Zelboraf it is.
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Zelboraf it is.

› Forums › General Melanoma Community › Zelboraf it is.

  • Post
    • February 25, 2012 at 4:12 am
    himynameiskevin
    Participant

    Well it turns out because of the recent brain mets and steroids, I don't qualify for any trials I was hoping for right now. The news was a little disappointing, but kind of expected and completely understandable. I know that if Zelboraf does work for me, it's only a temporary solution, which makes me a little nervous, but I remind myself a temporary solution is better than no solution, and if all works out, maybe it'll get me to a point of stability where I could qualify for a trial of some kind down the line.

    Well it turns out because of the recent brain mets and steroids, I don't qualify for any trials I was hoping for right now. The news was a little disappointing, but kind of expected and completely understandable. I know that if Zelboraf does work for me, it's only a temporary solution, which makes me a little nervous, but I remind myself a temporary solution is better than no solution, and if all works out, maybe it'll get me to a point of stability where I could qualify for a trial of some kind down the line. I'll be seeing a doctor on Wednesday and hopefully get started on Zelboraf as soon as possible. I also have another brain MRI Monday morning to assess what might be a possible lesion or two, but might just be blood vessels. I'd be ok with either, just praying that nothing new shows up. I'm a little anxious and a little nervous at the moment, having the weekend of waiting in front of me. But I'm hanging in there and know these feelings will pass, as they have before, just have to stay focused, and remember all the things to be thankful and hopeful for. Thanks for hearing me out.

    As always, I'm thinking and hoping for the best, for all of us.
    -Kevin

Viewing 23 reply threads
  • Replies
      • February 25, 2012 at 4:25 am
      WendyPam
      Participant

      Hi Kevin,

      Zeloraf doesn't have to be considered temporary. If you go on MIF a gentlemen Dick has been on it 2 years! (dick_k)  Kevin I am sending you great positive vibes. Others have had wonderful results with Zelboraf for over 6+ months and still going strong…

      My Mom is Stage 4 doing a reinduction of Yervoy,…….

       

      Wendy

        • February 25, 2012 at 3:45 pm
        Richard_K
        Participant

        I also post on this forum under Dick_K and my profile is current.

        Dick

        • February 25, 2012 at 3:45 pm
        Richard_K
        Participant

        I also post on this forum under Dick_K and my profile is current.

        Dick

        • February 25, 2012 at 3:45 pm
        Richard_K
        Participant

        I also post on this forum under Dick_K and my profile is current.

        Dick

      • February 25, 2012 at 4:25 am
      WendyPam
      Participant

      Hi Kevin,

      Zeloraf doesn't have to be considered temporary. If you go on MIF a gentlemen Dick has been on it 2 years! (dick_k)  Kevin I am sending you great positive vibes. Others have had wonderful results with Zelboraf for over 6+ months and still going strong…

      My Mom is Stage 4 doing a reinduction of Yervoy,…….

       

      Wendy

      • February 25, 2012 at 4:25 am
      WendyPam
      Participant

      Hi Kevin,

      Zeloraf doesn't have to be considered temporary. If you go on MIF a gentlemen Dick has been on it 2 years! (dick_k)  Kevin I am sending you great positive vibes. Others have had wonderful results with Zelboraf for over 6+ months and still going strong…

      My Mom is Stage 4 doing a reinduction of Yervoy,…….

       

      Wendy

      • February 25, 2012 at 11:23 am
      aldakota22
      Participant

      Hang in there . Zelboraf has shown to work and is working longer on average more than 2x than thought.Time is both our freind and enemy.Praying it all works out for you.

      • February 25, 2012 at 11:23 am
      aldakota22
      Participant

      Hang in there . Zelboraf has shown to work and is working longer on average more than 2x than thought.Time is both our freind and enemy.Praying it all works out for you.

      • February 25, 2012 at 11:23 am
      aldakota22
      Participant

      Hang in there . Zelboraf has shown to work and is working longer on average more than 2x than thought.Time is both our freind and enemy.Praying it all works out for you.

      • February 25, 2012 at 11:57 am
      scots
      Participant
      Keep that positive attitude . I will be praying for you.
      Scot
      • February 25, 2012 at 11:57 am
      scots
      Participant
      Keep that positive attitude . I will be praying for you.
      Scot
      • February 25, 2012 at 11:57 am
      scots
      Participant
      Keep that positive attitude . I will be praying for you.
      Scot
      • February 25, 2012 at 1:33 pm
      Lori C
      Participant

      That sounds like a good plan, Kevin.  You have been and will continue to be in my thoughts & prayers.  You are fighting this with courage and great spirit. 

