› Forums › General Melanoma Community › Yervoy Update (Bloodwork, etc)
- This topic has 18 replies, 9 voices, and was last updated 14 years, 4 months ago by
jim Breitfeller.
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- September 21, 2011 at 9:01 pm
Based on my bloodwork today, my LDH levels have gone from 245 to 187. This is good news, but my oncologist said it's a big jump and maybe perhaps it's nothing to get excited about as LD can be affected by many different events. I told him that I was going to believe it was the fact that I had tumours missing in my lungs. 🙂 Anyway, my Absolute Lymphocyte count when I first started was 1.85, now it's 2.28 which he said is a good trend. I really don't know what these numbers means exactly, but the fact my ALC is higher and my LD is lower is good news. As my Dr.
Based on my bloodwork today, my LDH levels have gone from 245 to 187. This is good news, but my oncologist said it's a big jump and maybe perhaps it's nothing to get excited about as LD can be affected by many different events. I told him that I was going to believe it was the fact that I had tumours missing in my lungs. 🙂 Anyway, my Absolute Lymphocyte count when I first started was 1.85, now it's 2.28 which he said is a good trend. I really don't know what these numbers means exactly, but the fact my ALC is higher and my LD is lower is good news. As my Dr. also pointed out, my bloodwork doesn't show any progression "it's beautiful".
I havn't been having many symptoms, but my Dr. confirmed that symptoms doesn't necessarily mean it's not working and that many people have been responding without any symptoms whatsoever in his trial. They are seeing more itching than rashes and that's the only thing I've had so far. We also discussed IL-2 after ipi (if this doesn't work) and he mentioned that the Dr. running the IL-2 program in Buffalo suggested these combo's of IL-2 after ipi were showing good results.
ipi #3 tomorrow and I'm going to keep hoping that I respond to this drug!
Lisa
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- September 21, 2011 at 9:19 pm
Sounds good to me. And thanks to Jimmy B and his work on following Ipi with Il-2. Amazing how some Onc actually listen and work with us.
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- September 21, 2011 at 9:19 pm
Sounds good to me. And thanks to Jimmy B and his work on following Ipi with Il-2. Amazing how some Onc actually listen and work with us.
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- September 22, 2011 at 12:25 am
Great news, Lisa!!!
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- September 22, 2011 at 12:25 am
Great news, Lisa!!!
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- September 22, 2011 at 1:33 am
Hi Lisa,
Congrats on the positive results! My husband sees Dr. Khushalani at Roswell in Buffalo, if that's the doctor you are referring to. He's a wonderful doctor and the nursing staff on 5West are wonderful.
And he's right about the combo – in both directions – IPI before or after – it is showing good results, and they are talking about doing clinical trials to combine them. They are also combining the Zelboraf and IL-2, but I know that doesn't apply to either of our situations.
Hopefully the IPI does it's thing and you won't have to come down here ! But if you do, you'll be in good hands 🙂
Best wishes,
Maria
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- September 22, 2011 at 1:33 am
Hi Lisa,
Congrats on the positive results! My husband sees Dr. Khushalani at Roswell in Buffalo, if that's the doctor you are referring to. He's a wonderful doctor and the nursing staff on 5West are wonderful.
And he's right about the combo – in both directions – IPI before or after – it is showing good results, and they are talking about doing clinical trials to combine them. They are also combining the Zelboraf and IL-2, but I know that doesn't apply to either of our situations.
Hopefully the IPI does it's thing and you won't have to come down here ! But if you do, you'll be in good hands 🙂
Best wishes,
Maria
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- September 22, 2011 at 2:00 am
Good luck with the next treatment! I'm glad to hear that no major signs, or just one sign, etc doesn't mean it's not working, I'm just so anxious too about mine working.
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- September 22, 2011 at 2:00 am
Good luck with the next treatment! I'm glad to hear that no major signs, or just one sign, etc doesn't mean it's not working, I'm just so anxious too about mine working.
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- September 22, 2011 at 2:45 am
I have been keeping an eye on you here.
Absolute value or Absolute lymphocyte counts (ALC) range:
720- 4400/µl or 0.72 – 4.4 x 10*9/L.The 1.85 number was good, as it was already well above the .72 minumum, and the 2.28 was even better.
As you know, LDH is also affected by many things, but to have it go down is great!
Keep it up Lisa! Both of these sound good.
ANON admirer.
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- September 22, 2011 at 2:45 am
I have been keeping an eye on you here.
Absolute value or Absolute lymphocyte counts (ALC) range:
720- 4400/µl or 0.72 – 4.4 x 10*9/L.The 1.85 number was good, as it was already well above the .72 minumum, and the 2.28 was even better.
As you know, LDH is also affected by many things, but to have it go down is great!
Keep it up Lisa! Both of these sound good.
ANON admirer.
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- September 22, 2011 at 2:54 am
Lisa, these results are certainly encouraging. Here is some info about LDH:
http://en.wikipedia.org/wiki/Lactate_dehydrogenase#Medical_use What all this means is
that since "tissue breakdown elevates levels of LDH", a lower level is always preferred.With ALC, a higher level is best from what I have read. Therefore, these are very good
results.Best wishes
Frank from Australia
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- September 22, 2011 at 2:54 am
Lisa, these results are certainly encouraging. Here is some info about LDH:
http://en.wikipedia.org/wiki/Lactate_dehydrogenase#Medical_use What all this means is
that since "tissue breakdown elevates levels of LDH", a lower level is always preferred.With ALC, a higher level is best from what I have read. Therefore, these are very good
results.Best wishes
Frank from Australia
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- September 22, 2011 at 12:09 pm
Thanks everyone! I hope and pray the trend for these numbers continues.
I have scans on Hallowe'en, so I don't have much longer to wait to see if this has worked. I don't fear the lung mets as I do the cancer going elsewhere.
Your encouragment keeps me going and I wish you all the very best.
Lisa
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- September 22, 2011 at 12:09 pm
Thanks everyone! I hope and pray the trend for these numbers continues.
I have scans on Hallowe'en, so I don't have much longer to wait to see if this has worked. I don't fear the lung mets as I do the cancer going elsewhere.
Your encouragment keeps me going and I wish you all the very best.
Lisa
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- September 22, 2011 at 2:36 pm
Lisa,
Based on the ALC numbers, it lloks like you are heading towards a clinical benefit with Yervoy.

As for the combinatorial therapy using IPI and IL-2, I am see more and more Melanoma Patients responding to this therapy.

best regards,
Jimmy B
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- September 22, 2011 at 2:36 pm
Lisa,
Based on the ALC numbers, it lloks like you are heading towards a clinical benefit with Yervoy.

As for the combinatorial therapy using IPI and IL-2, I am see more and more Melanoma Patients responding to this therapy.

best regards,
Jimmy B
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