› Forums › General Melanoma Community › Steroids and Colitis
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- March 11, 2016 at 8:34 pm
I am having a bad reaction to yervoy and radiation combined that i am doing at the moment.
I was up all and down from around midnight seven or eight times for bathroom visits and that is despite taking 12mg of steroid at onset of symptoms.
What would be the usual dose for a bad case ?
And is dose given a couple of times a day?
I will probablyhave to go to hospital anyway i think.
- Replies
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- March 11, 2016 at 8:48 pm
My dad is on Yervoy and radiation combo as well. Had his second infusion about 10 days ago and ended up with a high fever for 5 days. He had a couple of bouts of diarrhea as well. But nothing like you are describing. His doctor put him on 40 milligrams of steroids orally. Two days ago they called and said his Monday blood work had elevated liver enzymes. Not by a lot but still, they upped his steroids to 100 milligrams a day. So the dose you are taking does not sound very high at all. With that many incidents of diarrhea I would probably go have it checked out ASAP.They told him to take the full dose in the morning with breakfast. Make sure you call your own oncologist since emergency rooms might not know what to do with someone on this type of drug. This is the advice we got from our doctor. They can be in contact with the emergency room doctors.
Annie
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- March 11, 2016 at 8:48 pm
My dad is on Yervoy and radiation combo as well. Had his second infusion about 10 days ago and ended up with a high fever for 5 days. He had a couple of bouts of diarrhea as well. But nothing like you are describing. His doctor put him on 40 milligrams of steroids orally. Two days ago they called and said his Monday blood work had elevated liver enzymes. Not by a lot but still, they upped his steroids to 100 milligrams a day. So the dose you are taking does not sound very high at all. With that many incidents of diarrhea I would probably go have it checked out ASAP.They told him to take the full dose in the morning with breakfast. Make sure you call your own oncologist since emergency rooms might not know what to do with someone on this type of drug. This is the advice we got from our doctor. They can be in contact with the emergency room doctors.
Annie
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- March 11, 2016 at 8:48 pm
My dad is on Yervoy and radiation combo as well. Had his second infusion about 10 days ago and ended up with a high fever for 5 days. He had a couple of bouts of diarrhea as well. But nothing like you are describing. His doctor put him on 40 milligrams of steroids orally. Two days ago they called and said his Monday blood work had elevated liver enzymes. Not by a lot but still, they upped his steroids to 100 milligrams a day. So the dose you are taking does not sound very high at all. With that many incidents of diarrhea I would probably go have it checked out ASAP.They told him to take the full dose in the morning with breakfast. Make sure you call your own oncologist since emergency rooms might not know what to do with someone on this type of drug. This is the advice we got from our doctor. They can be in contact with the emergency room doctors.
Annie
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- March 12, 2016 at 12:39 am
Hi there – I second Annie's suggestion to call your oncologist right away to report a worsening condition despite being on steroid treatment. Also, maybe inquire about taking Imodium to also get this under control; worked for me under doc's advice…
Good luck!
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- March 12, 2016 at 12:39 am
Hi there – I second Annie's suggestion to call your oncologist right away to report a worsening condition despite being on steroid treatment. Also, maybe inquire about taking Imodium to also get this under control; worked for me under doc's advice…
Good luck!
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- March 12, 2016 at 12:39 am
Hi there – I second Annie's suggestion to call your oncologist right away to report a worsening condition despite being on steroid treatment. Also, maybe inquire about taking Imodium to also get this under control; worked for me under doc's advice…
Good luck!
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- March 12, 2016 at 3:09 am
I am in hospital and just got an infusion of 1gram of some steroid.
Will be here a few days at least.
Did xray of abdomen and blood test and urine and stool …all very quick and professional.
Thanks for the tips and advice and yeah they said leaving it could be disastrous as it can escalate alarmingly in a short period of time.
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- March 12, 2016 at 3:09 am
I am in hospital and just got an infusion of 1gram of some steroid.
Will be here a few days at least.
Did xray of abdomen and blood test and urine and stool …all very quick and professional.
Thanks for the tips and advice and yeah they said leaving it could be disastrous as it can escalate alarmingly in a short period of time.
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- March 12, 2016 at 3:09 am
I am in hospital and just got an infusion of 1gram of some steroid.
Will be here a few days at least.
Did xray of abdomen and blood test and urine and stool …all very quick and professional.
