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Hope in new treatment

› Forums › General Melanoma Community › Hope in new treatment

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      • June 5, 2011 at 4:35 pm
      nicoli
      Participant

        Hi, Gail. Thanks for posting this.

        I must admit that I don't do research but read the research posted on this board.

        I think it's a form of denial. Oh, well, whatever works.

        Nicki,Stage 3b

          • June 5, 2011 at 7:36 pm
          boot2aboot
          Participant

            vemurafenib is welcome news for those with certain genetic characteristics of the type of melanoma invading thier bodies…i think doctors should automatically genetically test tumors whether one is in stage 2,3, or 4…target therapies are the way to go…and certain combos seems to work the best as this stupid cancer rapidly mutates….it's good these guys are trying to find the dart board we are throwing darts at…

            i imagine there will be hundreds of melanoma types and once they know how the cancer works, it is easy to stop either angiogenisis, apopotosis, cytokine inflammations and RNA screw-ups…i hope i am around long enough to take advantage of new breakthroughs…

            • June 5, 2011 at 7:36 pm
            boot2aboot
            Participant

              vemurafenib is welcome news for those with certain genetic characteristics of the type of melanoma invading thier bodies…i think doctors should automatically genetically test tumors whether one is in stage 2,3, or 4…target therapies are the way to go…and certain combos seems to work the best as this stupid cancer rapidly mutates….it's good these guys are trying to find the dart board we are throwing darts at…

              i imagine there will be hundreds of melanoma types and once they know how the cancer works, it is easy to stop either angiogenisis, apopotosis, cytokine inflammations and RNA screw-ups…i hope i am around long enough to take advantage of new breakthroughs…

            • June 5, 2011 at 4:35 pm
            nicoli
            Participant

              Hi, Gail. Thanks for posting this.

              I must admit that I don't do research but read the research posted on this board.

              I think it's a form of denial. Oh, well, whatever works.

              Nicki,Stage 3b

              • June 5, 2011 at 9:03 pm
              Linny
              Participant

                To me, this is really encouraging for those with advanced melanoma:

                "The patients took either the standard chemotherapy drug dacarbazine or the new drug. After three months, the effectiveness was so stark that the study was stopped so those getting standard chemotherapy could switch."

                  • June 5, 2011 at 9:44 pm
                  Lisa13
                  Participant

                    I'm so happy for all the people who will benefit from this wonderful drug as well as PLX-4032 (BRAF). My tumour unfortunately tested negative for this mutation so I'm out of luck. I'm a bit bummed that they're finding all these wonderful drugs for BRAF mutations because it makes me wonder if they'll come up with something wonderful for the rest of us.   I do feel strongly that they're coming close to finding the best combo that will help so many of us.

                    Lisa

                    • June 5, 2011 at 9:44 pm
                    Lisa13
                    Participant

                      I'm so happy for all the people who will benefit from this wonderful drug as well as PLX-4032 (BRAF). My tumour unfortunately tested negative for this mutation so I'm out of luck. I'm a bit bummed that they're finding all these wonderful drugs for BRAF mutations because it makes me wonder if they'll come up with something wonderful for the rest of us.   I do feel strongly that they're coming close to finding the best combo that will help so many of us.

                      Lisa

                    • June 5, 2011 at 9:03 pm
                    Linny
                    Participant

                      To me, this is really encouraging for those with advanced melanoma:

                      "The patients took either the standard chemotherapy drug dacarbazine or the new drug. After three months, the effectiveness was so stark that the study was stopped so those getting standard chemotherapy could switch."

                      • June 5, 2011 at 11:45 pm
                      KellieSue
                      Participant

                        This is awesome news. I watched the CBS evening news segments tonight.

                        I'm currently on B-RAF clinical trial.  Since I tested positive for that does that mean I'm positive for being able to take vemurafenib when it becomes available? Or is it completely separate?

                        I'm always so confused about genetic mutations and certain genes concerning my melanoma.

                        Kellie(from Iowa) Stage IV on B-RAF

                          • June 6, 2011 at 11:08 pm
                          EmilyandMike
                          Participant

                            Kellie – Just to clarify:  vemurafenib – aka BRAF or PLX4032 is the same drug from the company Plexxikon.  We are seeing all of this news this week (but most of us already know all about these drugs) due to the ASCO conference.  The drug companies rename their drugs when they emerge from clinical trials – like Ipilumamab (Yervoy) and Vemurafenib (the new name for the BRAF drug).  It is confusing!

                            You can see all of the melanoma research abstracts from the conference here: 

                            http://abstract.asco.org/CatAbstView_102_121_AA.html 

                            Best,

                            Emily

                            • June 6, 2011 at 11:08 pm
                            EmilyandMike
                            Participant

                              Kellie – Just to clarify:  vemurafenib – aka BRAF or PLX4032 is the same drug from the company Plexxikon.  We are seeing all of this news this week (but most of us already know all about these drugs) due to the ASCO conference.  The drug companies rename their drugs when they emerge from clinical trials – like Ipilumamab (Yervoy) and Vemurafenib (the new name for the BRAF drug).  It is confusing!

                              You can see all of the melanoma research abstracts from the conference here: 

                              http://abstract.asco.org/CatAbstView_102_121_AA.html 

                              Best,

                              Emily

                            • June 5, 2011 at 11:45 pm
                            KellieSue
                            Participant

                              This is awesome news. I watched the CBS evening news segments tonight.

                              I'm currently on B-RAF clinical trial.  Since I tested positive for that does that mean I'm positive for being able to take vemurafenib when it becomes available? Or is it completely separate?

                              I'm always so confused about genetic mutations and certain genes concerning my melanoma.

                              Kellie(from Iowa) Stage IV on B-RAF

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