through my last round of this disease.  I have since been up to my elbows working to get our Canadian organization off the ground.  I would say we have made great progress http://www.melanomanetwork.ca

      There is a patient who is looking for help.  She is in her 40's, has spread of the disease widely with high concentration in the liver.  Was wondering what any of you might suggest for clinical trials that have been effective on liver mets.  Is anyone still doing hepatic infusion with any success?  Have any of you had successful treatment or regression in the liver?  I believe she has failed Zelboraf (vemurafenib) and is starting Yervoy tomorrow – but Yervoy may be too slow to respond in light of her rapid progression.  Any thoughts are very welcome.  Wishing you all a bright tomorrow.

      Annette IIIB

      Melanoma Network of Canada

    Viewing 8 reply threads
    • Replies
        • April 27, 2012 at 6:50 am
        LynnLuc
        Participant

          I have heard adoptive cell therapy has shown promise with liver mets…

          also surgery http://www.ncbi.nlm.nih.gov/pubmed/11485537

          and also liver profusion

          http://www.sciencedaily.com/releases/2011/09/110923194730.htm

          • April 27, 2012 at 6:50 am
          LynnLuc
          Participant

            I have heard adoptive cell therapy has shown promise with liver mets…

            also surgery http://www.ncbi.nlm.nih.gov/pubmed/11485537

            and also liver profusion

            http://www.sciencedaily.com/releases/2011/09/110923194730.htm

              • April 27, 2012 at 5:06 pm
              acyr
              Participant

                Thanks so much Lynn.  I know they had some trials by Delcath a couple of years ago and it seemed patients were having some good responses, but don't know if the results are out there yet or if the drug has been submitted to FDA for approval.

                If anyone has any other suggestions, I welcome those too!  Thanks again Lynn.  I will pass this on.

                • April 27, 2012 at 5:06 pm
                acyr
                Participant

                  Thanks so much Lynn.  I know they had some trials by Delcath a couple of years ago and it seemed patients were having some good responses, but don't know if the results are out there yet or if the drug has been submitted to FDA for approval.

                  If anyone has any other suggestions, I welcome those too!  Thanks again Lynn.  I will pass this on.

                  • April 27, 2012 at 5:06 pm
                  acyr
                  Participant

                    Thanks so much Lynn.  I know they had some trials by Delcath a couple of years ago and it seemed patients were having some good responses, but don't know if the results are out there yet or if the drug has been submitted to FDA for approval.

                    If anyone has any other suggestions, I welcome those too!  Thanks again Lynn.  I will pass this on.

                  • April 27, 2012 at 6:50 am
                  LynnLuc
                  Participant

                    I have heard adoptive cell therapy has shown promise with liver mets…

                    also surgery http://www.ncbi.nlm.nih.gov/pubmed/11485537

                    and also liver profusion

                    http://www.sciencedaily.com/releases/2011/09/110923194730.htm

                    • April 28, 2012 at 3:18 pm
                    Gene_S
                    Participant

                      Annette, Will she be on a clinical trial or the now standard ippi treatment?

                      Best wishes,

                      Gene

                        • April 29, 2012 at 2:12 pm
                        acyr
                        Participant

                          Hi Gene,

                          She is starting Ipi, but both her and husband are worried because of the tumour load that it may be too slow to act.  They were hoping there would be a clinical trial in the US or Canada that would control or irradicate the tumours in her liver, which are a big concern at the moment.  Any thoughts?

                          Annette IIIB

                          MNC

                          • April 29, 2012 at 2:12 pm
                          acyr
                          Participant

                            Hi Gene,

                            She is starting Ipi, but both her and husband are worried because of the tumour load that it may be too slow to act.  They were hoping there would be a clinical trial in the US or Canada that would control or irradicate the tumours in her liver, which are a big concern at the moment.  Any thoughts?

                            Annette IIIB

                            MNC

                            • April 29, 2012 at 2:12 pm
                            acyr
                            Participant

                              Hi Gene,

                              She is starting Ipi, but both her and husband are worried because of the tumour load that it may be too slow to act.  They were hoping there would be a clinical trial in the US or Canada that would control or irradicate the tumours in her liver, which are a big concern at the moment.  Any thoughts?

                              Annette IIIB

                              MNC

                              • April 29, 2012 at 4:22 pm
                              Gene_S
                              Participant

                                Hi Annette,

                                The following article was recently posted by Jimmy B under a different thread, it may be of some help to you

                                Released: 4/27/2012 1:00 PM EDT
                                Source: Moffitt Cancer Center

                                Newswise — TAMPA, Fla. (April 27, 2012) – At Moffitt Cancer Center, patients with stage III and IV unrespectable melanoma are now routinely genetically profiled for several gene mutations, including the BRAF gene, a known driver oncogene for melanoma. Research has shown that mutations in the BRAF gene determine sensitivity or resistance to a class of drugs that are BRAF inhibitors.

                                Moffitt Cancer Center Researchers Working at Frontiers of Melanoma Research  

                                ——————————————————————————————

                                Possibly  Vemurafenib would be a better first choice since I believe that it works faster than ippi?

