› Forums › General Melanoma Community › Trials for Joshie…and others…in one place
- This topic has 73 replies, 17 voices, and was last updated 6 years, 7 months ago by
Jess58.
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- December 17, 2016 at 7:15 pm
I put this together if you are interested, Joshie. Not alone….but with a lot of help from YOUR friends!!! Just so you'd have things in one place if you wanted to refer. MPIP won't allow a lot of links…so I put them in this blog post.
Perhaps this might be useful for others if needed….when you've been through a lot of therapies…but still need something…..
Don't know if it is of much help….but that's what we came up with. Hope you are back at home with your dear ones. Much love and hugs. Celeste
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- December 18, 2016 at 1:31 am
Ditto, you are amazing Celeste! This made me think of a conference I was just at in D.C. several weeks ago. It's called OpenCon and it's about OpenAccess and OpenData regarding federally funded research and how important it is that the public gets FREE access to the research results and raw data (i.e much of the research is funded by NIH, etc). And how this data AND publications should be freely available to the public rather than behind a wall of subscriptions, etc.
Well I was in a meeting with a bunch of health researchers and several young MDs from around the world. One of the ladies was from ClinicalTrials.gov. They were talking about how to use Open data, etc to help patients. Well I proceeded to tell them I was on the MPIP patient forum due to my husbands diagnosis and how much information is exchanged (not only information, but high level clinical/treatment information that patients don't get from their own doctors!). I mentioned how the patients on MPIP often know way more about clinical trials and all the requirements/stipulations of these trials and many times patients ARE NOT getting this from their own doctors, we trust the people on the board the most. And how advanced the discussions are about treatment protocols based on progression, stage, etc. on MPIP (I was mostly referring to you :)) And how much patients are tracking new research such as Ed and you. These researchers and doctors were STUNNED at how smart you all are, I told them I think they underestimate the patient population. I don't think they realized that patients are doing this every day. No one is more motivated to understand the research more than the patient.
You are amazing!
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- December 18, 2016 at 1:31 am
Ditto, you are amazing Celeste! This made me think of a conference I was just at in D.C. several weeks ago. It's called OpenCon and it's about OpenAccess and OpenData regarding federally funded research and how important it is that the public gets FREE access to the research results and raw data (i.e much of the research is funded by NIH, etc). And how this data AND publications should be freely available to the public rather than behind a wall of subscriptions, etc.
Well I was in a meeting with a bunch of health researchers and several young MDs from around the world. One of the ladies was from ClinicalTrials.gov. They were talking about how to use Open data, etc to help patients. Well I proceeded to tell them I was on the MPIP patient forum due to my husbands diagnosis and how much information is exchanged (not only information, but high level clinical/treatment information that patients don't get from their own doctors!). I mentioned how the patients on MPIP often know way more about clinical trials and all the requirements/stipulations of these trials and many times patients ARE NOT getting this from their own doctors, we trust the people on the board the most. And how advanced the discussions are about treatment protocols based on progression, stage, etc. on MPIP (I was mostly referring to you :)) And how much patients are tracking new research such as Ed and you. These researchers and doctors were STUNNED at how smart you all are, I told them I think they underestimate the patient population. I don't think they realized that patients are doing this every day. No one is more motivated to understand the research more than the patient.
You are amazing!
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- December 18, 2016 at 1:31 am
Ditto, you are amazing Celeste! This made me think of a conference I was just at in D.C. several weeks ago. It's called OpenCon and it's about OpenAccess and OpenData regarding federally funded research and how important it is that the public gets FREE access to the research results and raw data (i.e much of the research is funded by NIH, etc). And how this data AND publications should be freely available to the public rather than behind a wall of subscriptions, etc.
