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switching to taf/mek just after 2 infusion of ipi/nivo
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switching to taf/mek just after 2 infusion of ipi/nivo

› Forums › General Melanoma Community › switching to taf/mek just after 2 infusion of ipi/nivo

  • Post
    • July 12, 2019 at 3:13 pm
    obtu.bt
    Participant
      Hi folks,

      after my pet result with tumors in lungs and some bones I have started ipi/nivo combo.
      I have taken 2 round of combo however after my lost combo my LDH level increased from 200 to 400.
      My CT TORAX show many new activity on boths lung + liver + some other places….
      My onco decide to stop ipi/nivo combo and switch to taf/mek immediately.
      do you ever faced similar situation?
      Please share your experiences and ideas.

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    • Replies
        • July 12, 2019 at 4:23 pm
        AMcReader
        Participant
          Hello there fellow-fighter,

          When I was going through the Ipi/Nivo combo my LDH spiked from the 100s to 300+. It freaked me out but instead of being a sign of progression, it was a sign that my immune system was going into overdrive and causing inflammation in my body. That VERY well may be the case for you. In terms of new spots lighting up, 2 treatments is not enough time to gauge whether or not the treatment is working. Most people don’t see results for 12-16+ weeks after starting treatment. If it were me, I’d try to push through and get as many combo treatments as possible and another round of scans before switching. I don’t know your whole case though, so I’d encourage you to at least seek a second opinion.

          Fight on!

            • July 31, 2019 at 7:39 am
            obtu.bt
            Participant
              dear Amanda thanks for sharing your experience but in my case I had lot of new metastases on different part of the body at the same time that is why my onco decided to switch.
            • July 12, 2019 at 9:25 pm
            Summer S.
            Participant
              I think Amanda has a point,
              You can also up pseudoprogressiion on immunotherapy, it is not uncommon for melanoma to progress initially on immunotherapy before it regresses due to immune response.
              I would definitely seek another opinion if I were you, I wish you all the luck
              • July 13, 2019 at 11:00 pm
              Edwin
              Participant
                Because my March 1, 2016 PET scan showed melanoma in many bones, I began ipi + nivo immunotherapy on April 1, 2016. I had a PET scan on August 23, 2016. I did not have any scans between those two PET scans. My oncologist waited longer to check my cancer status than your oncologist did.
                  • July 31, 2019 at 7:38 am
                  obtu.bt
                  Participant
                    thanks for sharing your experience. In my case as blood work is applyied before each application of combo, due to high increase in LDH we switch the therapy
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