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Zeloraf approval(B-RAF)

Forums General Melanoma Community Zeloraf approval(B-RAF)

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      Tim–MRF
      Guest

      Kellie:

      Good question on the trials.  If you are on a standard clinical trial, it will continue as per the protocol.  If you are receiving the drug as part of the expanded access or compassionate use protocol then things will change.  Those programs will be shut down.

      I have spoken with the company extensively on this issue and they have assured me that no-one on the expanded access protocol will have to go without drug.  They will work with the doctors to ensure patients are covered through normal coverage procedures.  All the doctors involved with the expanded access protocol have been informed of this and have been given specific guidance on how to ensure that no patient is taken off the drug.

      Regarding future trials, both Zeloraf and other BRAF inhibitors will continue to be studied.  The most promising of these studies are those involving combinations of BRAF with other drugs.  Most researchers agree that long-lasting results will likely come through these combination studies.

      Tim–MRF

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      Tim–MRF
      Guest

      Kellie:

      Good question on the trials.  If you are on a standard clinical trial, it will continue as per the protocol.  If you are receiving the drug as part of the expanded access or compassionate use protocol then things will change.  Those programs will be shut down.

      I have spoken with the company extensively on this issue and they have assured me that no-one on the expanded access protocol will have to go without drug.  They will work with the doctors to ensure patients are covered through normal coverage procedures.  All the doctors involved with the expanded access protocol have been informed of this and have been given specific guidance on how to ensure that no patient is taken off the drug.

      Regarding future trials, both Zeloraf and other BRAF inhibitors will continue to be studied.  The most promising of these studies are those involving combinations of BRAF with other drugs.  Most researchers agree that long-lasting results will likely come through these combination studies.

      Tim–MRF

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        KellieSue
        Participant

        Thanks for responding Tim. That makes me feel better! I'm on a standard clinical trial just using Zelboraf.

        Kellie(from Iowa) Stage IV

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        KellieSue
        Participant

        Thanks for responding Tim. That makes me feel better! I'm on a standard clinical trial just using Zelboraf.

        Kellie(from Iowa) Stage IV

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        boot2aboot
        Participant

        Tim, what would they combo zelboraf with?  i know the GSK braf.mek trial but what else are they doing?

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        boot2aboot
        Participant

        Tim, what would they combo zelboraf with?  i know the GSK braf.mek trial but what else are they doing?

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      Harry in Fair Oaks
      Participant

      Remember that this drug isn't the only BRAF inhibitor in town.  There is also the GlaxoSmithKline version (GSK2118436) which is now in various clinical trials.  I'm on a trial which combines this drug with GSK's MEK inhibitor.

      Best wishes,

      Harry

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      Harry in Fair Oaks
      Participant

      Remember that this drug isn't the only BRAF inhibitor in town.  There is also the GlaxoSmithKline version (GSK2118436) which is now in various clinical trials.  I'm on a trial which combines this drug with GSK's MEK inhibitor.

      Best wishes,

      Harry

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