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BRAF/MEK fever/chills Advice???

Forums General Melanoma Community BRAF/MEK fever/chills Advice???

  • Post
    mommydog
    Participant

      My husband is starting his fifth week of GSK's  Braf/Mek trial.  The only side effects he has had prior to now are a fever and chills occurring 4 hours after his dose and lasting about two hours.  This did not occur every day, and when it did, it was with varying degrees of intensity.

      For the last 24 hours, he has had continuing fever and chills.  Sometimes the fever breaks for a short while, but returns.  My husband is afraid to call the doctor about this for fear of being taken off the trial, which otherswise seems to be working.

      My husband is starting his fifth week of GSK's  Braf/Mek trial.  The only side effects he has had prior to now are a fever and chills occurring 4 hours after his dose and lasting about two hours.  This did not occur every day, and when it did, it was with varying degrees of intensity.

      For the last 24 hours, he has had continuing fever and chills.  Sometimes the fever breaks for a short while, but returns.  My husband is afraid to call the doctor about this for fear of being taken off the trial, which otherswise seems to be working.

      Has anyone had these symptoms?  Any advice? 

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    • Replies
        dawn dion
        Participant

          I had the same problem with the fever and the god-awful chills – I could get it to come down and then it would come back – to the point of being exhausting.   My fevers got as high as 103.   The took me off for 72 hours started me back with the MEK for 72 hours and then the BRAF.   Haven't had any problems since then.   According to my Dr. the fevers are a VERY common side effect.

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          dawn dion
          Participant

            I had the same problem with the fever and the god-awful chills – I could get it to come down and then it would come back – to the point of being exhausting.   My fevers got as high as 103.   The took me off for 72 hours started me back with the MEK for 72 hours and then the BRAF.   Haven't had any problems since then.   According to my Dr. the fevers are a VERY common side effect.

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            deffk1105
            Participant

              I also had the same exact symptoms after 17 days (i started the same week as Dawn above :) ).  Same result.  I was also taken off the meds for 3 days, then put back on one at a time.  No problems since then.  I have my 2 month scans next week.  Definitely call your trial doc – they'll want to track his symptoms.  They won't take him off unless something else is worrying them – ie blood test results, etc.  I don't think he has anything to worry about :)  Good luck!

              -Kate

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                dawn dion
                Participant

                   

                  Hello Kate 

                  Big week coming up for us my friend.  My fingers are crossed for you!  The scanxiety is setting in big time over here.  What day are you going?  I will be there on Thursday.  Let me know if you will be around maybe we can hook up.   Keep me in the loop and let me know how things go.  Happy Easter to you!

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                  dawn dion
                  Participant

                     

                    Hello Kate 

                    Big week coming up for us my friend.  My fingers are crossed for you!  The scanxiety is setting in big time over here.  What day are you going?  I will be there on Thursday.  Let me know if you will be around maybe we can hook up.   Keep me in the loop and let me know how things go.  Happy Easter to you!

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                  deffk1105
                  Participant

                    I also had the same exact symptoms after 17 days (i started the same week as Dawn above :) ).  Same result.  I was also taken off the meds for 3 days, then put back on one at a time.  No problems since then.  I have my 2 month scans next week.  Definitely call your trial doc – they'll want to track his symptoms.  They won't take him off unless something else is worrying them – ie blood test results, etc.  I don't think he has anything to worry about :)  Good luck!

                    -Kate

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                    mommydog
                    Participant

                      Just an update–the doctor just advised my husband to take Tylenol and ride it through.  The fever finally broke and hasn't returned for two days now.  The doctor also said that the new shipment of  BRAF from GSK is stronger, so there could be additional side effects.  

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                        dawn dion
                        Participant

                          is he refering to the dosage that the switched from 3 of 50 to 2 of 75 twice a day.   If that is the case I have not noticed anything additional yet = although the "shedding" issues we were discussing did start after that.   Glad to hear that he is feeling better.    I tried the whole tylenol/advil and they just kept coming back – I wasn't happy about being off of it for the 72 hours but according to them it's very common.

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                          dawn dion
                          Participant

                            is he refering to the dosage that the switched from 3 of 50 to 2 of 75 twice a day.   If that is the case I have not noticed anything additional yet = although the "shedding" issues we were discussing did start after that.   Glad to hear that he is feeling better.    I tried the whole tylenol/advil and they just kept coming back – I wasn't happy about being off of it for the 72 hours but according to them it's very common.

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                          mommydog
                          Participant

                            Just an update–the doctor just advised my husband to take Tylenol and ride it through.  The fever finally broke and hasn't returned for two days now.  The doctor also said that the new shipment of  BRAF from GSK is stronger, so there could be additional side effects.  

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                            mrsmarilyn
                            Participant

                              Hi-I was just checking on the board tonight for that very same issue.  My brother really battling the fever and chills- and has not yet disclosed to trial doctor.  But now I will tell him it is common and they need to track.  That is great news that after a short while – maybe 72 hrs after being off the combo-it subsides.

                               

                              I am going to call him now–thank you for taking the time to post this-it really helped. Best of luck on your progress and keep me posted-feel free to email direct anytime.

                              MrsMarilyn

                              Sister of Gary (Stage IV)

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                                theonlydrea
                                Participant
                                  Husband on braf chills a few hours after dosage at night started Easter morning theyrdoc said to take Tylenol . Hair shedding more and more. Tylenol seemed to help. Apt today for 2 week check u

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                                  theonlydrea
                                  Participant
                                    Husband on braf chills a few hours after dosage at night started Easter morning theyrdoc said to take Tylenol . Hair shedding more and more. Tylenol seemed to help. Apt today for 2 week check u

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                                  mrsmarilyn
                                  Participant

                                    Hi-I was just checking on the board tonight for that very same issue.  My brother really battling the fever and chills- and has not yet disclosed to trial doctor.  But now I will tell him it is common and they need to track.  That is great news that after a short while – maybe 72 hrs after being off the combo-it subsides.

                                     

                                    I am going to call him now–thank you for taking the time to post this-it really helped. Best of luck on your progress and keep me posted-feel free to email direct anytime.

                                    MrsMarilyn

                                    Sister of Gary (Stage IV)

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