› Forums › General Melanoma Community › do braf combo works on brain met?
- This topic has 69 replies, 9 voices, and was last updated 8 years, 10 months ago by
Mat.
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- July 7, 2015 at 7:54 am
Sorry i mean:
anyone knows if braf combo (with zelboraf) works on brian mets?
Antonio
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- July 8, 2015 at 11:46 pm
I am fortunate to see a melanoma specialist at Penn, and without you or I asking this question, her answer last week on this very subject was (translated from fancy speak) "yes, the combo does cross into the brain and is effective at treating disease".
My radiation oncologist would agree with her also. I had SRS on a non-resected MET, and once I went on the combo, she also said "oh you will most likely see faster regression of the tumor now since that protocol does affect tumors in the brain".
So that's my answer, and if/when she is proven wrong and changes her answer, then mine will change also.
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- July 8, 2015 at 11:46 pm
I am fortunate to see a melanoma specialist at Penn, and without you or I asking this question, her answer last week on this very subject was (translated from fancy speak) "yes, the combo does cross into the brain and is effective at treating disease".
My radiation oncologist would agree with her also. I had SRS on a non-resected MET, and once I went on the combo, she also said "oh you will most likely see faster regression of the tumor now since that protocol does affect tumors in the brain".
So that's my answer, and if/when she is proven wrong and changes her answer, then mine will change also.
-
- July 8, 2015 at 11:46 pm
I am fortunate to see a melanoma specialist at Penn, and without you or I asking this question, her answer last week on this very subject was (translated from fancy speak) "yes, the combo does cross into the brain and is effective at treating disease".
My radiation oncologist would agree with her also. I had SRS on a non-resected MET, and once I went on the combo, she also said "oh you will most likely see faster regression of the tumor now since that protocol does affect tumors in the brain".
So that's my answer, and if/when she is proven wrong and changes her answer, then mine will change also.
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- July 10, 2015 at 2:27 am
Mat, I'm actually working with Dr. Tara Gangadhar who is another one of their up and coming specialists (apparently there are several). If I ever run into you in Perelman, the crab fries are on me 🙂
I don't remember how I originally stumbled upon this statical breakdown (probably Celeste's blog), but it helps show the benefits in OS of *just* the BRAF inhibitor in brain mets:
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- July 10, 2015 at 2:27 am
Mat, I'm actually working with Dr. Tara Gangadhar who is another one of their up and coming specialists (apparently there are several). If I ever run into you in Perelman, the crab fries are on me 🙂
I don't remember how I originally stumbled upon this statical breakdown (probably Celeste's blog), but it helps show the benefits in OS of *just* the BRAF inhibitor in brain mets:
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- July 10, 2015 at 2:27 am
Mat, I'm actually working with Dr. Tara Gangadhar who is another one of their up and coming specialists (apparently there are several). If I ever run into you in Perelman, the crab fries are on me 🙂
I don't remember how I originally stumbled upon this statical breakdown (probably Celeste's blog), but it helps show the benefits in OS of *just* the BRAF inhibitor in brain mets:
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- July 7, 2015 at 10:39 am
Short answer: Yes! Zelboraf is the same as vemurafenib. Here's some background on BRAF:http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's some older data, but with a link to a specific article re vemurafenib and the brain from ASCO 2014: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
I wish you my best. Celeste
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- July 7, 2015 at 9:18 pm
"Targeted therapies are also active in patients with brain metastases, who are often excluded from clinical trials and whose response rates to chemotherapy are usually very low. At MD Anderson, in the largest clinical trial ever conducted for melanoma patients with brain metastases, around 40% of patients treated with dabrafenib had clinical responses of their brain tumors."
http://www2.mdanderson.org/depts/oncolog/articles/14/2-feb/2-14-1.html
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- July 7, 2015 at 9:18 pm
"Targeted therapies are also active in patients with brain metastases, who are often excluded from clinical trials and whose response rates to chemotherapy are usually very low. At MD Anderson, in the largest clinical trial ever conducted for melanoma patients with brain metastases, around 40% of patients treated with dabrafenib had clinical responses of their brain tumors."
http://www2.mdanderson.org/depts/oncolog/articles/14/2-feb/2-14-1.html
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- July 7, 2015 at 9:18 pm
"Targeted therapies are also active in patients with brain metastases, who are often excluded from clinical trials and whose response rates to chemotherapy are usually very low. At MD Anderson, in the largest clinical trial ever conducted for melanoma patients with brain metastases, around 40% of patients treated with dabrafenib had clinical responses of their brain tumors."
