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Liver toxicity after one dose of pembro, any similar experiences?
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Liver toxicity after one dose of pembro, any similar experiences?

› Forums › General Melanoma Community › Liver toxicity after one dose of pembro, any similar experiences?

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    • June 27, 2019 at 11:53 am
    KAP715
    Participant
      Started pembro 3 weeks ago. I went in yesterday for round 2 but liver enzymes were too high. I was but on high dose prednisone for a month with weekly blood tests. My doc says liver problems usually take a few months to show up if they’re going to happen. I’ve also been told it’s a good sign that the pembro is stimulating my immune system. Anybody have a similar situation? Were you able to restart immunotherapy? How effective was it on your melanoma?
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        • June 27, 2019 at 8:36 pm
        WithinMySkin
        Participant
          I only made it through 2 rounds of Ipi/Nivo (about 3 weeks time) before I had gastritis, colitis, and high liver enzymes. Same as you, I went on steroids. I had an in-transit in my leg the size of a golfball that they purposely left so I’d be considered unresected stage 3C, my insurance would approve the treatment, and my immune system would have a blueprint to attack. I literally saw the in-transit melt away in week 3 before the side effects started. Normal treatment would then be Nivo alone, but my onc didn’t want to risk it since I responded so quickly. NED for over 2 years now, 3 year scans coming up in July (fingers and toes crossed for clean scans!!) So yeah, a quick body response is a good sign in my book!!

          Health and happiness,
          Lauren

            • June 28, 2019 at 10:21 pm
            MelMel
            Participant
              Lauren what treatment did you get after two dual drug infusions? I am in the same boat but my tumors although greatly reduced did not completely shrink so now I am on Opdivo alone.
              Melanie
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