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Failed Bio-Chemo Need Advise on PD-1 Antibody Combo

Forums General Melanoma Community Failed Bio-Chemo Need Advise on PD-1 Antibody Combo

  • Post
    Rocklove
    Participant

       

      I did the 6 rounds of Bio-Chemo things were shrinking well, then went on the maintenance part, did 2 rounds of maintenance then scans showed developed new tumors in the liver. There are multiple new lesions laterally in the liver in segment 8 there are new lesions in segment 5 and 6 as well. Existing tumors were stable or shrinking a little.

      Dr. Weber advised I go on the PD-1 Antibody Combo Trial. There will not be any openings until 4 weeks pass, so I am getting worried about waiting so long before I can jump into treatment.

       

      I did the 6 rounds of Bio-Chemo things were shrinking well, then went on the maintenance part, did 2 rounds of maintenance then scans showed developed new tumors in the liver. There are multiple new lesions laterally in the liver in segment 8 there are new lesions in segment 5 and 6 as well. Existing tumors were stable or shrinking a little.

      Dr. Weber advised I go on the PD-1 Antibody Combo Trial. There will not be any openings until 4 weeks pass, so I am getting worried about waiting so long before I can jump into treatment.

      My HLA Type is HLA2 Positive so Dr. Weber said I have good options. Asked if I could go on IPI first so I could get started on something quicker, he said I would not qualify on the PD-1 trial if IPI was first, but could do IPI  if the PD-1 trial did not work.

      Moffit sent slides and bloodwork to see what I am compatible with as far as BRAF & Mek inhibitor trials I won't get results for about 3 weeks.

      A friend found the MRI Guided Laser Ablation trial and I sent the contact a msg to see if I would qualify http://www.mayoclinic.org/news2010-jax/6006.html

      Looking for any comments or advice that I should consider while I wait.

      Thanks,

      Rocky (Stage IV Liver Mets)

    Viewing 11 reply threads
    • Replies
        molly
        Participant

          Rocky,

          I don't have any words of advice but just wanted to wish you well as you begin your new trial! 

          molly

            Rocklove
            Participant

              Thanks so much for your kind thoughts.

              Rocky

              Rocklove
              Participant

                Thanks so much for your kind thoughts.

                Rocky

              molly
              Participant

                Rocky,

                I don't have any words of advice but just wanted to wish you well as you begin your new trial! 

                molly

                makedoandmend
                Participant

                  just wanted to drop you a line and say my thoughts are with you.  I learn a lot of from following your posts and wish you the best with the next level of treatment.

                  pat on long island

                    Rocklove
                    Participant

                      Thanks so much Pat. I pray that we will be following each others post for many more years to come.

                      Rocky

                      Rocklove
                      Participant

                        Thanks so much Pat. I pray that we will be following each others post for many more years to come.

                        Rocky

                      makedoandmend
                      Participant

                        just wanted to drop you a line and say my thoughts are with you.  I learn a lot of from following your posts and wish you the best with the next level of treatment.

                        pat on long island

                        James from Sydney
                        Participant

                          Hi Rocky 

                          its frustrating waiting for things to start. I read Delcath presented their Liver Perfusion method at ASCO this year with promising results. It isolates the liver from your body so the rest of you does not get a punch. This might slow/stop progression until you start something else.

                          Look up Delcath.com

                           

                          best wishes

                          James

                          James from Sydney
                          Participant

                            Hi Rocky 

                            its frustrating waiting for things to start. I read Delcath presented their Liver Perfusion method at ASCO this year with promising results. It isolates the liver from your body so the rest of you does not get a punch. This might slow/stop progression until you start something else.

                            Look up Delcath.com

                             

                            best wishes

                            James

                              Rocklove
                              Participant

                                Thanks James, I will bring this up to the doctor. I think they do the Delcath system @ Moffit.. but not sure.

                                Rocky

                                Rocklove
                                Participant

                                  Thanks James, I will bring this up to the doctor. I think they do the Delcath system @ Moffit.. but not sure.

                                  Rocky

                                Amy Busby
                                Participant

                                  I hope whatever you end up doing will work for you.  Lord knows you've earned some serious break time from the Beast.