http://www2.mdanderson.org/depts/oncolog/articles/14/2-feb/2-14-1.html
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- July 7, 2015 at 10:39 am
Short answer: Yes! Zelboraf is the same as vemurafenib. Here's some background on BRAF:http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's some older data, but with a link to a specific article re vemurafenib and the brain from ASCO 2014: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
I wish you my best. Celeste
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- July 7, 2015 at 10:39 am
Short answer: Yes! Zelboraf is the same as vemurafenib. Here's some background on BRAF:http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's some older data, but with a link to a specific article re vemurafenib and the brain from ASCO 2014: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
I wish you my best. Celeste
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- July 8, 2015 at 1:30 am
Anon vs other anon!!! Let's go with real data, shall we? If you have data…would love to see it!
1: surgery and radiation (srs NOT whole brain) are not bad treatments.
2: Treatment patterns and outcomes in BRAF V600E mutant melanoma patients with brain metastases receiving vemurafenib in the real-world setting.
2014 ASCO abstract By: Gibney, Marynchenko, Galebach, et al….with info from Moffit, Boston, Montreal, and San Fran 36/283 patients (48.1%) were reported to achieve overall intracranial response. Survival at 6 months was 85.7%. CONCLUSION: In the real world setting, the use of vem treatment is associated with clinical benefit in BRAF V600E melanoma patients with active brain mets.3: BRAF therapy and BRAIN METS:
Patterns of response and progression in patients with BRAF-mutant melanoma metastatic to the brain who were treated with dabrafenib. Azer, et al. Cancer. 2/2014.23 patients studied. Response rates in intracranial (78%) and extracranial (90%) sites. Of 20 patients with progressive disease, 6 had IC progressive disease and 6 had progressive disease in EC only and 8 experienced progressive disease in both sites. 5 of 6 with isolated progressive disease to the brain underwent local therapy to the brain and continued on dabrafenib longer than 30 days. Bottom line: IC and EC tumors respond similarly to dabrafenib.
Vemurafenib in metastatic melanoma patients with brain metastasis: as open label, single-arm, phase 2 multicenter study. Kefford, et al.
As of April 2013, 146 patients with melanoma brain mets (Patients had an average number of 3 mets…though the range was from 1-30.) were treated with vemurafenib. In patients with previously untreated MBMs, vemurafenib produced a response in 61% of those patients. The median progression free survival was 3.7 months and the overall survival median was 7 months. So…Vemurafenib works on brain tumors, too.
4: From ASCO 2014 – On-demand Gamma Knife combined with BRAF inhibitors for the treatment of melanoma brain metastases. Abstract 9083 J Clin Oncol Marqueste, Carron, Delsanti, et al (out of France)
Cases of radiosensitization after conventional radiation therapy in BRAFi treated patients had caused concern about using this combo. In this study, blind review by 2 independent observers of brain MRI f/u scans and survival assessment in all patients treated with Gamma knife and BRAFi at a single institution, was completed. Gamma knife was done on 30 patients who had previously been given BRAFi, 24 patients were under BRAFi treatment (with only 4 of those interrupting the BRAFi for the gamma knife procedure) and 15 patients had Gamma knife before starting BRAFi. Out of 263 brain mets treated, only 3 edemas and 3 hemorrhages were detected within 2 months of gamma knife and 4/7 were noted later. No brain met radiation necrosis and no scalp radiation dermatitis occurred. Neither the MRI features nor the incidence of the rare adverse events were deemed unexpected in such a population. Conclusion: This series does not show immediate radiotoxicity nor radiation-recall in BRAFi patients treated with Gamma knife. Interrupting BRAFi for stereotactic radiosurgery of brain mets seems useless.
