Ipilimumab (Yervoy) – Long Term Response – Melanoma Research Foundation

This topic has 18 replies, 4 voices, and was last updated 12 years, 10 months ago by Rodensir.

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- November 7, 2011 at 8:17 pm
- Quote
premedy
Participant
Does anyone have any info,date, articles referring to the possibility of receiving a long term response from ipilimumab. More specifically I am looking to see if it is possible for a person with Stage IV Metastatic Melanoma who received a response from ipiliumab and is now NED to live for more than 3 years without reccurrence. I know it is a relatively new drug but it has been in trial since 2006 so was curious to see if there is any data or anything supporting the possibilty of a long term response to ipilimumab. thanks!

pat

Does anyone have any info,date, articles referring to the possibility of receiving a long term response from ipilimumab. More specifically I am looking to see if it is possible for a person with Stage IV Metastatic Melanoma who received a response from ipiliumab and is now NED to live for more than 3 years without reccurrence. I know it is a relatively new drug but it has been in trial since 2006 so was curious to see if there is any data or anything supporting the possibilty of a long term response to ipilimumab. thanks!

pat

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Replies

- - November 7, 2011 at 8:37 pm
  - Quote
  Lisa13
  Participant
  Hi Pat,
  
  On the melanoma international website, there is a presentation from Dr. Wolchuk on ipi. In it, there are 2 people he talks about who have been in remission for 4 years. One man's liver was covered in tumours, but after scans at 12 weeks, 24 weeks, etc, the tumours kept shrinking and then disappered completely. Another young woman with brain mets, liver and lung, completed responding over time and gave birth to 2 children. If you're lucky to be a complete responder, this cancer can stay away for 2-4 years, but there are no further results since the trials are not yet completed.
- - November 7, 2011 at 8:37 pm
  - Quote
  Lisa13
  Participant
  Hi Pat,
  
  On the melanoma international website, there is a presentation from Dr. Wolchuk on ipi. In it, there are 2 people he talks about who have been in remission for 4 years. One man's liver was covered in tumours, but after scans at 12 weeks, 24 weeks, etc, the tumours kept shrinking and then disappered completely. Another young woman with brain mets, liver and lung, completed responding over time and gave birth to 2 children. If you're lucky to be a complete responder, this cancer can stay away for 2-4 years, but there are no further results since the trials are not yet completed.
  - November 7, 2011 at 9:27 pm
    
    Quote
    premedy
    Participant
    
    hey lisa,
    
    you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again. I am thinking that if it works once then you could always use it again if the Mel comes back.
  - November 7, 2011 at 9:27 pm
    
    Quote
    premedy
    Participant
    
    hey lisa,
    
    you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again. I am thinking that if it works once then you could always use it again if the Mel comes back.
  - November 7, 2011 at 9:27 pm
    
    Quote
    premedy
    Participant
    
    hey lisa,
    
    you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again. I am thinking that if it works once then you could always use it again if the Mel comes back.
- - November 7, 2011 at 8:37 pm
  - Quote
  Lisa13
  Participant
  Hi Pat,
  
  On the melanoma international website, there is a presentation from Dr. Wolchuk on ipi. In it, there are 2 people he talks about who have been in remission for 4 years. One man's liver was covered in tumours, but after scans at 12 weeks, 24 weeks, etc, the tumours kept shrinking and then disappered completely. Another young woman with brain mets, liver and lung, completed responding over time and gave birth to 2 children. If you're lucky to be a complete responder, this cancer can stay away for 2-4 years, but there are no further results since the trials are not yet completed.
- - November 7, 2011 at 9:09 pm
  - Quote
  jim Breitfeller
  Participant
  http://4.bp.blogspot.com/-2kf6yK5jASU/TrhJMBWRUsI/AAAAAAAAAmU/XBKCwoasWRI/s1600/Ipi%2Bsurvival%2Brates%2B3-3-2010.jpg
  
  Best regards
  
  Jimmy B
- - November 7, 2011 at 9:09 pm
  - Quote
  jim Breitfeller
  Participant
  http://4.bp.blogspot.com/-2kf6yK5jASU/TrhJMBWRUsI/AAAAAAAAAmU/XBKCwoasWRI/s1600/Ipi%2Bsurvival%2Brates%2B3-3-2010.jpg
  
  Best regards
  
  Jimmy B
- - November 7, 2011 at 9:09 pm
  - Quote
  jim Breitfeller
  Participant
  http://4.bp.blogspot.com/-2kf6yK5jASU/TrhJMBWRUsI/AAAAAAAAAmU/XBKCwoasWRI/s1600/Ipi%2Bsurvival%2Brates%2B3-3-2010.jpg
  
  Best regards
  
  Jimmy B
- - November 7, 2011 at 9:19 pm
  - Quote
  jim Breitfeller
  Participant
  http://1.bp.blogspot.com/-fbdxZzRhh7w/TrhLqgcEKxI/AAAAAAAAAmg/z7JnO8t3B6c/s1600/CTLA-4%2BPatient%2Bresopnses%2BHodi%2B2007.jpg
- - November 7, 2011 at 9:19 pm
  - Quote
  jim Breitfeller
  Participant
  http://1.bp.blogspot.com/-fbdxZzRhh7w/TrhLqgcEKxI/AAAAAAAAAmg/z7JnO8t3B6c/s1600/CTLA-4%2BPatient%2Bresopnses%2BHodi%2B2007.jpg
- - November 7, 2011 at 9:19 pm
  - Quote
  jim Breitfeller
  Participant
  http://1.bp.blogspot.com/-fbdxZzRhh7w/TrhLqgcEKxI/AAAAAAAAAmg/z7JnO8t3B6c/s1600/CTLA-4%2BPatient%2Bresopnses%2BHodi%2B2007.jpg
- - November 7, 2011 at 9:42 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED
- - November 7, 2011 at 9:42 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED
- - November 7, 2011 at 9:42 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED
- - November 7, 2011 at 9:43 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED
- - November 7, 2011 at 9:43 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED
- - November 7, 2011 at 9:43 pm
  - Quote
  Rodensir
  Participant
  Yep I was on trial in 2004 and still NED

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