Thanks for the tips and advice and yeah they said leaving it could be disastrous as it can escalate alarmingly in a short period of time.
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- March 12, 2016 at 3:30 am
Are you taking anything else to control the diarrhoea? You could talk to your doctor about that.
I was prescribed Imodium (loperamide}.
For me steroids did not help control the diarrhoea. The steroids are needed to deal with the inflammation of the wall of the gut – the colitis.
Indeed, in me, steroids made the diarrhoea worse so because they depressed my usual gut bacteria. I know take probiotics to keep my gut bacteria 'topped up' so no nasty visitors can move in.
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- March 12, 2016 at 3:30 am
Are you taking anything else to control the diarrhoea? You could talk to your doctor about that.
I was prescribed Imodium (loperamide}.
For me steroids did not help control the diarrhoea. The steroids are needed to deal with the inflammation of the wall of the gut – the colitis.
Indeed, in me, steroids made the diarrhoea worse so because they depressed my usual gut bacteria. I know take probiotics to keep my gut bacteria 'topped up' so no nasty visitors can move in.
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- March 12, 2016 at 3:30 am
Are you taking anything else to control the diarrhoea? You could talk to your doctor about that.
I was prescribed Imodium (loperamide}.
For me steroids did not help control the diarrhoea. The steroids are needed to deal with the inflammation of the wall of the gut – the colitis.
Indeed, in me, steroids made the diarrhoea worse so because they depressed my usual gut bacteria. I know take probiotics to keep my gut bacteria 'topped up' so no nasty visitors can move in.
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- March 12, 2016 at 12:14 pm
I am glad you went! Not doing anything ASAP can escalate the problem severely. If you get to it early it seems it can usually be manageable fairly easily. I have heard that if you are indeed developing colitis, Imodium is not a good idea. Someone might be able to confirm this though. -
- March 12, 2016 at 12:14 pm
I am glad you went! Not doing anything ASAP can escalate the problem severely. If you get to it early it seems it can usually be manageable fairly easily. I have heard that if you are indeed developing colitis, Imodium is not a good idea. Someone might be able to confirm this though. -
- March 12, 2016 at 12:14 pm
I am glad you went! Not doing anything ASAP can escalate the problem severely. If you get to it early it seems it can usually be manageable fairly easily. I have heard that if you are indeed developing colitis, Imodium is not a good idea. Someone might be able to confirm this though. -
- March 12, 2016 at 1:07 pm
Doctors recommend taking 2 immodium after every bowel movement,
Not sure what the logic is but that is my experience.
Steroid worked to an extent but still have had a few false starts but not much to speak of and no real bowel movement per se,
I will probably get constipated now,
.
.
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- March 12, 2016 at 1:07 pm
Doctors recommend taking 2 immodium after every bowel movement,
Not sure what the logic is but that is my experience.
Steroid worked to an extent but still have had a few false starts but not much to speak of and no real bowel movement per se,
I will probably get constipated now,
.
.
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- March 12, 2016 at 1:07 pm
Doctors recommend taking 2 immodium after every bowel movement,
Not sure what the logic is but that is my experience.
Steroid worked to an extent but still have had a few false starts but not much to speak of and no real bowel movement per se,
I will probably get constipated now,
.
.
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- March 12, 2016 at 8:26 pm
Anon, as you know, you did the right thing! As you've learned, 12mg of a prednisone-like steroid is not nearly enough to deal with ipi-induced colitis or even diarrhea. Anyone who sees you post should know to immediately contact their onc if they are on ipi and their diarrhea cannot be controlled by Immodium, Lomotil, etc. within a few hours. At a minimum, your onc should see you the next day for a bag of IV fluids (if not IV steroids). As someone who had ipi-induced colitis, I can tell you that the grass is greener once you get past the taper.
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- March 12, 2016 at 10:17 pm
For my dad it was the combination of 5 days of fever and 2 bouts of diarrhea that made his doctor put him on Predisone. Add elevated liver enzymes to that and I think it was the right call for sure. Luke you said, after the diarrhea episodes he did 3 days of IV fluid, and felt ao much better. -
- March 12, 2016 at 10:17 pm
For my dad it was the combination of 5 days of fever and 2 bouts of diarrhea that made his doctor put him on Predisone. Add elevated liver enzymes to that and I think it was the right call for sure. Luke you said, after the diarrhea episodes he did 3 days of IV fluid, and felt ao much better. -
- March 12, 2016 at 10:17 pm
For my dad it was the combination of 5 days of fever and 2 bouts of diarrhea that made his doctor put him on Predisone. Add elevated liver enzymes to that and I think it was the right call for sure. Luke you said, after the diarrhea episodes he did 3 days of IV fluid, and felt ao much better. -
- March 13, 2016 at 3:41 am
Yep i was on an intravenous drip all day yesterday.