5. We have known about the effect of cytotoxic T cells on the brain….FOR A LOOOOONG TIME!!! Blood brain barrier not withstanding!!!!!! http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
6. Out of ASCO 2015…this may be a better treatment to brain mets for some: A multi-center phase II open-label study (CheckMate 204) to evaluate safety and efficacy of Nivolumab (NIVO) in combination with ipilimumab (IPI) followed by NIVO monotherapy in patients with metastatic melanoma to the brain. J Clin Oncol 33, 2015. Margolin, Tawbi, Hodi, et al. http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/05/asco-2015-new-trial-for-melanoma-brain.html
If you have data demonstrating that these facts and figures from the best and brightest melanoma researchers across the globe are inaccurate…please share. The sad fact of the matter is…we have absolutely NO TREATMENT that will rid ALL melanoma patients of ALL melanoma. Some things work for one person, while another treatment works better for another. Additionally, some of my dearest and brightest found NOTHING that worked for them permanently. BUT! We need to work together to share information that is real…not conjecture…so that others may do as well as we have…or hopefully…even better.
I wish you all my best. Celeste
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- July 8, 2015 at 1:30 am
Anon vs other anon!!! Let's go with real data, shall we? If you have data…would love to see it!
1: surgery and radiation (srs NOT whole brain) are not bad treatments.
2: Treatment patterns and outcomes in BRAF V600E mutant melanoma patients with brain metastases receiving vemurafenib in the real-world setting.
2014 ASCO abstract By: Gibney, Marynchenko, Galebach, et al….with info from Moffit, Boston, Montreal, and San Fran 36/283 patients (48.1%) were reported to achieve overall intracranial response. Survival at 6 months was 85.7%. CONCLUSION: In the real world setting, the use of vem treatment is associated with clinical benefit in BRAF V600E melanoma patients with active brain mets.3: BRAF therapy and BRAIN METS:
Patterns of response and progression in patients with BRAF-mutant melanoma metastatic to the brain who were treated with dabrafenib. Azer, et al. Cancer. 2/2014.23 patients studied. Response rates in intracranial (78%) and extracranial (90%) sites. Of 20 patients with progressive disease, 6 had IC progressive disease and 6 had progressive disease in EC only and 8 experienced progressive disease in both sites. 5 of 6 with isolated progressive disease to the brain underwent local therapy to the brain and continued on dabrafenib longer than 30 days. Bottom line: IC and EC tumors respond similarly to dabrafenib.
Vemurafenib in metastatic melanoma patients with brain metastasis: as open label, single-arm, phase 2 multicenter study. Kefford, et al.
As of April 2013, 146 patients with melanoma brain mets (Patients had an average number of 3 mets…though the range was from 1-30.) were treated with vemurafenib. In patients with previously untreated MBMs, vemurafenib produced a response in 61% of those patients. The median progression free survival was 3.7 months and the overall survival median was 7 months. So…Vemurafenib works on brain tumors, too.
4: From ASCO 2014 – On-demand Gamma Knife combined with BRAF inhibitors for the treatment of melanoma brain metastases. Abstract 9083 J Clin Oncol Marqueste, Carron, Delsanti, et al (out of France)
Cases of radiosensitization after conventional radiation therapy in BRAFi treated patients had caused concern about using this combo. In this study, blind review by 2 independent observers of brain MRI f/u scans and survival assessment in all patients treated with Gamma knife and BRAFi at a single institution, was completed. Gamma knife was done on 30 patients who had previously been given BRAFi, 24 patients were under BRAFi treatment (with only 4 of those interrupting the BRAFi for the gamma knife procedure) and 15 patients had Gamma knife before starting BRAFi. Out of 263 brain mets treated, only 3 edemas and 3 hemorrhages were detected within 2 months of gamma knife and 4/7 were noted later. No brain met radiation necrosis and no scalp radiation dermatitis occurred. Neither the MRI features nor the incidence of the rare adverse events were deemed unexpected in such a population. Conclusion: This series does not show immediate radiotoxicity nor radiation-recall in BRAFi patients treated with Gamma knife. Interrupting BRAFi for stereotactic radiosurgery of brain mets seems useless.
5. We have known about the effect of cytotoxic T cells on the brain….FOR A LOOOOONG TIME!!! Blood brain barrier not withstanding!!!!!! http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
6. Out of ASCO 2015…this may be a better treatment to brain mets for some: A multi-center phase II open-label study (CheckMate 204) to evaluate safety and efficacy of Nivolumab (NIVO) in combination with ipilimumab (IPI) followed by NIVO monotherapy in patients with metastatic melanoma to the brain. J Clin Oncol 33, 2015. Margolin, Tawbi, Hodi, et al. http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/05/asco-2015-new-trial-for-melanoma-brain.html
If you have data demonstrating that these facts and figures from the best and brightest melanoma researchers across the globe are inaccurate…please share. The sad fact of the matter is…we have absolutely NO TREATMENT that will rid ALL melanoma patients of ALL melanoma. Some things work for one person, while another treatment works better for another. Additionally, some of my dearest and brightest found NOTHING that worked for them permanently. BUT! We need to work together to share information that is real…not conjecture…so that others may do as well as we have…or hopefully…even better.
