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NRAS mutation question
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NRAS mutation question

› Forums › General Melanoma Community › NRAS mutation question

  • Post
    • August 4, 2017 at 9:43 pm
    adrianc
    Participant

       My tumors have been genetically tested and I  just have been found to have the NRAS mutation . I would appreciate feedback from  melanoma patients that have been found to have the NRAS expression.Have you been treated with  Mekinist targeting this specific  gene mutation and  were your a responder? What side effects assocoated with that drug have you experienced? Thanks a lot.

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    • Replies
        • August 5, 2017 at 11:06 pm
        Bubbles
        Participant

          Here are many links to treatments that have been studied recently in NRAS mutant melanoma:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/search?q=nras  

          Within there is info that addresses the use of trametinib as well as binimetinib (both are MEK inhibitors). Perhaps others will chime in with particulars…but maybe this will help.  Celeste

            • August 5, 2017 at 11:21 pm
            adrianc
            Participant

              Thank you for your reply

            • August 5, 2017 at 11:16 pm
            Scooby123
            Participant

              Hi , I am NRAS and was treated with ipi in 2015 50% reduction in all tumours . Had a pet scan 8 weeks ago and found 2 nodes up in chest but no other found from been treated with ipi from when started on treatment. This is new area but was in car accident and since then the nodes in chest came up. Biopsy results nodes contained Mel so treatment needed. 

               

              Ippi side idle effects for me was constipation and rash plus tiredness after treatment.

               

              Good luck in treatment and stay positive.

              Scooby❤️

                • August 5, 2017 at 11:26 pm
                adrianc
                Participant

                  Thank you, Scooby. How  Ipi was chosen as a treatment and not Mekinist inhibitor ,just curious?

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