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Biochemo

› Forums › General Melanoma Community › Biochemo

  • Post
    • July 12, 2011 at 2:25 am
    gabsound
    Participant
      Has anyone done biochemo with Temodar, IL 2 and interferon?

      I had an intransiti tumor w melanoma cells. My oncologist is suggesting this treatment. I’ve seen other regimens and wonder if anyone has heard of this one.

      Julie in Las Vegas

      Has anyone done biochemo with Temodar, IL 2 and interferon?

      I had an intransiti tumor w melanoma cells. My oncologist is suggesting this treatment. I’ve seen other regimens and wonder if anyone has heard of this one.

      Julie in Las Vegas

    Viewing 10 reply threads
    • Replies
        • July 12, 2011 at 12:15 pm
        jim Breitfeller
        Participant

          Julie,

          You may want to do radiation on the largest tumor if possible. Try to get it to shed tumor specific antigens so that the Macrophages can digest and present on their surfaces. Then, if you do Yervoy, it will block the surppresiveness of the the Tregs. Finnally, you do

          HD IL-2 to help grow and differeniate the Tcells into CD-8 t-cells, They mature into cytoxic T Lymphocytes and attack the tumors.

           

          http://www.box.net/shared/kjgr6dkztj

          http://www.box.net/shared/n0xcdimy5d

          Best regards

          Jimmy B

          http://melanomamissionary.blogspot.com/

            • July 13, 2011 at 5:54 pm
            gabsound
            Participant

              Jimmy,

              Thanks for sharing your personal research. I am trying to digest it and will copy it to bring along to my oncologist at my next visit.

              I had 3 lumps in my leg. The smallest one they left in. One was just a pseudocyst (removed) and the third was  also removed. That last one is the largest one and it had melanoma cells in it and was falling apart when they took it out.

              Tahnks for your thoughts,

              Julie

              • July 13, 2011 at 5:54 pm
              gabsound
              Participant

                Jimmy,

                Thanks for sharing your personal research. I am trying to digest it and will copy it to bring along to my oncologist at my next visit.

                I had 3 lumps in my leg. The smallest one they left in. One was just a pseudocyst (removed) and the third was  also removed. That last one is the largest one and it had melanoma cells in it and was falling apart when they took it out.

                Tahnks for your thoughts,

                Julie

              • July 12, 2011 at 12:15 pm
              jim Breitfeller
              Participant

                Julie,

                You may want to do radiation on the largest tumor if possible. Try to get it to shed tumor specific antigens so that the Macrophages can digest and present on their surfaces. Then, if you do Yervoy, it will block the surppresiveness of the the Tregs. Finnally, you do

                HD IL-2 to help grow and differeniate the Tcells into CD-8 t-cells, They mature into cytoxic T Lymphocytes and attack the tumors.

                 

                http://www.box.net/shared/kjgr6dkztj

                http://www.box.net/shared/n0xcdimy5d

                Best regards

                Jimmy B

                http://melanomamissionary.blogspot.com/

                • July 12, 2011 at 12:26 pm
                RMcLegal
                Participant

                  Hi Julie, I was diagnosed Stage IIIc (14 malignant nodes) in 2003 and did biochemo treatments with IL-2, Interferon, Dacarbazine, Vinblastin, and Cisplatin.  Today I'm still healthy and NED.  Hospitalization during biochemo was a great benefit because that allowed more aggressive treatment of side effects.  Rough stuff, but doable.  Best wishes to you.

                  Rich

                  http://www.hotelmelanoma.blogspot.com

                    • July 13, 2011 at 5:58 pm
                    gabsound
                    Participant

                      Rich,

                      Thank you for your reply. I have previously looked you up when I was looking for biochemo info from the bulletin board. I hope I have as good of a response as you had. I too, am glad that they do it in the hospital. I think the less my family sees of this part the better. Still hoping for the best!

                      Julie

                      • July 13, 2011 at 7:02 pm
                      RMcLegal
                      Participant

                        My wife and I made a joint decision to keep everyone (including immediate family) out of the hospital during biochemo treatment incarceration.  I looked a whole lot worse than I was (a student hospital chaplain once insisted it was time to call a priest), and we thought it'd just unnecessarily alarm people to see me in the hospital.  And I didn't care whether I had visitors or not.  Best wishes.

                        • July 13, 2011 at 9:50 pm
                        nicoli
                        Participant

                          I agree. I generally don't want anyone to visit me in the hospital and I didn't want anyone to visit when I did biochemo. Two of my adult children did come for a few minutes my first week but I told them not to bother the second week. My husband was there almost all day but left in the evening. I did need him there to encourage me to eat, answer the phone, etc.

                          Our children, and especially grandchildren, think of us as strong and in control. That's pretty much how we all feel about our parents, at least until they get really old and we switch positions. I think it is too traumatic for them to see biochemo. Although I agree that we probably looked worse than we were!

                          I mostly just looked tired and pale and I slept about 80% of the time.  I went potty every 20 minutes and had a potty chair  right by the bed so it wasn't too cool to visit me.

                          Nicki, Stage 3b

                          • July 13, 2011 at 9:50 pm
                          nicoli
                          Participant

                            I agree. I generally don't want anyone to visit me in the hospital and I didn't want anyone to visit when I did biochemo. Two of my adult children did come for a few minutes my first week but I told them not to bother the second week. My husband was there almost all day but left in the evening. I did need him there to encourage me to eat, answer the phone, etc.

