So sorry for your friend. There is Michael Postow, Jed Wolchok, and Paul Chapman at Memorial Sloan Kettering. Stephen Hodi at Dana-Farber. Mario Sznol at Yale. And…you know my fav, Jeffrey Weber at NYU. All of these docs are incredible in regard to melanoma care, with their names on a huge percentage of the research, with international reputations.
I have yelled about if so much…but…it sounds like what you friend's wife needs ASAP is SRS or gamma knife…localized radiaiton to her brain mets. We have learned that the combined effects of radiation WITH immunotherapy provides response that neither alone can achieve. There are a zillion posts/reports/abstracts on my blog. Just put radiation and immunotherapy in the search bubble.
Should LMD rear it's seriously ugly head… As far as what I've heard last, MD Anderson is the only place doing intrathecal infusions. Lately, starting a trial with intrathecal nivo along with intraveneous nivo. Check out Rob's posts…under 'Adriana Cooper'…if the need arises. I will keep all fingers and toes crossed that it will not.