       

      Lori, caregiver to Will

      • February 25, 2012 at 1:33 pm
      Lori C
      Participant

      That sounds like a good plan, Kevin.  You have been and will continue to be in my thoughts & prayers.  You are fighting this with courage and great spirit. 

       

      Lori, caregiver to Will

      • February 25, 2012 at 1:33 pm
      Lori C
      Participant

      That sounds like a good plan, Kevin.  You have been and will continue to be in my thoughts & prayers.  You are fighting this with courage and great spirit. 

       

      Lori, caregiver to Will

      • February 25, 2012 at 1:39 pm
      jag
      Participant

      Hey Kevin, the nice thing is to know that you haven't run out of treatment options.

      • February 25, 2012 at 1:39 pm
      jag
      Participant

      Hey Kevin, the nice thing is to know that you haven't run out of treatment options.

        • February 25, 2012 at 1:41 pm
        jag
        Participant

        Oops, hit the reply button to soon.  Best of Luck.

        John

        • February 25, 2012 at 1:41 pm
        jag
        Participant

        Oops, hit the reply button to soon.  Best of Luck.

        John

        • February 25, 2012 at 1:41 pm
        jag
        Participant

        Oops, hit the reply button to soon.  Best of Luck.

        John

      • February 25, 2012 at 1:39 pm
      jag
      Participant

      Hey Kevin, the nice thing is to know that you haven't run out of treatment options.

      • February 25, 2012 at 1:45 pm
      boot2aboot
      Participant

      If Zelboraf fails, you might consider a braf/mek combo…it is approved for prior braf users….more and more, i have come to realize we must not only act as advocates for ourselves but others suffering with the beast….

      Phase II Trial of Mitogen Activated Protein (MAP) Kinase Inhibition With AZD6244 and MK-2206 (Akt Inhibitor) in Patients With Relapsed (BRAF) V600E Mutant Advanced MelanomaNCT01510444

      exclusions: Patients with active central nervous system (CNS) metastases are excluded. Patients with a history of CNS metastasis that have been treated must be stable for 8 weeks after completion of treatment, with image documentation required.

      Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies

      NCT00948467

      exclusions:Symptomatic brain metastases

       

      i don't know if your brain tumors are 'stable' and unsymptomatic, but if they are then there are two studies currently available when and if zelboraf fails

      Please read my secondary cancer article also

      boots

      • February 25, 2012 at 1:45 pm
      boot2aboot
      Participant

      If Zelboraf fails, you might consider a braf/mek combo…it is approved for prior braf users….more and more, i have come to realize we must not only act as advocates for ourselves but others suffering with the beast….

      Phase II Trial of Mitogen Activated Protein (MAP) Kinase Inhibition With AZD6244 and MK-2206 (Akt Inhibitor) in Patients With Relapsed (BRAF) V600E Mutant Advanced MelanomaNCT01510444

      exclusions: Patients with active central nervous system (CNS) metastases are excluded. Patients with a history of CNS metastasis that have been treated must be stable for 8 weeks after completion of treatment, with image documentation required.

      Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies

      NCT00948467

      exclusions:Symptomatic brain metastases

       

      i don't know if your brain tumors are 'stable' and unsymptomatic, but if they are then there are two studies currently available when and if zelboraf fails

      Please read my secondary cancer article also

      boots

        • February 28, 2012 at 3:13 pm
        o2bcheri
        Participant

         

        Hi Kevin,

         

        you are so young…  i don't know how you feel about alternative therapy… but… check out http://www.ncrf.org….

        http://checkmedaily.com/health-beauty/diagnosed-no-evidence-of-cancer-treatment/ 

         

        some testimonials… if i had cancer… this is where i would run… have been reading up on it for a few weeks..

        have it myself.. and for my daughter who has MS… my intuition tells me its the real thing…

        good luck Kevin…  sending you many hugs and prayers…

         

        xx

        • February 28, 2012 at 3:13 pm
        o2bcheri
        Participant

         

        Hi Kevin,

         

        you are so young…  i don't know how you feel about alternative therapy… but… check out http://www.ncrf.org….

        http://checkmedaily.com/health-beauty/diagnosed-no-evidence-of-cancer-treatment/ 

         

        some testimonials… if i had cancer… this is where i would run… have been reading up on it for a few weeks..

