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Does prior IPI exclude you from other trials?
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Does prior IPI exclude you from other trials?

› Forums › General Melanoma Community › Does prior IPI exclude you from other trials?

  • Post
    • September 16, 2012 at 1:47 pm
    gabsound
    Participant
      I posted earlier about my last scans and started doing some reading on Anti PD1 trials, which I know are hard to come by. But the first two I read specifically excluded prior Anti CTLA or other immune treatment. My heart sank. If, I need another treatment I thought that would be the next one.

      Does Yervoy exclude you from all Anti PD 1 trials?

      I’m BRAF wild type (negative). I have the NRAS mutation. What else should I be looking at?

      Any advice would be appreciated.

      Julie

      I posted earlier about my last scans and started doing some reading on Anti PD1 trials, which I know are hard to come by. But the first two I read specifically excluded prior Anti CTLA or other immune treatment. My heart sank. If, I need another treatment I thought that would be the next one.

      Does Yervoy exclude you from all Anti PD 1 trials?

      I’m BRAF wild type (negative). I have the NRAS mutation. What else should I be looking at?

      Any advice would be appreciated.

      Julie

    Viewing 11 reply threads
    • Replies
        • September 16, 2012 at 1:49 pm
        gabsound
        Participant
          Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
          • September 16, 2012 at 1:49 pm
          gabsound
          Participant
            Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
              • September 16, 2012 at 2:04 pm
              awillett1991
              Participant
                I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

                http://clinicaltrials.gov/ct2/show/NCT01621490

                • September 16, 2012 at 2:06 pm
                awillett1991
                Participant
                  Failed IPI. Sorry. Best of luck to you!
                  • September 16, 2012 at 2:06 pm
                  awillett1991
                  Participant
                    Failed IPI. Sorry. Best of luck to you!
                    • September 16, 2012 at 2:06 pm
                    awillett1991
                    Participant
                      Failed IPI. Sorry. Best of luck to you!
                      • September 16, 2012 at 9:05 pm
                      gabsound
                      Participant
                        Thank you for the information.

                        Julie

                        • September 16, 2012 at 9:05 pm
                        gabsound
                        Participant
                          Thank you for the information.

                          Julie

                          • September 16, 2012 at 9:05 pm
                          gabsound
                          Participant
                            Thank you for the information.

                            Julie

                            • September 16, 2012 at 2:04 pm
                            awillett1991
                            Participant
                              I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

                              http://clinicaltrials.gov/ct2/show/NCT01621490

                              • September 16, 2012 at 2:04 pm
                              awillett1991
                              Participant
                                I know this is supposed to start soon because my doc at Vandy will have some people on it. Half the patients will be people who have ailed IPI. I don’t know where you are, but maybe if you call them they can give you some other trial sites so you can get on a list or something?? Haven’t had any success getting in trial yet and probably won’t, so I don’t know how these things work.

                                http://clinicaltrials.gov/ct2/show/NCT01621490

                              • September 16, 2012 at 1:49 pm
                              gabsound
                              Participant
                                Also, I should probably change my picture as my dear daughter just turned 17 yesterday 🙂
                                • September 16, 2012 at 5:49 pm
                                killmel
                                Participant

                                  Hi Julie,

                                   

                                  I read your post that you are looking for a PD1 trial.

                                  I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

                                  I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

                                  [email protected]
                                  310 206-3928

                                   

                                  Good Luck,

                                  Mary

                                  • September 16, 2012 at 5:49 pm
                                  killmel
                                  Participant

                                    Hi Julie,

                                     

                                    I read your post that you are looking for a PD1 trial.

                                    I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

                                    I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

                                    [email protected]
                                    310 206-3928

                                     

                                    Good Luck,

                                    Mary

                                      • September 16, 2012 at 9:07 pm
                                      gabsound
                                      Participant
                                        Than k you Mary.

                                        My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

                                        Julie

                                        • September 16, 2012 at 9:07 pm
                                        gabsound
                                        Participant
                                          Than k you Mary.

                                          My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

                                          Julie

                                          • September 16, 2012 at 9:07 pm
                                          gabsound
                                          Participant
                                            Than k you Mary.

                                            My oncologist is referring me to Angels clinic first. If they don’t have anything I will be right on the UCLA suggestion.

                                            Julie

                                          • September 16, 2012 at 5:49 pm
                                          killmel
                                          Participant

                                            Hi Julie,

                                             

                                            I read your post that you are looking for a PD1 trial.

