Carbo/Taxol or IPI?

This topic has 48 replies, 8 voices, and was last updated 12 years, 6 months ago by jim Breitfeller.

Post

- October 7, 2011 at 1:28 pm
- Quote
emilypen
Participant
Hi All,

My hubby started on chemo this week, Monday. My question is how quickly does it normally show results after 1 treatment?

He has a lot of sub-q mets on his back and chest, and we felt they were starting to shrink before the treatment on Monday although the doctor felt IPI had not been successfull in any way because his internal tumours had grown so much.

Now however , almost all of the sub-q's on his back and arms are starting to flatten out and get smaller. I noticed it on Tuesday and thought there is no way it's the chemo working this fast?

Hi All,

My hubby started on chemo this week, Monday. My question is how quickly does it normally show results after 1 treatment?

He has a lot of sub-q mets on his back and chest, and we felt they were starting to shrink before the treatment on Monday although the doctor felt IPI had not been successfull in any way because his internal tumours had grown so much.

Now however , almost all of the sub-q's on his back and arms are starting to flatten out and get smaller. I noticed it on Tuesday and thought there is no way it's the chemo working this fast?

Would love to hear others thoughts and/or experiences?

thanks,

Em

Viewing 14 reply threads

Replies

- - October 7, 2011 at 1:46 pm
  - Quote
  Carmon in NM
  Participant
  I haven't tried ipi but I did a trial combining carbo taxol and temodar over the winter. After one infusion the right adrenal lesion had shrunk by 53%. At the end of the six week trial the lesion was gone and so far no recurrance.
  
  These were six 28 day cycles.
- - October 7, 2011 at 1:46 pm
  - Quote
  Carmon in NM
  Participant
  I haven't tried ipi but I did a trial combining carbo taxol and temodar over the winter. After one infusion the right adrenal lesion had shrunk by 53%. At the end of the six week trial the lesion was gone and so far no recurrance.
  
  These were six 28 day cycles.
- - October 7, 2011 at 1:46 pm
  - Quote
  Carmon in NM
  Participant
  I haven't tried ipi but I did a trial combining carbo taxol and temodar over the winter. After one infusion the right adrenal lesion had shrunk by 53%. At the end of the six week trial the lesion was gone and so far no recurrance.
  
  These were six 28 day cycles.
- - October 7, 2011 at 2:03 pm
  - Quote
  lyndaloo
  Participant
  My hubby has finished two rounds of decarbazine chemo and we have noticed a couple of his surface lumps have shrunk somewhat and flattened out a bit. He is scheduled for the ipi trial next month, he was required to do two rounds of chemo first to see if this would work. He hasn't had his scan yet to see the internal results. I am wondering if you are a possible late responder to the ipi, when did you complete the ipi, was it four infusions three weeks apart? Regardless, this is great news!!
- - October 7, 2011 at 2:03 pm
  - Quote
  lyndaloo
  Participant
  My hubby has finished two rounds of decarbazine chemo and we have noticed a couple of his surface lumps have shrunk somewhat and flattened out a bit. He is scheduled for the ipi trial next month, he was required to do two rounds of chemo first to see if this would work. He hasn't had his scan yet to see the internal results. I am wondering if you are a possible late responder to the ipi, when did you complete the ipi, was it four infusions three weeks apart? Regardless, this is great news!!
- - October 7, 2011 at 2:03 pm
  - Quote
  lyndaloo
  Participant
  My hubby has finished two rounds of decarbazine chemo and we have noticed a couple of his surface lumps have shrunk somewhat and flattened out a bit. He is scheduled for the ipi trial next month, he was required to do two rounds of chemo first to see if this would work. He hasn't had his scan yet to see the internal results. I am wondering if you are a possible late responder to the ipi, when did you complete the ipi, was it four infusions three weeks apart? Regardless, this is great news!!
- - October 7, 2011 at 3:33 pm
  - Quote
  Cooper
  Participant
  When we were given options we found that carbo taxol had no research showing it did much for melanoma. IPI however showed 20% response in hundreds of patients. So we did that and have had good luck so far with it. It works on the immune system whereas carbo/taxol is a chemo working against the whole body.
- - October 7, 2011 at 3:33 pm
  - Quote
  Cooper
  Participant
  When we were given options we found that carbo taxol had no research showing it did much for melanoma. IPI however showed 20% response in hundreds of patients. So we did that and have had good luck so far with it. It works on the immune system whereas carbo/taxol is a chemo working against the whole body.
- - October 7, 2011 at 3:33 pm
  - Quote
  Cooper
  Participant
  When we were given options we found that carbo taxol had no research showing it did much for melanoma. IPI however showed 20% response in hundreds of patients. So we did that and have had good luck so far with it. It works on the immune system whereas carbo/taxol is a chemo working against the whole body.
- - October 7, 2011 at 5:55 pm
  - Quote
  jim Breitfeller
  Participant
  Em,
  
