Does nivo/ipi still work while treatment stopped on steroids to bring down liver enzymes?

It was 9 weeks between my 1st and 2nd ipi/nivo infusions. I received prednisone to help recover from that 1st infusion. The PET scan after my 4th ipi/nivo infusion showed tumor shrinkage. Because walking became a little less painful before my 2nd ipi/nivo infusion, I think bone tumors shrank while I was taking prednisone.

Hi Beany, some of the best data comes from checkmate 067 in regards to published melanoma patients who have been on ipi/nivo and had to stop because of side effects (IRAE’s). If you look at the link that follows and go to the safety section, you will see the data on how many had to stop due to side effects and how they did when compared to those who didn’t have to stop. In summary they did just as well and there didn’t seem to be any significant difference in outcomes for those who stopped early. Those that developed IRAE’s generally get prednisone to treat side effect, so when you look at safety data, you can assume the % of patients that developed grade 3 or 4 side effects where placed on prednisone. https://www.nejm.org/doi/full/10.1056/NEJMoa1709684