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Switching from Zelboraf to Taf/Mek Combo

Forums General Melanoma Community Switching from Zelboraf to Taf/Mek Combo

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    Summer S.
      Hi everybody,

      Does anybody have an experience switching from Zelboraf to the Taf/Mek combo?
      How did it go?
      Does it still work if you have already progressed on “Z”

      Am just really confused and a little scared now

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    • Replies
          I don’t have an absolute answer or data for you, Summer. (Maybe Ed can come through with something – he’s good like that, HA!) But I think since your mom was taking Zelboraf as a single agent there is a good chance that the Tafinilar combined with a MEK inhibitor could well be helpful. Hang in there. Your mom is blessed to have you! c
            Summer S.
              Thank you so much! Bubbles
              This is reassuring <3
              and yeah, Ed is awesome, you are right I should check if he has insights on this.
              Hi Summer – my husband was on Zelboraf for about 9 months in 2012-13 before progression. He switched to ipi and followed that with Tafinlar. He has been on Tafinlar since 2013 with mostly stable results after initial reduction in tumors. Added Keytruda in May 2018 after another brain met appeared. He’s doing great – still on Keytruda and Tafinlar. I realize his results are atypical with Tafinlar working for so long. Hope the combo works for you/your loved one. Take care.
                Summer S.
                  Hi Marta – am so happy to hear that it has been working well for your husband, I hope it continues to do wonders for him.
                  Thank you for sharing your experience with me, it is really helpful.
                  I wish you two a long life of health and happiness.
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