  Your oncologist is wrong!!!!
  
  your Hubby took the 4th dose of Ipilimumab (Yervoy) September 6, 2011. That was 84 days since the start of Ipi therapy.
  
  Today 10-7-11 would be another 30 days. So 84 + 30 = 114 days.
  
  http://2.bp.blogspot.com/-Bkp8ysLnlCY/ToXuykM4MVI/AAAAAAAAAgs/BRXLG5_YwfM/s1600/Yervoy%2BProtocol%2B2011.jpg
  
  Your doctor did not give the immune system enough time to mount an attack on the tumors. (see the graph with the time line.)
  
  If it was me, I would HOLD on the chemo. IT could kill the T-cells along with the Immune response.
  
  Best regards,
  
  Jimmy b
  - October 7, 2011 at 7:50 pm
    
    Quote
    emilypen
    Participant
    
    Hi Jim,
    
    We spoke with our oncologist and one other about whether or not to wait before trying the carbo/taxol combo becasue we too thought that IPI might need more time.
    
    Both opinions were the similar, and although they did not rule out response to IPI, the major concern they both had was life expectancy and if IPI did not kick in he may only have a 4-8 weeks. Which may have made him too sick or not here, to handle the chemo if we waited.
    
    Both doctors said that they felt the chemo worked on a different pathway then the IPI and would not effect a late reponse to IPI.
    
    While we know that chemo is not hugely succesfull we were hoping it would at least give more time if the IPI did not work.
    
    The one thing that both docs used a tool to say there were afraid IPI was not working was his lymphocyte count it started at a decent number before IPI then rose after the first infusion, then dropped steadily from then on. It is currently very low.
    
    Is there any research that backs up a low lymph counts and a response to ipi?
    
    thanks,
    
    Emily
  - October 7, 2011 at 8:41 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Emily,
    
    Something shut down the expansion of the (ALC) Absolute Lymphocyte count.
    
    It could have be the upregulation of the PD-1 making the CD8+ T-cell exhausted. Anti-PD-1 would reverse the suppression.
    
    Or could be the tumors secreting Galectin-3 which cobinds to ZAP 70 and makes the TCR complex unstable. The (TCR) T cell Receptor plays a major roll in the immune response. It is (Signal 1) with an tumor antigen. With out that signal, the activation is dead in the water.
    
    There is a possibility that there was not enough Tumor-specific antigens to go around to help activate the T-cells. It is possible that the chemo regime may help shed the tumor antigens.
    
    When will his next scan be?
    
    Best regards,
    
    Jimmy B
    
    If Only I was a Doc. I would check out my hyothisis, and trying adding anti-PD-1 and Anti-GAL-3 . on some of his tumor cells, and see what happens.
  - October 7, 2011 at 8:41 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Emily,
    
    Something shut down the expansion of the (ALC) Absolute Lymphocyte count.
    
    It could have be the upregulation of the PD-1 making the CD8+ T-cell exhausted. Anti-PD-1 would reverse the suppression.
    
