Response to Eva
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Response to Eva

› Forums › General Melanoma Community › Response to Eva

  • Post
    • August 16, 2016 at 6:10 pm
    Mat
    Participant

    Got spam-blocked on Eva's thread, so posting here:

    Eva, I'm sorry to hear about your present status.  When I met with Dr. Wolchok before starting ipi-nivo, he mentioned that Sloan has seen some patients do well on chemo following checkpoint inhibitors (synergistic-type effect).  I've kept this in mind for myself.  Chemo-only–not so exciting.  Chemo with the possibility of a synergistic effect and a bridge to something else–more interesting.  I'd also consider attempting another run on BRAF-MEK.  (My recollection is that you are BRAF+.)

Viewing 8 reply threads
  • Replies
      • August 16, 2016 at 7:09 pm
      khubes
      Participant

      Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

      I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

      Best,

      Katie 

      • August 16, 2016 at 7:09 pm
      khubes
      Participant

      Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

      I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

      Best,

      Katie 

      • August 16, 2016 at 7:09 pm
      khubes
      Participant

      Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

      I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

      Best,

      Katie 

      • August 16, 2016 at 10:13 pm
      Mli0709
      Participant

      Hi Mat,

      In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

       

      Its so painful even writing this. 

       

      Maria

      • August 16, 2016 at 10:13 pm
      Mli0709
      Participant

      Hi Mat,

      In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

       

      Its so painful even writing this. 

       

      Maria

      • August 16, 2016 at 10:13 pm
      Mli0709
      Participant

      Hi Mat,

      In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

       

      Its so painful even writing this. 

       

      Maria

      • August 17, 2016 at 3:13 am
      Bubbles
      Participant

      Hi Eva,

      So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

      It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

      There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

      Holding you in my heart.  Celeste

      • August 17, 2016 at 3:13 am
      Bubbles
      Participant

      Hi Eva,

      So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

      It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

      There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

      Holding you in my heart.  Celeste

      • August 17, 2016 at 3:13 am
      Bubbles
      Participant

      Hi Eva,

      So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

      It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

      There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

      Holding you in my heart.  Celeste

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