Well I was in a meeting with a bunch of health researchers and several young MDs from around the world. One of the ladies was from ClinicalTrials.gov. They were talking about how to use Open data, etc to help patients. Well I proceeded to tell them I was on the MPIP patient forum due to my husbands diagnosis and how much information is exchanged (not only information, but high level clinical/treatment information that patients don't get from their own doctors!). I mentioned how the patients on MPIP often know way more about clinical trials and all the requirements/stipulations of these trials and many times patients ARE NOT getting this from their own doctors, we trust the people on the board the most. And how advanced the discussions are about treatment protocols based on progression, stage, etc. on MPIP (I was mostly referring to you :)) And how much patients are tracking new research such as Ed and you. These researchers and doctors were STUNNED at how smart you all are, I told them I think they underestimate the patient population. I don't think they realized that patients are doing this every day. No one is more motivated to understand the research more than the patient.
You are amazing!
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- December 18, 2016 at 2:28 am
Yep, Celeste, you are amazing and an angel on earth. Looks like you have inspired others to help you (Ed). Sorry I don't know the names of the rest. Merry Christmas to all!
Corinne and Randy
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- December 18, 2016 at 3:33 am
Good luck Josh and Paul and many others here
Celeste thanks for posting amazing as always
Can be difficult reading this forum, sharing each others ups and downs, but so much great info and incredible people, really the best people are here which is so amazing
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- December 18, 2016 at 3:33 am
Good luck Josh and Paul and many others here
Celeste thanks for posting amazing as always
Can be difficult reading this forum, sharing each others ups and downs, but so much great info and incredible people, really the best people are here which is so amazing
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- December 18, 2016 at 3:33 am
Good luck Josh and Paul and many others here
Celeste thanks for posting amazing as always
Can be difficult reading this forum, sharing each others ups and downs, but so much great info and incredible people, really the best people are here which is so amazing
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- December 18, 2016 at 4:08 am
Hi Celeste,
I have not posted before but have taken much guidance from this site for some time now.
My husband has been stage 4 since October 2014 when CT Scan showed small lesions in liver and lungs. First diagnosed in April 2013 Stage 3, melanoma 9mm on back of scalp with gremlin cells showing up in the sentinel node.
He then did a) clinical trial of IL -2 High Dose followed by Ipi – but gremlins continued their march; b) 6 months of Opdivo – still no luck; c) Clinical trial IL-10 daily injections plus Keytruda. This took us to January 2016 and during the three months on c) there was a lot of progression including into bones (rib and spine).
So next we decided on TIL (have been at MDA since the beginning), some of liver tumour was used for harvesting but we needed to slow things down fast so he did a chemo combo for a few cycles and then twice Opdivo/Ipi combo while we waited for TIL.
TIL went well in May (2.5 weeks in hospital), Low Dose IL-2 this time. Unfortunately, not as many T-cells were harvested as hoped so the infusion was 4 billion but they were good quality. I think they said 92% efficient or something like that. Keytruda followed the TIL and we kept going on that until lumbar spine tumours got so painful that he needed radiation in August to try to relieve. This was followed by liver radioembolization Y-90 spheres as liver situation was getting worse. Unfortunately, the radiation on spine caused such inflammation to the largest tumour that it fractured the spine which resulted in emergency spine surgery end of August.
In September, he started back on Keytruda and they did another Y-90 on the other lobe of the liver. The good news at that time was that there was shrinkage from the procedure on the first lobe. This was the first time in 2 years since diagnosis of stage 4 that anything had ever shrunk! He has continued on Keytruda every 3 weeks and he will have body CT and MRI's of spine and brain in early January. At that point we will know where we stand.
In January we may be looking for another trial so this information you have provided is wonderful. My husband is such a fighter (we have an 11-year-old son), and he has been to hell and back over the last two years, we keep buying time and trying to find the magic bullet he needs.
Thank you again
Maria
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- December 18, 2016 at 4:08 am
Hi Celeste,
I have not posted before but have taken much guidance from this site for some time now.
My husband has been stage 4 since October 2014 when CT Scan showed small lesions in liver and lungs. First diagnosed in April 2013 Stage 3, melanoma 9mm on back of scalp with gremlin cells showing up in the sentinel node.
He then did a) clinical trial of IL -2 High Dose followed by Ipi – but gremlins continued their march; b) 6 months of Opdivo – still no luck; c) Clinical trial IL-10 daily injections plus Keytruda. This took us to January 2016 and during the three months on c) there was a lot of progression including into bones (rib and spine).
