I have been taking 500-1000 unites of Curcumin (Turmeric Extract -95% curcumin) with piperine daily since March 2009.  (Standard tumeric is two to five percent curcumin,   This is in addition to my targeted chemotherapy.   My tumors have stayed fairly stable.  (Some slight decrease!)

http://lpi.oregonstate.edu/infocenter/phytochemicals/curcumin/

http://www.mdanderson.org/newsroom/news-releases/2005/07-11-05-potent-spice-works-to-block-growth-of-melanoma-in-lab-test-news-release.html

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

Curcumin, the pungent yellow spice found in both turmeric and curry powders, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from The University of Texas M. D. Anderson Cancer Center.

Curcumin should be paused about two weeks before any surgery.

While researchers had thought curcumin primarily has anti-inflammatory properties, the growing realization that cancer can result from inflammation has spurred mounting interest in the spice as an anti-cancer agent, Aggarwal says. He adds that another fact has generated further excitement: "The incidence of the top four cancers in the U.S. – colon, breast, prostate, and lung – is ten times lower in India," he says.

This work is just the latest by M. D. Anderson researchers to show how curcumin can inhibit cancer growth. "Curcumin affects virtually every tumor biomarker that we have tried," says Aggarwal. "It works through a variety of mechanisms related to cancer development. We, and others, previously found that curcumin down regulates EGFR activity that mediates tumor cell proliferation, and VEGF that is involved in angiogenesis. Besides inhibiting NF-kB, curcumin was also found to suppress STAT3 pathway that is also involved in tumorigenesis. Both these pathways play a central role in cell survival and proliferation."

He said that an ability to suppress numerous biological routes to cancer development is important if an agent is to be effective. "Cells look at everything in a global way, and inhibiting just one pathway will not be effective," says Aggarwal.

In this study, the researchers treated three different melanoma cell lines with curcumin and assessed the activity of NF-kB, as well the protein, known as "IKK" that switches NF-kB "on." The spice kept both proteins from being activated, so worked to stop growth of the melanoma, and it also induced "apoptosis," or programmed death, in the cells.

Surprisingly, it didn't matter how much curcumin was used, says the researchers. "The NF-kB machinery is suppressed by both short exposures to high concentrations of curcumin as well as by longer exposure to lower concentrations of curcumin," they say in their study.

Broccoli and asparagus also contain ingredients believed to fight cancer.  I do not recommend going overboard with anything but in getting a steady amount from normal food.

I have been taking 500-1000 unites of Curcumin (Turmeric Extract -95% curcumin) with piperine daily since March 2009.  (Standard tumeric is two to five percent curcumin,   This is in addition to my targeted chemotherapy.   My tumors have stayed fairly stable.  (Some slight decrease!)

http://lpi.oregonstate.edu/infocenter/phytochemicals/curcumin/

http://www.mdanderson.org/newsroom/news-releases/2005/07-11-05-potent-spice-works-to-block-growth-of-melanoma-in-lab-test-news-release.html

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

Curcumin, the pungent yellow spice found in both turmeric and curry powders, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from The University of Texas M. D. Anderson Cancer Center.

Curcumin should be paused about two weeks before any surgery.

While researchers had thought curcumin primarily has anti-inflammatory properties, the growing realization that cancer can result from inflammation has spurred mounting interest in the spice as an anti-cancer agent, Aggarwal says. He adds that another fact has generated further excitement: "The incidence of the top four cancers in the U.S. – colon, breast, prostate, and lung – is ten times lower in India," he says.

This work is just the latest by M. D. Anderson researchers to show how curcumin can inhibit cancer growth. "Curcumin affects virtually every tumor biomarker that we have tried," says Aggarwal. "It works through a variety of mechanisms related to cancer development. We, and others, previously found that curcumin down regulates EGFR activity that mediates tumor cell proliferation, and VEGF that is involved in angiogenesis. Besides inhibiting NF-kB, curcumin was also found to suppress STAT3 pathway that is also involved in tumorigenesis. Both these pathways play a central role in cell survival and proliferation."

He said that an ability to suppress numerous biological routes to cancer development is important if an agent is to be effective. "Cells look at everything in a global way, and inhibiting just one pathway will not be effective," says Aggarwal.