                                  Hang in there Rocky!  You're a tough fighter. 

                                  Love,

                                  Amy

                                    Rocklove
                                    Participant

                                      Love You Too Amy… Your posting… and that is a wonderful thing.

                                      Rocky

                                      Rocklove
                                      Participant

                                        Love You Too Amy… Your posting… and that is a wonderful thing.

                                        Rocky

                                      Amy Busby
                                      Participant

                                        I hope whatever you end up doing will work for you.  Lord knows you've earned some serious break time from the Beast.

                                        Hang in there Rocky!  You're a tough fighter. 

                                        Love,

                                        Amy

                                        JuleFL
                                        Participant

                                          Wishing you the best, Rocky.

                                          Jule

                                          JuleFL
                                          Participant

                                            Wishing you the best, Rocky.

                                            Jule

                                              Vermont_Donna
                                              Participant

                                                Hi Rocky,

                                                I read with angst your news……I too learn a lot from your posts plus I admire your steady pace of searching, researching, and keeping optimistic in spite of certain drugs not working. I am keeping my fingers crossed that things will get sorted out very soon, I known none of us like waiting! I am sending positive thoughts and wishes for your melanoma to respond to a treatment soon!

                                                Hugs,

                                                Vermont_Donna

                                                Vermont_Donna
                                                Participant

                                                  Hi Rocky,

                                                  I read with angst your news……I too learn a lot from your posts plus I admire your steady pace of searching, researching, and keeping optimistic in spite of certain drugs not working. I am keeping my fingers crossed that things will get sorted out very soon, I known none of us like waiting! I am sending positive thoughts and wishes for your melanoma to respond to a treatment soon!

                                                  Hugs,

                                                  Vermont_Donna

                                                  Rocklove
                                                  Participant

                                                    Thanks Donna,

                                                    I appreciate the kind thoughts and wishes. We are going to keep moving forward as far as I can go. And keep fighting.

                                                    Rocky

                                                    Rocklove
                                                    Participant

                                                      Thanks Donna,

                                                      I appreciate the kind thoughts and wishes. We are going to keep moving forward as far as I can go. And keep fighting.

                                                      Rocky

                                                      Rocklove
                                                      Participant

                                                        Thanks Jule I appreciate the kind words.

                                                        Rocky

                                                        Rocklove
                                                        Participant

                                                          Thanks Jule I appreciate the kind words.

                                                          Rocky

                                                        stillhopeful
                                                        Participant

                                                          I'm on the ipi trial, but wish I had done the Anti PD1 trial first.  I've heard very good things about Anti PD 1, and there are fewer side effects than ipi.  

                                                          I cannot comment on how waiting 4 weeks will affect you, but I know I had to wait 28 days after chemo before I could begin the ipi trial.  It is possible that you will need to wait to start any trial.  

                                                          It is good to know if you are BRAF positive, but I think the probability of a durable response is much higher with antiPD1 than BRAF.  

                                                          I hope that things turn out well for you.

                                                          stillhopeful
                                                          Participant

                                                            I'm on the ipi trial, but wish I had done the Anti PD1 trial first.  I've heard very good things about Anti PD 1, and there are fewer side effects than ipi.  

                                                            I cannot comment on how waiting 4 weeks will affect you, but I know I had to wait 28 days after chemo before I could begin the ipi trial.  It is possible that you will need to wait to start any trial.  

                                                            It is good to know if you are BRAF positive, but I think the probability of a durable response is much higher with antiPD1 than BRAF.  

                                                            I hope that things turn out well for you.

                                                              Rocklove
                                                              Participant

                                                                Thanks stillhopeful,

                                                                I hope your ipi trial does well. I appreciate the advice and will keep it close to my thinking cap when conversations and options begin with the Dr….

                                                                Rocky

                                                                Rocklove
                                                                Participant

                                                                  Thanks stillhopeful,

                                                                  I hope your ipi trial does well. I appreciate the advice and will keep it close to my thinking cap when conversations and options begin with the Dr….

                                                                  Rocky

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