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Tim,

Please clarify the brain mets issue. The Merck site says no one with active central nervous system metasteses can get Merck 3475 but you say they can as long as they have been treated. This is critical in my husband's case as all the tumors are in his brain. He finsihed Yervoy one month ago. Current MRI shows some tumors shrank, some are stable, and some 'grew'. Or is it pseudo-progression??

Tim,

Please clarify the brain mets issue. The Merck site says no one with active central nervous system metasteses can get Merck 3475 but you say they can as long as they have been treated. This is critical in my husband's case as all the tumors are in his brain. He finsihed Yervoy one month ago. Current MRI shows some tumors shrank, some are stable, and some 'grew'. Or is it pseudo-progression??

Tim,

Please clarify the brain mets issue. The Merck site says no one with active central nervous system metasteses can get Merck 3475 but you say they can as long as they have been treated. This is critical in my husband's case as all the tumors are in his brain. He finsihed Yervoy one month ago. Current MRI shows some tumors shrank, some are stable, and some 'grew'. Or is it pseudo-progression??

my  husband has had significant fatigue and leg muscle weakness like what you have since his 3rd does of Yervoy. He finished by having the 4th dose on 2/14/14. His legs will just give out on him. The oncologist won't give me a reason and I can't find much detailed info on line. I'd like to know how long the fatigue and muscle weakness might last.

my  husband has had significant fatigue and leg muscle weakness like what you have since his 3rd does of Yervoy. He finished by having the 4th dose on 2/14/14. His legs will just give out on him. The oncologist won't give me a reason and I can't find much detailed info on line. I'd like to know how long the fatigue and muscle weakness might last.

my  husband has had significant fatigue and leg muscle weakness like what you have since his 3rd does of Yervoy. He finished by having the 4th dose on 2/14/14. His legs will just give out on him. The oncologist won't give me a reason and I can't find much detailed info on line. I'd like to know how long the fatigue and muscle weakness might last.

In my reading, some say that Yervoy can cause 'pseudo-progression' so scans can look worse before they get better (if they get better). Because Yervoy can ramp up the immune system, immune activity can go into the tumors and make them bigger. This is a very simple way of stating. it.

In my reading, some say that Yervoy can cause 'pseudo-progression' so scans can look worse before they get better (if they get better). Because Yervoy can ramp up the immune system, immune activity can go into the tumors and make them bigger. This is a very simple way of stating. it.

In my reading, some say that Yervoy can cause 'pseudo-progression' so scans can look worse before they get better (if they get better). Because Yervoy can ramp up the immune system, immune activity can go into the tumors and make them bigger. This is a very simple way of stating. it.

what is :Common Terminology Criteria for Adverse Events (CTCAE) Grade 1. I searched online and didn't find anything?

what is :Common Terminology Criteria for Adverse Events (CTCAE) Grade 1. I searched online and didn't find anything?

what is :Common Terminology Criteria for Adverse Events (CTCAE) Grade 1. I searched online and didn't find anything?