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Are there markers that can be used to determine Keytruda will work?
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Are there markers that can be used to determine Keytruda will work?

› Forums › General Melanoma Community › Are there markers that can be used to determine Keytruda will work?

  • Post
    • July 18, 2016 at 10:34 pm
    Edwilcox
    Participant

      A friend with stage 4 melanoma went through Ipilimumab treatment, but he subsequently had some new tumors show up. He was then put on the combination Dabrafenib and Tramethinib. His tumors are now escaping these enzyme blockers. His oncologist is now proposing to test him to see if Keytruda will work for him.

      I didn't know there were markers that could predict Keytruda response. What are they?

      Thanks for your help.

    Viewing 8 reply threads
    • Replies
        • July 18, 2016 at 10:51 pm
        Aaron
        Participant

          There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

          • July 18, 2016 at 10:51 pm
          Aaron
          Participant

            There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

            • July 18, 2016 at 10:51 pm
            Aaron
            Participant

              There are markers but they are not 100% accurate. They can be used to give a good indication but there are people who will respond who according to the markers should not respond. 

                • July 18, 2016 at 11:24 pm
                ed williams
                Participant

                  What are the markers Aaron?

                  • July 19, 2016 at 1:33 am
                  Aaron
                  Participant

                    I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

                    • July 19, 2016 at 1:33 am
                    Aaron
                    Participant

                      I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

                      • July 19, 2016 at 1:33 am
                      Aaron
                      Participant

                        I can not find the exact article where I first read about this but I did a Google search and found several articles/stories similar to the one I read.   I would provide links to the articles but since I am new to this I can't seem to figure it out how to post one.  I searched " pdl1 testing" along with "accuracy" and "efficacy" as well as immunotherapy testing accuracy and efficacy. Several stories come up about the tests and how they are not 100% accurate and should not solely be relied upon since some people do respond who in theory should not respond.  the fear I see possibly presenting itself is that if the test is done and comes back tht you may not be a responder that may make insurance assistance in getting treatment more difficult???? 

                        • July 18, 2016 at 11:24 pm
                        ed williams
                        Participant

                          What are the markers Aaron?

                          • July 18, 2016 at 11:24 pm
                          ed williams
                          Participant

                            What are the markers Aaron?

                          • July 19, 2016 at 6:22 am
                          MoiraM
                          Participant

                            I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

                            • July 19, 2016 at 6:22 am
                            MoiraM
                            Participant

                              I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

                              • July 19, 2016 at 6:22 am
                              MoiraM
                              Participant

                                I did not think any markers had been found that correlate with 'responder to Keytruda' or 'responder to Ipi'. I would also like to know the reference.

                                • July 20, 2016 at 4:45 am
                                Bubbles
                                Participant

                                  Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

                                  Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

                                  Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

                                  Wishing you all my best. Celeste

                                   

                                  • July 20, 2016 at 4:45 am
                                  Bubbles
                                  Participant

                                    Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

                                    Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

                                    Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

                                    Wishing you all my best. Celeste

                                     

                                      • July 20, 2016 at 6:30 am
                                      MoiraM
                                      Participant

                                        Thank you.

                                        • July 20, 2016 at 6:30 am
                                        MoiraM
                                        Participant

                                          Thank you.

                                          • July 20, 2016 at 6:30 am
                                          MoiraM
                                          Participant

                                            Thank you.

                                            • July 20, 2016 at 6:30 am
                                            MoiraM
                                            Participant

                                              Thank you.

                                              • July 20, 2016 at 6:30 am
                                              MoiraM
                                              Participant

                                                Thank you.

                                                • July 20, 2016 at 6:30 am
                                                MoiraM
                                                Participant

                                                  Thank you.

                                                • July 20, 2016 at 4:45 am
                                                Bubbles
                                                Participant

                                                  Markers that predict or measure reponse to various therapies are a point of inquiry for many researchers just now. Markers vary in what they are looking at, what they mean and some…though very good in theory…are not currently available for most patients.

                                                  Here is a post I put together on the topic…some of the abstracts are fresh out of ASCO this year….with abstracts and links to more within:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-measuring-t-cell-exhaution-to.html

                                                  Overall, LOW….LDH, AMC, and MDSC's bode well for those treated with immunotherapy.  (Follow the links and you will find abstracts and reports that explain.)

                                                  Wishing you all my best. Celeste

                                                   

                                              Viewing 8 reply threads
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