So next we decided on TIL (have been at MDA since the beginning), some of liver tumour was used for harvesting but we needed to slow things down fast so he did a chemo combo for a few cycles and then twice Opdivo/Ipi combo while we waited for TIL.
TIL went well in May (2.5 weeks in hospital), Low Dose IL-2 this time. Unfortunately, not as many T-cells were harvested as hoped so the infusion was 4 billion but they were good quality. I think they said 92% efficient or something like that. Keytruda followed the TIL and we kept going on that until lumbar spine tumours got so painful that he needed radiation in August to try to relieve. This was followed by liver radioembolization Y-90 spheres as liver situation was getting worse. Unfortunately, the radiation on spine caused such inflammation to the largest tumour that it fractured the spine which resulted in emergency spine surgery end of August.
In September, he started back on Keytruda and they did another Y-90 on the other lobe of the liver. The good news at that time was that there was shrinkage from the procedure on the first lobe. This was the first time in 2 years since diagnosis of stage 4 that anything had ever shrunk! He has continued on Keytruda every 3 weeks and he will have body CT and MRI's of spine and brain in early January. At that point we will know where we stand.
In January we may be looking for another trial so this information you have provided is wonderful. My husband is such a fighter (we have an 11-year-old son), and he has been to hell and back over the last two years, we keep buying time and trying to find the magic bullet he needs.
Thank you again
Maria
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- December 18, 2016 at 5:03 am
Thanks Paul
will you go in for TIL soon? Where will you do it? Good luck with it. I believe it will definitely help you and although tough you will be fine as you have passed the tests to do it (or should do as lung function good).
For those that can do it, it works so well for many.
for us it was a case that it bought us time… for which I am thankful.
thinking of you
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- December 18, 2016 at 5:03 am
Thanks Paul
will you go in for TIL soon? Where will you do it? Good luck with it. I believe it will definitely help you and although tough you will be fine as you have passed the tests to do it (or should do as lung function good).
For those that can do it, it works so well for many.
for us it was a case that it bought us time… for which I am thankful.
thinking of you
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- December 18, 2016 at 5:03 am
Thanks Paul
will you go in for TIL soon? Where will you do it? Good luck with it. I believe it will definitely help you and although tough you will be fine as you have passed the tests to do it (or should do as lung function good).
For those that can do it, it works so well for many.
for us it was a case that it bought us time… for which I am thankful.
thinking of you
-
- December 18, 2016 at 4:08 am
Hi Celeste,
I have not posted before but have taken much guidance from this site for some time now.
My husband has been stage 4 since October 2014 when CT Scan showed small lesions in liver and lungs. First diagnosed in April 2013 Stage 3, melanoma 9mm on back of scalp with gremlin cells showing up in the sentinel node.
He then did a) clinical trial of IL -2 High Dose followed by Ipi – but gremlins continued their march; b) 6 months of Opdivo – still no luck; c) Clinical trial IL-10 daily injections plus Keytruda. This took us to January 2016 and during the three months on c) there was a lot of progression including into bones (rib and spine).
So next we decided on TIL (have been at MDA since the beginning), some of liver tumour was used for harvesting but we needed to slow things down fast so he did a chemo combo for a few cycles and then twice Opdivo/Ipi combo while we waited for TIL.
TIL went well in May (2.5 weeks in hospital), Low Dose IL-2 this time. Unfortunately, not as many T-cells were harvested as hoped so the infusion was 4 billion but they were good quality. I think they said 92% efficient or something like that. Keytruda followed the TIL and we kept going on that until lumbar spine tumours got so painful that he needed radiation in August to try to relieve. This was followed by liver radioembolization Y-90 spheres as liver situation was getting worse. Unfortunately, the radiation on spine caused such inflammation to the largest tumour that it fractured the spine which resulted in emergency spine surgery end of August.
In September, he started back on Keytruda and they did another Y-90 on the other lobe of the liver. The good news at that time was that there was shrinkage from the procedure on the first lobe. This was the first time in 2 years since diagnosis of stage 4 that anything had ever shrunk! He has continued on Keytruda every 3 weeks and he will have body CT and MRI's of spine and brain in early January. At that point we will know where we stand.
