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Gene Mutation V600K
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Gene Mutation V600K

› Forums › General Melanoma Community › Gene Mutation V600K

  • Post
    • December 14, 2012 at 2:47 pm
    SidneyGracie
    Participant

      Are there any clinical trials specifically for this gene mutation?

      Are there any clinical trials specifically for this gene mutation?

    Viewing 11 reply threads
    • Replies
        • December 14, 2012 at 3:21 pm
        POW
        Participant

          No. Not that I know of.

          • December 14, 2012 at 3:21 pm
          POW
          Participant

            No. Not that I know of.

            • December 14, 2012 at 3:21 pm
            POW
            Participant

              No. Not that I know of.

              • December 14, 2012 at 3:31 pm
              jim Breitfeller
              Participant

                A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

                http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

                 

                Best regards,

                Jimmy b

                • December 14, 2012 at 3:31 pm
                jim Breitfeller
                Participant

                  A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

                  http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

                   

                  Best regards,

                  Jimmy b

                  • December 14, 2012 at 3:31 pm
                  jim Breitfeller
                  Participant

                    A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

                    http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

                     

                    Best regards,

                    Jimmy b

                    • December 14, 2012 at 10:13 pm
                    MichaelFL
                    Participant

                      There are currently 52 open studies concerning BRAF at clinicaltrials.gov

                      You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

                      and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

                      If you have any other questions, either specific or otherwise, feel free to post them.

                        • December 14, 2012 at 10:21 pm
                        POW
                        Participant

                          As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

                          • December 14, 2012 at 10:21 pm
                          POW
                          Participant

                            As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

                            • December 14, 2012 at 10:21 pm
                            POW
                            Participant

                              As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

                            • December 14, 2012 at 10:13 pm
                            MichaelFL
                            Participant

                              There are currently 52 open studies concerning BRAF at clinicaltrials.gov

                              You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

                              and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

                              If you have any other questions, either specific or otherwise, feel free to post them.

                              • December 14, 2012 at 10:13 pm
                              MichaelFL
                              Participant

                                There are currently 52 open studies concerning BRAF at clinicaltrials.gov

                                You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

                                and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

                                If you have any other questions, either specific or otherwise, feel free to post them.

                                • December 15, 2012 at 2:42 pm
                                awillett1991
                                Participant
                                  Try this website, it can find trials based on mutation

                                  http://www.mycancergenome.org/content/disease/melanoma/braf/116

                                  Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

                                  I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

                                  Best of luck to you!

                                  • December 15, 2012 at 2:42 pm
                                  awillett1991
                                  Participant
                                    Try this website, it can find trials based on mutation

                                    http://www.mycancergenome.org/content/disease/melanoma/braf/116

                                    Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

                                    I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

                                    Best of luck to you!

                                    • December 15, 2012 at 2:42 pm
                                    awillett1991
                                    Participant
                                      Try this website, it can find trials based on mutation

                                      http://www.mycancergenome.org/content/disease/melanoma/braf/116

                                      Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

                                      I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

                                      Best of luck to you!

                                  Viewing 11 reply threads
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