In this study, the researchers treated three different melanoma cell lines with curcumin and assessed the activity of NF-kB, as well the protein, known as "IKK" that switches NF-kB "on." The spice kept both proteins from being activated, so worked to stop growth of the melanoma, and it also induced "apoptosis," or programmed death, in the cells.

Surprisingly, it didn't matter how much curcumin was used, says the researchers. "The NF-kB machinery is suppressed by both short exposures to high concentrations of curcumin as well as by longer exposure to lower concentrations of curcumin," they say in their study.

Broccoli and asparagus also contain ingredients believed to fight cancer.  I do not recommend going overboard with anything but in getting a steady amount from normal food.

I have been taking 500-1000 unites of Curcumin (Turmeric Extract -95% curcumin) with piperine daily since March 2009.  (Standard tumeric is two to five percent curcumin,   This is in addition to my targeted chemotherapy.   My tumors have stayed fairly stable.  (Some slight decrease!)

http://lpi.oregonstate.edu/infocenter/phytochemicals/curcumin/

http://www.mdanderson.org/newsroom/news-releases/2005/07-11-05-potent-spice-works-to-block-growth-of-melanoma-in-lab-test-news-release.html

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

Curcumin, the pungent yellow spice found in both turmeric and curry powders, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from The University of Texas M. D. Anderson Cancer Center.

Curcumin should be paused about two weeks before any surgery.

While researchers had thought curcumin primarily has anti-inflammatory properties, the growing realization that cancer can result from inflammation has spurred mounting interest in the spice as an anti-cancer agent, Aggarwal says. He adds that another fact has generated further excitement: "The incidence of the top four cancers in the U.S. – colon, breast, prostate, and lung – is ten times lower in India," he says.

This work is just the latest by M. D. Anderson researchers to show how curcumin can inhibit cancer growth. "Curcumin affects virtually every tumor biomarker that we have tried," says Aggarwal. "It works through a variety of mechanisms related to cancer development. We, and others, previously found that curcumin down regulates EGFR activity that mediates tumor cell proliferation, and VEGF that is involved in angiogenesis. Besides inhibiting NF-kB, curcumin was also found to suppress STAT3 pathway that is also involved in tumorigenesis. Both these pathways play a central role in cell survival and proliferation."

He said that an ability to suppress numerous biological routes to cancer development is important if an agent is to be effective. "Cells look at everything in a global way, and inhibiting just one pathway will not be effective," says Aggarwal.

In this study, the researchers treated three different melanoma cell lines with curcumin and assessed the activity of NF-kB, as well the protein, known as "IKK" that switches NF-kB "on." The spice kept both proteins from being activated, so worked to stop growth of the melanoma, and it also induced "apoptosis," or programmed death, in the cells.

Surprisingly, it didn't matter how much curcumin was used, says the researchers. "The NF-kB machinery is suppressed by both short exposures to high concentrations of curcumin as well as by longer exposure to lower concentrations of curcumin," they say in their study.

Broccoli and asparagus also contain ingredients believed to fight cancer.  I do not recommend going overboard with anything but in getting a steady amount from normal food.

Jerry, I have a few questions on the curcumin/piperine combo:

1) Is it best to take it with a meal or or 2 hours before/after one?

2) I'd read a while back that in addition increasing the amount of curcumin your body absorbs, that piperine can also increase the amount of any supplement or prescription medicine your body absorbs. Can you shed any light on that? The supplement doesn't bother me as much as the prescription medicine. I don't want it to interfere with my blood pressure medication.

No one has been able to give me a definitive answer to that.

Jerry,

Can you share what brand you are using and any reason for that particular brand.  I think that's one of the tough things about supplements.  It's hard to determine whether you are really getting a quality supplement or not.  I've used "Doctor's Best" in the past mainly because a nurse told me once that they have an independent 3rd party vouch for the quality of their products.

Thanks,

Brian

Hey Brooke,

I've also heard good things about curcumin.  I think Jerry's reply definitely backs up that claim.

I've also heard a lot of good things about vitamin D.  I think there's a slight difference between D and D3.  I had a physician recommend vitamin D3.  Apparently the body processes that better if I remember correctly.

I've also heard a lot of good things about CoQ10 but haven't done the goggle research to back that up.

Resveratrol is supposed to be real good for you but I've seem to remember hearing something about your body not really being able to absorb much of it through supplements.  Red wine and red grapes are a good source.

