trafinlar+ mekinist

Nell, this is my personal experience on these drugs. I started taking them in August 2014 and few weeks after that I had fever and chills lasting for about 2 days. My hair was also shedding more than usual. In December I started getting painful mouth sores all over my mouth. The doctor suggested to stop for a few days and restart alternating days. The mouth sores got worse and then started going down my throat. At that point I stopped and now I'm doing Keytruda. I've done 2 infusions and so far no side effects yet, just fatigue. Hope you'll do better.

Nell, this is my personal experience on these drugs. I started taking them in August 2014 and few weeks after that I had fever and chills lasting for about 2 days. My hair was also shedding more than usual. In December I started getting painful mouth sores all over my mouth. The doctor suggested to stop for a few days and restart alternating days. The mouth sores got worse and then started going down my throat. At that point I stopped and now I'm doing Keytruda. I've done 2 infusions and so far no side effects yet, just fatigue. Hope you'll do better.

Nell, this is my personal experience on these drugs. I started taking them in August 2014 and few weeks after that I had fever and chills lasting for about 2 days. My hair was also shedding more than usual. In December I started getting painful mouth sores all over my mouth. The doctor suggested to stop for a few days and restart alternating days. The mouth sores got worse and then started going down my throat. At that point I stopped and now I'm doing Keytruda. I've done 2 infusions and so far no side effects yet, just fatigue. Hope you'll do better.

I know the fda says you have to do braf before pd1 if you are braf positive. But I've also read others being braf positive were somehow able to skip braf and go from Yervoy to pd1. Typically it is thought best to do braf when you have a heavy tumor load or need a quick response. There is talk that possibly later this year the fda will change it so you can get pd1 without braf but that is just talk.

As far as the tafinlar mekinist I was on them 8 weeks plus another 3 weeks waiting to start keytruda. They were way better than the zelboraf pills as far as side affects for me. I usually had a fever of about 103 every day but I didn't really feel it. The sun sensitivity was nothing compared to the zelboraf pills. I had a minor rash again nothing compared to the full body rash on zelboraf. Week 8 I had 3 really rough days of massive shakes and chills and fever and some throwing up. They quickly did a pet scan which showed most tumors stayed the same but a couple continued to grow like crazy and a couple new ones showed up. When I was on zelboraf everything continued to grow but no new stuff showed up.

If I were you I would do whatever you need to to get on one of the pd1s without doing braf. Although braf has been great for lots of people but to do them for one possible small tumor does not make sound medical sense to me but you have to do what your gut tells you. There's also some data that suggests doing braf meds make you less likely to respond to yervoy or pd1. I've had 15 doses of keytruda and side affects of first two doses were some fevers, grogginess. After that very minor fevers occasionally and rarely more than 101. The past 3 doses have had no side affects. First scan had 19 of 30 tumors shrinking. 2nd scan said some tumors had mild growth. In about 5 weeks I get my 3rd scan and am really hoping for a miracle.

Since you had such good success with yervoy and it's been a good 8 months already I've heard of people doing another round of it. Or maybe a maintenance dose if not the full 4 doses.

Well that gives you something to think about. Hope it helps.

Artie

I know the fda says you have to do braf before pd1 if you are braf positive. But I've also read others being braf positive were somehow able to skip braf and go from Yervoy to pd1. Typically it is thought best to do braf when you have a heavy tumor load or need a quick response. There is talk that possibly later this year the fda will change it so you can get pd1 without braf but that is just talk.

As far as the tafinlar mekinist I was on them 8 weeks plus another 3 weeks waiting to start keytruda. They were way better than the zelboraf pills as far as side affects for me. I usually had a fever of about 103 every day but I didn't really feel it. The sun sensitivity was nothing compared to the zelboraf pills. I had a minor rash again nothing compared to the full body rash on zelboraf. Week 8 I had 3 really rough days of massive shakes and chills and fever and some throwing up. They quickly did a pet scan which showed most tumors stayed the same but a couple continued to grow like crazy and a couple new ones showed up. When I was on zelboraf everything continued to grow but no new stuff showed up.

If I were you I would do whatever you need to to get on one of the pd1s without doing braf. Although braf has been great for lots of people but to do them for one possible small tumor does not make sound medical sense to me but you have to do what your gut tells you. There's also some data that suggests doing braf meds make you less likely to respond to yervoy or pd1. I've had 15 doses of keytruda and side affects of first two doses were some fevers, grogginess. After that very minor fevers occasionally and rarely more than 101. The past 3 doses have had no side affects. First scan had 19 of 30 tumors shrinking. 2nd scan said some tumors had mild growth. In about 5 weeks I get my 3rd scan and am really hoping for a miracle.

Since you had such good success with yervoy and it's been a good 8 months already I've heard of people doing another round of it. Or maybe a maintenance dose if not the full 4 doses.

Well that gives you something to think about. Hope it helps.

Artie

I know the fda says you have to do braf before pd1 if you are braf positive. But I've also read others being braf positive were somehow able to skip braf and go from Yervoy to pd1. Typically it is thought best to do braf when you have a heavy tumor load or need a quick response. There is talk that possibly later this year the fda will change it so you can get pd1 without braf but that is just talk.

As far as the tafinlar mekinist I was on them 8 weeks plus another 3 weeks waiting to start keytruda. They were way better than the zelboraf pills as far as side affects for me. I usually had a fever of about 103 every day but I didn't really feel it. The sun sensitivity was nothing compared to the zelboraf pills. I had a minor rash again nothing compared to the full body rash on zelboraf. Week 8 I had 3 really rough days of massive shakes and chills and fever and some throwing up. They quickly did a pet scan which showed most tumors stayed the same but a couple continued to grow like crazy and a couple new ones showed up. When I was on zelboraf everything continued to grow but no new stuff showed up.

If I were you I would do whatever you need to to get on one of the pd1s without doing braf. Although braf has been great for lots of people but to do them for one possible small tumor does not make sound medical sense to me but you have to do what your gut tells you. There's also some data that suggests doing braf meds make you less likely to respond to yervoy or pd1. I've had 15 doses of keytruda and side affects of first two doses were some fevers, grogginess. After that very minor fevers occasionally and rarely more than 101. The past 3 doses have had no side affects. First scan had 19 of 30 tumors shrinking. 2nd scan said some tumors had mild growth. In about 5 weeks I get my 3rd scan and am really hoping for a miracle.

Since you had such good success with yervoy and it's been a good 8 months already I've heard of people doing another round of it. Or maybe a maintenance dose if not the full 4 doses.

Well that gives you something to think about. Hope it helps.

Artie

I agree with Artie's sentiments, but if you move to BRAF-MEK, everyone is different (like with immunotherapy drugs).  For me, BRAF-MEK was like taking vitamins.  Very few side effects and all manageable.  They also improved over time, eg, minor joint pain.

I agree with Artie's sentiments, but if you move to BRAF-MEK, everyone is different (like with immunotherapy drugs).  For me, BRAF-MEK was like taking vitamins.  Very few side effects and all manageable.  They also improved over time, eg, minor joint pain.

I agree with Artie's sentiments, but if you move to BRAF-MEK, everyone is different (like with immunotherapy drugs).  For me, BRAF-MEK was like taking vitamins.  Very few side effects and all manageable.  They also improved over time, eg, minor joint pain.