› Forums › General Melanoma Community › Gene Mutation V600K
- This topic has 15 replies, 4 voices, and was last updated 11 years, 4 months ago by awillett1991.
- Post
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- December 14, 2012 at 2:47 pm
Are there any clinical trials specifically for this gene mutation?
Are there any clinical trials specifically for this gene mutation?
- Replies
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- December 14, 2012 at 3:31 pm
A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma
http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3
Best regards,
Jimmy b
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- December 14, 2012 at 3:31 pm
A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma
http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3
Best regards,
Jimmy b
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- December 14, 2012 at 3:31 pm
A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma
http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3
Best regards,
Jimmy b
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- December 14, 2012 at 10:13 pm
There are currently 52 open studies concerning BRAF at clinicaltrials.gov
You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open
and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.
If you have any other questions, either specific or otherwise, feel free to post them.
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- December 14, 2012 at 10:21 pm
As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.
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- December 14, 2012 at 10:21 pm
As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.
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- December 14, 2012 at 10:21 pm
As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.
-
- December 14, 2012 at 10:13 pm
There are currently 52 open studies concerning BRAF at clinicaltrials.gov
You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open
and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.
If you have any other questions, either specific or otherwise, feel free to post them.
-
- December 14, 2012 at 10:13 pm
There are currently 52 open studies concerning BRAF at clinicaltrials.gov
You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open
and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.
If you have any other questions, either specific or otherwise, feel free to post them.
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- December 15, 2012 at 2:42 pm
Try this website, it can find trials based on mutationhttp://www.mycancergenome.org/content/disease/melanoma/braf/116
Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.
I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.
Best of luck to you!
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- December 15, 2012 at 2:42 pm
Try this website, it can find trials based on mutationhttp://www.mycancergenome.org/content/disease/melanoma/braf/116
Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.
I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.
Best of luck to you!
-
- December 15, 2012 at 2:42 pm
Try this website, it can find trials based on mutationhttp://www.mycancergenome.org/content/disease/melanoma/braf/116
Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.
I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.
Best of luck to you!
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