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Failed Bio-Chemo Need Advise on PD-1 Antibody Combo

Forums General Melanoma Community Failed Bio-Chemo Need Advise on PD-1 Antibody Combo

  • Post
    Rocklove
    Participant

     

    I did the 6 rounds of Bio-Chemo things were shrinking well, then went on the maintenance part, did 2 rounds of maintenance then scans showed developed new tumors in the liver. There are multiple new lesions laterally in the liver in segment 8 there are new lesions in segment 5 and 6 as well. Existing tumors were stable or shrinking a little.

    Dr. Weber advised I go on the PD-1 Antibody Combo Trial. There will not be any openings until 4 weeks pass, so I am getting worried about waiting so long before I can jump into treatment.

     

    I did the 6 rounds of Bio-Chemo things were shrinking well, then went on the maintenance part, did 2 rounds of maintenance then scans showed developed new tumors in the liver. There are multiple new lesions laterally in the liver in segment 8 there are new lesions in segment 5 and 6 as well. Existing tumors were stable or shrinking a little.

    Dr. Weber advised I go on the PD-1 Antibody Combo Trial. There will not be any openings until 4 weeks pass, so I am getting worried about waiting so long before I can jump into treatment.

    My HLA Type is HLA2 Positive so Dr. Weber said I have good options. Asked if I could go on IPI first so I could get started on something quicker, he said I would not qualify on the PD-1 trial if IPI was first, but could do IPI  if the PD-1 trial did not work.

    Moffit sent slides and bloodwork to see what I am compatible with as far as BRAF & Mek inhibitor trials I won't get results for about 3 weeks.

    A friend found the MRI Guided Laser Ablation trial and I sent the contact a msg to see if I would qualify http://www.mayoclinic.org/news2010-jax/6006.html

    Looking for any comments or advice that I should consider while I wait.

    Thanks,

    Rocky (Stage IV Liver Mets)

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  • Replies
      molly
      Participant

      Rocky,

      I don't have any words of advice but just wanted to wish you well as you begin your new trial! 

      molly

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        Rocklove
        Participant

        Thanks so much for your kind thoughts.

        Rocky

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        Rocklove
        Participant

        Thanks so much for your kind thoughts.

        Rocky

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      molly
      Participant

      Rocky,

      I don't have any words of advice but just wanted to wish you well as you begin your new trial! 

      molly

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      makedoandmend
      Participant

      just wanted to drop you a line and say my thoughts are with you.  I learn a lot of from following your posts and wish you the best with the next level of treatment.

      pat on long island

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        Rocklove
        Participant

        Thanks so much Pat. I pray that we will be following each others post for many more years to come.

        Rocky

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        Rocklove
        Participant

        Thanks so much Pat. I pray that we will be following each others post for many more years to come.

        Rocky

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      makedoandmend
      Participant

      just wanted to drop you a line and say my thoughts are with you.  I learn a lot of from following your posts and wish you the best with the next level of treatment.

      pat on long island

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      James from Sydney
      Participant

      Hi Rocky 

      its frustrating waiting for things to start. I read Delcath presented their Liver Perfusion method at ASCO this year with promising results. It isolates the liver from your body so the rest of you does not get a punch. This might slow/stop progression until you start something else.

      Look up Delcath.com

       

      best wishes

      James

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      James from Sydney
      Participant

      Hi Rocky 

      its frustrating waiting for things to start. I read Delcath presented their Liver Perfusion method at ASCO this year with promising results. It isolates the liver from your body so the rest of you does not get a punch. This might slow/stop progression until you start something else.

      Look up Delcath.com

       

      best wishes

      James

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        Rocklove
        Participant

        Thanks James, I will bring this up to the doctor. I think they do the Delcath system @ Moffit.. but not sure.

        Rocky

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        Rocklove
        Participant

        Thanks James, I will bring this up to the doctor. I think they do the Delcath system @ Moffit.. but not sure.

        Rocky

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      Amy Busby
      Participant

      I hope whatever you end up doing will work for you.  Lord knows you've earned some serious break time from the Beast.

      Hang in there Rocky!  You're a tough fighter. 

      Love,

      Amy

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        Rocklove
        Participant

        Love You Too Amy… Your posting… and that is a wonderful thing.

        Rocky

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        Rocklove
        Participant

        Love You Too Amy… Your posting… and that is a wonderful thing.

        Rocky

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      Amy Busby
      Participant

      I hope whatever you end up doing will work for you.  Lord knows you've earned some serious break time from the Beast.

      Hang in there Rocky!  You're a tough fighter. 

      Love,

      Amy

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      JuleFL
      Participant

      Wishing you the best, Rocky.

      Jule

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      JuleFL
      Participant

      Wishing you the best, Rocky.

      Jule

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        Vermont_Donna
        Participant

        Hi Rocky,

        I read with angst your news……I too learn a lot from your posts plus I admire your steady pace of searching, researching, and keeping optimistic in spite of certain drugs not working. I am keeping my fingers crossed that things will get sorted out very soon, I known none of us like waiting! I am sending positive thoughts and wishes for your melanoma to respond to a treatment soon!

        Hugs,

        Vermont_Donna

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        Vermont_Donna
        Participant

        Hi Rocky,

        I read with angst your news……I too learn a lot from your posts plus I admire your steady pace of searching, researching, and keeping optimistic in spite of certain drugs not working. I am keeping my fingers crossed that things will get sorted out very soon, I known none of us like waiting! I am sending positive thoughts and wishes for your melanoma to respond to a treatment soon!

        Hugs,

        Vermont_Donna

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        Rocklove
        Participant

        Thanks Donna,

        I appreciate the kind thoughts and wishes. We are going to keep moving forward as far as I can go. And keep fighting.

        Rocky

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        Rocklove
        Participant

        Thanks Donna,

        I appreciate the kind thoughts and wishes. We are going to keep moving forward as far as I can go. And keep fighting.

        Rocky

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        Rocklove
        Participant

        Thanks Jule I appreciate the kind words.

        Rocky

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        Rocklove
        Participant

        Thanks Jule I appreciate the kind words.

        Rocky

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      stillhopeful
      Participant

      I'm on the ipi trial, but wish I had done the Anti PD1 trial first.  I've heard very good things about Anti PD 1, and there are fewer side effects than ipi.  

      I cannot comment on how waiting 4 weeks will affect you, but I know I had to wait 28 days after chemo before I could begin the ipi trial.  It is possible that you will need to wait to start any trial.  

      It is good to know if you are BRAF positive, but I think the probability of a durable response is much higher with antiPD1 than BRAF.  

      I hope that things turn out well for you.

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      stillhopeful
      Participant

      I'm on the ipi trial, but wish I had done the Anti PD1 trial first.  I've heard very good things about Anti PD 1, and there are fewer side effects than ipi.  

      I cannot comment on how waiting 4 weeks will affect you, but I know I had to wait 28 days after chemo before I could begin the ipi trial.  It is possible that you will need to wait to start any trial.  

      It is good to know if you are BRAF positive, but I think the probability of a durable response is much higher with antiPD1 than BRAF.  

      I hope that things turn out well for you.

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        Rocklove
        Participant

        Thanks stillhopeful,

        I hope your ipi trial does well. I appreciate the advice and will keep it close to my thinking cap when conversations and options begin with the Dr….

        Rocky

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        Rocklove
        Participant

        Thanks stillhopeful,

        I hope your ipi trial does well. I appreciate the advice and will keep it close to my thinking cap when conversations and options begin with the Dr….

        Rocky

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