    Or could be the tumors secreting Galectin-3 which cobinds to ZAP 70 and makes the TCR complex unstable. The (TCR) T cell Receptor plays a major roll in the immune response. It is (Signal 1) with an tumor antigen. With out that signal, the activation is dead in the water.
    
    There is a possibility that there was not enough Tumor-specific antigens to go around to help activate the T-cells. It is possible that the chemo regime may help shed the tumor antigens.
    
    When will his next scan be?
    
    Best regards,
    
    Jimmy B
    
    If Only I was a Doc. I would check out my hyothisis, and trying adding anti-PD-1 and Anti-GAL-3 . on some of his tumor cells, and see what happens.
  - October 7, 2011 at 8:41 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Emily,
    
    Something shut down the expansion of the (ALC) Absolute Lymphocyte count.
    
    It could have be the upregulation of the PD-1 making the CD8+ T-cell exhausted. Anti-PD-1 would reverse the suppression.
    
    Or could be the tumors secreting Galectin-3 which cobinds to ZAP 70 and makes the TCR complex unstable. The (TCR) T cell Receptor plays a major roll in the immune response. It is (Signal 1) with an tumor antigen. With out that signal, the activation is dead in the water.
    
    There is a possibility that there was not enough Tumor-specific antigens to go around to help activate the T-cells. It is possible that the chemo regime may help shed the tumor antigens.
    
    When will his next scan be?
    
    Best regards,
    
    Jimmy B
    
    If Only I was a Doc. I would check out my hyothisis, and trying adding anti-PD-1 and Anti-GAL-3 . on some of his tumor cells, and see what happens.
  - October 8, 2011 at 12:34 am
    
    Quote
    Lisa13
    Participant
    
    I tend to agree with Jimmy – that he is perhaps a late responder of ipi. This drug is still in trials, so I don't think Dr's know 100% what to expect. Maybe your husbands internal mets have grown, but perhaps ipi has worked it's magic on the sub q's instead?
    
    If your Dr suspects it's the chemo, then let's hope this helps with tumour burden to get him into another trial.
    
    Sending you best wishes and lots or prayers.
    
    Lisa
  - October 8, 2011 at 12:34 am
    
    Quote
    Lisa13
    Participant
    
    I tend to agree with Jimmy – that he is perhaps a late responder of ipi. This drug is still in trials, so I don't think Dr's know 100% what to expect. Maybe your husbands internal mets have grown, but perhaps ipi has worked it's magic on the sub q's instead?
    
    If your Dr suspects it's the chemo, then let's hope this helps with tumour burden to get him into another trial.
    
    Sending you best wishes and lots or prayers.
    
    Lisa
  - October 8, 2011 at 12:34 am
    
    Quote
    Lisa13
    Participant
    
    I tend to agree with Jimmy – that he is perhaps a late responder of ipi. This drug is still in trials, so I don't think Dr's know 100% what to expect. Maybe your husbands internal mets have grown, but perhaps ipi has worked it's magic on the sub q's instead?
    
    If your Dr suspects it's the chemo, then let's hope this helps with tumour burden to get him into another trial.
    
    Sending you best wishes and lots or prayers.
    
    Lisa
  - October 8, 2011 at 7:41 pm
    
    Quote
    Cooper
    Participant
    
    Jimmy, If you were a doc maybe you could spell "hypothesis" I wouldn't go so far to say someone's doc was right or wrong. That really isn't our place here, but to support them to learn more and use the doc as a consultant. Lots of unknowns with these new drugs that's for sure.
  - October 8, 2011 at 8:38 pm
    
    Quote
    jim Breitfeller
    Participant
    
    I am so sorry you feel that way.
    
    I call it like I see it. I am not here to sugar-coat things, I am here to educate and help save lives. If they want to take my information so be it, if not that is ok too. YOU have to live with your decision.
    
    Have you ever seen doctors make major mistakes? I have, and it has cost patients dearly. In my opinion, 86 days of yervoy tharapy is to short of a timespan to stop the therapy based on clinical data. (The delayed response associated with Yervoy).
    
