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Harry in Fair Oaks

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      Harry in Fair Oaks
      Participant

        I have been on the BRAF/MEK combo through the GSK trial for 2-1/2 years now (since May 2011) and I am basically disease-free.  I hope it works for you as well as it did for me.

        Best wishes,

        Harry

        Harry in Fair Oaks
        Participant

          I have been on the BRAF/MEK combo through the GSK trial for 2-1/2 years now (since May 2011) and I am basically disease-free.  I hope it works for you as well as it did for me.

          Best wishes,

          Harry

          Harry in Fair Oaks
          Participant

            I have been on the BRAF/MEK combo through the GSK trial for 2-1/2 years now (since May 2011) and I am basically disease-free.  I hope it works for you as well as it did for me.

            Best wishes,

            Harry

            Harry in Fair Oaks
            Participant

              Fabulous!  I have been on this drug combo for 2-1/2 years as part of the GSK clinical trial, and it's still keeping things at bay.  I hope your experience will be similar to mine.  I also had joint pains at the beginning, also fevers and chills/shakes.  The side-effects diminished with time. 

              One question:  You say the Dabrafenib was cut to 200 mg.  What was it originally?  I have been on 150mg/day since the beginning, together with 2 mg/day of the MEK.  My understanding is that what I am getting are the max amounts administered under the clinical trial protocol for the combo, so it's hard for me to understand why you are being prescribed at a dosage higher than was tested (for the combo).

              Best wishes,

              Harry

                Harry in Fair Oaks
                Participant

                  OOPS! (never mind).  I just turned 60 and I guess my mind fog is accelarating.  I am taking a total of 300mg/day (150mg twice a day).  So were you reduced to 200 from 300?

                  Harry in Fair Oaks
                  Participant

                    OOPS! (never mind).  I just turned 60 and I guess my mind fog is accelarating.  I am taking a total of 300mg/day (150mg twice a day).  So were you reduced to 200 from 300?

                    Harry in Fair Oaks
                    Participant

                      OOPS! (never mind).  I just turned 60 and I guess my mind fog is accelarating.  I am taking a total of 300mg/day (150mg twice a day).  So were you reduced to 200 from 300?

                    Harry in Fair Oaks
                    Participant

                      Fabulous!  I have been on this drug combo for 2-1/2 years as part of the GSK clinical trial, and it's still keeping things at bay.  I hope your experience will be similar to mine.  I also had joint pains at the beginning, also fevers and chills/shakes.  The side-effects diminished with time. 

                      One question:  You say the Dabrafenib was cut to 200 mg.  What was it originally?  I have been on 150mg/day since the beginning, together with 2 mg/day of the MEK.  My understanding is that what I am getting are the max amounts administered under the clinical trial protocol for the combo, so it's hard for me to understand why you are being prescribed at a dosage higher than was tested (for the combo).

                      Best wishes,

                      Harry

                      Harry in Fair Oaks
                      Participant

                        Fabulous!  I have been on this drug combo for 2-1/2 years as part of the GSK clinical trial, and it's still keeping things at bay.  I hope your experience will be similar to mine.  I also had joint pains at the beginning, also fevers and chills/shakes.  The side-effects diminished with time. 

                        One question:  You say the Dabrafenib was cut to 200 mg.  What was it originally?  I have been on 150mg/day since the beginning, together with 2 mg/day of the MEK.  My understanding is that what I am getting are the max amounts administered under the clinical trial protocol for the combo, so it's hard for me to understand why you are being prescribed at a dosage higher than was tested (for the combo).

                        Best wishes,

                        Harry

                        Harry in Fair Oaks
                        Participant

                          I have been on the this combo through the GSK trial for 2-1/2 years.  At the beginning (first couple of months), I had lots of high fever/chills/shakes/sweating (when fever broke).  Usually this was controllable with ibuprofen – sometimes I took ibu an hour before the drugs to ward off the fever, and I think that helped..  My body must have adjusted to the drugs, because I have not had a fever episode for at least 1-1/2 years.

                          Best wishes,

                          Harry

                          Harry in Fair Oaks
                          Participant

                            I have been on the this combo through the GSK trial for 2-1/2 years.  At the beginning (first couple of months), I had lots of high fever/chills/shakes/sweating (when fever broke).  Usually this was controllable with ibuprofen – sometimes I took ibu an hour before the drugs to ward off the fever, and I think that helped..  My body must have adjusted to the drugs, because I have not had a fever episode for at least 1-1/2 years.

                            Best wishes,

                            Harry

                            Harry in Fair Oaks
                            Participant

                              I have been on the this combo through the GSK trial for 2-1/2 years.  At the beginning (first couple of months), I had lots of high fever/chills/shakes/sweating (when fever broke).  Usually this was controllable with ibuprofen – sometimes I took ibu an hour before the drugs to ward off the fever, and I think that helped..  My body must have adjusted to the drugs, because I have not had a fever episode for at least 1-1/2 years.

                              Best wishes,

                              Harry

                              Harry in Fair Oaks
                              Participant

                                I get scanned every 12 weeks now.  At the beginning of the trial, the scans were every 8 weeks, but after the 2-year mark GSK gratefully relaxed this.  In addition to the CT/MRI scans, I also get ECHO cardiograms.  And every 8 weeks I have a dermatologist exam.

                                Best regards,

                                Harry

                                Harry in Fair Oaks
                                Participant

                                  I get scanned every 12 weeks now.  At the beginning of the trial, the scans were every 8 weeks, but after the 2-year mark GSK gratefully relaxed this.  In addition to the CT/MRI scans, I also get ECHO cardiograms.  And every 8 weeks I have a dermatologist exam.

                                  Best regards,

                                  Harry

                                  Harry in Fair Oaks
                                  Participant

                                    I get scanned every 12 weeks now.  At the beginning of the trial, the scans were every 8 weeks, but after the 2-year mark GSK gratefully relaxed this.  In addition to the CT/MRI scans, I also get ECHO cardiograms.  And every 8 weeks I have a dermatologist exam.

                                    Best regards,

                                    Harry

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