15 week scan results after 4th ipi infusion

This topic has 22 replies, 6 voices, and was last updated 12 years, 7 months ago by jim Breitfeller.

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- September 30, 2011 at 12:21 pm
- Quote
petie540
Participant
I'm in a clinical trial taking ipi at 10mg. plus GSM 250 14 out of 21 days. Finished 4th infusion two weeks ago, scan yesterday. Results showed over a 60% reduction in the lung mets, now nothing over 3mm. No spread any where else. My doctor was thrilled saying how unusual it is to show this kind of response on the first scan/mri. It's been quite a roller coaster with good and bad scans, but this feels like it could be really good. Very bad rash from ipi, taking prednisone 10-20mg for months,but of couse I'll take it.

I'm in a clinical trial taking ipi at 10mg. plus GSM 250 14 out of 21 days. Finished 4th infusion two weeks ago, scan yesterday. Results showed over a 60% reduction in the lung mets, now nothing over 3mm. No spread any where else. My doctor was thrilled saying how unusual it is to show this kind of response on the first scan/mri. It's been quite a roller coaster with good and bad scans, but this feels like it could be really good. Very bad rash from ipi, taking prednisone 10-20mg for months,but of couse I'll take it. My adrenals are enlarged but she is unconcerned saying it reveal the intensity of my immune response. Next scan in December with ipi maintenance also in december.

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Replies

- - September 30, 2011 at 12:40 pm
  - Quote
  Lisa13
  Participant
  I'm so happy for you! This is fabulous news and I know how relieved and thankful you must be.
  
  I'm also in a clinical trial with just ipi and have lung mets. I hope on Oct 31st, my scans prove to be as successful as yours.
  
  Best of luck with continued success and no further spread.
  
  Lisa – Stage 4
- - September 30, 2011 at 12:40 pm
  - Quote
  Lisa13
  Participant
  I'm so happy for you! This is fabulous news and I know how relieved and thankful you must be.
  
  I'm also in a clinical trial with just ipi and have lung mets. I hope on Oct 31st, my scans prove to be as successful as yours.
  
  Best of luck with continued success and no further spread.
  
  Lisa – Stage 4
  - September 30, 2011 at 4:31 pm
    
    Quote
    jim Breitfeller
    Participant
    
    4 courses of ipilimumab administered every 3 weeks intravenously in a dose of 10 mg/kg. 4 X 21 days Plus 2 weeks out (14 days) = 98 days from the start of your treatment with Ipi + GSM 250
    
    Check out the timeline Graph!!!
    
    You may be on your way to a compete response!!!! Congrats!!!
    
    Jimmy B
  - September 30, 2011 at 4:34 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Yervoy therapy graphic.
    
    Graphic for downloading.
    
    http://2.bp.blogspot.com/-Bkp8ysLnlCY/ToXuykM4MVI/AAAAAAAAAgs/BRXLG5_YwfM/s1600/Yervoy%2BProtocol%2B2011.jpg
  - September 30, 2011 at 4:34 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Yervoy therapy graphic.
    
    Graphic for downloading.
    
    http://2.bp.blogspot.com/-Bkp8ysLnlCY/ToXuykM4MVI/AAAAAAAAAgs/BRXLG5_YwfM/s1600/Yervoy%2BProtocol%2B2011.jpg
  - October 6, 2011 at 1:04 pm
    
    Quote
    petie540
    Participant
    
    Jimmy B. From your mouth…. How do you know so much and do you really think this could sggest a durable response
  - October 6, 2011 at 1:46 pm
    
    Quote
    jim Breitfeller
    Participant
    
    petie540,
    
    As a stage IV Melanoma Survivor, I spent the last 4 years educating myself on the drugs/therapies that activate the immune system response. I know I can relapse at anytime and I want to be prepared when that time arises.
    
    If you know how the immune system works and how the drugs interact with the immune system, then you can make educated decisions on the therapies that make the most sense.
    
    With that said, I am going to leave you with a graphic and a video.
    
    The graph is the culmination of my research.
    
    http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s400/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    The video is of a new drug called CT-011, Anti-PD-1 antibodies
    
    CT-011
    
    http://www.curetechbio.com/?TemplateID=29&PageID=181&TemplateType=14
    
    Best Regards,
    
    Jimmy B
  - October 6, 2011 at 1:46 pm
    
    Quote
    jim Breitfeller
    Participant
    
    petie540,
    
    As a stage IV Melanoma Survivor, I spent the last 4 years educating myself on the drugs/therapies that activate the immune system response. I know I can relapse at anytime and I want to be prepared when that time arises.
    
