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Response to Eva
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Response to Eva

› Forums › General Melanoma Community › Response to Eva

  • Post
    • August 16, 2016 at 6:10 pm
    Mat
    Participant

      Got spam-blocked on Eva's thread, so posting here:

      Eva, I'm sorry to hear about your present status.  When I met with Dr. Wolchok before starting ipi-nivo, he mentioned that Sloan has seen some patients do well on chemo following checkpoint inhibitors (synergistic-type effect).  I've kept this in mind for myself.  Chemo-only–not so exciting.  Chemo with the possibility of a synergistic effect and a bridge to something else–more interesting.  I'd also consider attempting another run on BRAF-MEK.  (My recollection is that you are BRAF+.)

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    • Replies
        • August 16, 2016 at 7:09 pm
        khubes
        Participant

          Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

          I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

          Best,

          Katie 

          • August 16, 2016 at 7:09 pm
          khubes
          Participant

            Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

            I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

            Best,

            Katie 

            • August 16, 2016 at 7:09 pm
            khubes
            Participant

              Echoing what Mat said!  My husband's mel specialist (Hamid) has mentioned several times to us in person and in presentations that chemo can absolutely have a synergistic effect.  I highly recommend you checking out this discussion from AACR 2016 (http://learn.peerviewpress.com/p/index.html?Promocode=815&collection=150203911-2-2&presentationid=p1).  Dr. Hamid is big on multiple combos, including chemo.  Might be worth discussing with your onc! 

              I am so incredibly sorry you are going through this, Eva.  My thoughts and prayers are with you! 

              Best,

              Katie 

              • August 16, 2016 at 10:13 pm
              Mli0709
              Participant

                Hi Mat,

                In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

                 

                Its so painful even writing this. 

                 

                Maria

                • August 16, 2016 at 10:13 pm
                Mli0709
                Participant

                  Hi Mat,

                  In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

                   

                  Its so painful even writing this. 

                   

                  Maria

                  • August 16, 2016 at 10:13 pm
                  Mli0709
                  Participant

                    Hi Mat,

                    In a similar situation. My mom tried chemo as last line but side effects were too much so they discountinued. Benefits on staying on it just weren't there. We've seen 2 oncologist so far and best they could offer is palliative care. I'm trying to look into clinical trials but I am overwhelmed bc it's so much out there and don't know where to start. She also has an autoimmune disease already (psoriasis) which excludes her from a lot of trials. I just don't know what else to do. Can't think of anything else. I want to keep looking and trying and praying but I'm so discouraged at this point. 

                     

                    Its so painful even writing this. 

                     

                    Maria

                    • August 17, 2016 at 3:13 am
                    Bubbles
                    Participant

                      Hi Eva,

                      So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

                      It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

                      There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

                      Holding you in my heart.  Celeste

                      • August 17, 2016 at 3:13 am
                      Bubbles
                      Participant

                        Hi Eva,

                        So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

                        It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

                        There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

                        Holding you in my heart.  Celeste

                        • August 17, 2016 at 3:13 am
                        Bubbles
                        Participant

                          Hi Eva,

                          So sorry for what you are going through.  I can't imagine.  I think someone had passed this on to you before….it is a list of possible options I had put together for Josh a bit ago….so here it is again….just in case:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/05/interesting-trial-options-for-josh.html

                          It covers IDO inhibitors, epacadostat, as well as a JAK inhibitor.

                          There is also this from Dr. Weber….touching on some of the same as well as atezolizumab with pembro, tvec with pembro, coxsackie virus therapy….for what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/03/immunology-updatewebinar-for-melanoma.html

                          Holding you in my heart.  Celeste

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