Are there markers that can be used to determine Keytruda will work?
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Are there markers that can be used to determine Keytruda will work?

› Forums › General Melanoma Community › Are there markers that can be used to determine Keytruda will work?

  • Post
    • July 18, 2016 at 10:34 pm
    Edwilcox
    Participant

    A friend with stage 4 melanoma went through Ipilimumab treatment, but he subsequently had some new tumors show up. He was then put on the combination Dabrafenib and Tramethinib. His tumors are now escaping these enzyme blockers. His oncologist is now proposing to test him to see if Keytruda will work for him.

    I didn't know there were markers that could predict Keytruda response. What are they?

    Thanks for your help.

Viewing 8 reply threads
  • Replies
      • July 18, 2016 at 10:51 pm
      Aaron
      Participant

      There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

      • July 18, 2016 at 10:51 pm
      Aaron
      Participant

      There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

      • July 18, 2016 at 10:51 pm
      Aaron
      Participant

      There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

        • July 18, 2016 at 11:24 pm
        ed williams
        Participant

        What are the markers Aaron?

        • July 18, 2016 at 11:24 pm
        ed williams
        Participant

        What are the markers Aaron?

        • July 18, 2016 at 11:24 pm
        ed williams
        Participant

        What are the markers Aaron?

        • July 19, 2016 at 1:33 am
        Aaron
        Participant

        I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

        • July 19, 2016 at 1:33 am
        Aaron
        Participant

        I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

        • July 19, 2016 at 1:33 am
        Aaron
        Participant

        I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

      • July 19, 2016 at 6:22 am
      MoiraM
      Participant

      I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

      • July 19, 2016 at 6:22 am
      MoiraM
      Participant

      I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

      • July 19, 2016 at 6:22 am
      MoiraM
      Participant

      I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

      • July 20, 2016 at 4:45 am
      Bubbles
      Participant

      Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

      Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

      Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

      Wishing you all my best. Celeste

       

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

        • July 20, 2016 at 6:30 am
        MoiraM
        Participant

        Thank you.

      • July 20, 2016 at 4:45 am
      Bubbles
      Participant

      Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

      Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

      Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

      Wishing you all my best. Celeste

       

      • July 20, 2016 at 4:45 am
      Bubbles
      Participant

      Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

      Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

      Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

      Wishing you all my best. Celeste

       

Viewing 8 reply threads
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