The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

GSK DERMA (MAGE A3) clinical trial ???

Forums General Melanoma Community GSK DERMA (MAGE A3) clinical trial ???

  • Post
    ockelly
    Participant

    Is anyone out there, besides Michelle in VA, in this clinical trial?  Wondering if you are having side effects after injections?  

    Any indication if you are receiving the drug vs the placebo?  We should hear this week if my husband, TJ (stage 3b), qualifies.

    Kelly

    Is anyone out there, besides Michelle in VA, in this clinical trial?  Wondering if you are having side effects after injections?  

    Any indication if you are receiving the drug vs the placebo?  We should hear this week if my husband, TJ (stage 3b), qualifies.

    Kelly

    Loading spinner
Viewing 5 reply threads
  • Replies
      carolegarry
      Participant

      Hi,

           I am just being tested to see if I qualify for the study (Derma Mage 3A) . I, too would love to know if there are any symptoms from the injections. I understand that you can get redness at the site. I just hate it that you can't have radiation treatment if you go on this study. I have stage 3C and would feel a lot better if I knew that I wasn't risking having no therapy at all. Very few research studies have a totally placebo arm now; I wonder just how ethical it is to have just placebo.  I am still debating the best road for me.

      Please keep in touch,

      Carole

      Loading spinner
        michelleg
        Participant

        Hi Carole,

        I do get several side effects.  I get swelling, redness and tenderness at the injection site.  I also have "flu-like" symptoms for a couple of days, along with some fatigue.  I usually have body aches, joint pain, sweats and just feel lousy.  It starts about 10-12 hours after my injection and the worst is over within 48 hours.  Based on the literature I have read, I assume I am getting the vaccine and not the placebo………but I do not know that for sure.  Maybe just wishful thinking on my part!  I am now 8 months out from my diagnosis and praying I stay NED.

        I had one positive node, so I am 3B.  My Dr did not think radiation was needed.  My only options were 1)watch and wait  2)interferon  3)DERMA trial since I qualified.  I was not OK with doing nothing and I really did not like the statisitcs for interferon……..so I decided to take the chance with the clinical trial. 

        Make your decision based on the best info for your case and try not to second guess yourself later.  It is difficult when there is no "right" answer.  Let me know what you decide and feel free to contact me any time.

        Michelle/3B

        Loading spinner
        carolegarry
        Participant

        Hi Michelle,

             I just had my first shot and I think I must be on the placebo. Absolutely no side effects. Not even a tender IJ site. Darn  darn darn! Is there anyone else out there on this trial?????

        Carole

        Loading spinner
        michelleg
        Participant

        Hey Carole,

        After my first injection all I had was MILD tenderness at injection site.  The first night I woke up around 2am and thought I did not feel well…..but I thought it could be my "wishful thinking" it was a side effect.  It was not until the 2nd injection that I knew I was having side effects.  I was told that some people peak with symptoms after 3rd or 4th injection with vaccines.  Mine did get a little worse each time and leveled off around the 4th one.  Wait until next injection to see what happens!!  I have to say, it was the first time I ever wished for the side effects!!

        Keep a positive outlook……I know it is hard sometimes!

         

        Keep me posted,

        Michelle

        Loading spinner
        michelleg
        Participant

        Hey Carole,

        After my first injection all I had was MILD tenderness at injection site.  The first night I woke up around 2am and thought I did not feel well…..but I thought it could be my "wishful thinking" it was a side effect.  It was not until the 2nd injection that I knew I was having side effects.  I was told that some people peak with symptoms after 3rd or 4th injection with vaccines.  Mine did get a little worse each time and leveled off around the 4th one.  Wait until next injection to see what happens!!  I have to say, it was the first time I ever wished for the side effects!!

        Keep a positive outlook……I know it is hard sometimes!

         

        Keep me posted,

        Michelle

        Loading spinner
        carolegarry
        Participant

        Thank you , thank you, thank you, Michelle. I will keep my hopes up for the next few rounds.

        Carole

        Loading spinner
        carolegarry
        Participant

        Thank you , thank you, thank you, Michelle. I will keep my hopes up for the next few rounds.

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi Michelle,

             I just had my first shot and I think I must be on the placebo. Absolutely no side effects. Not even a tender IJ site. Darn  darn darn! Is there anyone else out there on this trial?????

        Carole

        Loading spinner
        michelleg
        Participant

        Hi Carole,

        I do get several side effects.  I get swelling, redness and tenderness at the injection site.  I also have "flu-like" symptoms for a couple of days, along with some fatigue.  I usually have body aches, joint pain, sweats and just feel lousy.  It starts about 10-12 hours after my injection and the worst is over within 48 hours.  Based on the literature I have read, I assume I am getting the vaccine and not the placebo………but I do not know that for sure.  Maybe just wishful thinking on my part!  I am now 8 months out from my diagnosis and praying I stay NED.