In January we may be looking for another trial so this information you have provided is wonderful. My husband is such a fighter (we have an 11-year-old son), and he has been to hell and back over the last two years, we keep buying time and trying to find the magic bullet he needs.
Thank you again
Maria
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- December 18, 2016 at 1:54 pm
Celeste, I echo what others have said. After reading this post, all last night I was thinking about how you must have spent all day gathering this information. And all to help others. You are a wonderful angel on Earth and such a blessing to everyone around you!Annie
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- December 18, 2016 at 1:54 pm
Celeste, I echo what others have said. After reading this post, all last night I was thinking about how you must have spent all day gathering this information. And all to help others. You are a wonderful angel on Earth and such a blessing to everyone around you!Annie
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- December 18, 2016 at 1:54 pm
Celeste, I echo what others have said. After reading this post, all last night I was thinking about how you must have spent all day gathering this information. And all to help others. You are a wonderful angel on Earth and such a blessing to everyone around you!Annie
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- December 18, 2016 at 4:32 pm
Hi Celeste, just thought I might add another link for Josh and others to look at after they finish with your great list. I love the way drug companies come up with drug names and then make it so hard to get a description of what they are!!!! For example BMS-986205 that you have as your second on the list. I will take your word that it is a IDO inhibitor since I couldn't find out what the hell it was on my own. So, one of my favorite people to get information from is Dr. Omid Hamid of the Angeles Clinic and here is the link to the clinics page of clinical trials, and just scroll down to Melanoma and you will find 3 or 4 different categories for Melanoma. http://www.theangelesclinic.org/Home/ResearchClinicalTrials/ClinicalTrialList/tabid/19278/Default.aspx I would just like to point out that many of the new trials are using other Inhibitory signal pathways similiar to Ipi and Pd-1 like Tim-3, Vista and Lag-3. There are also some new drugs that are using the coactivation signal or stimulation signal on t-cells like OX-40, Gitr, CD137, CD27, CD28. I would like to also add how much I enjoy going to Celeste blog, oh bye the way where did you find that cute model for all your clothes? Best Wishes!!!!Ed
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- December 18, 2016 at 4:32 pm
Hi Celeste, just thought I might add another link for Josh and others to look at after they finish with your great list. I love the way drug companies come up with drug names and then make it so hard to get a description of what they are!!!! For example BMS-986205 that you have as your second on the list. I will take your word that it is a IDO inhibitor since I couldn't find out what the hell it was on my own. So, one of my favorite people to get information from is Dr. Omid Hamid of the Angeles Clinic and here is the link to the clinics page of clinical trials, and just scroll down to Melanoma and you will find 3 or 4 different categories for Melanoma. http://www.theangelesclinic.org/Home/ResearchClinicalTrials/ClinicalTrialList/tabid/19278/Default.aspx I would just like to point out that many of the new trials are using other Inhibitory signal pathways similiar to Ipi and Pd-1 like Tim-3, Vista and Lag-3. There are also some new drugs that are using the coactivation signal or stimulation signal on t-cells like OX-40, Gitr, CD137, CD27, CD28. I would like to also add how much I enjoy going to Celeste blog, oh bye the way where did you find that cute model for all your clothes? Best Wishes!!!!Ed
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- December 18, 2016 at 4:32 pm
Hi Celeste, just thought I might add another link for Josh and others to look at after they finish with your great list. I love the way drug companies come up with drug names and then make it so hard to get a description of what they are!!!! For example BMS-986205 that you have as your second on the list. I will take your word that it is a IDO inhibitor since I couldn't find out what the hell it was on my own. So, one of my favorite people to get information from is Dr. Omid Hamid of the Angeles Clinic and here is the link to the clinics page of clinical trials, and just scroll down to Melanoma and you will find 3 or 4 different categories for Melanoma. http://www.theangelesclinic.org/Home/ResearchClinicalTrials/ClinicalTrialList/tabid/19278/Default.aspx I would just like to point out that many of the new trials are using other Inhibitory signal pathways similiar to Ipi and Pd-1 like Tim-3, Vista and Lag-3. There are also some new drugs that are using the coactivation signal or stimulation signal on t-cells like OX-40, Gitr, CD137, CD27, CD28. I would like to also add how much I enjoy going to Celeste blog, oh bye the way where did you find that cute model for all your clothes? Best Wishes!!!!Ed
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- December 18, 2016 at 5:50 pm
Goodness, guys!!! I am no angel…and have PLENTY of folks who would testify to that!!! However, my heart is full with all the kindess you have shared.