    At least I don't hide behind the word Anonymous. I am not afraid to standup and fight for what I believe in. Do not throw rocks in the glass building, you may only hurt yourself.
  - October 8, 2011 at 8:38 pm
    
    Quote
    jim Breitfeller
    Participant
    
    I am so sorry you feel that way.
    
    I call it like I see it. I am not here to sugar-coat things, I am here to educate and help save lives. If they want to take my information so be it, if not that is ok too. YOU have to live with your decision.
    
    Have you ever seen doctors make major mistakes? I have, and it has cost patients dearly. In my opinion, 86 days of yervoy tharapy is to short of a timespan to stop the therapy based on clinical data. (The delayed response associated with Yervoy).
    
    At least I don't hide behind the word Anonymous. I am not afraid to standup and fight for what I believe in. Do not throw rocks in the glass building, you may only hurt yourself.
  - October 8, 2011 at 8:38 pm
    
    Quote
    jim Breitfeller
    Participant
    
    I am so sorry you feel that way.
    
    I call it like I see it. I am not here to sugar-coat things, I am here to educate and help save lives. If they want to take my information so be it, if not that is ok too. YOU have to live with your decision.
    
    Have you ever seen doctors make major mistakes? I have, and it has cost patients dearly. In my opinion, 86 days of yervoy tharapy is to short of a timespan to stop the therapy based on clinical data. (The delayed response associated with Yervoy).
    
    At least I don't hide behind the word Anonymous. I am not afraid to standup and fight for what I believe in. Do not throw rocks in the glass building, you may only hurt yourself.
  - October 8, 2011 at 9:17 pm
    
    Quote
    Cooper
    Participant
    
    Everyone is anonymous here, they just haven't made up clever names. Not a big deal when you look at the whole picture. You're not a doc and shouldn't be advising folks like a doctor, but with suggestions that perhaps you know are true. I think your intentions are probably good but even the experts can be wrong as well as you.
  - October 8, 2011 at 9:50 pm
    
    Quote
    jim Breitfeller
    Participant
    
    http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 9:50 pm
    
    Quote
    jim Breitfeller
    Participant
    
    http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 9:50 pm
    
    Quote
    jim Breitfeller
    Participant
    
    http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 9:56 pm
    
    Quote
    jim Breitfeller
    Participant
    
    assessment needs:
    
    Tumour response to YERVOY™ should be assessed only after completion of induction therapy, 12 weeks after treatment initiation to allow YERVOY™ time to trigger an anti-tumour immune response (1,2,4)
    
    Tumour response assessment prior to this time may fail to detect the delayed tumour responses characteristic of YERVOY™, resulting in some responses being mistaken for progressive disease and potentially premature discontinuation of treatment. (2,3)
    
    In the pivotal trial, further assessments were performed at week 16 and 24 and every 3 months thereafter. (4)
    
    Source:http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 9:56 pm
    
    Quote
    jim Breitfeller
    Participant
    
    assessment needs:
    
    Tumour response to YERVOY™ should be assessed only after completion of induction therapy, 12 weeks after treatment initiation to allow YERVOY™ time to trigger an anti-tumour immune response (1,2,4)
    
    Tumour response assessment prior to this time may fail to detect the delayed tumour responses characteristic of YERVOY™, resulting in some responses being mistaken for progressive disease and potentially premature discontinuation of treatment. (2,3)
    
    In the pivotal trial, further assessments were performed at week 16 and 24 and every 3 months thereafter. (4)
    
    Source:http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 10:45 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Jimmy is right. Bristol Myer Squibb's own site states at week 16 was where the pivotal trial evaluated the patients.
    
    Go jimmy go!!!!!
    
    A Stage IV Yervoy Survivor
  - October 8, 2011 at 10:45 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Jimmy is right. Bristol Myer Squibb's own site states at week 16 was where the pivotal trial evaluated the patients.
    
    Go jimmy go!!!!!
    
    A Stage IV Yervoy Survivor
  - October 8, 2011 at 10:45 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Jimmy is right. Bristol Myer Squibb's own site states at week 16 was where the pivotal trial evaluated the patients.
    
