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Nifuroxazide, an old antibiotic may be used to treat melanoma

Forums General Melanoma Community Nifuroxazide, an old antibiotic may be used to treat melanoma

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      Nifuroxazide is an oral nitrofuran antibiotic, patented since 1966 and used to treat colitis and diarrhoea in humans and non-humans.

      The following three links may be of interest


      ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
      Sarvi S, et al. Cell Chem Biol. 2018.

      5-Nitrofurans are antibiotic pro-drugs that have potential as cancer therapeutics. Here, we show that 5-nitrofurans can be bio-activated by aldehyde dehydrogenase (ALDH) 1A1/1A3 enzymes that are highly expressed in a subpopulation of cancer-initiating (stem) cells. We discover that the 5-nitrofuran, nifuroxazide, is selective for bio-activation by ALDH1 isoforms over ALDH2, whereby it both oxidizes ALDH1 and is converted to cytotoxic metabolites in a two-hit pro-drug mechanism. We show that ALDH1High melanoma cells are sensitive to nifuroxazide, while ALDH1A3 loss-of-function mutations confer drug resistance. In tumors, nifuroxazide targets ALDH1High melanoma subpopulations with the subsequent loss of melanoma-initiating cell potential. BRAF and MEK inhibitor therapy increases ALDH1 expression in patient melanomas, and effectively combines with nifuroxazide in melanoma cell models. The selective eradication of ALDH1High cells by nifuroxazide-ALDH1 activation goes beyond current strategies based on inhibiting ALDH1 and provides a rational basis for the nifuroxazide mechanism of action in cancer.

      Nifuroxazide exerts potent anti-tumor and anti-
      metastasis activity in melanoma

      Existing antibiotic could help treat melanoma

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          Pretty cool!! So far it has only been tested in rats, mice and petri dishes, but fingers crossed!!!

          I am never without hope for the next breakthrough or additional effective drug in our melanoma therapy arsenal. However, I’ve learned the hard way to take these grand announcements with a grain of salt. Here are 11 installments of similar reports in an ongoing series “EVERYTHING CURES MELANOMA!!!” –

          Despite the difficulty we have in getting rid of it in our body – melanoma is apparently pretty easy to kill as cells in a dish. Within these reports you will find that in mice and petri dishes (and a rare few in real live ratties and one in horses), in between the banana peels, snail slime and bull frog juice, these additional currently existing drugs have been effective against melanoma: Propranolol, propofol, thioridazine, NSAID’s, cimetadine as well as the antibiotics doxycycline and ciprofloxacin.

          Now the discussion of antibiotic use as a cure flies in the face of recent reports on decreased response to therapy in those melanoma peeps who unfortunately had to take antibiotics prior to or at the start of immunotherapy. You can see the report here:

          Or these reports (lots of links within) on antibiotic use specifically and the microbiome generally as it relates to melanoma patients’ response to therapy:

          Still, I think there is much here we don’t understand and lots to learn. Fingers crossed that nitrofuran will be something that really works to make life better for many melanoma patients. Thanks for sharing. Celeste

              In keeping with the idea of old drugs employed for new purposes, this new research, reported just 3 days ago, is pretty interesting:

              In part this report notes ~ “In the new study, published Monday in Nature Cancer, Corsello and his colleagues systematically tested 4,518 compounds from the DRH (of which 3,350 are already approved for use in the U.S. or Europe) against 578 cancer cell lines. Most were developed to treat diseases other than cancer; about a quarter were originally developed for cancer. Using a molecular bar-coding method to keep track of the vast array of cancer cell lines, which employs short sequences of DNA as “bar codes,” the researchers were able to test multiple cancer cell types simultaneously in each Petri dish, speeding the process considerably. In total, the team identified nearly 50 compounds that killed cancer cells and left other cells unscathed.”

              AWESOMENESS!!! Researchers sharing data and gleaning new information from it! THIS – is science!! May it benefit all sorts of cancer peeps!!! – “The more you know….” Celeste

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