                            Our children, and especially grandchildren, think of us as strong and in control. That's pretty much how we all feel about our parents, at least until they get really old and we switch positions. I think it is too traumatic for them to see biochemo. Although I agree that we probably looked worse than we were!

                            I mostly just looked tired and pale and I slept about 80% of the time.  I went potty every 20 minutes and had a potty chair  right by the bed so it wasn't too cool to visit me.

                            Nicki, Stage 3b

                            • July 13, 2011 at 7:02 pm
                            RMcLegal
                            Participant

                              My wife and I made a joint decision to keep everyone (including immediate family) out of the hospital during biochemo treatment incarceration.  I looked a whole lot worse than I was (a student hospital chaplain once insisted it was time to call a priest), and we thought it'd just unnecessarily alarm people to see me in the hospital.  And I didn't care whether I had visitors or not.  Best wishes.

                              • July 13, 2011 at 5:58 pm
                              gabsound
                              Participant

                                Rich,

                                Thank you for your reply. I have previously looked you up when I was looking for biochemo info from the bulletin board. I hope I have as good of a response as you had. I too, am glad that they do it in the hospital. I think the less my family sees of this part the better. Still hoping for the best!

                                Julie

                              • July 12, 2011 at 12:26 pm
                              RMcLegal
                              Participant

                                Hi Julie, I was diagnosed Stage IIIc (14 malignant nodes) in 2003 and did biochemo treatments with IL-2, Interferon, Dacarbazine, Vinblastin, and Cisplatin.  Today I'm still healthy and NED.  Hospitalization during biochemo was a great benefit because that allowed more aggressive treatment of side effects.  Rough stuff, but doable.  Best wishes to you.

                                Rich

                                http://www.hotelmelanoma.blogspot.com

                                • July 12, 2011 at 3:32 pm
                                DonW
                                Participant

                                  Julie — the 'normal' biochemo is what Rich described: cisplatin, vinblastine and decarbazine (DVD) plus IL2 and inf. Sometimes they subsitute Temodar for decarbazine (DTIC) because they are two forms of the same drug and the Temoder version is thought to cross the barrier into the brian. The regimen they are recommending for you is Temodar alone plus IL2 and inf? I've never heard of that one.

                                  • July 12, 2011 at 3:32 pm
                                  DonW
                                  Participant

                                    Julie — the 'normal' biochemo is what Rich described: cisplatin, vinblastine and decarbazine (DVD) plus IL2 and inf. Sometimes they subsitute Temodar for decarbazine (DTIC) because they are two forms of the same drug and the Temoder version is thought to cross the barrier into the brian. The regimen they are recommending for you is Temodar alone plus IL2 and inf? I've never heard of that one.

                                      • July 13, 2011 at 6:00 pm
                                      gabsound
                                      Participant

                                        Don,

                                        I am going to have to call the oncologists office and see if they have some study on this. I haven't found anything about this combo yet.

                                        Thank for your reply,

                                        Julie

                                        • July 13, 2011 at 6:00 pm
                                        gabsound
                                        Participant

                                          Don,

                                          I am going to have to call the oncologists office and see if they have some study on this. I haven't found anything about this combo yet.

                                          Thank for your reply,

                                          Julie

                                        • July 13, 2011 at 6:32 pm
                                        lhaley
                                        Participant

                                          Since there is something left in to measure, is there a reason they aren't doing Yervoy or IL2?  Biochemo is known to be a rough treatment and the numbers don't back it.

                                            • July 14, 2011 at 12:49 pm
                                            gabsound
                                            Participant
                                              Hi,
                                              The Oncologist is reserving the Yervoy for later if needed. I was also told that they are going to test tumor for BRAF.

                                              Part of the biochemo is IL-2.

                                              Still researching.

                                              Julie

                                              • July 15, 2011 at 4:26 am
                                              kylez
                                              Participant

                                                Hi Julie,

                                                Last year I was given the choice of doing either biochemotherapy (including Il-2) or high-dose IL2 alone. They are very different treatments in my understanding. Biochemo includes IL-2 but at a much lower dose.

                                                I honestly don't know which I consider a "better" treatment of the two. I didn't get biochemo but did 2 courses/4 cycles of IL-2.

                                                – Kyle

                                                • July 15, 2011 at 4:26 am
                                                kylez
                                                Participant

                                                  Hi Julie,

                                                  Last year I was given the choice of doing either biochemotherapy (including Il-2) or high-dose IL2 alone. They are very different treatments in my understanding. Biochemo includes IL-2 but at a much lower dose.

                                                  I honestly don't know which I consider a "better" treatment of the two. I didn't get biochemo but did 2 courses/4 cycles of IL-2.

                                                  – Kyle

                                                  • July 14, 2011 at 12:49 pm
                                                  gabsound
                                                  Participant
                                                    Hi,
                                                    The Oncologist is reserving the Yervoy for later if needed. I was also told that they are going to test tumor for BRAF.

                                                    Part of the biochemo is IL-2.

                                                    Still researching.

                                                    Julie

                                                  • July 13, 2011 at 6:32 pm
                                                  lhaley
                                                  Participant

                                                    Since there is something left in to measure, is there a reason they aren't doing Yervoy or IL2?  Biochemo is known to be a rough treatment and the numbers don't back it.

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                                                    Participant
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