    Go jimmy go!!!!!
    
    A Stage IV Yervoy Survivor
  - October 8, 2011 at 9:56 pm
    
    Quote
    jim Breitfeller
    Participant
    
    assessment needs:
    
    Tumour response to YERVOY™ should be assessed only after completion of induction therapy, 12 weeks after treatment initiation to allow YERVOY™ time to trigger an anti-tumour immune response (1,2,4)
    
    Tumour response assessment prior to this time may fail to detect the delayed tumour responses characteristic of YERVOY™, resulting in some responses being mistaken for progressive disease and potentially premature discontinuation of treatment. (2,3)
    
    In the pivotal trial, further assessments were performed at week 16 and 24 and every 3 months thereafter. (4)
    
    Source:http://www.bms.se/se/onkologi/yervoy/efficacy/Specific-patterns-of-response/
  - October 8, 2011 at 9:17 pm
    
    Quote
    Cooper
    Participant
    
    Everyone is anonymous here, they just haven't made up clever names. Not a big deal when you look at the whole picture. You're not a doc and shouldn't be advising folks like a doctor, but with suggestions that perhaps you know are true. I think your intentions are probably good but even the experts can be wrong as well as you.
  - October 8, 2011 at 9:17 pm
    
    Quote
    Cooper
    Participant
    
    Everyone is anonymous here, they just haven't made up clever names. Not a big deal when you look at the whole picture. You're not a doc and shouldn't be advising folks like a doctor, but with suggestions that perhaps you know are true. I think your intentions are probably good but even the experts can be wrong as well as you.
  - October 8, 2011 at 7:41 pm
    
    Quote
    Cooper
    Participant
    
    Jimmy, If you were a doc maybe you could spell "hypothesis" I wouldn't go so far to say someone's doc was right or wrong. That really isn't our place here, but to support them to learn more and use the doc as a consultant. Lots of unknowns with these new drugs that's for sure.
  - October 8, 2011 at 7:41 pm
    
    Quote
    Cooper
    Participant
    
    Jimmy, If you were a doc maybe you could spell "hypothesis" I wouldn't go so far to say someone's doc was right or wrong. That really isn't our place here, but to support them to learn more and use the doc as a consultant. Lots of unknowns with these new drugs that's for sure.
  - October 7, 2011 at 7:50 pm
    
    Quote
    emilypen
    Participant
    
    Hi Jim,
    
    We spoke with our oncologist and one other about whether or not to wait before trying the carbo/taxol combo becasue we too thought that IPI might need more time.
    
    Both opinions were the similar, and although they did not rule out response to IPI, the major concern they both had was life expectancy and if IPI did not kick in he may only have a 4-8 weeks. Which may have made him too sick or not here, to handle the chemo if we waited.
    
    Both doctors said that they felt the chemo worked on a different pathway then the IPI and would not effect a late reponse to IPI.
    
    While we know that chemo is not hugely succesfull we were hoping it would at least give more time if the IPI did not work.
    
    The one thing that both docs used a tool to say there were afraid IPI was not working was his lymphocyte count it started at a decent number before IPI then rose after the first infusion, then dropped steadily from then on. It is currently very low.
    
    Is there any research that backs up a low lymph counts and a response to ipi?
    
    thanks,
    
    Emily
  - October 7, 2011 at 7:50 pm
    
    Quote
    emilypen
    Participant
    
    Hi Jim,
    
    We spoke with our oncologist and one other about whether or not to wait before trying the carbo/taxol combo becasue we too thought that IPI might need more time.
    
    Both opinions were the similar, and although they did not rule out response to IPI, the major concern they both had was life expectancy and if IPI did not kick in he may only have a 4-8 weeks. Which may have made him too sick or not here, to handle the chemo if we waited.
    
    Both doctors said that they felt the chemo worked on a different pathway then the IPI and would not effect a late reponse to IPI.
    
    While we know that chemo is not hugely succesfull we were hoping it would at least give more time if the IPI did not work.
    
