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2nd scans post Yervoy (IPPI)
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2nd scans post Yervoy (IPPI)

› Forums › General Melanoma Community › 2nd scans post Yervoy (IPPI)

  • Post
    • April 12, 2012 at 7:24 pm
    gabsound
    Participant
      I finally have some good news to report!

      Quick review: Dx Feb 2011 WLE SNLB positive microscopic 1 node. Complete rt groin dissection- rest of nodes negative. Did high dose interferon May 2011, 1 high dose injection then stopped. Surgery July 1 for recurrence at bottom of lymph node scar. Did 4 rounds biochemo- July , august, sep, oct. Recurrence again in same area surgery end November. Started Yervoy end dec had 2 rounds then did radiation to right leg 20 treatments. Finished 4th Yervoy on 2/15/2012.

      First PET/CT post Yervoy 02/28/2012 showed “Extensive progression of malignant disease with development of multiple, hepatic, osseous and pulmonary metastatic lesions.”

      Labs were also awful- LDH got up to 414. Liver enzymes markedly elevated alk phosphatase 374, ast 499, alt 1106.

      Labs yesterday-LDH 152 normal!!. Liver enzymes alk phosphotase 142, ast 81, alt, 111 these are still a little high, but markedly improved.
      PET/CT: ” Very pronounced improvement in metastatic disease. Most of the pulmonary modules noted previously are no longer visible. A few small punctate nodules remain. Only one has identifiable activity on PET portion with < 1 SUV. It measures only a few millimeters. Hepatic metastatic disease has significantly improved. Very significant improvement in skeletal metastatic disease. Many lesions are no longer visible." Hallelujah!!!!!!!! Can't stop doing the happy dance. I'm praying for all to see some improvement in their disease and even a cure. Hope this post gives some hope to others. I really wonder if the biochemo with IL2 followed by Yervoy along with some radiation is the key to my body finally getting the message. Julie in Las Vegas

    Viewing 17 reply threads
    • Replies
        • April 12, 2012 at 10:27 pm
        H555
        Participant

          congratulations. a very very good reason to celebrate. I am very happy for you and your family.

          • April 12, 2012 at 10:27 pm
          H555
          Participant

            congratulations. a very very good reason to celebrate. I am very happy for you and your family.

            • April 12, 2012 at 10:27 pm
            H555
            Participant

              congratulations. a very very good reason to celebrate. I am very happy for you and your family.

              • April 13, 2012 at 3:36 am
              UrsulaZ
              Participant

                OK: That's the best news I've heard all day! A clink of the glass to you. 

                • April 13, 2012 at 3:36 am
                UrsulaZ
                Participant

                  OK: That's the best news I've heard all day! A clink of the glass to you. 

                  • April 13, 2012 at 3:36 am
                  UrsulaZ
                  Participant

                    OK: That's the best news I've heard all day! A clink of the glass to you. 

                    • April 13, 2012 at 6:53 am
                    LynnLuc
                    Participant

                      great news!!

                      • April 13, 2012 at 6:53 am
                      LynnLuc
                      Participant

                        great news!!

                        • April 13, 2012 at 6:53 am
                        LynnLuc
                        Participant

                          great news!!

                          • April 13, 2012 at 12:26 pm
                          jim Breitfeller
                          Participant

                            Julie, Congrats!!!!!

                            "I really wonder if the biochemo with IL2 followed by Yervoy along with some radiation is the key to my body finally getting the message .".."

                            You are right on target. The biochem with IL-2 primed your Immune system, while Yervoy deactivated the T-Regs cell suppression of your T-cells. Radiation added the tumor cell debris that is needed to be presented on the Dendritic Cells which are acting as the Antigen Presenting Cells (APCs). It can be presented in this Diagram.

                             

                             

                             

                            Best regards,

                             

                            Jimmy B

                            • April 13, 2012 at 12:26 pm
                            jim Breitfeller
                            Participant

                              Julie, Congrats!!!!!

                              "I really wonder if the biochemo with IL2 followed by Yervoy along with some radiation is the key to my body finally getting the message .".."

                              You are right on target. The biochem with IL-2 primed your Immune system, while Yervoy deactivated the T-Regs cell suppression of your T-cells. Radiation added the tumor cell debris that is needed to be presented on the Dendritic Cells which are acting as the Antigen Presenting Cells (APCs). It can be presented in this Diagram.

                               

                               

                               

                              Best regards,

                               

                              Jimmy B

                              • April 13, 2012 at 12:26 pm
                              jim Breitfeller
                              Participant

                                Julie, Congrats!!!!!

                                "I really wonder if the biochemo with IL2 followed by Yervoy along with some radiation is the key to my body finally getting the message .".."

                                You are right on target. The biochem with IL-2 primed your Immune system, while Yervoy deactivated the T-Regs cell suppression of your T-cells. Radiation added the tumor cell debris that is needed to be presented on the Dendritic Cells which are acting as the Antigen Presenting Cells (APCs). It can be presented in this Diagram.

                                 

                                 

                                 

                                Best regards,

                                 

                                Jimmy B

                                • April 13, 2012 at 9:59 pm
                                MeNDave
                                Participant

                                  I am so glad I checked the board today…. I needed to see a positive post!  I am so happy for you and your family.  Keep going… you got this girl!

                                  • April 13, 2012 at 9:59 pm
                                  MeNDave
                                  Participant

                                    I am so glad I checked the board today…. I needed to see a positive post!  I am so happy for you and your family.  Keep going… you got this girl!

                                    • April 13, 2012 at 9:59 pm
                                    MeNDave
                                    Participant

                                      I am so glad I checked the board today…. I needed to see a positive post!  I am so happy for you and your family.  Keep going… you got this girl!

                                      • April 14, 2012 at 1:24 am
                                      SABKLYN
                                      Participant

                                        Great news! 

                                        • April 14, 2012 at 1:24 am
                                        SABKLYN
                                        Participant

                                          Great news! 

                                          • April 14, 2012 at 1:24 am
                                          SABKLYN
                                          Participant

                                            Great news! 

                                        Viewing 17 reply threads
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