                                            I know there are openings in the Merck pd1 trial with Dr. Ribas, @UCLA…he is  the BEST Doctor. I understand that he has open seats now.

                                            I suggest you contact him ASAP. He does reply to emails. You can ask him if he has any PD1 trial for patients who took IPI.

                                            [email protected]
                                            310 206-3928

                                             

                                            Good Luck,

                                            Mary

                                            • September 16, 2012 at 9:16 pm
                                            audgator
                                            Participant

                                              I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

                                              • September 16, 2012 at 9:16 pm
                                              audgator
                                              Participant

                                                I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

                                                • September 16, 2012 at 9:16 pm
                                                audgator
                                                Participant

                                                  I'm an ipi failure and, If I'm not mistaken, that was a requirement for my arm of the trial.   Dan

                                                    • September 16, 2012 at 9:20 pm
                                                    gabsound
                                                    Participant
                                                      I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

                                                      In the mean time, trying to get next treatment lined up.

                                                      Thanks,

                                                      Julie

                                                      • September 16, 2012 at 9:20 pm
                                                      gabsound
                                                      Participant
                                                        I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

                                                        In the mean time, trying to get next treatment lined up.

                                                        Thanks,

                                                        Julie

                                                        • September 16, 2012 at 9:20 pm
                                                        gabsound
                                                        Participant
                                                          I’m scheduled for another PET/CT in 5-6 weeks. So I dont think I’ve failed yet, but I’m not optimistic that I will be NED by then.

                                                          In the mean time, trying to get next treatment lined up.

                                                          Thanks,

                                                          Julie

                                                        • September 17, 2012 at 2:19 am
                                                        LynnLuc
                                                        Participant

                                                          I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

                                                          • September 17, 2012 at 2:19 am
                                                          LynnLuc
                                                          Participant

                                                            I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

                                                              • September 17, 2012 at 2:33 am
                                                              LynnLuc
                                                              Participant

                                                                PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. [email protected] . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

                                                                 

                                                                http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

                                                                Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

                                                                http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

                                                                Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

                                                                • September 17, 2012 at 2:33 am
                                                                LynnLuc
                                                                Participant

                                                                  PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. [email protected] . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

                                                                   

                                                                  http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

                                                                  Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

                                                                  http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

                                                                  Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

                                                                  • September 17, 2012 at 2:34 am
                                                                  LynnLuc
                                                                  Participant

                                                                    The opening for 21 are for those NOT NED…

                                                                    • September 17, 2012 at 2:34 am
                                                                    LynnLuc
                                                                    Participant

                                                                      The opening for 21 are for those NOT NED…

                                                                      • September 17, 2012 at 3:54 am
                                                                      gabsound
                                                                      Participant
                                                                        Lynn,

                                                                        Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

                                                                        Julie

                                                                        • September 17, 2012 at 3:54 am
                                                                        gabsound
                                                                        Participant
                                                                          Lynn,

                                                                          Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

                                                                          Julie

                                                                          • September 17, 2012 at 3:54 am
                                                                          gabsound
                                                                          Participant
                                                                            Lynn,

                                                                            Thanks for the information. Unfortunately I live on the other side of the country. I’m so inspired by your story. You are the poster child for this drug! I’ll be looking at California first- much closer to las Vegas.

                                                                            Julie

                                                                            • September 17, 2012 at 2:34 am
                                                                            LynnLuc
                                                                            Participant

                                                                              The opening for 21 are for those NOT NED…

                                                                              • September 17, 2012 at 2:33 am
                                                                              LynnLuc
                                                                              Participant

                                                                                PS. Moffitt has 4 opening in the Anti PD 1 trial for those who are NED  and they have extended the group and have openings for 21. There is a 6 week wait for the latter one. You can contact my dr… Dr. Jeffrey Weber who is a medical oncologist in the Department of Cutaneous Oncology at Moffitt and director of Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center. [email protected] . He will reply to your e-mails personally. He is accessable and friendly and an AWESOME onc!! I am bias for Moffitt and Dr Weber because I am in the trial and have remained Stage IV- NED for 2 1/2 years.

                                                                                 

                                                                                http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

                                                                                Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IIIC or IV Melanoma

                                                                                http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

                                                                                Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma

                                                                              • September 17, 2012 at 2:19 am
                                                                              LynnLuc
                                                                              Participant

                                                                                I know Moffitt is allowing people who failed Ipi- ( Yervoy) in their anti PD-1 trials…although originally they did not.

                                                                            Viewing 11 reply threads
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