› Forums › General Melanoma Community › BRAF/MEK fever/chills Advice???
- This topic has 14 replies, 5 voices, and was last updated 13 years, 6 months ago by theonlydrea.
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- April 19, 2011 at 2:34 pm
My husband is starting his fifth week of GSK's Braf/Mek trial. The only side effects he has had prior to now are a fever and chills occurring 4 hours after his dose and lasting about two hours. This did not occur every day, and when it did, it was with varying degrees of intensity.
For the last 24 hours, he has had continuing fever and chills. Sometimes the fever breaks for a short while, but returns. My husband is afraid to call the doctor about this for fear of being taken off the trial, which otherswise seems to be working.
My husband is starting his fifth week of GSK's Braf/Mek trial. The only side effects he has had prior to now are a fever and chills occurring 4 hours after his dose and lasting about two hours. This did not occur every day, and when it did, it was with varying degrees of intensity.
For the last 24 hours, he has had continuing fever and chills. Sometimes the fever breaks for a short while, but returns. My husband is afraid to call the doctor about this for fear of being taken off the trial, which otherswise seems to be working.
Has anyone had these symptoms? Any advice?
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- April 19, 2011 at 3:01 pm
I had the same problem with the fever and the god-awful chills – I could get it to come down and then it would come back – to the point of being exhausting. My fevers got as high as 103. The took me off for 72 hours started me back with the MEK for 72 hours and then the BRAF. Haven't had any problems since then. According to my Dr. the fevers are a VERY common side effect.
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- April 19, 2011 at 3:01 pm
I had the same problem with the fever and the god-awful chills – I could get it to come down and then it would come back – to the point of being exhausting. My fevers got as high as 103. The took me off for 72 hours started me back with the MEK for 72 hours and then the BRAF. Haven't had any problems since then. According to my Dr. the fevers are a VERY common side effect.
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- April 19, 2011 at 9:31 pm
I also had the same exact symptoms after 17 days (i started the same week as Dawn above ๐ ). Same result. I was also taken off the meds for 3 days, then put back on one at a time. No problems since then. I have my 2 month scans next week. Definitely call your trial doc – they'll want to track his symptoms. They won't take him off unless something else is worrying them – ie blood test results, etc. I don't think he has anything to worry about ๐ Good luck!
-Kate
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- April 22, 2011 at 9:58 pm
Hello Kate
Big week coming up for us my friend. My fingers are crossed for you! The scanxiety is setting in big time over here. What day are you going? I will be there on Thursday. Let me know if you will be around maybe we can hook up. Keep me in the loop and let me know how things go. Happy Easter to you!
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- April 22, 2011 at 9:58 pm
Hello Kate
Big week coming up for us my friend. My fingers are crossed for you! The scanxiety is setting in big time over here. What day are you going? I will be there on Thursday. Let me know if you will be around maybe we can hook up. Keep me in the loop and let me know how things go. Happy Easter to you!
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- April 19, 2011 at 9:31 pm
I also had the same exact symptoms after 17 days (i started the same week as Dawn above ๐ ). Same result. I was also taken off the meds for 3 days, then put back on one at a time. No problems since then. I have my 2 month scans next week. Definitely call your trial doc – they'll want to track his symptoms. They won't take him off unless something else is worrying them – ie blood test results, etc. I don't think he has anything to worry about ๐ Good luck!
-Kate
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- April 21, 2011 at 11:04 pm
Just an update–the doctor just advised my husband to take Tylenol and ride it through. The fever finally broke and hasn't returned for two days now. The doctor also said that the new shipment of BRAF from GSK is stronger, so there could be additional side effects.
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- April 21, 2011 at 11:25 pm
is he refering to the dosage that the switched from 3 of 50 to 2 of 75 twice a day. If that is the case I have not noticed anything additional yet = although the "shedding" issues we were discussing did start after that. Glad to hear that he is feeling better. I tried the whole tylenol/advil and they just kept coming back – I wasn't happy about being off of it for the 72 hours but according to them it's very common.
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- April 21, 2011 at 11:25 pm
is he refering to the dosage that the switched from 3 of 50 to 2 of 75 twice a day. If that is the case I have not noticed anything additional yet = although the "shedding" issues we were discussing did start after that. Glad to hear that he is feeling better. I tried the whole tylenol/advil and they just kept coming back – I wasn't happy about being off of it for the 72 hours but according to them it's very common.
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- April 21, 2011 at 11:04 pm
Just an update–the doctor just advised my husband to take Tylenol and ride it through. The fever finally broke and hasn't returned for two days now. The doctor also said that the new shipment of BRAF from GSK is stronger, so there could be additional side effects.
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- April 25, 2011 at 12:04 am
Hi-I was just checking on the board tonight for that very same issue. My brother really battling the fever and chills- and has not yet disclosed to trial doctor. But now I will tell him it is common and they need to track. That is great news that after a short while – maybe 72 hrs after being off the combo-it subsides.
I am going to call him now–thank you for taking the time to post this-it really helped. Best of luck on your progress and keep me posted-feel free to email direct anytime.
MrsMarilyn
Sister of Gary (Stage IV)
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- April 27, 2011 at 5:55 pm
Husband on braf chills a few hours after dosage at night started Easter morning theyrdoc said to take Tylenol . Hair shedding more and more. Tylenol seemed to help. Apt today for 2 week check u -
- April 27, 2011 at 5:55 pm
Husband on braf chills a few hours after dosage at night started Easter morning theyrdoc said to take Tylenol . Hair shedding more and more. Tylenol seemed to help. Apt today for 2 week check u
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- April 25, 2011 at 12:04 am
Hi-I was just checking on the board tonight for that very same issue. My brother really battling the fever and chills- and has not yet disclosed to trial doctor. But now I will tell him it is common and they need to track. That is great news that after a short while – maybe 72 hrs after being off the combo-it subsides.
I am going to call him now–thank you for taking the time to post this-it really helped. Best of luck on your progress and keep me posted-feel free to email direct anytime.
MrsMarilyn
Sister of Gary (Stage IV)
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