    If you know how the immune system works and how the drugs interact with the immune system, then you can make educated decisions on the therapies that make the most sense.
    
    With that said, I am going to leave you with a graphic and a video.
    
    The graph is the culmination of my research.
    
    http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s400/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    The video is of a new drug called CT-011, Anti-PD-1 antibodies
    
    CT-011
    
    http://www.curetechbio.com/?TemplateID=29&PageID=181&TemplateType=14
    
    Best Regards,
    
    Jimmy B
  - October 6, 2011 at 1:52 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Sorry,
    
    I gave the wrong address for graph. The size setting was wrong.
    
    <a href="http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s1600/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    Jimmy B
  - October 6, 2011 at 1:52 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Sorry,
    
    I gave the wrong address for graph. The size setting was wrong.
    
    <a href="http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s1600/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    Jimmy B
  - October 6, 2011 at 1:52 pm
    
    Quote
    jim Breitfeller
    Participant
    
    Sorry,
    
    I gave the wrong address for graph. The size setting was wrong.
    
    <a href="http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s1600/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    Jimmy B
  - October 6, 2011 at 1:46 pm
    
    Quote
    jim Breitfeller
    Participant
    
    petie540,
    
    As a stage IV Melanoma Survivor, I spent the last 4 years educating myself on the drugs/therapies that activate the immune system response. I know I can relapse at anytime and I want to be prepared when that time arises.
    
    If you know how the immune system works and how the drugs interact with the immune system, then you can make educated decisions on the therapies that make the most sense.
    
    With that said, I am going to leave you with a graphic and a video.
    
    The graph is the culmination of my research.
    
    http://4.bp.blogspot.com/-lBVrZ5Y1Gkw/Tn0284c9_cI/AAAAAAAAAe8/57kjY15jf90/s400/The%2Bultimate%2Bcombo%2Btherapy%2B9-23-11.jpg
    
    The video is of a new drug called CT-011, Anti-PD-1 antibodies
    
    CT-011
    
    http://www.curetechbio.com/?TemplateID=29&PageID=181&TemplateType=14
    
    Best Regards,
    
    Jimmy B
  - October 6, 2011 at 1:04 pm
    
    Quote
    petie540
    Participant
    
    Jimmy B. From your mouth…. How do you know so much and do you really think this could sggest a durable response
  - October 6, 2011 at 1:04 pm
    
    Quote
    petie540
    Participant
    
    Jimmy B. From your mouth…. How do you know so much and do you really think this could sggest a durable response
  - September 30, 2011 at 4:31 pm
    
    Quote
    jim Breitfeller
    Participant
    
    4 courses of ipilimumab administered every 3 weeks intravenously in a dose of 10 mg/kg. 4 X 21 days Plus 2 weeks out (14 days) = 98 days from the start of your treatment with Ipi + GSM 250
    
    Check out the timeline Graph!!!
    
    You may be on your way to a compete response!!!! Congrats!!!
    
    Jimmy B
- - September 30, 2011 at 11:40 pm
  - Quote
  LynnLuc
  Participant
  This is very good news!! Blessings !
  - October 1, 2011 at 11:44 am
    
    Quote
    Vermont_Donna
    Participant
    
    Yay! Sounds like great news!
    
    Vermont_Donna, stage 3a, NED
    
    complete responder to yervoy
  - October 6, 2011 at 1:13 pm
    
    Quote
    NYKaren
    Participant
    
    Great news! Hope it's contageous.
    
    karen
  - October 6, 2011 at 1:13 pm
    
    Quote
    NYKaren
    Participant
    
    Great news! Hope it's contageous.
    
    karen
  - October 6, 2011 at 1:13 pm
    
    Quote
    NYKaren
    Participant
    
    Great news! Hope it's contageous.
    
    karen
  - October 1, 2011 at 11:44 am
    
    Quote
    Vermont_Donna
    Participant
    
    Yay! Sounds like great news!
    
    Vermont_Donna, stage 3a, NED
    
    complete responder to yervoy
- - September 30, 2011 at 11:40 pm
  - Quote
  LynnLuc
  Participant
  This is very good news!! Blessings !