Oddly enough, I did not do this research for myself. But, I had a dedicated love who did. I guess I feel that if I can help another in that way, I should. I also imagine, that if one person is out-right asking the question, there have to be many more who need the same answer. Access to real scientific information and trial data, as Jackie noted, is hard to come by. I am lucky enough to have access to at least some of it and training that hopefully allows me to make it somewhat comprehensible. Additionally, like most things in life, fighting melanoma takes a village. To that point, we all know those, like my Edster and many others who routinely offer good contacts, sources, and intel. However, you should also know that there is another entire group of folks who send me warm wishes and ideas on behalf of those who are struggling here. I will not name them now as I figure if they wanted to be named, they would post these things themselves. But…Josh and Paul…..you would be amazed at the love and hope that has been sent to me….to pass on to you. So….here it is…. Hugs and support from the world over!!!! Really.
Ed, is exactly right. His sources are spot on and there is hardly a better melanoma source than Dr. Hamid. All the new inhibitors and compounds that are recently being combined with immunotherapy, or given on their own, are very exciting and I am sure that the coming years will find promise in at least several of them. However, it is very frustrating (to say the least) that many that are currently in trials will not allow folks who have already utilized immunotherapy. However, we will prevail!!!!
And because my cogs are always turning….my poor husband….imagine will you????!!!!! I suddenly remembered a patient's report and found this:
https://clinicaltrials.gov/ct2/show/NCT02253992?term=urelumab&rank=5
A trial that is combining urelumab with nivo. It is ongoing at Stanford in CA, Moffitt in FL, Chicago, John Hopkins in MD, Boston, NYU, Penn, Tx as well as France, Germany and Spain. Perhaps more importantly, I know 2 melanoma patients who were in rather dire straits, progressing in a frightening way, after having been treated with most everything, now at Yale, who are taking this combo currently and are finally having a response and/or lack of progression. It is early days, but something worth checking to my mind. Here's a report (from the company, mind you!!!, but still…): http://news.bms.com/press-release/bmy/phase-12-data-combining-urelumab-opdivo-nivolumab-hematologic-and-solid-tumors-sug
Oh, and Ed….that model??? Just a rattie…willing to put it on the line, while wishing she was a mouse!!! Love and hope to each of you. celeste
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- December 18, 2016 at 5:50 pm
Goodness, guys!!! I am no angel…and have PLENTY of folks who would testify to that!!! However, my heart is full with all the kindess you have shared.
Oddly enough, I did not do this research for myself. But, I had a dedicated love who did. I guess I feel that if I can help another in that way, I should. I also imagine, that if one person is out-right asking the question, there have to be many more who need the same answer. Access to real scientific information and trial data, as Jackie noted, is hard to come by. I am lucky enough to have access to at least some of it and training that hopefully allows me to make it somewhat comprehensible. Additionally, like most things in life, fighting melanoma takes a village. To that point, we all know those, like my Edster and many others who routinely offer good contacts, sources, and intel. However, you should also know that there is another entire group of folks who send me warm wishes and ideas on behalf of those who are struggling here. I will not name them now as I figure if they wanted to be named, they would post these things themselves. But…Josh and Paul…..you would be amazed at the love and hope that has been sent to me….to pass on to you. So….here it is…. Hugs and support from the world over!!!! Really.
Ed, is exactly right. His sources are spot on and there is hardly a better melanoma source than Dr. Hamid. All the new inhibitors and compounds that are recently being combined with immunotherapy, or given on their own, are very exciting and I am sure that the coming years will find promise in at least several of them. However, it is very frustrating (to say the least) that many that are currently in trials will not allow folks who have already utilized immunotherapy. However, we will prevail!!!!