I wish you all my best. Celeste
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- July 8, 2015 at 5:52 pm
Exactly, the sad fact is only radiation (SRS) and surgery gets rid of brain mets. lots of studies showing some activity of drugs on body but not directly on/in brain. So studies are great but only conjecture and how you read the results. A drug that crosses the barrier would be awesome.
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- July 8, 2015 at 5:52 pm
Exactly, the sad fact is only radiation (SRS) and surgery gets rid of brain mets. lots of studies showing some activity of drugs on body but not directly on/in brain. So studies are great but only conjecture and how you read the results. A drug that crosses the barrier would be awesome.
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- July 8, 2015 at 7:51 pm
The studies you're referring to generally refer to actual observations in real patients, i.e. not just conjecture. For another reference, http://www.dermnetnz.org/treatments/dabrafenib.html states "Dabrafenib has proven activity in patients with BRAF V600E and BRAF V600K metastatic melanoma, including those with brain metastases." As for crossing the blood-brain barrier, intrathecal injection can be one way around that, e.g. with IL-2 http://jco.ascopubs.org/content/32/33/e111.full. I'm unaware of any studies using intrathecal BRAF inhibitors, but given the systemic mechanism by which such drugs work, spinal injection seems likely to be both impracticable and unnecessary.
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- July 8, 2015 at 7:51 pm
The studies you're referring to generally refer to actual observations in real patients, i.e. not just conjecture. For another reference, http://www.dermnetnz.org/treatments/dabrafenib.html states "Dabrafenib has proven activity in patients with BRAF V600E and BRAF V600K metastatic melanoma, including those with brain metastases." As for crossing the blood-brain barrier, intrathecal injection can be one way around that, e.g. with IL-2 http://jco.ascopubs.org/content/32/33/e111.full. I'm unaware of any studies using intrathecal BRAF inhibitors, but given the systemic mechanism by which such drugs work, spinal injection seems likely to be both impracticable and unnecessary.
-
- July 8, 2015 at 7:51 pm
The studies you're referring to generally refer to actual observations in real patients, i.e. not just conjecture. For another reference, http://www.dermnetnz.org/treatments/dabrafenib.html states "Dabrafenib has proven activity in patients with BRAF V600E and BRAF V600K metastatic melanoma, including those with brain metastases." As for crossing the blood-brain barrier, intrathecal injection can be one way around that, e.g. with IL-2 http://jco.ascopubs.org/content/32/33/e111.full. I'm unaware of any studies using intrathecal BRAF inhibitors, but given the systemic mechanism by which such drugs work, spinal injection seems likely to be both impracticable and unnecessary.
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- July 9, 2015 at 1:29 am
Anon,
Please educate yourself. Cytotoxic T cells DO cross the blood brain barrier. Many, many scientific studies show that all current treatments…BRAFi, immunotherapies (anti-PD1 and ipi)….work as well in the brain as the do in the body. Additionally…given all the data we have also accumulated about the synergistic effects of radiation when COMBINED with other systemic treatment, you are selling yourself short to stop at radiation and surgery. You may risk your own heath as well as that of others when you spew and believe old news. Thankfully, melanoma treatments have advanced. We have to move with the times. Don't risk your life because you remain rooted in the past. By the way, there is an intrathecal treatment for leptomeningeal disease…IL2 has been used in that way for some time at MD Anderson. Additonally, I entered my Nivo study with a brain met. It disappeared with no surgery or radiation. I am not the only person for whom this is true. c
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- July 9, 2015 at 1:29 am
Anon,
Please educate yourself. Cytotoxic T cells DO cross the blood brain barrier. Many, many scientific studies show that all current treatments…BRAFi, immunotherapies (anti-PD1 and ipi)….work as well in the brain as the do in the body. Additionally…given all the data we have also accumulated about the synergistic effects of radiation when COMBINED with other systemic treatment, you are selling yourself short to stop at radiation and surgery. You may risk your own heath as well as that of others when you spew and believe old news. Thankfully, melanoma treatments have advanced. We have to move with the times. Don't risk your life because you remain rooted in the past. By the way, there is an intrathecal treatment for leptomeningeal disease…IL2 has been used in that way for some time at MD Anderson. Additonally, I entered my Nivo study with a brain met. It disappeared with no surgery or radiation. I am not the only person for whom this is true. c
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- July 9, 2015 at 1:52 pm
This is getting better than watching Wimbledon tennis, your serve Bubbles!