        have it myself.. and for my daughter who has MS… my intuition tells me its the real thing…

        good luck Kevin…  sending you many hugs and prayers…

         

        xx

        • February 28, 2012 at 3:13 pm
        o2bcheri
        Participant

         

        Hi Kevin,

         

        you are so young…  i don't know how you feel about alternative therapy… but… check out http://www.ncrf.org….

        http://checkmedaily.com/health-beauty/diagnosed-no-evidence-of-cancer-treatment/ 

         

        some testimonials… if i had cancer… this is where i would run… have been reading up on it for a few weeks..

        have it myself.. and for my daughter who has MS… my intuition tells me its the real thing…

        good luck Kevin…  sending you many hugs and prayers…

         

        xx

        • February 29, 2012 at 5:29 pm
        jag
        Participant

        Kevin, if you are even considering looking at this crap, don't waste your time.  Another sleazebag hawking snake oil on the internet.  Don't get distracted and focus on your care.  

        • February 29, 2012 at 5:29 pm
        jag
        Participant

        Kevin, if you are even considering looking at this crap, don't waste your time.  Another sleazebag hawking snake oil on the internet.  Don't get distracted and focus on your care.  

        • February 29, 2012 at 5:29 pm
        jag
        Participant

        Kevin, if you are even considering looking at this crap, don't waste your time.  Another sleazebag hawking snake oil on the internet.  Don't get distracted and focus on your care.  

      • February 25, 2012 at 1:45 pm
      boot2aboot
      Participant

      If Zelboraf fails, you might consider a braf/mek combo…it is approved for prior braf users….more and more, i have come to realize we must not only act as advocates for ourselves but others suffering with the beast….

      Phase II Trial of Mitogen Activated Protein (MAP) Kinase Inhibition With AZD6244 and MK-2206 (Akt Inhibitor) in Patients With Relapsed (BRAF) V600E Mutant Advanced MelanomaNCT01510444

      exclusions: Patients with active central nervous system (CNS) metastases are excluded. Patients with a history of CNS metastasis that have been treated must be stable for 8 weeks after completion of treatment, with image documentation required.

      Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies

      NCT00948467

      exclusions:Symptomatic brain metastases

       

      i don't know if your brain tumors are 'stable' and unsymptomatic, but if they are then there are two studies currently available when and if zelboraf fails

      Please read my secondary cancer article also

      boots

      • February 29, 2012 at 3:38 pm
      davidfromsingapore
      Participant
      Kevin- you are going to beat this disease. The drugs are getting better each month. For example scientists just came out with a way to overcome Zelboraf’s resistance. Stay strong! David
      • February 29, 2012 at 3:38 pm
      davidfromsingapore
      Participant
      Kevin- you are going to beat this disease. The drugs are getting better each month. For example scientists just came out with a way to overcome Zelboraf’s resistance. Stay strong! David
      • February 29, 2012 at 3:38 pm
      davidfromsingapore
      Participant
      Kevin- you are going to beat this disease. The drugs are getting better each month. For example scientists just came out with a way to overcome Zelboraf’s resistance. Stay strong! David
      • February 29, 2012 at 4:12 pm
      himynameiskevin
      Participant

      Thank you all for the replies, thoughts and information. I see a doctor in 6 hours about the results of Monday's brain MRI (hoping for stability and shrinkage, but if need be, another round of SRS would be fine, just praying nothing new is showing up, and hopefully get clearance to get off this steroid).  And in 7 1/2 hours, I'll be talking to another doctor about starting the Zelboraf. Big day. Hoping and praying for the best. -Kevin

      • February 29, 2012 at 4:12 pm
      himynameiskevin
      Participant

      Thank you all for the replies, thoughts and information. I see a doctor in 6 hours about the results of Monday's brain MRI (hoping for stability and shrinkage, but if need be, another round of SRS would be fine, just praying nothing new is showing up, and hopefully get clearance to get off this steroid).  And in 7 1/2 hours, I'll be talking to another doctor about starting the Zelboraf. Big day. Hoping and praying for the best. -Kevin

      • February 29, 2012 at 4:12 pm
      himynameiskevin
      Participant

      Thank you all for the replies, thoughts and information. I see a doctor in 6 hours about the results of Monday's brain MRI (hoping for stability and shrinkage, but if need be, another round of SRS would be fine, just praying nothing new is showing up, and hopefully get clearance to get off this steroid).  And in 7 1/2 hours, I'll be talking to another doctor about starting the Zelboraf. Big day. Hoping and praying for the best. -Kevin

Viewing 23 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

Popular Topics