Does prior IPI exclude you from other trials?
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Does prior IPI exclude you from other trials?

› Forums › General Melanoma Community › Does prior IPI exclude you from other trials?

  • Post
    • September 16, 2012 at 1:47 pm
    gabsound
    Participant
    I posted earlier about my last scans and started doing some reading on Anti PD1 trials, which I know are hard to come by. But the first two I read specifically excluded prior Anti CTLA or other immune treatment. My heart sank. If, I need another treatment I thought that would be the next one.

    Does Yervoy exclude you from all Anti PD 1 trials?

    I’m BRAF wild type (negative). I have the NRAS mutation. What else should I be looking at?

    Any advice would be appreciated.

    Julie

    I posted earlier about my last scans and started doing some reading on Anti PD1 trials, which I know are hard to come by. But the first two I read specifically excluded prior Anti CTLA or other immune treatment. My heart sank. If, I need another treatment I thought that would be the next one.

    Does Yervoy exclude you from all Anti PD 1 trials?

    I’m BRAF wild type (negative). I have the NRAS mutation. What else should I be looking at?

    Any advice would be appreciated.

    Julie

Viewing 11 reply threads
  • Replies
      • September 16, 2012 at 1:49 pm
      gabsound
      Participant
      Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
        • September 16, 2012 at 2:04 pm
        awillett1991
        Participant
        I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

        http://clinicaltrials.gov/ct2/show/NCT01621490

        • September 16, 2012 at 2:06 pm
        awillett1991
        Participant
        Failed IPI. Sorry. Best of luck to you!
        • September 16, 2012 at 9:05 pm
        gabsound
        Participant
        Thank you for the information.

        Julie

        • September 16, 2012 at 9:05 pm
        gabsound
        Participant
        Thank you for the information.

        Julie

        • September 16, 2012 at 9:05 pm
        gabsound
        Participant
        Thank you for the information.

        Julie

        • September 16, 2012 at 2:06 pm
        awillett1991
        Participant
        Failed IPI. Sorry. Best of luck to you!
        • September 16, 2012 at 2:06 pm
        awillett1991
        Participant
        Failed IPI. Sorry. Best of luck to you!
        • September 16, 2012 at 2:04 pm
        awillett1991
        Participant
        I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

        http://clinicaltrials.gov/ct2/show/NCT01621490

        • September 16, 2012 at 2:04 pm
        awillett1991
        Participant
        I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

        http://clinicaltrials.gov/ct2/show/NCT01621490

      • September 16, 2012 at 1:49 pm
      gabsound
      Participant
      Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
      • September 16, 2012 at 1:49 pm
      gabsound
      Participant
      Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
      • September 16, 2012 at 5:49 pm
      killmel
      Participant

      Hi Julie,

       

      I read your post that you are looking for a PD1 trial.

      I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

      I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

      aribas@mednet.ucla.edu
      310 206-3928

       

      Good Luck,

      Mary

        • September 16, 2012 at 9:07 pm
        gabsound
        Participant
        Than k you Mary.

        My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

        Julie

        • September 16, 2012 at 9:07 pm
        gabsound
        Participant
        Than k you Mary.

        My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

        Julie

        • September 16, 2012 at 9:07 pm
        gabsound
        Participant
        Than k you Mary.

        My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

        Julie

      • September 16, 2012 at 5:49 pm
      killmel
      Participant

      Hi Julie,

       

      I read your post that you are looking for a PD1 trial.

      I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

      I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

      aribas@mednet.ucla.edu
      310 206-3928

       

      Good Luck,

      Mary

      • September 16, 2012 at 5:49 pm
      killmel
      Participant

      Hi Julie,

       

      I read your post that you are looking for a PD1 trial.

      I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

      I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

      aribas@mednet.ucla.edu
      310 206-3928

       

      Good Luck,

      Mary

      • September 16, 2012 at 9:16 pm
      audgator
      Participant

      I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

      • September 16, 2012 at 9:16 pm
      audgator
      Participant

      I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

        • September 16, 2012 at 9:20 pm
        gabsound
        Participant
        I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

        In the mean time, trying to get next treatment lined up.

        Thanks,

        Julie

        • September 16, 2012 at 9:20 pm
        gabsound
        Participant
        I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

        In the mean time, trying to get next treatment lined up.

        Thanks,

        Julie

        • September 16, 2012 at 9:20 pm
        gabsound
        Participant
        I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

        In the mean time, trying to get next treatment lined up.

        Thanks,

        Julie

      • September 16, 2012 at 9:16 pm
      audgator
      Participant

      I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

      • September 17, 2012 at 2:19 am
      LynnLuc
      Participant

      I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

      • September 17, 2012 at 2:19 am
      LynnLuc
      Participant

      I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

      • September 17, 2012 at 2:19 am
      LynnLuc
      Participant

      I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

        • September 17, 2012 at 2:33 am
        LynnLuc
        Participant

        PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. jeffrey.weber@moffitt.org . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

         

        http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

        http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

        • September 17, 2012 at 2:33 am
        LynnLuc
        Participant

        PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. jeffrey.weber@moffitt.org . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

         

        http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

        http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

        • September 17, 2012 at 2:33 am
        LynnLuc
        Participant

        PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. jeffrey.weber@moffitt.org . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

         

        http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

        http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

        • September 17, 2012 at 2:34 am
        LynnLuc
        Participant

        The opening for 21 are for those NOT NED…

        • September 17, 2012 at 2:34 am
        LynnLuc
        Participant

        The opening for 21 are for those NOT NED…

        • September 17, 2012 at 2:34 am
        LynnLuc
        Participant

        The opening for 21 are for those NOT NED…

        • September 17, 2012 at 3:54 am
        gabsound
        Participant
        Lynn,

        Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

        Julie

        • September 17, 2012 at 3:54 am
        gabsound
        Participant
        Lynn,

        Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

        Julie

        • September 17, 2012 at 3:54 am
        gabsound
        Participant
        Lynn,

        Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

        Julie

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