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  • This topic has 9 replies, 3 voices, and was last updated 9 years ago by RGal.
  • Post
    • April 9, 2015 at 4:10 pm
    RGal
    Participant

      My father has been on a study for only 6 wks.  PD-1 infusion every 2 wks + inhibitor.  He went today for scans which according to my mother "aren't good" so they are stopping this regimen and beginning something else in 3 wks.  Two questions, why wouldn't they give it more time and also, do they need to wait 3 wks for these drugs to be eliminated from his system.  I hate the fact that nothing will be done for so long.

      Any advice would be most appreciated.  

    Viewing 5 reply threads
    • Replies
        • April 9, 2015 at 6:58 pm
        Mat
        Participant

          Sorry to hear. The 3 weeks sounds to me like they want to move him to another clinical trial. Clinical trials often require a 3 week (or more) washout period. As for why not more time, I suspect that the trial has rules around progression and when one must be taken out of the trial. If your father's onc thinks it makes sense to move to PD-1 or BRAF/MEK (you said "inhibitor" but didn't specify) individually, then your father would not need to wait 3 weeks and could start treatment immediately since these are FDA-approved drugs. (In the case of PD-1, your father might be required to try and fail ipi first.)

          • April 9, 2015 at 6:58 pm
          Mat
          Participant

            Sorry to hear. The 3 weeks sounds to me like they want to move him to another clinical trial. Clinical trials often require a 3 week (or more) washout period. As for why not more time, I suspect that the trial has rules around progression and when one must be taken out of the trial. If your father's onc thinks it makes sense to move to PD-1 or BRAF/MEK (you said "inhibitor" but didn't specify) individually, then your father would not need to wait 3 weeks and could start treatment immediately since these are FDA-approved drugs. (In the case of PD-1, your father might be required to try and fail ipi first.)

            • April 9, 2015 at 6:58 pm
            Mat
            Participant

              Sorry to hear. The 3 weeks sounds to me like they want to move him to another clinical trial. Clinical trials often require a 3 week (or more) washout period. As for why not more time, I suspect that the trial has rules around progression and when one must be taken out of the trial. If your father's onc thinks it makes sense to move to PD-1 or BRAF/MEK (you said "inhibitor" but didn't specify) individually, then your father would not need to wait 3 weeks and could start treatment immediately since these are FDA-approved drugs. (In the case of PD-1, your father might be required to try and fail ipi first.)

              • April 9, 2015 at 10:19 pm
              ed williams
              Participant

                RGal, I have a couple of questions? Where is he being seen for treatment? What has changed in his status over the 6 weeks of treatment? What is the name of the Inhibitor he is getting? My first thought is they are not letting the Pd-1 drug have enough time, during the first phase trials of Pd-1 they did scans at 8 weeks to check for status if I am remembering correctly. In my phase 3 trial of (Pd-1) Nivolumab and Ipi they did first set of scans at 12 weeks. Wishing you the best!!!! Ed

                  • April 10, 2015 at 2:59 pm
                  RGal
                  Participant

                    Thanks for your response.  I know it was a INCB inhibitor, but can't find the full name.  Other than some fluid in his lungs they had to drain after the first treatment, nothing else has really happened so I am a bit curious why they scanned so early and why they are stopping so soon.  

                    • April 10, 2015 at 2:59 pm
                    RGal
                    Participant

                      Thanks for your response.  I know it was a INCB inhibitor, but can't find the full name.  Other than some fluid in his lungs they had to drain after the first treatment, nothing else has really happened so I am a bit curious why they scanned so early and why they are stopping so soon.  

                      • April 10, 2015 at 2:59 pm
                      RGal
                      Participant

                        Thanks for your response.  I know it was a INCB inhibitor, but can't find the full name.  Other than some fluid in his lungs they had to drain after the first treatment, nothing else has really happened so I am a bit curious why they scanned so early and why they are stopping so soon.  

                      • April 9, 2015 at 10:19 pm
                      ed williams
                      Participant

                        RGal, I have a couple of questions? Where is he being seen for treatment? What has changed in his status over the 6 weeks of treatment? What is the name of the Inhibitor he is getting? My first thought is they are not letting the Pd-1 drug have enough time, during the first phase trials of Pd-1 they did scans at 8 weeks to check for status if I am remembering correctly. In my phase 3 trial of (Pd-1) Nivolumab and Ipi they did first set of scans at 12 weeks. Wishing you the best!!!! Ed

                        • April 9, 2015 at 10:19 pm
                        ed williams
                        Participant

                          RGal, I have a couple of questions? Where is he being seen for treatment? What has changed in his status over the 6 weeks of treatment? What is the name of the Inhibitor he is getting? My first thought is they are not letting the Pd-1 drug have enough time, during the first phase trials of Pd-1 they did scans at 8 weeks to check for status if I am remembering correctly. In my phase 3 trial of (Pd-1) Nivolumab and Ipi they did first set of scans at 12 weeks. Wishing you the best!!!! Ed

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