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- July 9, 2015 at 1:52 pm
This is getting better than watching Wimbledon tennis, your serve Bubbles!
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- July 9, 2015 at 1:52 pm
This is getting better than watching Wimbledon tennis, your serve Bubbles!
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- July 9, 2015 at 6:35 pm
It would be a miracle to cross the barrier! Nature made us with a few of these and the brain barrier is a strong one (others are the placenta, and testicular) It is not well proven, but activated tcells can cross over. But there is not study showing the DRUG crosses over. Some spec about activation only.
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- July 9, 2015 at 6:35 pm
It would be a miracle to cross the barrier! Nature made us with a few of these and the brain barrier is a strong one (others are the placenta, and testicular) It is not well proven, but activated tcells can cross over. But there is not study showing the DRUG crosses over. Some spec about activation only.
-
- July 9, 2015 at 6:35 pm
It would be a miracle to cross the barrier! Nature made us with a few of these and the brain barrier is a strong one (others are the placenta, and testicular) It is not well proven, but activated tcells can cross over. But there is not study showing the DRUG crosses over. Some spec about activation only.
-
- July 9, 2015 at 1:29 am
Anon,
Please educate yourself. Cytotoxic T cells DO cross the blood brain barrier. Many, many scientific studies show that all current treatments…BRAFi, immunotherapies (anti-PD1 and ipi)….work as well in the brain as the do in the body. Additionally…given all the data we have also accumulated about the synergistic effects of radiation when COMBINED with other systemic treatment, you are selling yourself short to stop at radiation and surgery. You may risk your own heath as well as that of others when you spew and believe old news. Thankfully, melanoma treatments have advanced. We have to move with the times. Don't risk your life because you remain rooted in the past. By the way, there is an intrathecal treatment for leptomeningeal disease…IL2 has been used in that way for some time at MD Anderson. Additonally, I entered my Nivo study with a brain met. It disappeared with no surgery or radiation. I am not the only person for whom this is true. c
-
- July 8, 2015 at 5:52 pm
Exactly, the sad fact is only radiation (SRS) and surgery gets rid of brain mets. lots of studies showing some activity of drugs on body but not directly on/in brain. So studies are great but only conjecture and how you read the results. A drug that crosses the barrier would be awesome.
-
- July 8, 2015 at 1:30 am
Anon vs other anon!!! Let's go with real data, shall we? If you have data…would love to see it!
1: surgery and radiation (srs NOT whole brain) are not bad treatments.
2: Treatment patterns and outcomes in BRAF V600E mutant melanoma patients with brain metastases receiving vemurafenib in the real-world setting.
2014 ASCO abstract By: Gibney, Marynchenko, Galebach, et al….with info from Moffit, Boston, Montreal, and San Fran 36/283 patients (48.1%) were reported to achieve overall intracranial response. Survival at 6 months was 85.7%. CONCLUSION: In the real world setting, the use of vem treatment is associated with clinical benefit in BRAF V600E melanoma patients with active brain mets.3: BRAF therapy and BRAIN METS:
Patterns of response and progression in patients with BRAF-mutant melanoma metastatic to the brain who were treated with dabrafenib. Azer, et al. Cancer. 2/2014.23 patients studied. Response rates in intracranial (78%) and extracranial (90%) sites. Of 20 patients with progressive disease, 6 had IC progressive disease and 6 had progressive disease in EC only and 8 experienced progressive disease in both sites. 5 of 6 with isolated progressive disease to the brain underwent local therapy to the brain and continued on dabrafenib longer than 30 days. Bottom line: IC and EC tumors respond similarly to dabrafenib.
Vemurafenib in metastatic melanoma patients with brain metastasis: as open label, single-arm, phase 2 multicenter study. Kefford, et al.
As of April 2013, 146 patients with melanoma brain mets (Patients had an average number of 3 mets…though the range was from 1-30.) were treated with vemurafenib. In patients with previously untreated MBMs, vemurafenib produced a response in 61% of those patients. The median progression free survival was 3.7 months and the overall survival median was 7 months. So…Vemurafenib works on brain tumors, too.