        I had one positive node, so I am 3B.  My Dr did not think radiation was needed.  My only options were 1)watch and wait  2)interferon  3)DERMA trial since I qualified.  I was not OK with doing nothing and I really did not like the statisitcs for interferon……..so I decided to take the chance with the clinical trial. 

        Make your decision based on the best info for your case and try not to second guess yourself later.  It is difficult when there is no "right" answer.  Let me know what you decide and feel free to contact me any time.

        Michelle/3B

        Loading spinner
        Linny
        Participant

        Just had my 3rd injection yesterday. Not sure if I had any side effects because what I experienced yesterday was different that what I experienced earlier. Didn't have the hot flashes that I experienced after the first two shots, but I did feel like I was run over by a truck after I got home. I was tired, had chills, felt queasy, had no appetite, had a headache, and a stiff achy back. Also experienced a few heart minor heart palpitations. I was so tired that I just headed to bead between 9:30-10:00 and didn't open my eyes until the alarm went off in the morning. I felt fine when I got up this morning.

        About all I can hope is pray that I have the same reaction after shot #4. smiley

        Loading spinner
        Linny
        Participant

        Just had my 3rd injection yesterday. Not sure if I had any side effects because what I experienced yesterday was different that what I experienced earlier. Didn't have the hot flashes that I experienced after the first two shots, but I did feel like I was run over by a truck after I got home. I was tired, had chills, felt queasy, had no appetite, had a headache, and a stiff achy back. Also experienced a few heart minor heart palpitations. I was so tired that I just headed to bead between 9:30-10:00 and didn't open my eyes until the alarm went off in the morning. I felt fine when I got up this morning.

        About all I can hope is pray that I have the same reaction after shot #4. smiley

        Loading spinner
      carolegarry
      Participant

      Hi,

           I am just being tested to see if I qualify for the study (Derma Mage 3A) . I, too would love to know if there are any symptoms from the injections. I understand that you can get redness at the site. I just hate it that you can't have radiation treatment if you go on this study. I have stage 3C and would feel a lot better if I knew that I wasn't risking having no therapy at all. Very few research studies have a totally placebo arm now; I wonder just how ethical it is to have just placebo.  I am still debating the best road for me.

      Please keep in touch,

      Carole

      Loading spinner
      Linny
      Participant

      I just received my first shot today. I had read about the trial and was hoping that I would qualify for it.

      My doctor offered the same treatment options as Carole's: observation only, interferon, or clinical trial. From what I understand of interferon it's very hard on you. Close observation was OK, but why not go for the clinical trial, which includes close observation? So that's what I did.

      So far I haven't noticed much since getting the shot. But while my husband and I were having lunch I felt my face get really hot. It was like a hot flash except it affected my face only.

      My next appointment is April 19.

      I have Stage III Melanoma with an Unknown Primary.

      Loading spinner
        Linny
        Participant

        OOPS! I was given the same treatment options that Michelle's doctor gave her.

        Loading spinner
        carolegarry
        Participant

        My next treatment (shot) is April 13. I'll let you all know how it goes.

        It sure is great to be in contact with someone else in the trial!

        Carole

        Loading spinner
        Linny
        Participant

        Carole,

        How did your shot go?

        Linda

        Loading spinner
        carolegarry
        Participant

        Hi Linda,

             How are you doing?

             I've had 2 shots now. No side effects locally at the injection site, and the only possible side effect that I can think is fatigue. I am really tired, spend most evenings on the couch, not like me at all.  Do anything physical and find I have to have a rest.

        Nothing else to report. Although I am praying that I am on the drug, I am certainly not counting on it.

        watchful waiting with a few shots now and again is where I'm at.

        How about the others on this trial????? How are you all doing????? Any new symptoms?????

        Keep healthy, Everyone,

        Carole

        Loading spinner
        Linny
        Participant

        I've had two shots as well. Can't say with 100% certainty whether I've had a reaction yet or not. A few hours after my first shot I had an intense hot flash — more intense than any hormonal hot flash I've had.  This was followed by feeling really cold shortly afteward. i didn't know what to make of it, Had a similar experience after my second shot during the drive home from the hospital, which was repeated after we arrived home but with a headache to boot.

        Now, the hospital where I'm going for treatments is a 2 hour drive each way so I'm not sure if my body's reacting to the long day or to the vaccine. The nurse at the hospital did say that other patients have reported "hot flashes" like mine.

        Shot #3 will come on May 10, so we'll see what happens this time.

        But regardless, I'm glad to have the close observation along wtih a 2 out of 3 chance of receiving the vaccine. So for me, this is win-win.

