Gene Mutation V600K
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Gene Mutation V600K

› Forums › General Melanoma Community › Gene Mutation V600K

  • Post
    • December 14, 2012 at 2:47 pm
    SidneyGracie
    Participant

    Are there any clinical trials specifically for this gene mutation?

    Are there any clinical trials specifically for this gene mutation?

Viewing 11 reply threads
  • Replies
      • December 14, 2012 at 3:21 pm
      POW
      Participant

      No. Not that I know of.

      • December 14, 2012 at 3:21 pm
      POW
      Participant

      No. Not that I know of.

      • December 14, 2012 at 3:21 pm
      POW
      Participant

      No. Not that I know of.

      • December 14, 2012 at 3:31 pm
      jim Breitfeller
      Participant

      A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

      http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

       

      Best regards,

      Jimmy b

      • December 14, 2012 at 3:31 pm
      jim Breitfeller
      Participant

      A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

      http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

       

      Best regards,

      Jimmy b

      • December 14, 2012 at 3:31 pm
      jim Breitfeller
      Participant

      A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 

      http://www.clinicaltrials.gov/ct2/show/NCT01584648?term=melanoma++V600K&rank=3 

       

      Best regards,

      Jimmy b

      • December 14, 2012 at 10:13 pm
      MichaelFL
      Participant

      There are currently 52 open studies concerning BRAF at clinicaltrials.gov

      You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

      and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

      If you have any other questions, either specific or otherwise, feel free to post them.

        • December 14, 2012 at 10:21 pm
        POW
        Participant

        As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

        • December 14, 2012 at 10:21 pm
        POW
        Participant

        As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

        • December 14, 2012 at 10:21 pm
        POW
        Participant

        As far as I know, one can hve either the V600E mutation or the V600K mutation and still qualify for  any of the BRAF clinical trials. As a matter of fact, quite a few protocols now refer to a "V600 mutation". I thought that the OP was asking about trials specifically for V600K. I am unaware of any trials ONLY for V600K.

      • December 14, 2012 at 10:13 pm
      MichaelFL
      Participant

      There are currently 52 open studies concerning BRAF at clinicaltrials.gov

      You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

      and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

      If you have any other questions, either specific or otherwise, feel free to post them.

      • December 14, 2012 at 10:13 pm
      MichaelFL
      Participant

      There are currently 52 open studies concerning BRAF at clinicaltrials.gov

      You may want to go to a trial website such as http://clinicaltrials.gov/ct2/results?term=braf+melanoma&recr=Open

      and do a search for BRAF & melanoma or something of that nature as one has to be positive for the V600E mutation to use one of the BRAF inhibitors in a trial setting or otherwise.

      If you have any other questions, either specific or otherwise, feel free to post them.

      • December 15, 2012 at 2:42 pm
      awillett1991
      Participant
      Try this website, it can find trials based on mutation

      http://www.mycancergenome.org/content/disease/melanoma/braf/116

      Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

      I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

      Best of luck to you!

      • December 15, 2012 at 2:42 pm
      awillett1991
      Participant
      Try this website, it can find trials based on mutation

      http://www.mycancergenome.org/content/disease/melanoma/braf/116

      Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

      I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

      Best of luck to you!

      • December 15, 2012 at 2:42 pm
      awillett1991
      Participant
      Try this website, it can find trials based on mutation

      http://www.mycancergenome.org/content/disease/melanoma/braf/116

      Since this mutation is rare – only about 5% of BRAF mutations, it probably not going to get its own study but they are allowing a certain number of these patients in other BRAF trials, past and present, and Zelboraf has been shown to work.

      I’m thankful everyday Zelboraf works for me, I’m V600D which is more rare. I really hope you are seeing a melanoma oncologist. I was diagnosed in January with a tumor in my heart and my doc is one of the best, Dr Jeffrey Sosman at Vanderbilt. Without him, I probably wouldn’t still be here. He’s and expert researcher on all this mutation stuff.

      Best of luck to you!

Viewing 11 reply threads
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