    The one thing that both docs used a tool to say there were afraid IPI was not working was his lymphocyte count it started at a decent number before IPI then rose after the first infusion, then dropped steadily from then on. It is currently very low.
    
    Is there any research that backs up a low lymph counts and a response to ipi?
    
    thanks,
    
    Emily
- - October 7, 2011 at 5:55 pm
  - Quote
  jim Breitfeller
  Participant
  Em,
  
  Your oncologist is wrong!!!!
  
  your Hubby took the 4th dose of Ipilimumab (Yervoy) September 6, 2011. That was 84 days since the start of Ipi therapy.
  
  Today 10-7-11 would be another 30 days. So 84 + 30 = 114 days.
  
  http://2.bp.blogspot.com/-Bkp8ysLnlCY/ToXuykM4MVI/AAAAAAAAAgs/BRXLG5_YwfM/s1600/Yervoy%2BProtocol%2B2011.jpg
  
  Your doctor did not give the immune system enough time to mount an attack on the tumors. (see the graph with the time line.)
  
  If it was me, I would HOLD on the chemo. IT could kill the T-cells along with the Immune response.
  
  Best regards,
  
  Jimmy b
- - October 7, 2011 at 5:55 pm
  - Quote
  jim Breitfeller
  Participant
  Em,
  
  Your oncologist is wrong!!!!
  
  your Hubby took the 4th dose of Ipilimumab (Yervoy) September 6, 2011. That was 84 days since the start of Ipi therapy.
  
  Today 10-7-11 would be another 30 days. So 84 + 30 = 114 days.
  
  http://2.bp.blogspot.com/-Bkp8ysLnlCY/ToXuykM4MVI/AAAAAAAAAgs/BRXLG5_YwfM/s1600/Yervoy%2BProtocol%2B2011.jpg
  
  Your doctor did not give the immune system enough time to mount an attack on the tumors. (see the graph with the time line.)
  
  If it was me, I would HOLD on the chemo. IT could kill the T-cells along with the Immune response.
  
  Best regards,
  
  Jimmy b
- - October 8, 2011 at 1:41 am
  - Quote
  FormerCaregiver
  Participant
  Em, your husband could be experiencing a late response to ipi. However, something is preventing this response from being effective, and Jimmy's explanation in this thread sounds reasonable to me.
  
  The problem now is compounded by a sense that time is short, so does one keep going with the chemo, try to get treated with Anti PD-1, or wait to see if there is any late response to ipi?
  
  I am not sure that there are any easy answers.
  
  My thoughts and prayers are with you and your husband.
  
  Frank from Australia
- - October 8, 2011 at 1:41 am
  - Quote
  FormerCaregiver
  Participant
  Em, your husband could be experiencing a late response to ipi. However, something is preventing this response from being effective, and Jimmy's explanation in this thread sounds reasonable to me.
  
  The problem now is compounded by a sense that time is short, so does one keep going with the chemo, try to get treated with Anti PD-1, or wait to see if there is any late response to ipi?
  
  I am not sure that there are any easy answers.
  
  My thoughts and prayers are with you and your husband.
  
  Frank from Australia
- - October 8, 2011 at 1:41 am
  - Quote
  FormerCaregiver
  Participant
  Em, your husband could be experiencing a late response to ipi. However, something is preventing this response from being effective, and Jimmy's explanation in this thread sounds reasonable to me.
  
  The problem now is compounded by a sense that time is short, so does one keep going with the chemo, try to get treated with Anti PD-1, or wait to see if there is any late response to ipi?
  
  I am not sure that there are any easy answers.
  
  My thoughts and prayers are with you and your husband.
  
  Frank from Australia
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.
  - October 8, 2011 at 10:27 am
    
    Quote
    Terra
    Participant
    
    It is a very difficult decision Emily. We are still hoping Derek is a late responder as well but time is short. I think with chemo they can tell very soon. They scanned us after 3 injections. How soon can they rescan him? We are thinking of you guys.