I recently started a thread on a product called avemar.  It seems to have some clinical proof of benefit but it isn't cheap.  http://www.melanoma.org/community/mpip-melanoma-patients-information-page/avemar 

There's also another theory out there called anti-angiogenisis.  Here's a couple links:  http://www.ted.com/talks/william_li.html  ,  http://www.doctoroz.com/videos/stop-cancer-growing    ,   http://www.alternativecancer.me/therapy/anti-angiogenesis-foods-agents-fight-cancer-natural/ 

If you find others please post.

Brian

Hey Brooke,

I've also heard good things about curcumin.  I think Jerry's reply definitely backs up that claim.

I've also heard a lot of good things about vitamin D.  I think there's a slight difference between D and D3.  I had a physician recommend vitamin D3.  Apparently the body processes that better if I remember correctly.

I've also heard a lot of good things about CoQ10 but haven't done the goggle research to back that up.

Resveratrol is supposed to be real good for you but I've seem to remember hearing something about your body not really being able to absorb much of it through supplements.  Red wine and red grapes are a good source.

I recently started a thread on a product called avemar.  It seems to have some clinical proof of benefit but it isn't cheap.  http://www.melanoma.org/community/mpip-melanoma-patients-information-page/avemar 

There's also another theory out there called anti-angiogenisis.  Here's a couple links:  http://www.ted.com/talks/william_li.html  ,  http://www.doctoroz.com/videos/stop-cancer-growing    ,   http://www.alternativecancer.me/therapy/anti-angiogenesis-foods-agents-fight-cancer-natural/ 

If you find others please post.

Brian

Hey Brooke,

I've also heard good things about curcumin.  I think Jerry's reply definitely backs up that claim.

I've also heard a lot of good things about vitamin D.  I think there's a slight difference between D and D3.  I had a physician recommend vitamin D3.  Apparently the body processes that better if I remember correctly.

I've also heard a lot of good things about CoQ10 but haven't done the goggle research to back that up.

Resveratrol is supposed to be real good for you but I've seem to remember hearing something about your body not really being able to absorb much of it through supplements.  Red wine and red grapes are a good source.

I recently started a thread on a product called avemar.  It seems to have some clinical proof of benefit but it isn't cheap.  http://www.melanoma.org/community/mpip-melanoma-patients-information-page/avemar 

There's also another theory out there called anti-angiogenisis.  Here's a couple links:  http://www.ted.com/talks/william_li.html  ,  http://www.doctoroz.com/videos/stop-cancer-growing    ,   http://www.alternativecancer.me/therapy/anti-angiogenesis-foods-agents-fight-cancer-natural/ 

If you find others please post.

Brian

Best wishes!

Best wishes!

Best wishes!

I also take CoQ10 300 mg per day.

Anti-angiogenisis is the process of eliminating the blood supply to tumors.

It is believed tht one way Curcummin has a positive effect on many things in the body is that it is an anti-inflamatory agent. In that way it and aspirin works at least partially along some of the same lines.

Some people take Piperine as a sepearate item to further control the amaoaunt anad timing with regard to other meds.

While taking anything with extra piperine I would take regular BP readings aand keep a record of them and talk to your PCP as well. My BP used to run between 115 aand 130. Most of the time now it is between 111 and 120.

In studies of piperine be sure of what the amounts theyare using and what they are giving it to. (often mice and rats.)

Search for BLOOD Pressure " AND piperine

http://www.ncbi.nlm.nih.gov/pubmed/19033825

Blood pressure lowering and vasomodulator effects of piperine.

Taqvi SI, Shah AJ, Gilani AH.

Source

Department of Pharmaceutical Sciences; Federal Urdu University of Arts, Science and Technology, Gulshan Campus Karachi-75300, Pakistan.

Abstract

This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure (MAP) in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in MAP. The fall in blood pressure (BP) was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K+ (80 mM) precontractions and partially inhibited phenylephrine (PE), suggesting Ca2+ channel blockade (CCB), which was further confirmed when pretreatment of tissues with piperine caused rightward shift in Ca2+ concentration-response curves, similar to verapamil. In Ca2+-free medium, piperine (1 to 30 microM) exhibited vasoconstrictor effect. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K+ precontractions than PE. In bovine coronary artery preparations, piperine inhibited high K+ precontractions completely. These data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through CCB, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the CCB effect of piperine.

http://www.ncbi.nlm.nih.gov/pubmed/21033621

Bratisl Lek Listy. 2010;111(8):426-31.

Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.

Hlavackova L, Urbanova A, Ulicna O, Janega P, Cerna A, Babal P.

Source

Department of Pathology, Faculty of Medicine, Comenus University, Bratislava, Slovakia.

Abstract

OBJECTIVES:

The presented study is aimed on exploring the effects of black pepper on blood pressure in the rat model of experimental hypertension induced by chronic NO synthesis inhibition.

BACKGROUND:

Piperine, the compound of black pepper, can cause a significant decrease of blood pressure in normotensive rats possibly via calcium channel blockade, a pathway that is known to be effective in prevention of L-NAME (N(G)-nitro-L-arginine methyl ester) induced hypertension.

METHODS:

Wistar rats were administered clear water (C), L-NAME (40 mg/kg/day, L), piperine (20 mg/kg/day) in corn oil by oral gavage with L-NAME (LP) or without it (P) for 6 weeks. The systolic blood pressure was measured weekly. Specimens of thoracic aorta were processed in paraffin and histological slices were stained with hematoxylin and eosin, Mallory's phosphotungstic acid hematoxylin (PTAH), orcein, antibodies against inducible NO synthase (iNOS) and smooth muscle cells actin (SMCA). Microscopic pictures were digitally processed and morphometrically evaluated.

RESULTS:

L-NAME increased the blood pressure, cross-sectional area of aorta, media thickness, elastin and SMCA synthesis and PTAH positive myofibrils relative and absolute content in the aortic media, wheras it decreased percentual content of iNOS, elastin and SMCA. Piperine decreased the blood pressure rise from the third week of treatment, synthesis of elastin and the percentual and absolute content of PTAH positive myofibrils, however, it did not affect other parameters.

CONCLUSION:

Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration. This effect is probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly (Tab. 1, Fig. 2, Ref. 35).

***********************************************

http://www.ncbi.nlm.nih.gov/pubmed/18639606

Piperine, the potential functional food for mood and cognitive disorders.

Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O.

Source

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]

Abstract

The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now. In the present study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required.

Piperine: Increase Absorption of Herbs and Supplements

http://www.heart-health-guide.com/Piperine.html‎

Scientific studies have shown different results when it comes to piperine and its affect on blood pressure. Some claim that it can decrease high blood pressure …

https://www.google.com/search?q=%22BLOOD+Pressure+Medicatioin%22+AND+peperine&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a

http://thetreeofliberty.com/vb/showthread.php?t=166242&page=2

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

I also take CoQ10 300 mg per day.

Anti-angiogenisis is the process of eliminating the blood supply to tumors.

It is believed tht one way Curcummin has a positive effect on many things in the body is that it is an anti-inflamatory agent. In that way it and aspirin works at least partially along some of the same lines.

Some people take Piperine as a sepearate item to further control the amaoaunt anad timing with regard to other meds.

While taking anything with extra piperine I would take regular BP readings aand keep a record of them and talk to your PCP as well. My BP used to run between 115 aand 130. Most of the time now it is between 111 and 120.

In studies of piperine be sure of what the amounts theyare using and what they are giving it to. (often mice and rats.)

Search for BLOOD Pressure " AND piperine

http://www.ncbi.nlm.nih.gov/pubmed/19033825

Blood pressure lowering and vasomodulator effects of piperine.

Taqvi SI, Shah AJ, Gilani AH.

Source

Department of Pharmaceutical Sciences; Federal Urdu University of Arts, Science and Technology, Gulshan Campus Karachi-75300, Pakistan.

Abstract

This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure (MAP) in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in MAP. The fall in blood pressure (BP) was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K+ (80 mM) precontractions and partially inhibited phenylephrine (PE), suggesting Ca2+ channel blockade (CCB), which was further confirmed when pretreatment of tissues with piperine caused rightward shift in Ca2+ concentration-response curves, similar to verapamil. In Ca2+-free medium, piperine (1 to 30 microM) exhibited vasoconstrictor effect. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K+ precontractions than PE. In bovine coronary artery preparations, piperine inhibited high K+ precontractions completely. These data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through CCB, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the CCB effect of piperine.

http://www.ncbi.nlm.nih.gov/pubmed/21033621

Bratisl Lek Listy. 2010;111(8):426-31.

Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.

Hlavackova L, Urbanova A, Ulicna O, Janega P, Cerna A, Babal P.

Source

Department of Pathology, Faculty of Medicine, Comenus University, Bratislava, Slovakia.

Abstract

OBJECTIVES:

The presented study is aimed on exploring the effects of black pepper on blood pressure in the rat model of experimental hypertension induced by chronic NO synthesis inhibition.

BACKGROUND:

Piperine, the compound of black pepper, can cause a significant decrease of blood pressure in normotensive rats possibly via calcium channel blockade, a pathway that is known to be effective in prevention of L-NAME (N(G)-nitro-L-arginine methyl ester) induced hypertension.

METHODS:

Wistar rats were administered clear water (C), L-NAME (40 mg/kg/day, L), piperine (20 mg/kg/day) in corn oil by oral gavage with L-NAME (LP) or without it (P) for 6 weeks. The systolic blood pressure was measured weekly. Specimens of thoracic aorta were processed in paraffin and histological slices were stained with hematoxylin and eosin, Mallory's phosphotungstic acid hematoxylin (PTAH), orcein, antibodies against inducible NO synthase (iNOS) and smooth muscle cells actin (SMCA). Microscopic pictures were digitally processed and morphometrically evaluated.

RESULTS:

L-NAME increased the blood pressure, cross-sectional area of aorta, media thickness, elastin and SMCA synthesis and PTAH positive myofibrils relative and absolute content in the aortic media, wheras it decreased percentual content of iNOS, elastin and SMCA. Piperine decreased the blood pressure rise from the third week of treatment, synthesis of elastin and the percentual and absolute content of PTAH positive myofibrils, however, it did not affect other parameters.

CONCLUSION:

Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration. This effect is probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly (Tab. 1, Fig. 2, Ref. 35).

***********************************************

http://www.ncbi.nlm.nih.gov/pubmed/18639606

Piperine, the potential functional food for mood and cognitive disorders.

Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O.

Source

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]

Abstract

The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now. In the present study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required.

Piperine: Increase Absorption of Herbs and Supplements

http://www.heart-health-guide.com/Piperine.html‎

Scientific studies have shown different results when it comes to piperine and its affect on blood pressure. Some claim that it can decrease high blood pressure …

https://www.google.com/search?q=%22BLOOD+Pressure+Medicatioin%22+AND+peperine&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a

http://thetreeofliberty.com/vb/showthread.php?t=166242&page=2

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

I also take CoQ10 300 mg per day.

Anti-angiogenisis is the process of eliminating the blood supply to tumors.

It is believed tht one way Curcummin has a positive effect on many things in the body is that it is an anti-inflamatory agent. In that way it and aspirin works at least partially along some of the same lines.

Some people take Piperine as a sepearate item to further control the amaoaunt anad timing with regard to other meds.

While taking anything with extra piperine I would take regular BP readings aand keep a record of them and talk to your PCP as well. My BP used to run between 115 aand 130. Most of the time now it is between 111 and 120.

In studies of piperine be sure of what the amounts theyare using and what they are giving it to. (often mice and rats.)

Search for BLOOD Pressure " AND piperine

http://www.ncbi.nlm.nih.gov/pubmed/19033825

Blood pressure lowering and vasomodulator effects of piperine.

Taqvi SI, Shah AJ, Gilani AH.

Source

Department of Pharmaceutical Sciences; Federal Urdu University of Arts, Science and Technology, Gulshan Campus Karachi-75300, Pakistan.

Abstract

This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure (MAP) in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in MAP. The fall in blood pressure (BP) was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K+ (80 mM) precontractions and partially inhibited phenylephrine (PE), suggesting Ca2+ channel blockade (CCB), which was further confirmed when pretreatment of tissues with piperine caused rightward shift in Ca2+ concentration-response curves, similar to verapamil. In Ca2+-free medium, piperine (1 to 30 microM) exhibited vasoconstrictor effect. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K+ precontractions than PE. In bovine coronary artery preparations, piperine inhibited high K+ precontractions completely. These data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through CCB, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the CCB effect of piperine.

http://www.ncbi.nlm.nih.gov/pubmed/21033621

Bratisl Lek Listy. 2010;111(8):426-31.

Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.

Hlavackova L, Urbanova A, Ulicna O, Janega P, Cerna A, Babal P.

Source

Department of Pathology, Faculty of Medicine, Comenus University, Bratislava, Slovakia.

Abstract

OBJECTIVES:

The presented study is aimed on exploring the effects of black pepper on blood pressure in the rat model of experimental hypertension induced by chronic NO synthesis inhibition.

BACKGROUND:

Piperine, the compound of black pepper, can cause a significant decrease of blood pressure in normotensive rats possibly via calcium channel blockade, a pathway that is known to be effective in prevention of L-NAME (N(G)-nitro-L-arginine methyl ester) induced hypertension.

METHODS:

Wistar rats were administered clear water (C), L-NAME (40 mg/kg/day, L), piperine (20 mg/kg/day) in corn oil by oral gavage with L-NAME (LP) or without it (P) for 6 weeks. The systolic blood pressure was measured weekly. Specimens of thoracic aorta were processed in paraffin and histological slices were stained with hematoxylin and eosin, Mallory's phosphotungstic acid hematoxylin (PTAH), orcein, antibodies against inducible NO synthase (iNOS) and smooth muscle cells actin (SMCA). Microscopic pictures were digitally processed and morphometrically evaluated.

RESULTS:

L-NAME increased the blood pressure, cross-sectional area of aorta, media thickness, elastin and SMCA synthesis and PTAH positive myofibrils relative and absolute content in the aortic media, wheras it decreased percentual content of iNOS, elastin and SMCA. Piperine decreased the blood pressure rise from the third week of treatment, synthesis of elastin and the percentual and absolute content of PTAH positive myofibrils, however, it did not affect other parameters.

CONCLUSION:

Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration. This effect is probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly (Tab. 1, Fig. 2, Ref. 35).

***********************************************

http://www.ncbi.nlm.nih.gov/pubmed/18639606

Piperine, the potential functional food for mood and cognitive disorders.

Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O.

Source

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]

Abstract

The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now. In the present study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required.

Piperine: Increase Absorption of Herbs and Supplements

http://www.heart-health-guide.com/Piperine.html‎

Scientific studies have shown different results when it comes to piperine and its affect on blood pressure. Some claim that it can decrease high blood pressure …

https://www.google.com/search?q=%22BLOOD+Pressure+Medicatioin%22+AND+peperine&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a

http://thetreeofliberty.com/vb/showthread.php?t=166242&page=2

http://www.cmjournal.org/content/pdf/1749-8546-6-31.pdf

I am using the Doctors Best brand now.  I have used the 95% curcumin and used extra pepper when I am out of thowe with piperine.  I also heard they are supposed to be checked as to the actuaally content.  I got my last 2 – 120 pill bottles for $28.80 each on the internet.

I also take the curcumin and also my onc said to take trans reservatrol. He said he takes it himself and there are studies where it's been shown to fight even cancers that attack other cancers. I'm IIIb as well, I've had local re-currences and we're using DPCP to battle that. Been IIIb now for over 3 years. I've been working out daily, I also have my green smoothies (not too much fruit, mostly water, add a banana, blueberries, kale, spinach, brocolli, ginger, chia seeds, hemp seeds, etc). Takes some getting used to but this last year haven't felt better!

Hope that helps!

Dave

I also take the curcumin and also my onc said to take trans reservatrol. He said he takes it himself and there are studies where it's been shown to fight even cancers that attack other cancers. I'm IIIb as well, I've had local re-currences and we're using DPCP to battle that. Been IIIb now for over 3 years. I've been working out daily, I also have my green smoothies (not too much fruit, mostly water, add a banana, blueberries, kale, spinach, brocolli, ginger, chia seeds, hemp seeds, etc). Takes some getting used to but this last year haven't felt better!

Hope that helps!

Dave

I also take the curcumin and also my onc said to take trans reservatrol. He said he takes it himself and there are studies where it's been shown to fight even cancers that attack other cancers. I'm IIIb as well, I've had local re-currences and we're using DPCP to battle that. Been IIIb now for over 3 years. I've been working out daily, I also have my green smoothies (not too much fruit, mostly water, add a banana, blueberries, kale, spinach, brocolli, ginger, chia seeds, hemp seeds, etc). Takes some getting used to but this last year haven't felt better!