Things have improved but i am really hyped on the steroids.
Hopefully i dont get stuck in hospital for too long and i can get off the steroids and back to another round of infusions.
Luckily i didnt wait another day so anybody who gets in the same situation you need to act asap otherwise it could be a major problem.
Finally thanks for all the great here that has really helped me.
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- March 13, 2016 at 3:41 am
Yep i was on an intravenous drip all day yesterday.
Things have improved but i am really hyped on the steroids.
Hopefully i dont get stuck in hospital for too long and i can get off the steroids and back to another round of infusions.
Luckily i didnt wait another day so anybody who gets in the same situation you need to act asap otherwise it could be a major problem.
Finally thanks for all the great here that has really helped me.
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- March 13, 2016 at 6:36 pm
So glad you went in immidiately. Hope things stabilize quickly and you can go on with tteatment.Annie
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- March 13, 2016 at 6:36 pm
So glad you went in immidiately. Hope things stabilize quickly and you can go on with tteatment.Annie
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- March 13, 2016 at 6:36 pm
So glad you went in immidiately. Hope things stabilize quickly and you can go on with tteatment.Annie
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- March 13, 2016 at 3:41 am
Yep i was on an intravenous drip all day yesterday.
Things have improved but i am really hyped on the steroids.
Hopefully i dont get stuck in hospital for too long and i can get off the steroids and back to another round of infusions.
Luckily i didnt wait another day so anybody who gets in the same situation you need to act asap otherwise it could be a major problem.
Finally thanks for all the great here that has really helped me.
-
- March 12, 2016 at 8:26 pm
Anon, as you know, you did the right thing! As you've learned, 12mg of a prednisone-like steroid is not nearly enough to deal with ipi-induced colitis or even diarrhea. Anyone who sees you post should know to immediately contact their onc if they are on ipi and their diarrhea cannot be controlled by Immodium, Lomotil, etc. within a few hours. At a minimum, your onc should see you the next day for a bag of IV fluids (if not IV steroids). As someone who had ipi-induced colitis, I can tell you that the grass is greener once you get past the taper.
-
- March 12, 2016 at 8:26 pm
Anon, as you know, you did the right thing! As you've learned, 12mg of a prednisone-like steroid is not nearly enough to deal with ipi-induced colitis or even diarrhea. Anyone who sees you post should know to immediately contact their onc if they are on ipi and their diarrhea cannot be controlled by Immodium, Lomotil, etc. within a few hours. At a minimum, your onc should see you the next day for a bag of IV fluids (if not IV steroids). As someone who had ipi-induced colitis, I can tell you that the grass is greener once you get past the taper.
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- March 17, 2016 at 9:32 pm
As it turns out i really didnt have diarhea but i had the runs with blockage up the top of the intestines so ended up having to take laxative formulas to move it all and it still isnt really resolved although i have full proper bowel movements but still am blocked.
Probably because i am on hydro morphine for nearly two months now it had blocked me up. So a bit complicated but i am out of hospital today having resolved that but generally feelling much worse than what i came in.
Not sure if i will do any more treatments now anyway as i am getting too weak i think.
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- March 17, 2016 at 9:32 pm
As it turns out i really didnt have diarhea but i had the runs with blockage up the top of the intestines so ended up having to take laxative formulas to move it all and it still isnt really resolved although i have full proper bowel movements but still am blocked.
Probably because i am on hydro morphine for nearly two months now it had blocked me up. So a bit complicated but i am out of hospital today having resolved that but generally feelling much worse than what i came in.
Not sure if i will do any more treatments now anyway as i am getting too weak i think.
-
- March 17, 2016 at 9:32 pm
As it turns out i really didnt have diarhea but i had the runs with blockage up the top of the intestines so ended up having to take laxative formulas to move it all and it still isnt really resolved although i have full proper bowel movements but still am blocked.
Probably because i am on hydro morphine for nearly two months now it had blocked me up. So a bit complicated but i am out of hospital today having resolved that but generally feelling much worse than what i came in.
Not sure if i will do any more treatments now anyway as i am getting too weak i think.
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