And because my cogs are always turning….my poor husband….imagine will you????!!!!! I suddenly remembered a patient's report and found this:
https://clinicaltrials.gov/ct2/show/NCT02253992?term=urelumab&rank=5
A trial that is combining urelumab with nivo. It is ongoing at Stanford in CA, Moffitt in FL, Chicago, John Hopkins in MD, Boston, NYU, Penn, Tx as well as France, Germany and Spain. Perhaps more importantly, I know 2 melanoma patients who were in rather dire straits, progressing in a frightening way, after having been treated with most everything, now at Yale, who are taking this combo currently and are finally having a response and/or lack of progression. It is early days, but something worth checking to my mind. Here's a report (from the company, mind you!!!, but still…): http://news.bms.com/press-release/bmy/phase-12-data-combining-urelumab-opdivo-nivolumab-hematologic-and-solid-tumors-sug
Oh, and Ed….that model??? Just a rattie…willing to put it on the line, while wishing she was a mouse!!! Love and hope to each of you. celeste
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- December 18, 2016 at 5:50 pm
Goodness, guys!!! I am no angel…and have PLENTY of folks who would testify to that!!! However, my heart is full with all the kindess you have shared.
Oddly enough, I did not do this research for myself. But, I had a dedicated love who did. I guess I feel that if I can help another in that way, I should. I also imagine, that if one person is out-right asking the question, there have to be many more who need the same answer. Access to real scientific information and trial data, as Jackie noted, is hard to come by. I am lucky enough to have access to at least some of it and training that hopefully allows me to make it somewhat comprehensible. Additionally, like most things in life, fighting melanoma takes a village. To that point, we all know those, like my Edster and many others who routinely offer good contacts, sources, and intel. However, you should also know that there is another entire group of folks who send me warm wishes and ideas on behalf of those who are struggling here. I will not name them now as I figure if they wanted to be named, they would post these things themselves. But…Josh and Paul…..you would be amazed at the love and hope that has been sent to me….to pass on to you. So….here it is…. Hugs and support from the world over!!!! Really.
Ed, is exactly right. His sources are spot on and there is hardly a better melanoma source than Dr. Hamid. All the new inhibitors and compounds that are recently being combined with immunotherapy, or given on their own, are very exciting and I am sure that the coming years will find promise in at least several of them. However, it is very frustrating (to say the least) that many that are currently in trials will not allow folks who have already utilized immunotherapy. However, we will prevail!!!!
And because my cogs are always turning….my poor husband….imagine will you????!!!!! I suddenly remembered a patient's report and found this:
https://clinicaltrials.gov/ct2/show/NCT02253992?term=urelumab&rank=5
A trial that is combining urelumab with nivo. It is ongoing at Stanford in CA, Moffitt in FL, Chicago, John Hopkins in MD, Boston, NYU, Penn, Tx as well as France, Germany and Spain. Perhaps more importantly, I know 2 melanoma patients who were in rather dire straits, progressing in a frightening way, after having been treated with most everything, now at Yale, who are taking this combo currently and are finally having a response and/or lack of progression. It is early days, but something worth checking to my mind. Here's a report (from the company, mind you!!!, but still…): http://news.bms.com/press-release/bmy/phase-12-data-combining-urelumab-opdivo-nivolumab-hematologic-and-solid-tumors-sug
Oh, and Ed….that model??? Just a rattie…willing to put it on the line, while wishing she was a mouse!!! Love and hope to each of you. celeste
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- December 18, 2016 at 11:06 pm
Thanks to my amazing dear one Eric and his tireless efforts on behalf of all of us!!!…..we have this bit of intel from a CV of sorts….but here is the pertinent part:
"Significant Accomplishments in Drug Discovery at Flexus Biosciences
I oversaw discovery and/or development of several clinical candidates:
FLX287 (BMS-986205) (Solid and hematological tumors) Selective inhibitor of IDO1. Acquired by BMS in April 2015 in connection with the acquisition of Flexus Biosciences, Phase 1 trial (combination with nivo) initiated February 2016."