Hope that helps!

Dave

Hi Brooke,

I see that you guys are in Colorado, I grew up there.  Too high an altitude, too much sunshine, and too many sunburns as a child!  Now in FL, I'm Stage IV and in the Moffitt Mage vaccine  trial.  The trial is going very well for me, one year out and still NED.

My doctor says that I am his healthiest Melanoma patient and I hope and pray to keep that honor.  When I was diagnosed, I changed my diet and supplements quickly.  I try to eat foods that are anti-angiogenic. Stopped eating red meat, sugar, cheese and dairy.  Research Dr. Li at the Aangiogenic  Institute and check out the video "Forks over knives".

I stopped juicing in favor of a Vitamix drink every morning with strawberries, blueberries, apple, banana, spinach, kale,carrots, brocolli and mushrooms.  It's sounds bad but its actually really good! After drinking my shake, i usually have two cups of tea, one green tea and one earl gray.

I don't take a lot of supplements but here are the ones I do take:

1 Curcumin (500 mg)

1 capful of Isotonic OPC-3 (liquid anti-oxidants that have great absorption)

2 Reishi mushroom extract capsules (500mg)

Omega D3 package

Other than MD Anderson's work on Curcumin, I didn't find any solid scientific studies that many supplements fight or prevent cancer.  If someone on the forum has the data, let me know.

 All that I can say is that regardless of the Mage vaccine, I am still NED and feel great! I intend to keep taking my supplements as a precautionary measure.

All the best!

Hi Brooke,

I see that you guys are in Colorado, I grew up there.  Too high an altitude, too much sunshine, and too many sunburns as a child!  Now in FL, I'm Stage IV and in the Moffitt Mage vaccine  trial.  The trial is going very well for me, one year out and still NED.

My doctor says that I am his healthiest Melanoma patient and I hope and pray to keep that honor.  When I was diagnosed, I changed my diet and supplements quickly.  I try to eat foods that are anti-angiogenic. Stopped eating red meat, sugar, cheese and dairy.  Research Dr. Li at the Aangiogenic  Institute and check out the video "Forks over knives".

I stopped juicing in favor of a Vitamix drink every morning with strawberries, blueberries, apple, banana, spinach, kale,carrots, brocolli and mushrooms.  It's sounds bad but its actually really good! After drinking my shake, i usually have two cups of tea, one green tea and one earl gray.

I don't take a lot of supplements but here are the ones I do take:

1 Curcumin (500 mg)

1 capful of Isotonic OPC-3 (liquid anti-oxidants that have great absorption)

2 Reishi mushroom extract capsules (500mg)

Omega D3 package

Other than MD Anderson's work on Curcumin, I didn't find any solid scientific studies that many supplements fight or prevent cancer.  If someone on the forum has the data, let me know.

 All that I can say is that regardless of the Mage vaccine, I am still NED and feel great! I intend to keep taking my supplements as a precautionary measure.

All the best!

Hi Brooke,

I see that you guys are in Colorado, I grew up there.  Too high an altitude, too much sunshine, and too many sunburns as a child!  Now in FL, I'm Stage IV and in the Moffitt Mage vaccine  trial.  The trial is going very well for me, one year out and still NED.

My doctor says that I am his healthiest Melanoma patient and I hope and pray to keep that honor.  When I was diagnosed, I changed my diet and supplements quickly.  I try to eat foods that are anti-angiogenic. Stopped eating red meat, sugar, cheese and dairy.  Research Dr. Li at the Aangiogenic  Institute and check out the video "Forks over knives".

I stopped juicing in favor of a Vitamix drink every morning with strawberries, blueberries, apple, banana, spinach, kale,carrots, brocolli and mushrooms.  It's sounds bad but its actually really good! After drinking my shake, i usually have two cups of tea, one green tea and one earl gray.

I don't take a lot of supplements but here are the ones I do take:

1 Curcumin (500 mg)

1 capful of Isotonic OPC-3 (liquid anti-oxidants that have great absorption)

2 Reishi mushroom extract capsules (500mg)

Omega D3 package

Other than MD Anderson's work on Curcumin, I didn't find any solid scientific studies that many supplements fight or prevent cancer.  If someone on the forum has the data, let me know.

