Started Ipi nivo 10 days ago….inflammatory CRP now 5 times normal ?

Oh Goodness Deb, I don't have any insights, but I hope someone chimes in here to give you some advise.  I am so sorry you are going through all of this, I know its been difficult for you and the family.  

Feel better my friend, keep the fine fight!

xo

Oh Goodness Deb, I don't have any insights, but I hope someone chimes in here to give you some advise.  I am so sorry you are going through all of this, I know its been difficult for you and the family.  

Feel better my friend, keep the fine fight!

xo

Oh Goodness Deb, I don't have any insights, but I hope someone chimes in here to give you some advise.  I am so sorry you are going through all of this, I know its been difficult for you and the family.  

Feel better my friend, keep the fine fight!

xo

Hi Deb,

It seem counter-intuitive, but all evidence I've read here points to side-effects being a sign of response.  In other words, no pain, no gain.  As for tenderness at tumor site, this may indeed be pseudo-progression or a common inflammation of the tumor brought on by immune system attack.  Again, an excellent sign of response, and not to be confused with progression at this early stage.  Not sure about blood-work issues but unless your doc is very concerned, I wouldn't be.  Best to you being a complete responder.

Gary

Hi Deb,

It seem counter-intuitive, but all evidence I've read here points to side-effects being a sign of response.  In other words, no pain, no gain.  As for tenderness at tumor site, this may indeed be pseudo-progression or a common inflammation of the tumor brought on by immune system attack.  Again, an excellent sign of response, and not to be confused with progression at this early stage.  Not sure about blood-work issues but unless your doc is very concerned, I wouldn't be.  Best to you being a complete responder.

Gary

Hi Deb,

It seem counter-intuitive, but all evidence I've read here points to side-effects being a sign of response.  In other words, no pain, no gain.  As for tenderness at tumor site, this may indeed be pseudo-progression or a common inflammation of the tumor brought on by immune system attack.  Again, an excellent sign of response, and not to be confused with progression at this early stage.  Not sure about blood-work issues but unless your doc is very concerned, I wouldn't be.  Best to you being a complete responder.

Gary

Hi Deb,

My mother's liver numbers went sky high around 2 weeks after her dose of ipi/nivo.  She is currently on steroids and cannot continue treatment until the steroids are tapered off.  We did try milk thistle and papaya leaf tea, which has helped bring her numbers down pretty quickly.  It's still not optimal because she can't continue treatment, but we are hopeful to get back on track soon. 

She did have dull to sharp pains in the area where her liver is (although she does not have any liver mets), and those turned out to have gone away with the steroids.  I would keep your doctor posted, because this could be sign of colitis, which they told me was life threatening if not treated early enough with the steroids. 

Hi Deb,

My mother's liver numbers went sky high around 2 weeks after her dose of ipi/nivo.  She is currently on steroids and cannot continue treatment until the steroids are tapered off.  We did try milk thistle and papaya leaf tea, which has helped bring her numbers down pretty quickly.  It's still not optimal because she can't continue treatment, but we are hopeful to get back on track soon. 

She did have dull to sharp pains in the area where her liver is (although she does not have any liver mets), and those turned out to have gone away with the steroids.  I would keep your doctor posted, because this could be sign of colitis, which they told me was life threatening if not treated early enough with the steroids. 

Hi Deb,

My mother's liver numbers went sky high around 2 weeks after her dose of ipi/nivo.  She is currently on steroids and cannot continue treatment until the steroids are tapered off.  We did try milk thistle and papaya leaf tea, which has helped bring her numbers down pretty quickly.  It's still not optimal because she can't continue treatment, but we are hopeful to get back on track soon. 

She did have dull to sharp pains in the area where her liver is (although she does not have any liver mets), and those turned out to have gone away with the steroids.  I would keep your doctor posted, because this could be sign of colitis, which they told me was life threatening if not treated early enough with the steroids. 

I am on the combo, in second stage of just nivo alone. About a couple of weeks after my 2nd dose I started running fever, was told to report to nearest ER. Oncologist put me on antibiotics even though lab results on white blood cell count were normal as was liver. 3 days later I saw my oncologist and was admitted to the hospital because my lab that morning had my liver counts 6 times above normal. They stopped the antibiotics and after 3 days of every test for infection I was released due to my liver counts going back down and no infection. I ran fever for 6 weeks and it was determined the antibiotics increased my liver counts but they are normal now. They have only been high after taking antibiotics. 

I am on the combo, in second stage of just nivo alone. About a couple of weeks after my 2nd dose I started running fever, was told to report to nearest ER. Oncologist put me on antibiotics even though lab results on white blood cell count were normal as was liver. 3 days later I saw my oncologist and was admitted to the hospital because my lab that morning had my liver counts 6 times above normal. They stopped the antibiotics and after 3 days of every test for infection I was released due to my liver counts going back down and no infection. I ran fever for 6 weeks and it was determined the antibiotics increased my liver counts but they are normal now. They have only been high after taking antibiotics. 

I am on the combo, in second stage of just nivo alone. About a couple of weeks after my 2nd dose I started running fever, was told to report to nearest ER. Oncologist put me on antibiotics even though lab results on white blood cell count were normal as was liver. 3 days later I saw my oncologist and was admitted to the hospital because my lab that morning had my liver counts 6 times above normal. They stopped the antibiotics and after 3 days of every test for infection I was released due to my liver counts going back down and no infection. I ran fever for 6 weeks and it was determined the antibiotics increased my liver counts but they are normal now. They have only been high after taking antibiotics.