        Loading spinner
        carolegarry
        Participant

        Hi Linny,

             My next shot is on May 4th. I "ll let you know how I go on. I really appreciate knowing  about your experience with this trial. What a journey we are all sharing!

        Keep well,

        Carole

        Loading spinner
        Linny
        Participant

        Just read on a different post that you had your lymphadenectomy done in January. So did I! Mine was done January 27.

        It's some journey, isn't it?

        Loading spinner
        carolegarry
        Participant

        Hi Linny,

        Sure is!!!!!

        I had mine done on Jan 24th. Isn't it amazing how all these dates stay with us?? Do keep in touch.

        Carole

        Loading spinner
        carolegarry
        Participant

        Just had my 3rd injection as part of this DERMA trial. It really hurt while being injected, but within an few hours I couldn't even find the injection site. Some fatigue, but nil else. Life is going on. This trial is really very easy to be involved with….now if only the drug works!!!

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi

        Four days after the IJ , I felt really lethargic.  Couldn't keep my eyes open. Had a nap and then went to bed early. Better the next day and now fell only slightly tired all the time.

        How is everyone lese doing on this trial????

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi

        Four days after the IJ , I felt really lethargic.  Couldn't keep my eyes open. Had a nap and then went to bed early. Better the next day and now fell only slightly tired all the time.

        How is everyone lese doing on this trial????

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi,

             Just had the 3 month CT scan. Feel fine. Sure do hate the waiting for results! We live in Manitoba on the lake which is flooding badly. Spent many hours sand-bagging …and am relived to say that I am having no trouble with my arm  (node removal in Jan) except a little local numbness.

             How is everyone else doing on the trial????

        Carole   back 3C

        Loading spinner
        carolegarry
        Participant

        Hi,

             Just had the 3 month CT scan. Feel fine. Sure do hate the waiting for results! We live in Manitoba on the lake which is flooding badly. Spent many hours sand-bagging …and am relived to say that I am having no trouble with my arm  (node removal in Jan) except a little local numbness.

             How is everyone else doing on the trial????

        Carole   back 3C

        Loading spinner
        michelleg
        Participant

        I will have my 8th injection on July 11.  So far, I am still NED.  I will have CTs the first week of July before my appt………so hopefully, I can still report NED after that!  I still have about the same symptoms after each injection….sweats,chills, "flu-like" body aches, fatique,etc.  My 1 year anniversay  of my diagnosis is next week.  So at least I have made it to see the first one, and I plan on celebrating many more! 

        Michelle/3B

        Loading spinner
        michelleg
        Participant

        I will have my 8th injection on July 11.  So far, I am still NED.  I will have CTs the first week of July before my appt………so hopefully, I can still report NED after that!  I still have about the same symptoms after each injection….sweats,chills, "flu-like" body aches, fatique,etc.  My 1 year anniversay  of my diagnosis is next week.  So at least I have made it to see the first one, and I plan on celebrating many more! 

        Michelle/3B

        Loading spinner
        carolegarry
        Participant

        Just had my 3rd injection as part of this DERMA trial. It really hurt while being injected, but within an few hours I couldn't even find the injection site. Some fatigue, but nil else. Life is going on. This trial is really very easy to be involved with….now if only the drug works!!!

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi Linny,

        Sure is!!!!!

        I had mine done on Jan 24th. Isn't it amazing how all these dates stay with us?? Do keep in touch.

        Carole

        Loading spinner
        Linny
        Participant

        Just read on a different post that you had your lymphadenectomy done in January. So did I! Mine was done January 27.

        It's some journey, isn't it?

        Loading spinner
        carolegarry
        Participant

        Hi Linny,

             My next shot is on May 4th. I "ll let you know how I go on. I really appreciate knowing  about your experience with this trial. What a journey we are all sharing!

        Keep well,

        Carole

        Loading spinner
        Linny
        Participant

        I've had two shots as well. Can't say with 100% certainty whether I've had a reaction yet or not. A few hours after my first shot I had an intense hot flash — more intense than any hormonal hot flash I've had.  This was followed by feeling really cold shortly afteward. i didn't know what to make of it, Had a similar experience after my second shot during the drive home from the hospital, which was repeated after we arrived home but with a headache to boot.

        Now, the hospital where I'm going for treatments is a 2 hour drive each way so I'm not sure if my body's reacting to the long day or to the vaccine. The nurse at the hospital did say that other patients have reported "hot flashes" like mine.

        Shot #3 will come on May 10, so we'll see what happens this time.

        But regardless, I'm glad to have the close observation along wtih a 2 out of 3 chance of receiving the vaccine. So for me, this is win-win.

        Loading spinner
        carolegarry
        Participant

        Hi Linda,

             How are you doing?

