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Does nivo/ipi still work while treatment stopped on steroids to bring down liver enzymes?

Forums General Melanoma Community Does nivo/ipi still work while treatment stopped on steroids to bring down liver enzymes?

  • Post
    Beany
    Participant
      Hello,
      Due to elevated liver enzymes, I had to stop nivo/ipi after three infusion. I am on 35mg of prednisone to bring down the enzymes. My question is did anyone here who had the experience of stopping treatment while on prednisone still achieve tumour shrinkage during this time?
      Thanks in advance,
      Adam
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    • Replies
        Edwin
        Participant
          It was 9 weeks between my 1st and 2nd ipi/nivo infusions. I received prednisone to help recover from that 1st infusion. The PET scan after my 4th ipi/nivo infusion showed tumor shrinkage. Because walking became a little less painful before my 2nd ipi/nivo infusion, I think bone tumors shrank while I was taking prednisone.
            bjeans
            Participant
              Edwin, you might want to watch this Johns Hopkins video where the docto answers just that question (good news).. If the link doesn’t work, you can search on youtube for “Managing Immunotherapy Side Effects” by Evan J. Lipson.. https://m.youtube.com/watch?v=2MAmESB4czA

              Beth

            ed williams
            Participant
              Hi Beany, some of the best data comes from checkmate 067 in regards to published melanoma patients who have been on ipi/nivo and had to stop because of side effects (IRAE’s). If you look at the link that follows and go to the safety section, you will see the data on how many had to stop due to side effects and how they did when compared to those who didn’t have to stop. In summary they did just as well and there didn’t seem to be any significant difference in outcomes for those who stopped early. Those that developed IRAE’s generally get prednisone to treat side effect, so when you look at safety data, you can assume the % of patients that developed grade 3 or 4 side effects where placed on prednisone. https://www.nejm.org/doi/full/10.1056/NEJMoa1709684
                Beany
                Participant
                  Thanks Edwin and Ed,
                  So I can assume that even though I gave stopped immunotherapy and am on immunosuppressive drugs that the immunotherapy may still be working?
                  bjeans
                  Participant
                    Beany, sorry – the link to the Hopkins video, above, was meant for you.
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