Questions regarding TAF/MEK Combo
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Questions regarding TAF/MEK Combo

› Forums › General Melanoma Community › Questions regarding TAF/MEK Combo

  • Post
    • February 1, 2017 at 3:27 pm
    Jahendry12
    Participant

    Hello – I have 2 questions I wanted to pose to the group regarding the TAF/MEK combo.

     

    1)  Has anyone NEVER had a fever but still responded?

    2)  For those that did have fevers, how long did it take for them to start?

     

    Thanks for any input you can provide.  Much appreciated!

Viewing 5 reply threads
  • Replies
      • February 1, 2017 at 6:00 pm
      Mat
      Participant

      Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

      • February 1, 2017 at 6:00 pm
      Mat
      Participant

      Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

        • February 1, 2017 at 6:02 pm
        Jahendry12
        Participant

        Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

        • February 1, 2017 at 6:02 pm
        Jahendry12
        Participant

        Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

        • February 5, 2017 at 10:45 pm
        ilikepralinen
        Participant

        I had fever after 2 months (38 – 39 Degrees with Shivering).

        Doctor advised me to take Paracetamol 500mg (1-1-1)..

        The fever went away after 3 Days.

        Doctor also advised me not to STOP TAF/MEK combo because of fever.

        These days i have fever every 2 – 4 Weeks.

        • February 5, 2017 at 10:45 pm
        ilikepralinen
        Participant

        I had fever after 2 months (38 – 39 Degrees with Shivering).

        Doctor advised me to take Paracetamol 500mg (1-1-1)..

        The fever went away after 3 Days.

        Doctor also advised me not to STOP TAF/MEK combo because of fever.

        These days i have fever every 2 – 4 Weeks.

        • February 5, 2017 at 10:45 pm
        ilikepralinen
        Participant

        I had fever after 2 months (38 – 39 Degrees with Shivering).

        Doctor advised me to take Paracetamol 500mg (1-1-1)..

        The fever went away after 3 Days.

        Doctor also advised me not to STOP TAF/MEK combo because of fever.

        These days i have fever every 2 – 4 Weeks.

        • February 1, 2017 at 6:02 pm
        Jahendry12
        Participant

        Thank you Mat. Very helpful.   My husband has been on the combo for 12 days now and so far he has not had any side effects (maybe a little more tired than ususal). 

      • February 1, 2017 at 6:00 pm
      Mat
      Participant

      Never had a high fever.  Maybe an occassional fever below 100.  Responded for 18 months.

      • February 1, 2017 at 7:05 pm
      Polymath
      Participant

      After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

      Gary

      • February 1, 2017 at 7:05 pm
      Polymath
      Participant

      After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

      Gary

        • February 1, 2017 at 7:08 pm
        Jahendry12
        Participant

        Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

        • February 1, 2017 at 7:08 pm
        Jahendry12
        Participant

        Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

        • February 2, 2017 at 3:29 pm
        Polymath
        Participant

        Hi Julie,

        I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

        Gary

        • February 2, 2017 at 3:29 pm
        Polymath
        Participant

        Hi Julie,

        I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

        Gary

        • February 2, 2017 at 3:29 pm
        Polymath
        Participant

        Hi Julie,

        I'd say nothing is true for all.  If there's anything we have learned is that as much as we are all the same, we are in-fact different.  I still lean toward the side-effects equal response since overall, I have suffered few side-effects from a long list of treatments, and have also been mostly a non-responder.  I do very much hope your husband does get great benefits from TAF/MEK without suffering too many side-effects.  best in the battle.

        Gary

        • February 1, 2017 at 7:08 pm
        Jahendry12
        Participant

        Thanks Gary – so I guess the thought that more side effects = better response may not be true for all.

      • February 1, 2017 at 7:05 pm
      Polymath
      Participant

      After an initial and very effective beat-down with BRAF inhibitor Zelboraf (with horrendous side-effects) I did TAF/MEK and got stable disease for about 6 months.  No side-effects to speak of from TAF/MEK.

      Gary

Viewing 5 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.