 All that I can say is that regardless of the Mage vaccine, I am still NED and feel great! I intend to keep taking my supplements as a precautionary measure.

All the best!

Do a seearch on "curcumin  AND melanoma AND piperine"

HTML] The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with …

CMA Bill, JR Fuchs, C Li, J Yui, C Bakan… – Molecular …, 2010 – biomedcentral.com

http://www.molecular-cancer.com/content/9/1/165

OSU-Curcumin

http://jnci.oxfordjournals.org/content/100/9/616.short

Curcumin

Pharmacology & Pharmaceutical Medicine PUP – NOT FREE

Hope th is will go out.

Do a seearch on "curcumin  AND melanoma AND piperine"

HTML] The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with …

CMA Bill, JR Fuchs, C Li, J Yui, C Bakan… – Molecular …, 2010 – biomedcentral.com

http://www.molecular-cancer.com/content/9/1/165

OSU-Curcumin

http://jnci.oxfordjournals.org/content/100/9/616.short

Curcumin

Pharmacology & Pharmaceutical Medicine PUP – NOT FREE

Hope th is will go out.

Do a seearch on "curcumin  AND melanoma AND piperine"

HTML] The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with …

CMA Bill, JR Fuchs, C Li, J Yui, C Bakan… – Molecular …, 2010 – biomedcentral.com

http://www.molecular-cancer.com/content/9/1/165

OSU-Curcumin

http://jnci.oxfordjournals.org/content/100/9/616.short

Curcumin

Pharmacology & Pharmaceutical Medicine PUP – NOT FREE

Hope th is will go out.

Thanks to all for this informtion. I want to share something I found online about extract of hibiscus flower. This is being studied in mice and anti melanoma effects being found. See link below. You can buy the flowers in bulk at your local coop and drink it as a tea.

http://www.medicalnewstoday.com/articles/258937.php

Chris Kielb

Thanks to all for this informtion. I want to share something I found online about extract of hibiscus flower. This is being studied in mice and anti melanoma effects being found. See link below. You can buy the flowers in bulk at your local coop and drink it as a tea.

http://www.medicalnewstoday.com/articles/258937.php

Chris Kielb

Thanks to all for this informtion. I want to share something I found online about extract of hibiscus flower. This is being studied in mice and anti melanoma effects being found. See link below. You can buy the flowers in bulk at your local coop and drink it as a tea.

http://www.medicalnewstoday.com/articles/258937.php

Chris Kielb

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Just looked at the responses to this post.  Who remembers JerryfromFauq?  I know you do Celeste.  He was quite a character and extremely sharp.  Had the pleasure of meeting him in person once at UVA.  One of our members I miss the most.

Brian

I am using the Doctors Best brand now.  I have used the 95% curcumin and used extra pepper when I am out of thowe with piperine.  I also heard they are supposed to be checked as to the actuaally content.  I got my last 2 – 120 pill bottles for $28.80 each on the internet.

I am using the Doctors Best brand now.  I have used the 95% curcumin and used extra pepper when I am out of thowe with piperine.  I also heard they are supposed to be checked as to the actuaally content.  I got my last 2 – 120 pill bottles for $28.80 each on the internet.

Any suggestions on dosage of Vitamin C during and after radiation treatment.  Oncologists say don't take it, natural health people say it is benefiial.  I have purchased buffered C in ascorbate form as recommended by Dr. Russel Blaylock in his book, I need some guidance on dose amount—especially if I'm going to go against my oncologists.

Thanks,

Technigrannis

Any suggestions on dosage of Vitamin C during and after radiation treatment.  Oncologists say don't take it, natural health people say it is benefiial.  I have purchased buffered C in ascorbate form as recommended by Dr. Russel Blaylock in his book, I need some guidance on dose amount—especially if I'm going to go against my oncologists.

Thanks,

Technigrannis

Any suggestions on dosage of Vitamin C during and after radiation treatment.  Oncologists say don't take it, natural health people say it is benefiial.  I have purchased buffered C in ascorbate form as recommended by Dr. Russel Blaylock in his book, I need some guidance on dose amount—especially if I'm going to go against my oncologists.

Thanks,

Technigrannis