             I've had 2 shots now. No side effects locally at the injection site, and the only possible side effect that I can think is fatigue. I am really tired, spend most evenings on the couch, not like me at all.  Do anything physical and find I have to have a rest.

        Nothing else to report. Although I am praying that I am on the drug, I am certainly not counting on it.

        watchful waiting with a few shots now and again is where I'm at.

        How about the others on this trial????? How are you all doing????? Any new symptoms?????

        Keep healthy, Everyone,

        Carole

        Loading spinner
        Linny
        Participant

        Carole,

        How did your shot go?

        Linda

        Loading spinner
        carolegarry
        Participant

        My next treatment (shot) is April 13. I'll let you all know how it goes.

        It sure is great to be in contact with someone else in the trial!

        Carole

        Loading spinner
        Linny
        Participant

        OOPS! I was given the same treatment options that Michelle's doctor gave her.

        Loading spinner
      Linny
      Participant

      I just received my first shot today. I had read about the trial and was hoping that I would qualify for it.

      My doctor offered the same treatment options as Carole's: observation only, interferon, or clinical trial. From what I understand of interferon it's very hard on you. Close observation was OK, but why not go for the clinical trial, which includes close observation? So that's what I did.

      So far I haven't noticed much since getting the shot. But while my husband and I were having lunch I felt my face get really hot. It was like a hot flash except it affected my face only.

      My next appointment is April 19.

      I have Stage III Melanoma with an Unknown Primary.

      Loading spinner
      Linny
      Participant

      I have no idea where this reply will show up. I just hope it won't be indented far off to the right. cool

      I go for my CAT scan this Friday (June 17) and will get the results at my appointment the following Tuesday (June 21).  If I'm still NED then I'll get my 5th shot and won't need to see the doc until September!

      My reaction to the shot has been varied: from hot flashes to feeling like I've been hit by a truck. After the last two shots I felt fatigued, queasy, and achy about 4-6 hours after getting the shot. Fortunately I was so fatigued after the last shot, that I slept right through the queasiness…LOL. These symptoms do not last long — I'm done with them within 24 hours and have been able to return to work the next day.

      Linda

      Loading spinner
      Linny
      Participant

      I have no idea where this reply will show up. I just hope it won't be indented far off to the right. cool

      I go for my CAT scan this Friday (June 17) and will get the results at my appointment the following Tuesday (June 21).  If I'm still NED then I'll get my 5th shot and won't need to see the doc until September!

      My reaction to the shot has been varied: from hot flashes to feeling like I've been hit by a truck. After the last two shots I felt fatigued, queasy, and achy about 4-6 hours after getting the shot. Fortunately I was so fatigued after the last shot, that I slept right through the queasiness…LOL. These symptoms do not last long — I'm done with them within 24 hours and have been able to return to work the next day.

      Linda

      Loading spinner
        carolegarry
        Participant

        Hi Everyone,

        I started the DERMA trial in Feb of this year. Unfortunately have developed bone mets in my right knee so will be out of the trial. I see the radiation oncologist to get some pain control tomorrow. Ibelieve that I was on the placebo arm as I had no local reaction to the injections.

             So am now a new Stage 4! Hope to get on Ipi after all scans have been done.

        Good luck to the rest of you. I will be watching how you all get on.

        Carole

        Loading spinner
        carolegarry
        Participant

        Hi Everyone,

        I started the DERMA trial in Feb of this year. Unfortunately have developed bone mets in my right knee so will be out of the trial. I see the radiation oncologist to get some pain control tomorrow. Ibelieve that I was on the placebo arm as I had no local reaction to the injections.

             So am now a new Stage 4! Hope to get on Ipi after all scans have been done.

        Good luck to the rest of you. I will be watching how you all get on.

        Carole

        Loading spinner
        michelleg
        Participant

        I am so sorry to hear about your recent progression.  Keep us posted and I pray the radiation and ipi will take care of all this for you. 

         

        Michelle/3B

        Loading spinner
        michelleg
        Participant

        I am so sorry to hear about your recent progression.  Keep us posted and I pray the radiation and ipi will take care of all this for you. 

         

        Michelle/3B

        Loading spinner
        Linny
        Participant

        I am sorry to hear that you're a member of the Stage IV club now. Thank goodness that IPi and Zelboraf are now available as treatments. At least your options are better than they were a year ago.

        I'm not sure you'll ever know if you received the placebo or the MAGE vaccine.

        Am sending prayers and healing thoughts your way.

        Linda

        Loading spinner
        Linny
        Participant

        I am sorry to hear that you're a member of the Stage IV club now. Thank goodness that IPi and Zelboraf are now available as treatments. At least your options are better than they were a year ago.

        I'm not sure you'll ever know if you received the placebo or the MAGE vaccine.

        Am sending prayers and healing thoughts your way.

        Linda

        Loading spinner
Viewing 5 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.