Obviously the "I" is neither myself nor Eric but the guy on the CV. Anyhow…guess we all have to be thankful for the internet, good friends and the fact that drug company and business big whigs like to post crap.
But….I know what I'm gonna do in my next life….be a PI!!!! And I know exactly the peeps I want on my team.
Love to you all. Celeste
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- December 18, 2016 at 11:06 pm
Thanks to my amazing dear one Eric and his tireless efforts on behalf of all of us!!!…..we have this bit of intel from a CV of sorts….but here is the pertinent part:
"Significant Accomplishments in Drug Discovery at Flexus Biosciences
I oversaw discovery and/or development of several clinical candidates:
FLX287 (BMS-986205) (Solid and hematological tumors) Selective inhibitor of IDO1. Acquired by BMS in April 2015 in connection with the acquisition of Flexus Biosciences, Phase 1 trial (combination with nivo) initiated February 2016."
Obviously the "I" is neither myself nor Eric but the guy on the CV. Anyhow…guess we all have to be thankful for the internet, good friends and the fact that drug company and business big whigs like to post crap.
But….I know what I'm gonna do in my next life….be a PI!!!! And I know exactly the peeps I want on my team.
Love to you all. Celeste
-
- December 18, 2016 at 11:06 pm
Thanks to my amazing dear one Eric and his tireless efforts on behalf of all of us!!!…..we have this bit of intel from a CV of sorts….but here is the pertinent part:
"Significant Accomplishments in Drug Discovery at Flexus Biosciences
I oversaw discovery and/or development of several clinical candidates:
FLX287 (BMS-986205) (Solid and hematological tumors) Selective inhibitor of IDO1. Acquired by BMS in April 2015 in connection with the acquisition of Flexus Biosciences, Phase 1 trial (combination with nivo) initiated February 2016."
Obviously the "I" is neither myself nor Eric but the guy on the CV. Anyhow…guess we all have to be thankful for the internet, good friends and the fact that drug company and business big whigs like to post crap.
But….I know what I'm gonna do in my next life….be a PI!!!! And I know exactly the peeps I want on my team.
Love to you all. Celeste
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- December 19, 2016 at 12:26 am
Keep in mind…I ain't selling this mess….but there is this as well (see page 13):
Eric rocks! I'm telling you!! – c
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- December 19, 2016 at 12:26 am
Keep in mind…I ain't selling this mess….but there is this as well (see page 13):
Eric rocks! I'm telling you!! – c
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- December 19, 2016 at 12:26 am
Keep in mind…I ain't selling this mess….but there is this as well (see page 13):
Eric rocks! I'm telling you!! – c
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- December 19, 2016 at 12:37 am
Celeste,
I'd like to start out my post by saying you suck simply so your head doesn't explode from all the praise you are receiving on this thread;)
In all serious though thank you so much for putting this together. Even though I know you have help I also know that it is no small effort to gather the info and present it as well as you do. This thread is definitely giving me more hope and that can make all the difference.
Love,
Brian
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- December 19, 2016 at 12:37 am
Celeste,
I'd like to start out my post by saying you suck simply so your head doesn't explode from all the praise you are receiving on this thread;)
In all serious though thank you so much for putting this together. Even though I know you have help I also know that it is no small effort to gather the info and present it as well as you do. This thread is definitely giving me more hope and that can make all the difference.
Love,
Brian
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- December 19, 2016 at 12:37 am
Celeste,
I'd like to start out my post by saying you suck simply so your head doesn't explode from all the praise you are receiving on this thread;)
In all serious though thank you so much for putting this together. Even though I know you have help I also know that it is no small effort to gather the info and present it as well as you do. This thread is definitely giving me more hope and that can make all the difference.
Love,
Brian
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- December 19, 2016 at 2:34 am
Thank you our dear Celeste for all that you do!!! I can't even imagine the task of putting this together even with help, its all so confusing. I don't know that I need the info right now for my Dad, but it is such a relief knowing that its there for the future. I appreciate all of your efforts.
Jen
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- December 19, 2016 at 2:34 am
Thank you our dear Celeste for all that you do!!! I can't even imagine the task of putting this together even with help, its all so confusing. I don't know that I need the info right now for my Dad, but it is such a relief knowing that its there for the future. I appreciate all of your efforts.