                                Hopefully others will add to this thread. If you are considering any other treatments outside the USA

                                my first choice would be to contact Ralph Moss. Do a search on "Ralph Moss and melanoma".

                                I would also suggest that she be tested for a vitamin D-3 deficiency.

                                Best wishes,

                                Gene

                                • April 29, 2012 at 4:22 pm
                                Gene_S
                                Participant

                                  Hi Annette,

                                  The following article was recently posted by Jimmy B under a different thread, it may be of some help to you

                                  Released: 4/27/2012 1:00 PM EDT
                                  Source: Moffitt Cancer Center

                                  Newswise — TAMPA, Fla. (April 27, 2012) – At Moffitt Cancer Center, patients with stage III and IV unrespectable melanoma are now routinely genetically profiled for several gene mutations, including the BRAF gene, a known driver oncogene for melanoma. Research has shown that mutations in the BRAF gene determine sensitivity or resistance to a class of drugs that are BRAF inhibitors.

                                  Moffitt Cancer Center Researchers Working at Frontiers of Melanoma Research  

                                  ——————————————————————————————

                                  Possibly  Vemurafenib would be a better first choice since I believe that it works faster than ippi?

                                  Hopefully others will add to this thread. If you are considering any other treatments outside the USA

                                  my first choice would be to contact Ralph Moss. Do a search on "Ralph Moss and melanoma".

                                  I would also suggest that she be tested for a vitamin D-3 deficiency.

                                  Best wishes,

                                  Gene

                                  • April 29, 2012 at 4:22 pm
                                  Gene_S
                                  Participant

                                    Hi Annette,

                                    The following article was recently posted by Jimmy B under a different thread, it may be of some help to you

                                    Released: 4/27/2012 1:00 PM EDT
                                    Source: Moffitt Cancer Center

                                    Newswise — TAMPA, Fla. (April 27, 2012) – At Moffitt Cancer Center, patients with stage III and IV unrespectable melanoma are now routinely genetically profiled for several gene mutations, including the BRAF gene, a known driver oncogene for melanoma. Research has shown that mutations in the BRAF gene determine sensitivity or resistance to a class of drugs that are BRAF inhibitors.

                                    Moffitt Cancer Center Researchers Working at Frontiers of Melanoma Research  

                                    ——————————————————————————————

                                    Possibly  Vemurafenib would be a better first choice since I believe that it works faster than ippi?

                                    Hopefully others will add to this thread. If you are considering any other treatments outside the USA

                                    my first choice would be to contact Ralph Moss. Do a search on "Ralph Moss and melanoma".

                                    I would also suggest that she be tested for a vitamin D-3 deficiency.

                                    Best wishes,

                                    Gene

                                  • April 28, 2012 at 3:18 pm
                                  Gene_S
                                  Participant

                                    Annette, Will she be on a clinical trial or the now standard ippi treatment?

                                    Best wishes,

                                    Gene

                                    • April 28, 2012 at 3:18 pm
                                    Gene_S
                                    Participant

                                      Annette, Will she be on a clinical trial or the now standard ippi treatment?

                                      Best wishes,

                                      Gene

                                      • April 30, 2012 at 11:40 am
                                      FormerCaregiver
                                      Participant

                                        Annette, the big problem with liver mets is that action needs to be taken quickly. I
                                        feel that surgery, if possible, is the best option. However, if melanoma is widespread
                                        the surgical oncologist may be reluctant to operate.

                                        If the patient has already tried Zelboraf, then BRAF inhibitor resistance and its
                                        consequences raise another problem. Therefore, drugs such as MEK/PI3K or HSP90
                                        inhibitors (XL888) may be beneficial. See:
                                        http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612

                                        Hope this helps

                                        Frank from Australia

                                        • April 30, 2012 at 11:40 am
                                        FormerCaregiver
                                        Participant

                                          Annette, the big problem with liver mets is that action needs to be taken quickly. I
                                          feel that surgery, if possible, is the best option. However, if melanoma is widespread
                                          the surgical oncologist may be reluctant to operate.

                                          If the patient has already tried Zelboraf, then BRAF inhibitor resistance and its
                                          consequences raise another problem. Therefore, drugs such as MEK/PI3K or HSP90
                                          inhibitors (XL888) may be beneficial. See:
                                          http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612

                                          Hope this helps

                                          Frank from Australia

                                          • April 30, 2012 at 11:40 am
                                          FormerCaregiver
                                          Participant

                                            Annette, the big problem with liver mets is that action needs to be taken quickly. I
                                            feel that surgery, if possible, is the best option. However, if melanoma is widespread
                                            the surgical oncologist may be reluctant to operate.

                                            If the patient has already tried Zelboraf, then BRAF inhibitor resistance and its
                                            consequences raise another problem. Therefore, drugs such as MEK/PI3K or HSP90
                                            inhibitors (XL888) may be beneficial. See:
                                            http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612

                                            Hope this helps

                                            Frank from Australia

                                        Viewing 8 reply threads
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