4: From ASCO 2014 – On-demand Gamma Knife combined with BRAF inhibitors for the treatment of melanoma brain metastases. Abstract 9083 J Clin Oncol Marqueste, Carron, Delsanti, et al (out of France)
Cases of radiosensitization after conventional radiation therapy in BRAFi treated patients had caused concern about using this combo. In this study, blind review by 2 independent observers of brain MRI f/u scans and survival assessment in all patients treated with Gamma knife and BRAFi at a single institution, was completed. Gamma knife was done on 30 patients who had previously been given BRAFi, 24 patients were under BRAFi treatment (with only 4 of those interrupting the BRAFi for the gamma knife procedure) and 15 patients had Gamma knife before starting BRAFi. Out of 263 brain mets treated, only 3 edemas and 3 hemorrhages were detected within 2 months of gamma knife and 4/7 were noted later. No brain met radiation necrosis and no scalp radiation dermatitis occurred. Neither the MRI features nor the incidence of the rare adverse events were deemed unexpected in such a population. Conclusion: This series does not show immediate radiotoxicity nor radiation-recall in BRAFi patients treated with Gamma knife. Interrupting BRAFi for stereotactic radiosurgery of brain mets seems useless.
5. We have known about the effect of cytotoxic T cells on the brain….FOR A LOOOOONG TIME!!! Blood brain barrier not withstanding!!!!!! http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/cytotoxic-t-cells-and-brafi-work-on.html
6. Out of ASCO 2015…this may be a better treatment to brain mets for some: A multi-center phase II open-label study (CheckMate 204) to evaluate safety and efficacy of Nivolumab (NIVO) in combination with ipilimumab (IPI) followed by NIVO monotherapy in patients with metastatic melanoma to the brain. J Clin Oncol 33, 2015. Margolin, Tawbi, Hodi, et al. http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/05/asco-2015-new-trial-for-melanoma-brain.html
If you have data demonstrating that these facts and figures from the best and brightest melanoma researchers across the globe are inaccurate…please share. The sad fact of the matter is…we have absolutely NO TREATMENT that will rid ALL melanoma patients of ALL melanoma. Some things work for one person, while another treatment works better for another. Additionally, some of my dearest and brightest found NOTHING that worked for them permanently. BUT! We need to work together to share information that is real…not conjecture…so that others may do as well as we have…or hopefully…even better.
I wish you all my best. Celeste
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- July 9, 2015 at 8:21 pm
Anon,
At least one of you… You need to read what you are responding to. I have NEVER said that the meds we've been discussing cross the blood brain barrier. I have ALWAYS said that the effects they create…by a variety of mechanisms…can eradicate tumors in the brain as well as they statistically do in the body. Whatever else you want to think…go right ahead. I think I've made the research clear enough for others.
Ed and Mat…you boys always make me laugh! Now go find another match. I got stuff to do and folks that I might actually be able to help.
Antonio, I hope you have at least gotten some help with your original question. You have certainly gained a lot of different perspectives to say the least.
I wish you all well! C
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- July 9, 2015 at 8:21 pm
Anon,
At least one of you… You need to read what you are responding to. I have NEVER said that the meds we've been discussing cross the blood brain barrier. I have ALWAYS said that the effects they create…by a variety of mechanisms…can eradicate tumors in the brain as well as they statistically do in the body. Whatever else you want to think…go right ahead. I think I've made the research clear enough for others.
Ed and Mat…you boys always make me laugh! Now go find another match. I got stuff to do and folks that I might actually be able to help.
Antonio, I hope you have at least gotten some help with your original question. You have certainly gained a lot of different perspectives to say the least.
I wish you all well! C
-
- July 9, 2015 at 8:21 pm
Anon,
At least one of you… You need to read what you are responding to. I have NEVER said that the meds we've been discussing cross the blood brain barrier. I have ALWAYS said that the effects they create…by a variety of mechanisms…can eradicate tumors in the brain as well as they statistically do in the body. Whatever else you want to think…go right ahead. I think I've made the research clear enough for others.
Ed and Mat…you boys always make me laugh! Now go find another match. I got stuff to do and folks that I might actually be able to help.
Antonio, I hope you have at least gotten some help with your original question. You have certainly gained a lot of different perspectives to say the least.
I wish you all well! C
-
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