Jen
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- December 19, 2016 at 2:34 am
Thank you our dear Celeste for all that you do!!! I can't even imagine the task of putting this together even with help, its all so confusing. I don't know that I need the info right now for my Dad, but it is such a relief knowing that its there for the future. I appreciate all of your efforts.
Jen
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- December 19, 2016 at 2:33 pm
Holy wow… this thread was a lot of reading. : ) Celeste, THANK YOU for compiling the latest info in one bookmarkable blog page! There is a comfort factor in seeing all of the potential opportunities in current research. Have you ever read "The Tipping Point" by Malcom Gladwell? You are both a "connector" and a "maven", putting you in a rare breed category. The book is more about marketing success and how things become fads….. but the worker bee personality types that he describes are fitting for nearly everything that ends up successful. Anyway, side track aside… thank you. : )
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- December 19, 2016 at 2:33 pm
Holy wow… this thread was a lot of reading. : ) Celeste, THANK YOU for compiling the latest info in one bookmarkable blog page! There is a comfort factor in seeing all of the potential opportunities in current research. Have you ever read "The Tipping Point" by Malcom Gladwell? You are both a "connector" and a "maven", putting you in a rare breed category. The book is more about marketing success and how things become fads….. but the worker bee personality types that he describes are fitting for nearly everything that ends up successful. Anyway, side track aside… thank you. : )
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- December 19, 2016 at 2:33 pm
Holy wow… this thread was a lot of reading. : ) Celeste, THANK YOU for compiling the latest info in one bookmarkable blog page! There is a comfort factor in seeing all of the potential opportunities in current research. Have you ever read "The Tipping Point" by Malcom Gladwell? You are both a "connector" and a "maven", putting you in a rare breed category. The book is more about marketing success and how things become fads….. but the worker bee personality types that he describes are fitting for nearly everything that ends up successful. Anyway, side track aside… thank you. : )
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- December 19, 2016 at 2:48 pm
Hi Celeste-
I just had to chime in with everyone else….doing what you do takes so much time, of which none of us has enough!!!
(yikes had to get that grammar right…My Dad would kill me if i ended that senetence with a preposition)
In all seriousness……you are an invaluable resource to this group…..as i said recently i am always waiting for the other shoe to drop…..I have been stage 3b for 2 years….and so afraid of when (and hopefully never) that may change.
I hope you have a great holiday with your family. and again heartfelt thanks for your MANY contributions to everyone here.
Best,
Jenny
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- December 19, 2016 at 2:48 pm
Hi Celeste-
I just had to chime in with everyone else….doing what you do takes so much time, of which none of us has enough!!!
(yikes had to get that grammar right…My Dad would kill me if i ended that senetence with a preposition)
In all seriousness……you are an invaluable resource to this group…..as i said recently i am always waiting for the other shoe to drop…..I have been stage 3b for 2 years….and so afraid of when (and hopefully never) that may change.
I hope you have a great holiday with your family. and again heartfelt thanks for your MANY contributions to everyone here.
Best,
Jenny
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- December 19, 2016 at 2:48 pm
Hi Celeste-
I just had to chime in with everyone else….doing what you do takes so much time, of which none of us has enough!!!
(yikes had to get that grammar right…My Dad would kill me if i ended that senetence with a preposition)
In all seriousness……you are an invaluable resource to this group…..as i said recently i am always waiting for the other shoe to drop…..I have been stage 3b for 2 years….and so afraid of when (and hopefully never) that may change.
I hope you have a great holiday with your family. and again heartfelt thanks for your MANY contributions to everyone here.
Best,
Jenny
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- September 25, 2017 at 5:04 pm
Hi we contacted Moffitt in Florida regarding the below trial posted by Celeste and they said that the trial is on hold. does anyone know if the trial is a go at any of the location as we are willing to travel. we are getting desperate as she has been disqualified for all trials up to now by her concurrent condition of follicular lymphoma.The trial we are interested in is
“Study of the Safety and Tolerability of Urelumab Administered in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkins Lymphoma”
Thanks for any information.
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